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BAG1 Gene

protein-coding GIFtS: 68

GC09M033245

BCL2-associated athanogene
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BAG-1 ^³
HAP ^³
RAP46 ^²

Descriptions
BCL2-associated athanogene ^²
BCL2-associated athanogene 1 ^²
Bcl-2-associated athanogene 1 ^³
Glucocorticoid receptor-associated protein RAP46 ^³

External Ids
HGNC: 937¹
Entrez Gene: 573²
UniProtKB: Q99933³
Ensembl: ENSG00000107262⁷

Search outside databases for aliases for BAG1 gene

Previous GC identifers: GC09M033567 GC09M033423 GC09M033244

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BAG1:

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or

programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as

BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link

between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are

encoded by this mRNA through the use of a non-AUG (CUG) start site, and alternative, downstream,

AUG translation initiation sites. [provided by RefSeq]

UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933

Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits

the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the

anti-cell death function of BCL2 induced by various stimuli

Gene Wiki entry for BAG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BAG1 gene

Entrez Gene cytogenetic band: 9p12 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p12

BAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M033245: (about GC identifiers)

Start:	33,242,469 bp from pter
End:	33,254,761 bp from pter
Size:	12,293 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933 (See protein sequence)

Recommended Name: BAG family molecular chaperone regulator 1

Size: 345 amino acids; 38878 Da

Subunit: Binds to the ATPase domain of HSP70/HSC chaperones. Binds to BCL2 and NR3C1. Interacts

with N-terminal region of STK19. Interacts with PPP1R15A. Isoform 2 doesn't interact with

HSP70/HSC or BCL2

Subcellular location: Isoform 2: Cytoplasm. Nucleus. Note=Isoform2 localizes to the cytoplasm and

shuttles into the nucleus in response to heat shock

PDB structures from and Proteopedia :

1HX1 (3D)

1WXV (3D)

3FZF (3D)

3FZH (3D)

3FZK (3D)

3FZL (3D)

3FZM (3D)

Secondary accessions: O75315 Q14414 Q96TG2 Q9Y2V4

Alternative splicing: 2 isoforms: Q99933-1 Q99933-2

Post-translational modifications:

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation

(Probable)¹

REFSEQ proteins: NP_004314.4

ENSEMBL proteins:

ENSP00000369023 ENSP00000369029 ENSP00000369026 ENSP00000224112 ENSP00000369022 ENSP00000368916

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Bag1)
	Human Recombinant Proteins from Abnova (BAG1)

OriGene Purified Recombinant Human Protein: BAG1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	8947043

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Antibodies for BAG1:

	Invitrogen Antibodies for BAG1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for BAG1
	R&D Systems Antibodies for BAG1 (Bag-1)
	Antibodies from Abcam (Bag1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for BAG1

Assays for BAG1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q99933

ProtoNet protein and cluster: Q99933

2 Blocks protein families:

IPB000626 Ubiquitin domain

IPB003103 Apoptosis regulator Bcl-2 protein

UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933

Similarity: Contains 1 BAG domain

Similarity: Contains 1 ubiquitin-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BAG1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BAG1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004323

Applied Biosystems Silencer® siRNAs for BAG1

Sigma-Aldrich siRNA and siRNA Panels for BAG1

Sigma-Aldrich shRNA Panels and shRNA for BAG1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004323
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004323
untagged cDNA clone in CMV expression vector: NM_004323

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004323

UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933

Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits

the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the

anti-cell death function of BCL2 induced by various stimuli

Genatlas biochemistry entry for BAG1:

BCL2-associated athanogene 1 (antiapoptotic),negative regulator of Hsp70 chaperone

activity,multifunctional protein interacting with several types of proteins,including BCL2 family

proteins,certain tyrosine-kinase receptors such as hepatocyte growth factor receptor (MET) and

PDGFR and steroid receptors,mouse Bag1 homolog,with four isoforms (50,46 (RAP46),33 and

29kDa),overexpressed in cervical,breast (invasive carcinomas) and lung cancer cell lines

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bag1):

lethality-prenatal/perinatal

liver/biliary system

tumorigenesis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005057	receptor signaling protein activity	TAS	8947043
GO:0005515	protein binding	IPI	11222862

