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Aliases for ZIC4 Gene

Aliases for ZIC4 Gene

  • Zic Family Member 4 2 3
  • Zinc Finger Protein Of The Cerebellum 4 2 4

External Ids for ZIC4 Gene

Previous GeneCards Identifiers for ZIC4 Gene

  • GC03M143947
  • GC03M147990
  • GC03M148386
  • GC03M148426
  • GC03M148587
  • GC03M147103
  • GC03M144480

Summaries for ZIC4 Gene

Entrez Gene Summary for ZIC4 Gene

  • This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for ZIC4 Gene

ZIC4 (Zic Family Member 4) is a Protein Coding gene. Diseases associated with ZIC4 include isolated dandy-walker malformation without hydrocephalus and isolated dandy-walker malformation with hydrocephalus. An important paralog of this gene is ZIC3.

UniProtKB/Swiss-Prot for ZIC4 Gene

  • Binds to DNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZIC4 Gene

Genomics for ZIC4 Gene

Regulatory Elements for ZIC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZIC4 Gene

147,386,046 bp from pter
147,406,860 bp from pter
20,815 bases
Minus strand

Genomic View for ZIC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZIC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZIC4 Gene

Proteins for ZIC4 Gene

  • Protein details for ZIC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein ZIC 4
    Protein Accession:
    Secondary Accessions:
    • A0AVA2
    • B2RMQ8
    • B4DF89
    • B7Z2L2
    • C9J7D5
    • J3KQG1
    • Q4G157
    • Q9BZ94

    Protein attributes for ZIC4 Gene

    334 amino acids
    Molecular mass:
    36567 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH29507.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 229.; Evidence={ECO:0000305}; Sequence=AAK06845.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZIC4 Gene


neXtProt entry for ZIC4 Gene

Proteomics data for ZIC4 Gene at MOPED

Post-translational modifications for ZIC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZIC4 Gene

Domains for ZIC4 Gene

Gene Families for ZIC4 Gene

Protein Domains for ZIC4 Gene

Suggested Antigen Peptide Sequences for ZIC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GLI C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
  • Belongs to the GLI C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZIC4: view

Function for ZIC4 Gene

Molecular function for ZIC4 Gene

UniProtKB/Swiss-Prot Function:
Binds to DNA.

Gene Ontology (GO) - Molecular Function for ZIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZIC4: view
genes like me logo Genes that share phenotypes with ZIC4: view

Animal Models for ZIC4 Gene

MGI Knock Outs for ZIC4:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZIC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for ZIC4 Gene

Localization for ZIC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZIC4 Gene

Subcellular locations from

Jensen Localization Image for ZIC4 Gene COMPARTMENTS Subcellular localization image for ZIC4 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ZIC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with ZIC4: view

Pathways for ZIC4 Gene

SuperPathways for ZIC4 Gene

No Data Available

Interacting Proteins for ZIC4 Gene

Gene Ontology (GO) - Biological Process for ZIC4 Gene


No data available for Pathways by source for ZIC4 Gene

Transcripts for ZIC4 Gene

Unigene Clusters for ZIC4 Gene

Zic family member 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZIC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZIC4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - - - - - - - - -
SP5: - - -
SP6: -
SP9: -

Relevant External Links for ZIC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZIC4 Gene

mRNA expression in normal human tissues for ZIC4 Gene

mRNA differential expression in normal tissues according to GTEx for ZIC4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (24.1) and Brain - Cerebellum (21.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZIC4 Gene

SOURCE GeneReport for Unigene cluster for ZIC4 Gene Hs.415766

genes like me logo Genes that share expressions with ZIC4: view

Expression partners for ZIC4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZIC4 Gene

Orthologs for ZIC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZIC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZIC4 35
  • 92.62 (n)
  • 92.71 (a)
ZIC4 36
  • 93 (a)
(Canis familiaris)
Mammalia ZIC4 35
  • 92.02 (n)
  • 93.11 (a)
ZIC4 36
  • 93 (a)
(Mus musculus)
Mammalia Zic4 35
  • 87.03 (n)
  • 87.43 (a)
Zic4 16
Zic4 36
  • 87 (a)
(Pan troglodytes)
Mammalia ZIC4 35
  • 99.74 (n)
  • 99.74 (a)
ZIC4 36
  • 100 (a)
(Monodelphis domestica)
Mammalia ZIC4 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia ZIC4 36
  • 75 (a)
(Gallus gallus)
Aves ZIC4 35
  • 74.84 (n)
  • 77.64 (a)
ZIC4 36
  • 80 (a)
(Anolis carolinensis)
Reptilia ZIC4 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zic4 35
  • 73.19 (n)
  • 76.45 (a)
(Danio rerio)
Actinopterygii zic4 35
  • 73.21 (n)
  • 81.92 (a)
zic4 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta opa 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for ZIC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZIC4 Gene

Gene Tree for ZIC4 (if available)
Gene Tree for ZIC4 (if available)

Paralogs for ZIC4 Gene

Paralogs for ZIC4 Gene

genes like me logo Genes that share paralogs with ZIC4: view

Variants for ZIC4 Gene

Sequence variations from dbSNP and Humsavar for ZIC4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs954735 -- 147,403,499(-) TCTTA(C/T)GGGAG intron-variant
rs1394043 -- 147,394,791(-) CCCTT(C/T)CCGGG intron-variant
rs1394044 -- 147,394,712(-) TATTT(C/T)TAAAG intron-variant
rs1394045 -- 147,394,675(-) GAGTT(C/T)TTTTC intron-variant
rs1503734 -- 147,401,852(-) CTTTT(A/G)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZIC4 Gene

Variant ID Type Subtype PubMed ID
nsv822285 CNV Gain 20364138

Relevant External Links for ZIC4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZIC4 Gene

Disorders for ZIC4 Gene

(1) University of Copenhagen DISEASES for ZIC4 Gene

Relevant External Links for ZIC4

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ZIC4: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ZIC4 Gene

Publications for ZIC4 Gene

  1. Comparative analysis of a 229-kb medaka genomic region, containing the zic1 and zic4 genes, with Fugu, human, and mouse. (PMID: 15177559) Ohtsuka M. … Kimura M. (Genomics 2004) 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Antibodies to Zic4 in paraneoplastic neurologic disorders and small-cell lung cancer. (PMID: 15007130) Bataller L. … Dalmau J. (Neurology 2004) 3
  5. Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation. (PMID: 15338008) Grinberg I. … Millen K.J. (Nat. Genet. 2004) 3

Products for ZIC4 Gene

Sources for ZIC4 Gene

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