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Aliases for RBM10 Gene

Aliases for RBM10 Gene

  • RNA Binding Motif Protein 10 2 3 5
  • G Patch Domain-Containing Protein 9 3 4
  • RNA-Binding Protein S1-1 3 4
  • DXS8237E 3 4
  • GPATCH9 3 4
  • GPATC9 3 4
  • S1-1 3 4
  • RNA-Binding Motif Protein 10 4
  • KIAA0122 4
  • ZRANB5 3
  • TARPS 3

External Ids for RBM10 Gene

Previous GeneCards Identifiers for RBM10 Gene

  • GC0XP045807
  • GC0XP045265
  • GC0XP045830
  • GC0XP046050
  • GC0XP046760
  • GC0XP046889
  • GC0XP047004
  • GC0XP044717

Summaries for RBM10 Gene

Entrez Gene Summary for RBM10 Gene

  • This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

GeneCards Summary for RBM10 Gene

RBM10 (RNA Binding Motif Protein 10) is a Protein Coding gene. Diseases associated with RBM10 include Tarp Syndrome and Talipes Equinovarus. GO annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is RBM5.

UniProtKB/Swiss-Prot for RBM10 Gene

  • May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).

Gene Wiki entry for RBM10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM10 Gene

Genomics for RBM10 Gene

Regulatory Elements for RBM10 Gene

Enhancers for RBM10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RBM10 on UCSC Golden Path with GeneCards custom track

Promoters for RBM10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RBM10 on UCSC Golden Path with GeneCards custom track

Genomic Location for RBM10 Gene

Chromosome:
X
Start:
47,144,869 bp from pter
End:
47,186,815 bp from pter
Size:
41,947 bases
Orientation:
Plus strand

Genomic View for RBM10 Gene

Genes around RBM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM10 Gene

Proteins for RBM10 Gene

  • Protein details for RBM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98175-RBM10_HUMAN
    Recommended name:
    RNA-binding protein 10
    Protein Accession:
    P98175
    Secondary Accessions:
    • C4AM81
    • Q14136
    • Q5JRR2
    • Q9BTE4
    • Q9BTX0
    • Q9NTB1

    Protein attributes for RBM10 Gene

    Size:
    930 amino acids
    Molecular mass:
    103533 Da
    Quaternary structure:
    • Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5.
    SequenceCaution:
    • Sequence=AAB33572.1; Type=Frameshift; Positions=696; Evidence={ECO:0000305}; Sequence=BAA09471.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB70731.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB70731.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM10 Gene

    Alternative splice isoforms for RBM10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM10 Gene

Proteomics data for RBM10 Gene at MOPED

Post-translational modifications for RBM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM10 Gene

No data available for DME Specific Peptides for RBM10 Gene

Domains & Families for RBM10 Gene

Suggested Antigen Peptide Sequences for RBM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P98175

UniProtKB/Swiss-Prot:

RBM10_HUMAN :
  • Contains 1 G-patch domain.
  • Contains 1 C2H2-type zinc finger.
Domain:
  • Contains 1 G-patch domain.
  • Contains 2 RRM (RNA recognition motif) domains.
Similarity:
  • Contains 1 C2H2-type zinc finger.
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with RBM10: view

Function for RBM10 Gene

Molecular function for RBM10 Gene

GENATLAS Biochemistry:
RNA binding motif protein 10,expressed probe DXS8237-clone1,1,3kb,homolog to RBM5 located on chromosome 3,in a region duplicated from Xp11.3-p11.23
UniProtKB/Swiss-Prot Function:
May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).

Gene Ontology (GO) - Molecular Function for RBM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0032403 protein complex binding IDA 17707232
genes like me logo Genes that share ontologies with RBM10: view
genes like me logo Genes that share phenotypes with RBM10: view

Human Phenotype Ontology for RBM10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM10 Gene

Localization for RBM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM10 Gene

Nucleus. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM10 Gene COMPARTMENTS Subcellular localization image for RBM10 gene
Compartment Confidence
nucleus 5
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for RBM10 Gene

Pathways & Interactions for RBM10 Gene

SuperPathways for RBM10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA --
GO:0008380 RNA splicing IEA --
GO:0034391 regulation of smooth muscle cell apoptotic process IEA --
GO:0070935 3-UTR-mediated mRNA stabilization IEA --
genes like me logo Genes that share ontologies with RBM10: view

No data available for Pathways by source and SIGNOR curated interactions for RBM10 Gene

