Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHD1L Gene

Aliases for CHD1L Gene

  • Chromodomain Helicase DNA Binding Protein 1-Like 2 3 5
  • Amplified In Liver Cancer Protein 1 3 4
  • Amplified In Liver Cancer 1 2 3
  • ALC1 3 4
  • EC 3.6.4.12 4
  • EC 3.6.1 63
  • CHDL 3

External Ids for CHD1L Gene

Previous GeneCards Identifiers for CHD1L Gene

  • GC01U990222
  • GC01P143439
  • GC01P144058
  • GC01P144221
  • GC01P143939
  • GC01P145180
  • GC01P146717
  • GC01P120126
  • GC01P147174

Summaries for CHD1L Gene

Entrez Gene Summary for CHD1L Gene

  • This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CHD1L Gene

CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like) is a Protein Coding gene. Diseases associated with CHD1L include Fibrosarcoma Of Bone. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA Double-Strand Break Repair. GO annotations related to this gene include nucleic acid binding and hydrolase activity.

UniProtKB/Swiss-Prot for CHD1L Gene

  • DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.

Gene Wiki entry for CHD1L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHD1L Gene

Genomics for CHD1L Gene

Regulatory Elements for CHD1L Gene

Enhancers for CHD1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CHD1L on UCSC Golden Path with GeneCards custom track

Promoters for CHD1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHD1L on UCSC Golden Path with GeneCards custom track

Genomic Location for CHD1L Gene

Chromosome:
1
Start:
147,242,641 bp from pter
End:
147,295,766 bp from pter
Size:
53,126 bases
Orientation:
Plus strand

Genomic View for CHD1L Gene

Genes around CHD1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHD1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHD1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHD1L Gene

Proteins for CHD1L Gene

  • Protein details for CHD1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WJ1-CHD1L_HUMAN
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 1-like
    Protein Accession:
    Q86WJ1
    Secondary Accessions:
    • A5YM64
    • B4DDE1
    • B5MDZ7
    • Q53EZ3
    • Q5VXX7
    • Q6DD94
    • Q6PK83
    • Q86XH3
    • Q96HF7
    • Q96SP3
    • Q9BVJ1
    • Q9NVV8

    Protein attributes for CHD1L Gene

    Size:
    897 amino acids
    Molecular mass:
    100984 Da
    Quaternary structure:
    • Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated).
    SequenceCaution:
    • Sequence=BAB55248.1; Type=Frameshift; Positions=597; Evidence={ECO:0000305};

    Alternative splice isoforms for CHD1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHD1L Gene

Proteomics data for CHD1L Gene at MOPED

Post-translational modifications for CHD1L Gene

  • Ubiquitination at Lys 793
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CHD1L (CHD1L)

Domains & Families for CHD1L Gene

Suggested Antigen Peptide Sequences for CHD1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WJ1

UniProtKB/Swiss-Prot:

CHD1L_HUMAN :
  • The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.
  • Belongs to the SNF2/RAD54 helicase family.
Domain:
  • The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 Macro domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with CHD1L: view

No data available for Gene Families for CHD1L Gene

Function for CHD1L Gene

Molecular function for CHD1L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.

Enzyme Numbers (IUBMB) for CHD1L Gene

Gene Ontology (GO) - Molecular Function for CHD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IDA 19661379
GO:0004003 ATP-dependent DNA helicase activity TAS 19661379
GO:0008026 ATP-dependent helicase activity IEA --
genes like me logo Genes that share ontologies with CHD1L: view
genes like me logo Genes that share phenotypes with CHD1L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHD1L

miRNA for CHD1L Gene

miRTarBase miRNAs that target CHD1L

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHD1L Gene

Localization for CHD1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHD1L Gene

Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHD1L Gene COMPARTMENTS Subcellular localization image for CHD1L gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for CHD1L Gene

Pathways & Interactions for CHD1L Gene

genes like me logo Genes that share pathways with CHD1L: view

Pathways by source for CHD1L Gene

Gene Ontology (GO) - Biological Process for CHD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS --
GO:0006293 nucleotide-excision repair, preincision complex stabilization TAS --
GO:0006338 chromatin remodeling IDA 19661379
GO:0006974 cellular response to DNA damage stimulus IDA 19661379
GO:0070911 global genome nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with CHD1L: view

