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Aliases for RBM10 Gene

Aliases for RBM10 Gene

  • RNA Binding Motif Protein 10 2 3
  • DXS8237E 3 4 6
  • G Patch Domain-Containing Protein 9 3 4
  • RNA-Binding Protein S1-1 3 4
  • KIAA0122 4 6
  • GPATCH9 3 4
  • GPATC9 3 4
  • TARPS 3 6
  • S1-1 3 4
  • RNA-Binding Motif Protein 10 4
  • RNA-Binding Protein 10 3
  • ZRANB5 3

External Ids for RBM10 Gene

Previous GeneCards Identifiers for RBM10 Gene

  • GC0XP045807
  • GC0XP045265
  • GC0XP045830
  • GC0XP046050
  • GC0XP046760
  • GC0XP046889
  • GC0XP047004
  • GC0XP044717

Summaries for RBM10 Gene

Entrez Gene Summary for RBM10 Gene

  • This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

GeneCards Summary for RBM10 Gene

RBM10 (RNA Binding Motif Protein 10) is a Protein Coding gene. Diseases associated with RBM10 include tarp syndrome and lymphogranuloma venereum. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM5.

UniProtKB/Swiss-Prot for RBM10 Gene

  • May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).

Gene Wiki entry for RBM10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM10 Gene

Genomics for RBM10 Gene

Regulatory Elements for RBM10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBM10 Gene

47,144,869 bp from pter
47,186,815 bp from pter
41,947 bases
Plus strand

Genomic View for RBM10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM10 Gene

Proteins for RBM10 Gene

  • Protein details for RBM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein 10
    Protein Accession:
    Secondary Accessions:
    • C4AM81
    • Q14136
    • Q5JRR2
    • Q9BTE4
    • Q9BTX0
    • Q9NTB1

    Protein attributes for RBM10 Gene

    930 amino acids
    Molecular mass:
    103533 Da
    Quaternary structure:
    • Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5.
    • Sequence=AAB33572.1; Type=Frameshift; Positions=696; Evidence={ECO:0000305}; Sequence=BAA09471.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB70731.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB70731.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM10 Gene

    Alternative splice isoforms for RBM10 Gene


neXtProt entry for RBM10 Gene

Proteomics data for RBM10 Gene at MOPED

Post-translational modifications for RBM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM10 Gene

Antibody Products

No data available for DME Specific Peptides for RBM10 Gene

Domains for RBM10 Gene

Gene Families for RBM10 Gene

  • GPATCH :G patch domain containing
  • RBM :RNA binding motif (RRM) containing
  • ZRANB :Zinc fingers, RAN-binding domain containing

Suggested Antigen Peptide Sequences for RBM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P98175
  • Contains 1 G-patch domain.
  • Contains 2 RRM (RNA recognition motif) domains.
  • Contains 1 C2H2-type zinc finger.
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with RBM10: view

Function for RBM10 Gene

Molecular function for RBM10 Gene

GENATLAS Biochemistry:
RNA binding motif protein 10,expressed probe DXS8237-clone1,1,3kb,homolog to RBM5 located on chromosome 3,in a region duplicated from Xp11.3-p11.23
UniProtKB/Swiss-Prot Function:
May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).

Gene Ontology (GO) - Molecular Function for RBM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 22365833
GO:0008270 zinc ion binding IEA --
GO:0032403 protein complex binding IDA 17707232
genes like me logo Genes that share ontologies with RBM10: view

Phenotypes for RBM10 Gene

MGI mutant phenotypes for RBM10:
inferred from 1 alleles
GenomeRNAi human phenotypes for RBM10:
genes like me logo Genes that share phenotypes with RBM10: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM10 Gene

Localization for RBM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM10 Gene

Nucleus. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).