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for BAG1 (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway
Glucocorticoid Receptor Signaling

GeneDecks BAG1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for BAG1

5/10 Interacting proteins for BAG1 (ENSP00000368916³ Q99933^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 10 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPA8 HSPA8 (xeno)	P19120¹	EBI-1030678, EBI-907802
ENSG00000204388	P08107²	MINT-45860 MINT-45859
ENSG00000212866	P08107²	MINT-45860 MINT-45859
ENSG00000215292	P08107²	MINT-45860 MINT-45859
HSPA1A	P08107²	MINT-45860 MINT-45859

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	IEA	--
GO:0006915	apoptosis	IEA	--
GO:0006916	anti-apoptosis	TAS	8947043
GO:0007166	cell surface receptor linked signal transduction	TAS	8947043

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BAG1
6 Novoseek chemical compound relationships for BAG1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
steroid	39.66	23	10567384 (3), 15297164 (1), 17323428 (1), 9305631 (1) (see all 15)
atp	15.61	3	9321400 (1), 9305631 (1), 11741305 (1)
progesterone	12.94	10	18430249 (3), 15026618 (3), 15297164 (1), 11181661 (1) (see all 6)
adp	0.00	2	9321400 (2)
tyrosine	0.00	8	8943845 (2), 8947043 (1), 9305631 (1), 9679980 (1) (see all 5)
thymidine	0.00	1	15198484 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BAG1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BAG1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004323

Sigma-Aldrich siRNA and siRNA Panels for BAG1

Sigma-Aldrich shRNA Panels and shRNA for BAG1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004323

REFSEQ mRNAs for BAG1 gene:

NM_004323.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004323

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004323
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004323
                                 untagged cDNA clone in CMV expression vector: NM_004323

Additional cDNA sequence:

AF022224.1 AF116273.1 AK093238.1 AK096038.1 AK222749.1 AK316577.1 BC001936.1 BC014774.1

BC073955.1 CR600928.1 CR603873.1 CR605802.1 CR614940.1 CR618366.1 CR618567.1 U46917.1

Z35491.1

17 DOTS entries:

DT.315269 DT.97839334 DT.100837530 DT.101963542 DT.111920 DT.100028750 DT.100837517 DT.100837526

DT.80100284 DT.100837522 DT.95343676 DT.111921 DT.75195442 DT.92407910 DT.95328823 DT.407507

DT.92439425

24/321 AceView cDNA sequences (see all 321 ):

BC001936 CR605802 CF126150 BM768501 BM824290 BQ673460 AI656087 CD366964

CR618366 BQ669503 BC014774 CB306226 AW769375 AA027283 AI659059 BX363633

D31323 BM702786 BM924910 BM699480 AI924573 AL600147 BM695593 BQ017480

highest scoring ESTs for BAG1:

Z35491 AF022224 AW024280 AW024313 AW410499 BC001936 BC014774 BE260047 BE270208 BE336832

Unigene Cluster for BAG1:

BCL2-associated athanogene

Hs.377484 [show with all ESTs]

Unigene Representative Sequence: NM_004323

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for BAG1

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8
SP1:									-						-				-
SP2:
SP3:															-
SP4:
SP5:							-		-

About this scheme

ECgene alternative splicing isoforms for BAG1

6 Ensembl transcripts including schematic representations:

ENST00000379701 ENST00000379707 ENST00000379704 ENST00000224112 ENST00000379700 ENST00000317902

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BAG1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BAG1

¹ / ² / ³

11 probe-sets matching BAG1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
71009_at²^{, 3}	U95-E	1	1.00	1.00	0.10	0.88	T97294	0.60	1.00	0.82	1
47643_at²^{, 3}	U95-B	1	1.00	1.00	-0.16	0.75	H10322	0.40	1.00	0.76	1
34798_at²^{, 3}	U95-A	2	1.00	0.94	0.93	0.95	Z35491	1.00	1.00	1.00	1
80600_s_at²^{, 3}	U95-E	2	1.00	0.78	0.94	1.29	AW024280	0.80	1.00	0.91	1
75105_f_at²^{, 3}	U95-D	1	0.62	1.00	0.91	1.14	AW024313	0.80	1.00	0.91	1
202387_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004323	0.60	1.00	0.82	1
229720_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA394039	0.20	1.00	0.72	1
211475_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AF116273	0.60	1.00	0.82	1
202387_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229720_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211475_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks BAG1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAATTGGGA

