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Aliases for RNF135 Gene

Aliases for RNF135 Gene

  • Ring Finger Protein 135 2 3
  • Riplet 2 3 4
  • RIG-I E3 Ubiquitin Ligase 3 4
  • MMFD 3 6
  • REUL 3 4
  • E3 Ubiquitin-Protein Ligase RNF135 3
  • RING Finger Protein 135 4
  • EC 6.3.2.- 4
  • L13 3

External Ids for RNF135 Gene

Previous GeneCards Identifiers for RNF135 Gene

  • GC17P029147
  • GC17P029443
  • GC17P026322
  • GC17P029297
  • GC17P025508

Summaries for RNF135 Gene

Entrez Gene Summary for RNF135 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF135 Gene

RNF135 (Ring Finger Protein 135) is a Protein Coding gene. Diseases associated with RNF135 include macrocephaly, macrosomia, facial dysmorphism syndrome and overgrowth - macrocephaly - facial dysmorphism. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include ubiquitin-protein transferase activity and ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot for RNF135 Gene

  • Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.

Gene Wiki entry for RNF135 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF135 Gene

Genomics for RNF135 Gene

Regulatory Elements for RNF135 Gene

Transcription factor binding sites by QIAGEN in the RNF135 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF135 Gene

30,958,292 bp from pter
30,999,911 bp from pter
41,620 bases
Plus strand

Genomic View for RNF135 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF135 Gene

Proteins for RNF135 Gene

  • Protein details for RNF135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF135
    Protein Accession:
    Secondary Accessions:
    • A0AVM5
    • B2R7G9
    • B6ZLM5
    • F5GX60
    • Q9BSE9

    Protein attributes for RNF135 Gene

    432 amino acids
    Molecular mass:
    47888 Da
    Quaternary structure:
    • Interacts with DDX58. Interacts with PCBP2.

    Alternative splice isoforms for RNF135 Gene


neXtProt entry for RNF135 Gene

Proteomics data for RNF135 Gene at MOPED

Post-translational modifications for RNF135 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF135 Gene

No data available for DME Specific Peptides for RNF135 Gene

Domains for RNF135 Gene

Gene Families for RNF135 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Graphical View of Domain Structure for InterPro Entry



  • Q8IUD6
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF135: view

Function for RNF135 Gene

Molecular function for RNF135 Gene

UniProtKB/Swiss-Prot Function: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.

Enzyme Numbers (IUBMB) for RNF135 Gene

Gene Ontology (GO) - Molecular Function for RNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 19484123
GO:0005515 protein binding IPI 19017631
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0043021 ribonucleoprotein complex binding IPI 19881509
genes like me logo Genes that share ontologies with RNF135: view

Phenotypes for RNF135 Gene

GenomeRNAi human phenotypes for RNF135:
genes like me logo Genes that share phenotypes with RNF135: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNF135 Gene

Localization for RNF135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF135 Gene


Subcellular locations from

Jensen Localization Image for RNF135 Gene COMPARTMENTS Subcellular localization image for RNF135 gene
Compartment Confidence
cytosol 4
nucleus 3
endosome 1

Gene Ontology (GO) - Cellular Components for RNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19484123
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RNF135: view

Pathways for RNF135 Gene

genes like me logo Genes that share pathways with RNF135: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q8IUD6-RN135_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0032728 positive regulation of interferon-beta production IMP 19017631
GO:0045087 innate immune response TAS --
GO:0045088 regulation of innate immune response IMP 19017631
genes like me logo Genes that share ontologies with RNF135: view

Transcripts for RNF135 Gene

Unigene Clusters for RNF135 Gene

Ring finger protein 135:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF135

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF135 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP2: -
SP3: - -
SP4: - - -
SP5: - - - -
SP6: -

Relevant External Links for RNF135 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF135 Gene

mRNA expression in normal human tissues for RNF135 Gene

mRNA differential expression in normal tissues according to GTEx for RNF135 Gene

This gene is overexpressed in Whole Blood (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF135 Gene

SOURCE GeneReport for Unigene cluster for RNF135 Gene Hs.29874

mRNA Expression by UniProt/SwissProt for RNF135 Gene

Tissue specificity: Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung.
genes like me logo Genes that share expressions with RNF135: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RNF135 Gene

Orthologs for RNF135 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF135 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF135 35
  • 98.92 (n)
  • 98.15 (a)
RNF135 36
  • 97 (a)
(Bos Taurus)
Mammalia RNF135 35
  • 77.75 (n)
  • 66.75 (a)
RNF135 36
  • 67 (a)
(Canis familiaris)
Mammalia RNF135 35
  • 81.54 (n)
  • 71.18 (a)
RNF135 36
  • 62 (a)
(Mus musculus)
Mammalia Rnf135 35
  • 72.98 (n)
  • 61.41 (a)
Rnf135 16
Rnf135 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia RNF135 36
  • 38 (a)
(Rattus norvegicus)
Mammalia Rnf135 35
  • 74.15 (n)
  • 63.66 (a)
(Anolis carolinensis)
Reptilia RNF135 36
  • 38 (a)
(Danio rerio)
Actinopterygii AL954746.1 36
  • 26 (a)
Species with no ortholog for RNF135:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF135 Gene

Gene Tree for RNF135 (if available)
Gene Tree for RNF135 (if available)

Paralogs for RNF135 Gene

Selected SIMAP similar genes for RNF135 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RNF135: view

No data available for Paralogs for RNF135 Gene

Variants for RNF135 Gene

Sequence variations from dbSNP and Humsavar for RNF135 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13373 -- 30,999,628(-) GTCTC(C/T)TCAGC utr-variant-3-prime
rs952189 -- 30,982,497(-) atgca(A/G)cccat intron-variant
rs952190 -- 30,982,397(-) ttgtc(A/G)cttca intron-variant
rs1039723 -- 30,959,829(+) tgggc(A/G)acaag intron-variant
rs1039724 -- 30,959,837(+) aagag(C/G)gaaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF135 Gene

Variant ID Type Subtype PubMed ID
esv2715813 CNV Deletion 23290073
nsv457720 CNV Loss 19166990
nsv833412 CNV Loss 17160897
nsv908056 CNV Loss 21882294
esv24402 CNV Loss 19812545

Relevant External Links for RNF135 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF135 Gene

Disorders for RNF135 Gene

(1) OMIM Diseases for RNF135 Gene (611358)


  • Macrocephaly, macrosomia, facial dysmorphism syndrome (MMFD) [MIM:614192]: An autosomal dominant disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without renal dysfunction. {ECO:0000269 PubMed:17632510}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RNF135 Gene

Relevant External Links for RNF135

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RNF135: view

Publications for RNF135 Gene

  1. Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. (PMID: 19017631) Oshiumi H. … Seya T. (J. Biol. Chem. 2009) 2 3 4
  2. RNF135 mutations are not present in patients with Sotos syndrome-like features. (PMID: 19291764) Visser R. … Losekoot M. (Am. J. Med. Genet. A 2009) 3 4 48
  3. REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid- inducible gene-I. (PMID: 19484123) Gao D. … Chen D.Y. (PLoS ONE 2009) 3 4
  4. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. (PMID: 19881509) You F. … Jiang Z. (Nat. Immunol. 2009) 3 4
  5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 48

Products for RNF135 Gene

Sources for RNF135 Gene

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