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Aliases for IFNG Gene

Aliases for IFNG Gene

  • Interferon, Gamma 2 3 5
  • Immune Interferon 3 4
  • IFN-Gamma 3 4
  • IFG 3
  • IFI 3

External Ids for IFNG Gene

Previous GeneCards Identifiers for IFNG Gene

  • GC12M068352
  • GC12M068265
  • GC12M066834
  • GC12M068548
  • GC12M065599

Summaries for IFNG Gene

Entrez Gene Summary for IFNG Gene

  • This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

GeneCards Summary for IFNG Gene

IFNG (Interferon, Gamma) is a Protein Coding gene. Diseases associated with IFNG include Aplastic Anemia and Hepatitis C Virus. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and Th17 Differentiation Pathway. GO annotations related to this gene include cytokine activity and interferon-gamma receptor binding.

UniProtKB/Swiss-Prot for IFNG Gene

  • Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

Gene Wiki entry for IFNG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNG Gene

Genomics for IFNG Gene

Regulatory Elements for IFNG Gene

Enhancers for IFNG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFNG on UCSC Golden Path with GeneCards custom track

Genomic Location for IFNG Gene

68,154,768 bp from pter
68,159,747 bp from pter
4,980 bases
Minus strand

Genomic View for IFNG Gene

Genes around IFNG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNG Gene

Proteins for IFNG Gene

  • Protein details for IFNG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon gamma
    Protein Accession:
    Secondary Accessions:
    • B5BU88
    • Q53ZV4

    Protein attributes for IFNG Gene

    166 amino acids
    Molecular mass:
    19348 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IFNG Gene

neXtProt entry for IFNG Gene

Proteomics data for IFNG Gene at MOPED

Post-translational modifications for IFNG Gene

  • Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • Glycosylation at Asn 48 and Asn 120
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNG Gene

Domains & Families for IFNG Gene

Gene Families for IFNG Gene

Protein Domains for IFNG Gene

Suggested Antigen Peptide Sequences for IFNG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type II (or gamma) interferon family.
  • Belongs to the type II (or gamma) interferon family.
genes like me logo Genes that share domains with IFNG: view

Function for IFNG Gene

Molecular function for IFNG Gene

GENATLAS Biochemistry:
interferon type II,gamma,19.3kDa,expressed by lymphocytes,involved in immunoregulation
UniProtKB/Swiss-Prot Function:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

LifeMap Function Summary for IFNG Gene

IFNG as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
genes like me logo Genes that share phenotypes with IFNG: view

Human Phenotype Ontology for IFNG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IFNG Gene

MGI Knock Outs for IFNG:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for IFNG Gene

Localization for IFNG Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNG Gene


Subcellular locations from

Jensen Localization Image for IFNG Gene COMPARTMENTS Subcellular localization image for IFNG gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
mitochondrion 2
vacuole 2
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for IFNG Gene

Pathways & Interactions for IFNG Gene

genes like me logo Genes that share pathways with IFNG: view

Pathways by source for IFNG Gene

SIGNOR curated interactions for IFNG Gene


Gene Ontology (GO) - Biological Process for IFNG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 15604419
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA,ISS --
GO:0001781 neutrophil apoptotic process IEA --
GO:0002250 adaptive immune response IEA,IBA --
GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response IEA --
genes like me logo Genes that share ontologies with IFNG: view

Drugs & Compounds for IFNG Gene

(73) Drugs for IFNG Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olsalazine Approved Pharma Target 1
Glucosamine Approved Nutra Target 158
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 499
Fontolizumab Investigational Pharma antibody, Target 0
VIR201 Investigational Pharma Target 0

(53) Additional Compounds for IFNG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNG: view

Transcripts for IFNG Gene

mRNA/cDNA for IFNG Gene

(1) REFSEQ mRNAs :
(20) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNG Gene

Interferon, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFNG Gene

No ASD Table

Relevant External Links for IFNG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNG Gene

mRNA expression in normal human tissues for IFNG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFNG Gene

This gene is overexpressed in Whole Blood (x29.9).

Protein differential expression in normal tissues from HIPED for IFNG Gene

This gene is overexpressed in Testis (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFNG Gene

SOURCE GeneReport for Unigene cluster for IFNG Gene Hs.856

mRNA Expression by UniProt/SwissProt for IFNG Gene

Tissue specificity: Released primarily from activated T lymphocytes.
genes like me logo Genes that share expression patterns with IFNG: view

Protein tissue co-expression partners for IFNG Gene

Primer Products

Orthologs for IFNG Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IFNG 35
  • 75.35 (n)
  • 61.82 (a)
  • 61 (a)
(Canis familiaris)
Mammalia IFNG 35
  • 77.71 (n)
  • 65.66 (a)
  • 66 (a)
(Mus musculus)
Mammalia Ifng 35
  • 62.99 (n)
  • 41.56 (a)
Ifng 16
Ifng 36
  • 41 (a)
(Pan troglodytes)
Mammalia IFNG 35
  • 99.2 (n)
  • 99.4 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ifng 35
  • 60.65 (n)
  • 39.35 (a)
(Ornithorhynchus anatinus)
Mammalia IFNG 36
  • 32 (a)
(Gallus gallus)
  • 33 (a)
Species with no ortholog for IFNG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNG Gene

Gene Tree for IFNG (if available)
Gene Tree for IFNG (if available)

Paralogs for IFNG Gene

No data available for Paralogs for IFNG Gene

Variants for IFNG Gene

Sequence variations from dbSNP and Humsavar for IFNG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_004017 -
rs201359065 - 68,155,375(+) GACCT(C/T)GAAAC reference, missense
rs2069705 -- 68,161,231(-) AGAAG(C/T)TAACT upstream-variant-2KB
rs2069706 -- 68,160,536(-) CACTG(C/T)GTCTG upstream-variant-2KB
rs2069707 -- 68,160,508(-) ATTCT(C/G)TACAC upstream-variant-2KB

Variation tolerance for IFNG Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFNG Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IFNG Gene

Disorders for IFNG Gene

MalaCards: The human disease database

(209) MalaCards diseases for IFNG Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
aplastic anemia
  • pulmonary fibrosis, idiopathic
hepatitis c virus
  • hepatitic c virus
tsc2 angiomyolipomas, renal, modifier of
  • tuberous sclerosis-2
  • aids, slow progression to
aplastic anemia, ifng-related
- elite association - COSMIC cancer census association via MalaCards
Search IFNG in MalaCards View complete list of genes associated with diseases


  • Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. {ECO:0000269 PubMed:15327519}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for IFNG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IFNG: view

No data available for Genatlas for IFNG Gene

Publications for IFNG Gene

  1. Homozygosis for (12) CA repeats in the first intron of the human IFN- gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. (PMID: 15327519) Dufour C. … Iolascon A. (Br. J. Haematol. 2004) 3 4 48 67
  2. Interferon-gamma-mediated pathways are induced in human CD34(+) haematopoietic stem cells. (PMID: 19765856) Kurz K. … Fuchs D. (Immunobiology 2010) 3 23
  3. Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-gamma production. (PMID: 20008289) Basu A. … Briscoe D.M. (J. Immunol. 2010) 3 23
  4. Impact of genomic risk factors on outcome after hematopoietic stem cell transplantation for patients with chronic myeloid leukemia. (PMID: 20305143) Dickinson A.M. … Gratwohl A. (Haematologica 2010) 3 23
  5. Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart. (PMID: 20388088) Licastro F. … Ferrari R. (Curr. Pharm. Des. 2010) 3 23

Products for IFNG Gene

Sources for IFNG Gene