SOURCE GeneReport for Unigene cluster: Hs.377484
Expression variation in blood from EXPOLDB for BAG1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BAG1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BAG1¹	--	BCL2-associated athanogene	87.75(n) 82.87(a)	611781 XM_849492.1 XP_854585.1
chimpanzee (Pan troglodytes)	BAG1¹	--	BCL2-associated athanogene	94.34(n) 93.52(a)	465041 XM_520528.2 XP_520528.2
cow (Bos taurus)	BAG1¹	--	BCL2-associated athanogene	81.92(n) 75.49(a)	781741 XM_001250234.1 XP_001250235.1
rat (Rattus norvegicus)	Bag1¹	--	BCL2-associated athanogene	83.33(n) 78.5(a)	297994 XM_216377.4 XP_216377.3
mouse (Mus musculus)	Bag1^{1, 5}	4⁵	BCL2-associated athanogene 1^{1, 5}	81.35(n)¹ 73.04(a)¹	12017¹ NM_009736.1¹ NP_033866.3¹ AF019889⁵ AF022223⁵ (see all 21)

About this table Species with no ortholog for BAG1

ENSEMBL Gene Tree for BAG1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/63 NCBI SNPs in BAG1 are shown (see all 63 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs706115^1,2	A,C,F,H,O	33243605(+)	`GAGGTC/GTTAAC`	1	--	ut3¹		12		MN EU EA WA NA	1106
	rs16919129^1,2	C,F,H	33244674(+)	`TAGAAC/ACCAAC`	1	--	ut3¹ ese³		11		NA EU EA WA	966
--	rs474884^1,2	A,C	33243833(+)	`TTTATC/TTATCT`	1	--	ut3¹		0	--	--	--	--
	rs16919125^1,2	F,H	33242803(+)	`TTCTCC/AATGCA`	1	--	ut3¹		7		NA EU EA WA	562
--	rs542912^1,2	A,F	33242783(+)	`CTCAAC/GACAGT`	1	--	ut3¹		1		MN	184
--	rs10121459^1,2	C	33244923(+)	`CCCAAA/GGAAAG`	1	--	ut3¹		0	--	--	--	--
	rs706116^1,2	H	33243737(+)	`GAGCCA/CCAGAA`	1	--	ut3¹		5		MN EU EA WA	600
	rs706120^1,2	A,C,F,H	33250384(-)	`GAGAAA/GTGAAT`	1	--	int¹		8		EU EA WA	838
	rs706121^1,2	A,C,F,H	33250632(-)	`GAAAGA/GAAGGT`	1	--	int¹ trp³		11		EA NA EU WA	888
	rs706119^1,2	A,C,F,H	33249777(-)	`AGGAGA/CGCTCA`	1	--	int¹		8		EU EA WA	838

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HapMap Linkage Disequilibrium images for BAG1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601497

UniProtKB/Swiss-Prot: BAG1_HUMAN, Q99933

May be linked to the cryptophthalmos syndrome (Fraser syndrome), an autosomal recessive

disorder characterized by the failure of eyes fissures to form during embryogenesis, webbed

fingers, and atresia of ear canals, anus, vagina, alimentary tract, or larynx. All these

developmental processes require cell death

10/26 Novoseek disease relationships for BAG1 gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	57.10	25	11494137 (2), 12558971 (2), 15003494 (2), 12874020 (2) (see all 15)
breast cancer	40.58	69	10576663 (5), 11181661 (5), 15026618 (4), 12874020 (4) (see all 21)
cancer	34.73	33	12373595 (5), 10772821 (2), 15297164 (2), 15033003 (2) (see all 15)
tumors	24.78	33	18795671 (3), 10467399 (3), 18430249 (2), 11494232 (2) (see all 18)
cervical carcinoma	19.85	5	10772821 (2), 10047462 (2), 12370827 (1)
carcinoma	19.44	21	17549665 (5), 16457154 (3), 15297164 (1), 10430086 (1) (see all 9)
colon carcinoma	18.60	8	17657847 (8)
metastasis	17.69	13	17657847 (3), 10964051 (1), 15474970 (1), 15033003 (1) (see all 8)
leukaemia lymphocytic	15.14	1	16501812 (1)
breast carcinoma	13.37	7	10561207 (4), 15026618 (2), 19066611 (1)

