Aliases for PROS1 Gene
External Ids for PROS1 Gene
Previous Symbols for PROS1 Gene
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]
GeneCards Summary for PROS1 Gene
PROS1 (Protein S (Alpha)) is a Protein Coding gene. Diseases associated with PROS1 include thrombophilia due to protein s deficiency, autosomal dominant and thrombophilia due to protein s deficiency, autosomal recessive. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include calcium ion binding and endopeptidase inhibitor activity. An important paralog of this gene is SHBG.
UniProtKB/Swiss-Prot for PROS1 Gene
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis