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Aliases for STS Gene

Aliases for STS Gene

  • Steroid Sulfatase (Microsomal), Isozyme S 2 3 5
  • Arylsulfatase C 2 3 4
  • Steryl-Sulfate Sulfohydrolase 3 4
  • EC 4 63
  • ARSC1 3 4
  • ASC 3 4
  • Steroid Sulfatase (Microsomal), Arylsulfatase C, Isozyme S 2
  • Estrone Sulfatase 3
  • Steroid Sulfatase 4
  • EC 3.1.6 63
  • ARSC 3
  • SSDD 3
  • XLI 3
  • ES 3

External Ids for STS Gene

Previous HGNC Symbols for STS Gene

  • ARSC1

Previous GeneCards Identifiers for STS Gene

  • GC0XP002655
  • GC0XP005924
  • GC0XP006533
  • GC0XP006599
  • GC0XP006997
  • GC0XP004994

Summaries for STS Gene

Entrez Gene Summary for STS Gene

  • This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016]

GeneCards Summary for STS Gene

STS (Steroid Sulfatase (Microsomal), Isozyme S) is a Protein Coding gene. Diseases associated with STS include Ichthyosis, X-Linked and Ichthyosis Vulgaris. Among its related pathways are Estrone metabolism and Sphingolipid metabolism. GO annotations related to this gene include sulfuric ester hydrolase activity and steryl-sulfatase activity. An important paralog of this gene is ARSJ.

UniProtKB/Swiss-Prot for STS Gene

  • Conversion of sulfated steroid precursors to estrogens during pregnancy.

Gene Wiki entry for STS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STS Gene

Genomics for STS Gene

Regulatory Elements for STS Gene

Enhancers for STS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STS on UCSC Golden Path with GeneCards custom track

Promoters for STS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STS on UCSC Golden Path with GeneCards custom track

Genomic Location for STS Gene

7,146,517 bp from pter
7,354,810 bp from pter
208,294 bases
Plus strand

Genomic View for STS Gene

Genes around STS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STS Gene

Proteins for STS Gene

  • Protein details for STS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RA47

    Protein attributes for STS Gene

    583 amino acids
    Molecular mass:
    65492 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for STS Gene

neXtProt entry for STS Gene

Proteomics data for STS Gene at MOPED

Selected DME Specific Peptides for STS Gene

Post-translational modifications for STS Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn 47 and Asn 259
  • Modification sites at PhosphoSitePlus

Other Protein References for STS Gene

Antibody Products

Domains & Families for STS Gene

Gene Families for STS Gene

Protein Domains for STS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfatase family.
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with STS: view

Function for STS Gene

Molecular function for STS Gene

GENATLAS Biochemistry:
steroid,arylsulfatase C,X-linked,steroid sulfatase,microsomal,slow isoform,membrane bound,escaping inactivation
UniProtKB/Swiss-Prot CatalyticActivity:
3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H(2)O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.
UniProtKB/Swiss-Prot Function:
Conversion of sulfated steroid precursors to estrogens during pregnancy.

Enzyme Numbers (IUBMB) for STS Gene

genes like me logo Genes that share phenotypes with STS: view

Human Phenotype Ontology for STS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for STS Gene

Localization for STS Gene

Subcellular locations from UniProtKB/Swiss-Prot for STS Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for STS Gene COMPARTMENTS Subcellular localization image for STS gene
Compartment Confidence
endoplasmic reticulum 5
lysosome 5
plasma membrane 5
vacuole 5
endosome 4
golgi apparatus 4
nucleus 2
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 2668275
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
genes like me logo Genes that share ontologies with STS: view

Pathways & Interactions for STS Gene

genes like me logo Genes that share pathways with STS: view

Interacting Proteins for STS Gene

Gene Ontology (GO) - Biological Process for STS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0007611 learning or memory IEA --
GO:0008152 metabolic process IEA --
GO:0008544 epidermis development TAS 9252398
GO:0014070 response to organic cyclic compound IEA --
genes like me logo Genes that share ontologies with STS: view

No data available for SIGNOR curated interactions for STS Gene

Drugs & Compounds for STS Gene

(65) Drugs for STS Gene - From: DrugBank, ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Norelgestromin Approved Pharma Enzyme, inhibitor 24
Estrone Approved Pharma Agonist Estrogenic hormone 19
Axitinib Approved, Investigational Pharma Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 103
Benzocaine Approved Pharma 1733
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 1910

(39) Additional Compounds for STS Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
estrone sulfate
  • Conestoral
  • Estrogenic substances
  • Estrone
  • Estrone hydrogen sulfate
  • Estrone hydrogen sulphate
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
3beta-Hydroxypregn-5-en-20-one sulfate
Androsterone sulfate
  • 3alpha-Sulfate-5alpha-androstan-17-one
  • 5alpha-Androsterone sulfate
  • 5alpha-Androsterone sulphate
  • Andros-S
  • Androsterone 3alpha-sulfate
Cholesterol sulfate
  • 5-Cholesten-3b-yl sulfate
  • 5-Cholesten-3b-yl sulphate
  • Cholest-5-en-3b-ol sulfate
  • Cholest-5-en-3b-ol sulphate
  • Cholesterol 3-sulfate
genes like me logo Genes that share compounds with STS: view