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Genetic Association Database: BAG1
Human Genome Epidemiology Navigator: BAG1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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12/181 PubMed articles for BAG1 gene (see all 181 ):

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. (PubMed id 9582267)^{1, 3, 4} Matsuzawa S.... Reed J.C. (1998)
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. (PubMed id 7834747)^{1, 2, 3} Takayama S....Reed J.C. (1995)
Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. (PubMed id 12724406)^{1, 3, 4} Hung W.J.... Wu D.Y. (2003)
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PubMed id 9873016)^{1, 3, 4} Takayama S.... Reed J.C. (1999)
Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity. (PubMed id 15986447)^{3, 4} Wadle A.... Renner C. (2005)
Screening for candidate gene regions in narcolepsy using a microsatellite based approach and pooled DNA. (PubMed id 15309313)^{3, 6} Wieczorek S....Epplen J.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. (PubMed id 11222862)^{3, 4} Sondermann H....Moarefi I. (2001)
A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity. (PubMed id 10477749)^{3, 4} Schneikert J.... Cato A.B.C. (1999)
Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. (PubMed id 8812483)^{3, 4} Takayama S.... Reed J.C. (1996)
The BAG-1 cochaperone is a negative regulator of p73-dependent transcription. (PubMed id 19293798)^{1, 3} Wang X.H....Packham G. (2009)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Search String
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 573	HGNC: 937	AceView: BAG1	Ensembl:ENSG00000107262	euGenes: HUgn573
ECgene: BAG1	H-InvDB: BAG1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BAG1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for BAG1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BAG1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BAG1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BAG1		Antibodies for BAG1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BAG1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BAG1)
	Search for Antibodies
	Chimera RNAi (BAG1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Bag1)
	Antibodies (Bag1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for BAG1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BAG1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BAG1 Gene at Home site.
Version 2.41.1
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BAG1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for BAG1

Summaries
for BAG1

Genomic Location
for BAG1

Proteins
for BAG1

Protein Domains/
Families
for BAG1

Gene Function
for BAG1

Pathways & Interactions
for BAG1

Drugs & Compounds
for BAG1

Transcripts
for BAG1

Expression
for BAG1

Orthologs
for BAG1

Paralogs
for BAG1

SNPs/Variants
for BAG1

Disorders & Mutations
for BAG1

Medical News
for BAG1

Publications
for BAG1

Search for BAG1

Genome Databases showing BAG1

Other Databases showing BAG1

Specialized Databases showing BAG1

Licensable Technologies
for BAG1

Services
for BAG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BAG1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor BAG1

Summariesfor BAG1

Genomic Locationfor BAG1

Proteinsfor BAG1

Protein Domains/Familiesfor BAG1

Gene Functionfor BAG1

Pathways & Interactionsfor BAG1

Drugs & Compoundsfor BAG1

Transcriptsfor BAG1

Expression for BAG1

Orthologsfor BAG1

Paralogsfor BAG1

SNPs/Variantsfor BAG1

Disorders & Mutationsfor BAG1

Medical Newsfor BAG1

Publicationsfor BAG1

Search for BAG1

Genome Databases showing BAG1

Other Databases showing BAG1

Specialized Databases showing BAG1

Licensable Technologiesfor BAG1

Servicesfor BAG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BAG1

Summaries
for BAG1

Genomic Location
for BAG1

Proteins
for BAG1

Protein Domains/
Families
for BAG1

Gene Function
for BAG1

Pathways & Interactions
for BAG1

Drugs & Compounds
for BAG1

Transcripts
for BAG1

Expression
for BAG1

Orthologs
for BAG1

Paralogs
for BAG1

SNPs/Variants
for BAG1

Disorders & Mutations
for BAG1

Medical News
for BAG1

Publications
for BAG1

Licensable Technologies
for BAG1

Services
for BAG1