Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IFNG Gene

Aliases for IFNG Gene

  • Interferon, Gamma 2 3
  • Immune Interferon 3 4
  • IFN-Gamma 3 4
  • IFG 3 6
  • IFI 3 6
  • Interferon Gamma 3

External Ids for IFNG Gene

Previous GeneCards Identifiers for IFNG Gene

  • GC12M068352
  • GC12M068265
  • GC12M066834
  • GC12M068548
  • GC12M065599

Summaries for IFNG Gene

Entrez Gene Summary for IFNG Gene

  • This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]

GeneCards Summary for IFNG Gene

IFNG (Interferon, Gamma) is a Protein Coding gene. Diseases associated with IFNG include aplastic anemia and tsc2 angiomyolipomas, renal, modifier of. Among its related pathways are TGF-Beta Pathway and Epstein-Barr virus infection. GO annotations related to this gene include cytokine activity and interferon-gamma receptor binding.

UniProtKB/Swiss-Prot for IFNG Gene

  • Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons

Gene Wiki entry for IFNG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNG Gene

Genomics for IFNG Gene

Regulatory Elements for IFNG Gene

Genomic Location for IFNG Gene

Start:
68,154,768 bp from pter
End:
68,159,747 bp from pter
Size:
4,980 bases
Orientation:
Minus strand

Genomic View for IFNG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IFNG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNG Gene

Proteins for IFNG Gene

  • Protein details for IFNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01579-IFNG_HUMAN
    Recommended name:
    Interferon gamma
    Protein Accession:
    P01579
    Secondary Accessions:
    • B5BU88
    • Q53ZV4

    Protein attributes for IFNG Gene

    Size:
    166 amino acids
    Molecular mass:
    19348 Da
    Quaternary structure:
    • Homodimer

    Three dimensional structures from OCA and Proteopedia for IFNG Gene

neXtProt entry for IFNG Gene

Proteomics data for IFNG Gene at MOPED

Post-translational modifications for IFNG Gene

  • Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • Glycosylation at Asn48 and Asn120
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IFNG (IFNG)

Protein Products

No data available for DME Specific Peptides for IFNG Gene

Domains for IFNG Gene

Gene Families for IFNG Gene

HGNC:
  • IFN :Interferons

Protein Domains for IFNG Gene

Suggested Antigen Peptide Sequences for IFNG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01579

UniProtKB/Swiss-Prot:

IFNG_HUMAN :
  • P01579
Family:
  • Belongs to the type II (or gamma) interferon family.
genes like me logo Genes that share domains with IFNG: view

Function for IFNG Gene

Molecular function for IFNG Gene

GENATLAS Biochemistry: interferon type II,gamma,19.3kDa,expressed by lymphocytes,involved in immunoregulation
UniProtKB/Swiss-Prot Function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons

LifeMap Function Summary for IFNG Gene

IFNG as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for IFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005133 interferon-gamma receptor binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IFNG: view
genes like me logo Genes that share phenotypes with IFNG: view

Animal Models for IFNG Gene

MGI Knock Outs for IFNG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IFNG Gene

Localization for IFNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFNG Gene COMPARTMENTS Subcellular localization image for IFNG gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for IFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IFNG: view

Pathways for IFNG Gene

genes like me logo Genes that share pathways with IFNG: view

PCR Array Products

Gene Ontology (GO) - Biological Process for IFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 15604419
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001781 neutrophil apoptotic process IEA --
GO:0002026 regulation of the force of heart contraction IEA --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
genes like me logo Genes that share ontologies with IFNG: view

Compounds for IFNG Gene

UniProtKB/Swiss-Prot:

P01579-IFNG_HUMAN
Pharmaceutical: Available under the name Actimmune (Genentech). Used for reducing the frequency and severity of serious infections associated with chronic granulomatous disease (CGD)

(1) HMDB Compounds for IFNG Gene

Compound Synonyms Cas Number PubMed IDs
Simvastatin
  • (+)-Simvastatin
79902-63-9

(2) Drugbank Compounds for IFNG Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glucosamine
3416-24-8 target
Olsalazine
15722-48-2 target

(121) Novoseek inferred chemical compound relationships for IFNG Gene

Compound -log(P) Hits PubMed IDs
rantes 82.3 198
tuberculin 81.7 136
indoleamine 81.5 118
neopterin 80.5 210
il 10 79.5 155
genes like me logo Genes that share compounds with IFNG: view

Transcripts for IFNG Gene

mRNA/cDNA for IFNG Gene

(40) Selected AceView cDNA sequences:
(20) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNG Gene