No data available for SIGNOR curated interactions for CHD1L Gene

Drugs & Compounds for CHD1L Gene

(1) Drugs for CHD1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for CHD1L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with CHD1L: view

Transcripts for CHD1L Gene

Unigene Clusters for CHD1L Gene

Chromodomain helicase DNA binding protein 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHD1L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: -
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: -
SP12:
SP13:
SP14: - -
SP15:

ExUns: 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CHD1L Gene

GeneLoc Exon Structure for
CHD1L
ECgene alternative splicing isoforms for
CHD1L

Expression for CHD1L Gene

mRNA expression in normal human tissues for CHD1L Gene

Protein differential expression in normal tissues from HIPED for CHD1L Gene

This gene is overexpressed in Lymph node (22.5) and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHD1L Gene



SOURCE GeneReport for Unigene cluster for CHD1L Gene Hs.191164

mRNA Expression by UniProt/SwissProt for CHD1L Gene

Q86WJ1-CHD1L_HUMAN
Tissue specificity: Frequently overexpressed in hepatomacellular carcinomas.
genes like me logo Genes that share expression patterns with CHD1L: view

Protein tissue co-expression partners for CHD1L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHD1L Gene

Orthologs for CHD1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHD1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHD1L 35
  • 90.34 (n)
  • 91.61 (a)
CHD1L 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHD1L 35
  • 88.45 (n)
  • 88.04 (a)
CHD1L 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chd1l 35
  • 85.34 (n)
  • 87.64 (a)
Chd1l 16
Chd1l 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHD1L 35
  • 99.14 (n)
  • 99 (a)
CHD1L 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chd1l 35
  • 86.07 (n)
  • 88.18 (a)
oppossum
(Monodelphis domestica)
Mammalia CHD1L 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHD1L 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHD1L 35
  • 72.61 (n)
  • 73.45 (a)
CHD1L 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHD1L 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii chd1l 35
  • 64.05 (n)
  • 66.51 (a)
zgc56084 35
chd1l 36
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ISW2 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G44980 35
  • 51.06 (n)
  • 44.9 (a)
rice
(Oryza sativa)
Liliopsida Os03g0101700 35
  • 48.15 (n)
  • 41.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToOne
Species with no ortholog for CHD1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHD1L Gene

ENSEMBL:
Gene Tree for CHD1L (if available)
TreeFam:
Gene Tree for CHD1L (if available)

Paralogs for CHD1L Gene

(10) SIMAP similar genes for CHD1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHD1L: view

No data available for Paralogs for CHD1L Gene

Variants for CHD1L Gene

Sequence variations from dbSNP and Humsavar for CHD1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11588753 - 147,242,777(+) GGGCC(A/C/G)AGCCG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs17356233 - 147,268,843(+) CTTCA(A/C/G)CTGCT nc-transcript-variant, reference, missense
rs13374920 - 147,285,415(+) ACAAG(A/C)AGCAG nc-transcript-variant, downstream-variant-500B, reference, missense
rs2275249 - 147,287,641(+) TGACT(C/G)TGGCC nc-transcript-variant, reference, missense
rs4950394 - 147,295,468(+) TTCAT(G/T)CACAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CHD1L Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
nsv872251 CNV Gain 21882294
nsv872255 CNV Gain 21882294
nsv872257 CNV Gain 21882294
nsv437047 CNV Loss 16327808
nsv872259 CNV Loss 21882294
esv2717529 CNV Deletion 23290073
dgv354n71 CNV Loss 21882294
dgv355n71 CNV Loss 21882294

Variation tolerance for CHD1L Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.20; 92.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHD1L Gene

Human Gene Mutation Database (HGMD)
CHD1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHD1L Gene

Disorders for CHD1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CHD1L Gene - From: DISEASES

Disorder Aliases PubMed IDs
fibrosarcoma of bone
  • fibrosarcoma of the bone
- elite association - COSMIC cancer census association via MalaCards
Search CHD1L in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHD1L

Genetic Association Database (GAD)
CHD1L
Human Genome Epidemiology (HuGE) Navigator
CHD1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHD1L
genes like me logo Genes that share disorders with CHD1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHD1L Gene

Publications for CHD1L Gene

  1. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. (PMID: 19661379) Ahel D. … Boulton S.J. (Science 2009) 3 4 23 67
  2. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for CHD1L Gene

Sources for CHD1L Gene

Content