Transcripts for STS Gene

Alternative Splicing Database (ASD) splice patterns (SP) for STS Gene

No ASD Table

Relevant External Links for STS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STS Gene

mRNA expression in normal human tissues for STS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STS Gene

This gene is overexpressed in Nasal epithelium (37.8) and Placenta (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for STS Gene

SOURCE GeneReport for Unigene cluster for STS Gene Hs.522578

genes like me logo Genes that share expression patterns with STS: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for STS Gene

Orthologs for STS Gene

This gene was present in the common ancestor of animals.

Orthologs for STS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STS 35
  • 77.11 (n)
  • 78.23 (a)
STS 36
  • 77 (a)
(Canis familiaris)
Mammalia STS 35
  • 79.27 (n)
  • 79.51 (a)
STS 36
  • 77 (a)
(Pan troglodytes)
Mammalia STS 35
  • 99.65 (n)
  • 99.48 (a)
STS 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sts 35
  • 63.37 (n)
  • 64.73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
-- 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia STS 36
  • 71 (a)
(Gallus gallus)
Aves STS 35
  • 67.97 (n)
  • 66.37 (a)
STS 36
  • 63 (a)
(Anolis carolinensis)
Reptilia STS 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sts 35
  • 62.92 (n)
  • 62.92 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32728 35
(Danio rerio)
Actinopterygii sec61a 35
sts 35
  • 62.05 (n)
  • 60.07 (a)
sts 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea sul-2 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for STS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STS Gene

Gene Tree for STS (if available)
Gene Tree for STS (if available)

Paralogs for STS Gene

Paralogs for STS Gene

(5) SIMAP similar genes for STS Gene using alignment to 5 proteins: Pseudogenes for STS Gene

genes like me logo Genes that share paralogs with STS: view

Variants for STS Gene

Sequence variations from dbSNP and Humsavar for STS Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_007240 Ichthyosis, X-linked (IXL)
VAR_007241 Ichthyosis, X-linked (IXL)
VAR_007242 Ichthyosis, X-linked (IXL)
VAR_014020 Ichthyosis, X-linked (IXL)
VAR_014021 Ichthyosis, X-linked (IXL)

Structural Variations from Database of Genomic Variants (DGV) for STS Gene

Variant ID Type Subtype PubMed ID
esv2657313 CNV Deletion 23128226
nsv9931 CNV Gain 18304495
dgv2435e1 CNV Complex 17122850
esv2678334 CNV Deletion 23128226

Variation tolerance for STS Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for STS Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STS Gene

Disorders for STS Gene

MalaCards: The human disease database

(24) MalaCards diseases for STS Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ichthyosis, x-linked
  • x-linked ichthyosis
ichthyosis vulgaris
  • dominant congenital ichthyosiform erythroderma
syndromic x-linked ichthyosis
  • syndromic rxli
pre-descemet corneal dystrophy
  • pdcd
smith-lemli-opitz syndrome
  • rutledge lethal multiple congenital anomaly syndrome
- elite association - COSMIC cancer census association via MalaCards
Search STS in MalaCards View complete list of genes associated with diseases


  • Ichthyosis, X-linked (IXL) [MIM:308100]: A keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. {ECO:0000269 PubMed:10679952, ECO:0000269 PubMed:10844566, ECO:0000269 PubMed:1539590, ECO:0000269 PubMed:9252398}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for STS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with STS: view

No data available for Genatlas for STS Gene

Publications for STS Gene

  1. PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene. (PMID: 10679952) Sugawara T. … Fujimoto S. (Hum. Mutat. 2000) 3 4 23 67
  2. Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer. (PMID: 15860265) Pasqualini J.R. … Chetrite G.S. (J. Steroid Biochem. Mol. Biol. 2005) 23 25 26
  3. The selective estrogen enzyme modulators in breast cancer: a review. (PMID: 15172700) Pasqualini J.R. (Biochim. Biophys. Acta 2004) 23 25 26
  4. Norelgestromin as selective estrogen enzyme modulator in human breast cancer cell lines. Effect on sulfatase activity in comparison to medroxyprogesterone acetate. (PMID: 12711003) Pasqualini J.R. … Chetrite G.S. (J. Steroid Biochem. Mol. Biol. 2003) 23 25 26
  5. Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients. (PMID: 20151319) Chanplakorn N. … Sasano H. (Breast Cancer Res. Treat. 2010) 3 23

Products for STS Gene

Sources for STS Gene