Interferon, gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IFNG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNG Gene

No ASD Table

Relevant External Links for IFNG Gene

GeneLoc Exon Structure for
IFNG
ECgene alternative splicing isoforms for
IFNG

Expression for IFNG Gene

mRNA expression in normal human tissues for IFNG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFNG Gene

This gene is overexpressed in Whole Blood (29.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IFNG Gene

SOURCE GeneReport for Unigene cluster for IFNG Gene Hs.856

mRNA Expression by UniProt/SwissProt for IFNG Gene

P01579-IFNG_HUMAN
Tissue specificity: Released primarily from activated T lymphocytes
genes like me logo Genes that share expressions with IFNG: view

In Situ Assay Products

Orthologs for IFNG Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNG 35
  • 99.2 (n)
  • 99.4 (a)
IFNG 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IFNG 35
  • 75.35 (n)
  • 61.82 (a)
IFNG 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFN-GAMMA 36
  • 66 (a)
OneToOne
IFNG 35
  • 77.71 (n)
  • 65.66 (a)
mouse
(Mus musculus)
Mammalia Ifng 35
  • 62.99 (n)
  • 41.56 (a)
Ifng 16
Ifng 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFNG 36
  • 32 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifng 35
  • 60.65 (n)
  • 39.35 (a)
chicken
(Gallus gallus)
Aves IFN-GAMMA 36
  • 33 (a)
OneToOne
Species with no ortholog for IFNG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNG Gene

ENSEMBL:
Gene Tree for IFNG (if available)
TreeFam:
Gene Tree for IFNG (if available)

Paralogs for IFNG Gene

No data available for Paralogs for IFNG Gene

Variants for IFNG Gene

Sequence variations from dbSNP and Humsavar for IFNG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1042274 -- 68,155,338(-) TGCCT(A/G)Caata utr-variant-3-prime
rs1861493 -- 68,157,416(+) AGTGA(A/G)CCTAA intron-variant
rs1861494 -- 68,157,629(+) CTCCC(C/T)GCTTC intron-variant
rs2069705 -- 68,161,231(-) AGAAG(C/T)TAACT upstream-variant-2KB
rs2069706 -- 68,160,536(-) CACTG(C/T)GTCTG upstream-variant-2KB

Relevant External Links for IFNG Gene

HapMap Linkage Disequilibrium report
IFNG
Human Gene Mutation Database (HGMD)
IFNG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IFNG Gene

Disorders for IFNG Gene

(5) OMIM Diseases for IFNG Gene (147570)

UniProtKB/Swiss-Prot

IFNG_HUMAN
  • Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

(5) University of Copenhagen DISEASES for IFNG Gene

(97) Novoseek inferred disease relationships for IFNG Gene

Disease -log(P) Hits PubMed IDs
necrosis 92.8 269
tumors 86.1 381
inflammation 81.3 133
tuberculosis 79.2 313
autoimmune diseases 76.4 97

Relevant External Links for IFNG

Genetic Association Database (GAD)
IFNG
Human Genome Epidemiology (HuGE) Navigator
IFNG
genes like me logo Genes that share disorders with IFNG: view

Publications for IFNG Gene

  1. Homozygosis for (12) CA repeats in the first intron of the human IFN- gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. (PMID: 15327519) Dufour C. … Iolascon A. (Br. J. Haematol. 2004) 3 4 23 48
  2. Association between IFNA genotype and the risk of sarcoidosis. (PMID: 15004750) Akahoshi M. … Shirakawa T. (Hum. Genet. 2004) 3 23 48
  3. A polymorphism of interferon-gamma gene associated with changes of anti-thyrotropin receptor antibodies induced by antithyroid drug treatment for Graves' disease in Japanese patients. (PMID: 15068623) Fukutani T. … Yamada K. (Thyroid 2004) 3 23 48
  4. Lack of IFN-gamma 2/2 homozygous genotype independently of recipient age and intensity of conditioning regimen influences the risk of aGVHD manifestation after HLA-matched sibling haematopoietic stem cell transplantation. (PMID: 15235581) Mlynarczewska A. … Lange A. (Bone Marrow Transplant. 2004) 3 23 48
  5. Single nucleotide polymorphisms in the interferon-gamma and interleukin-10 genes do not influence chronic hepatitis C severity or T-cell reactivity to hepatitis C virus. (PMID: 15078471) Abbott W.G. … Naoumov N.V. (Liver Int. 2004) 3 23 48

Products for IFNG Gene

  • Addgene plasmids for IFNG

Sources for IFNG Gene

Back to Top

Content