Subcellular locations from

Jensen Localization Image for RBM10 Gene COMPARTMENTS Subcellular localization image for RBM10 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RBM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with RBM10: view

Pathways for RBM10 Gene

SuperPathways for RBM10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter --
GO:0006397 mRNA processing IEA --
GO:0008150 biological_process ND --
GO:0008285 negative regulation of cell proliferation --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with RBM10: view

No data available for Pathways by source for RBM10 Gene

Transcripts for RBM10 Gene

Unigene Clusters for RBM10 Gene

RNA binding motif protein 10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBM10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBM10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: -
SP3: -
SP5: -
SP6: - - - - - - - - - - - - - - - - -
SP8: - -
SP9: -
SP10: - - - - - - - -
SP11: -

ExUns: 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27

Relevant External Links for RBM10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBM10 Gene

mRNA expression in normal human tissues for RBM10 Gene

Protein differential expression in normal tissues for RBM10 Gene

This gene is overexpressed in Bone marrow stromal cell (15.1), Peripheral blood mononuclear cells (15.0), and Pancreas (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM10 Gene

SOURCE GeneReport for Unigene cluster for RBM10 Gene Hs.401509

genes like me logo Genes that share expressions with RBM10: view

Expression partners for RBM10 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM10 Gene

Orthologs for RBM10 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RBM10 35
  • 91.99 (n)
  • 97.09 (a)
RBM10 36
  • 89 (a)
(Canis familiaris)
Mammalia RBM10 35
  • 92.27 (n)
  • 96.15 (a)
RBM10 36
  • 87 (a)
(Mus musculus)
Mammalia Rbm10 35
  • 90.2 (n)
  • 96.23 (a)
Rbm10 16
Rbm10 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Rbm10 35
  • 88.36 (n)
  • 95.03 (a)
(Monodelphis domestica)
Mammalia RBM10 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia RBM10 36
  • 75 (a)
(Pan troglodytes)
Mammalia RBM10 36
  • 86 (a)
(Anolis carolinensis)
Reptilia RBM10 36
  • 77 (a)
(Danio rerio)
Actinopterygii LOC101882554 35
  • 64.17 (n)
  • 62.77 (a)
rbm10 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4896 37
  • 29 (a)
CG4896 35
  • 48.72 (n)
  • 39.5 (a)
CG4887 36
  • 25 (a)
CG4896 36
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008577 35
  • 34.89 (n)
  • 17.33 (a)
(Caenorhabditis elegans)
Secernentea T08B2.5 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for RBM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBM10 Gene

Gene Tree for RBM10 (if available)
Gene Tree for RBM10 (if available)

Paralogs for RBM10 Gene

Paralogs for RBM10 Gene

Selected SIMAP similar genes for RBM10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBM10: view

Variants for RBM10 Gene

Sequence variations from dbSNP and Humsavar for RBM10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1141139 -- 47,149,972(-) gtggt(A/G)gcgca intron-variant
rs1141140 -- 47,149,970(-) ggtgg(C/T)gcatg intron-variant
rs4824601 -- 47,182,893(+) ACACA(A/G)ATAAA intron-variant
rs5902385 -- 47,170,177(+) CCCAG(-/C)CCTGG intron-variant
rs5905593 -- 47,150,925(+) GTCAT(C/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM10 Gene

Variant ID Type Subtype PubMed ID
esv2740135 CNV Deletion 23290073
esv2740136 CNV Deletion 23290073
nsv6886 CNV Loss 18451855

Relevant External Links for RBM10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM10 Gene

Disorders for RBM10 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RBM10 Gene in MalaCards »

(4) Diseases for RBM10 Gene including...

(1) OMIM Diseases for RBM10 Gene (300080)


  • TARP syndrome (TARPS) [MIM:311900]: A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects. {ECO:0000269 PubMed:20451169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RBM10 Gene

genes like me logo Genes that share disorders with RBM10: view

No data available for Novoseek inferred disease relationships , Genatlas and External Links for RBM10 Gene

Publications for RBM10 Gene

  1. A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. (PMID: 8808293) Coleman M.P. … Davies K.E. (Genomics 1996) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PMID: 11944989) Thiselton D.L. … Meindl A. (Genomics 2002) 3 23
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for RBM10 Gene

Sources for RBM10 Gene

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