Drugs & Compounds for RBM10 Gene

No Compound Related Data Available

Transcripts for RBM10 Gene

Unigene Clusters for RBM10 Gene

RNA binding motif protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: -
SP3: -
SP4:
SP5: -
SP6: - - - - - - - - - - - - - - - - -
SP7:
SP8: - -
SP9: -
SP10: - - - - - - - -
SP11: -
SP12:

ExUns: 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RBM10 Gene

GeneLoc Exon Structure for
RBM10
ECgene alternative splicing isoforms for
RBM10

Expression for RBM10 Gene

mRNA expression in normal human tissues for RBM10 Gene

Protein differential expression in normal tissues from HIPED for RBM10 Gene

This gene is overexpressed in Bone marrow stromal cell (15.1), Peripheral blood mononuclear cells (15.0), and Pancreas (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM10 Gene



SOURCE GeneReport for Unigene cluster for RBM10 Gene Hs.401509

genes like me logo Genes that share expression patterns with RBM10: view

Protein tissue co-expression partners for RBM10 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM10 Gene

Orthologs for RBM10 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RBM10 35
  • 91.99 (n)
  • 97.09 (a)
RBM10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM10 35
  • 92.27 (n)
  • 96.15 (a)
RBM10 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm10 35
  • 90.2 (n)
  • 96.23 (a)
Rbm10 16
Rbm10 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm10 35
  • 88.36 (n)
  • 95.03 (a)
oppossum
(Monodelphis domestica)
Mammalia RBM10 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM10 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RBM10 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RBM10 36
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101882554 35
  • 64.17 (n)
  • 62.77 (a)
rbm10 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4896 37
  • 29 (a)
CG4896 35
  • 48.72 (n)
  • 39.5 (a)
CG4887 36
  • 25 (a)
ManyToMany
CG4896 36
  • 27 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008577 35
  • 34.89 (n)
  • 17.33 (a)
worm
(Caenorhabditis elegans)
Secernentea T08B2.5 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for RBM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBM10 Gene

ENSEMBL:
Gene Tree for RBM10 (if available)
TreeFam:
Gene Tree for RBM10 (if available)

Paralogs for RBM10 Gene

Paralogs for RBM10 Gene

(2) SIMAP similar genes for RBM10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBM10: view

Variants for RBM10 Gene

Sequence variations from dbSNP and Humsavar for RBM10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_035486 A colorectal cancer sample
rs1141139 -- 47,149,972(-) gtggt(A/G)gcgca intron-variant
rs1141140 -- 47,149,970(-) ggtgg(C/T)gcatg intron-variant
rs4824601 -- 47,182,893(+) ACACA(A/G)ATAAA intron-variant
rs5902385 -- 47,170,177(+) CCCAG(-/C)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM10 Gene

Variant ID Type Subtype PubMed ID
esv2740135 CNV Deletion 23290073
esv2740136 CNV Deletion 23290073
nsv6886 CNV Loss 18451855

Variation tolerance for RBM10 Gene

Residual Variation Intolerance Score: 7.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM10 Gene

Human Gene Mutation Database (HGMD)
RBM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM10 Gene

Disorders for RBM10 Gene

MalaCards: The human disease database

(8) MalaCards diseases for RBM10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
tarp syndrome
  • pierre robin sequence - congenital heart defect - talipes
talipes equinovarus
  • clubfoot
spinal cord ependymoma
  • ependymal neoplasm of the spinal cord
spinal cord glioma
  • glial neoplasm spinal cord
lymphogranuloma venereum
  • climatic or tropical bubo
- elite association - COSMIC cancer census association via MalaCards
Search RBM10 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RBM10_HUMAN
  • TARP syndrome (TARPS) [MIM:311900]: A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects. {ECO:0000269 PubMed:20451169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RBM10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM10
genes like me logo Genes that share disorders with RBM10: view

No data available for Genatlas for RBM10 Gene

Publications for RBM10 Gene

  1. A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. (PMID: 8808293) Coleman M.P. … Davies K.E. (Genomics 1996) 2 3 4 23 67
  2. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PMID: 11944989) Thiselton D.L. … Meindl A. (Genomics 2002) 3 23
  3. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3
  4. Insight into the role of alternative splicing within the RBM10v1 exon 10 tandem donor site. (PMID: 25889998) Tessier S.J. … Sutherland L.C. (BMC Res Notes 2015) 3
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3

Products for RBM10 Gene

Sources for RBM10 Gene

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