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Aliases for RBM10 Gene

Aliases for RBM10 Gene

  • RNA Binding Motif Protein 10 2 3
  • DXS8237E 3 4 6
  • G Patch Domain-Containing Protein 9 3 4
  • RNA-Binding Protein S1-1 3 4
  • KIAA0122 4 6
  • GPATCH9 3 4
  • GPATC9 3 4
  • TARPS 3 6
  • S1-1 3 4
  • RNA-Binding Motif Protein 10 4
  • RNA-Binding Protein 10 3
  • ZRANB5 3

External Ids for RBM10 Gene

Summaries for RBM10 Gene

Entrez Gene Summary for RBM10 Gene

  • This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

GeneCards Summary for RBM10 Gene

RBM10 (RNA Binding Motif Protein 10) is a Protein Coding gene. Diseases associated with RBM10 include tarp syndrome and lymphogranuloma venereum. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM5.

UniProtKB/Swiss-Prot for RBM10 Gene

  • May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).

Gene Wiki entry for RBM10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM10 Gene

Genomics for RBM10 Gene

Genomic Location for RBM10 Gene

Start:
47,144,869 bp from pter
End:
47,186,815 bp from pter
Size:
41,947 bases
Orientation:
Plus strand

Genomic View for RBM10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM10 Gene

Regulatory Elements for RBM10 Gene

Proteins for RBM10 Gene

  • Protein details for RBM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P98175-RBM10_HUMAN
    Recommended name:
    RNA-binding protein 10
    Protein Accession:
    P98175
    Secondary Accessions:
    • C4AM81
    • Q14136
    • Q5JRR2
    • Q9BTE4
    • Q9BTX0
    • Q9NTB1

    Protein attributes for RBM10 Gene

    Size:
    930 amino acids
    Molecular mass:
    103533 Da
    Quaternary structure:
    • Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5.
    SequenceCaution:
    • Sequence=AAB33572.1; Type=Frameshift; Positions=696; Evidence={ECO:0000305}; Sequence=BAA09471.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB70731.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB70731.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM10 Gene

    Alternative splice isoforms for RBM10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM10 Gene

Proteomics data for RBM10 Gene at MOPED

Post-translational modifications for RBM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM10 Gene

No data available for DME Specific Peptides for RBM10 Gene

Domains for RBM10 Gene

Gene Families for RBM10 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • GPATCH :G patch domain containing
  • ZRANB :Zinc fingers, RAN-binding domain containing

UniProtKB/Swiss-Prot:

RBM10_HUMAN
Domain:
  • Contains 1 G-patch domain.:
    • P98175
  • Contains 2 RRM (RNA recognition motif) domains.:
    • P98175
Similarity:
  • Contains 1 C2H2-type zinc finger.:
    • P98175
  • Contains 1 RanBP2-type zinc finger.:
    • P98175
genes like me logo Genes that share domains with RBM10: view

Function for RBM10 Gene

Molecular function for RBM10 Gene

GENATLAS Biochemistry: RNA binding motif protein 10,expressed probe DXS8237-clone1,1,3kb,homolog to RBM5 located on chromosome 3,in a region duplicated from Xp11.3-p11.23
UniProtKB/Swiss-Prot Function: May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity).

Gene Ontology (GO) - Molecular Function for RBM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 22365833
GO:0008270 zinc ion binding IEA --
GO:0032403 protein complex binding IDA 17707232
genes like me logo Genes that share ontologies with RBM10: view

Phenotypes for RBM10 Gene

MGI mutant phenotypes for RBM10:
inferred from 1 alleles
GenomeRNAi human phenotypes for RBM10:
genes like me logo Genes that share phenotypes with RBM10: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RBM10 Gene

Localization for RBM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM10 Gene

Nucleus. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM10 Gene COMPARTMENTS Subcellular localization image for RBM10 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RBM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with RBM10: view

Pathways for RBM10 Gene

SuperPathways for RBM10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RBM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter --
GO:0006397 mRNA processing IEA --
GO:0008150 biological_process ND --
GO:0008285 negative regulation of cell proliferation --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with RBM10: view

No data available for Pathways by source for RBM10 Gene

Transcripts for RBM10 Gene

Unigene Clusters for RBM10 Gene

RNA binding motif protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: -
SP3: -
SP4:
SP5: -
SP6: - - - - - - - - - - - - - - - - -
SP7:
SP8: - -
SP9: -
SP10: - - - - - - - -
SP11: -
SP12:

ExUns: 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RBM10 Gene

GeneLoc Exon Structure for
RBM10
ECgene alternative splicing isoforms for
RBM10

Expression for RBM10 Gene

mRNA expression in normal human tissues for RBM10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM10 Gene

SOURCE GeneReport for Unigene cluster for RBM10 Gene Hs.401509

genes like me logo Genes that share expressions with RBM10: view

Orthologs for RBM10 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM10 37
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM10 36
  • 91.99 (n)
  • 97.09 (a)
RBM10 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM10 36
  • 92.27 (n)
  • 96.15 (a)
RBM10 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm10 36
  • 90.2 (n)
  • 96.23 (a)
Rbm10 16
Rbm10 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM10 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM10 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm10 36
  • 88.36 (n)
  • 95.03 (a)
lizard
(Anolis carolinensis)
Reptilia RBM10 37
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101882554 36
  • 64.17 (n)
  • 62.77 (a)
rbm10 37
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008577 36
  • 34.89 (n)
  • 17.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4887 37
  • 25 (a)
ManyToMany
CG4896 36
  • 48.72 (n)
  • 39.5 (a)
CG4896 37
  • 27 (a)
ManyToMany
CG4896 38
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea T08B2.5 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToMany
Species with no ortholog for RBM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RBM10 Gene

ENSEMBL:
Gene Tree for RBM10 (if available)
TreeFam:
Gene Tree for RBM10 (if available)

Paralogs for RBM10 Gene

Paralogs for RBM10 Gene

Selected SIMAP similar genes for RBM10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBM10: view

Variants for RBM10 Gene

Sequence variations from dbSNP and Humsavar for RBM10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1141139 -- 47,149,972(-) gtggt(A/G)gcgca intron-variant
rs1141140 -- 47,149,970(-) ggtgg(C/T)gcatg intron-variant
rs4824601 -- 47,182,893(+) ACACA(A/G)ATAAA intron-variant
rs5902385 -- 47,170,177(+) CCCAG(-/C)CCTGG intron-variant
rs5905593 -- 47,150,925(+) GTCAT(C/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM10 Gene

Variant ID Type Subtype PubMed ID
esv2740135 CNV Deletion 23290073
esv2740136 CNV Deletion 23290073
nsv6886 CNV Loss 18451855

Relevant External Links for RBM10 Gene

HapMap Linkage Disequilibrium report
RBM10
Human Gene Mutation Database (HGMD)
RBM10
Locus Specific Mutation Databases (LSDB)
RBM10

Disorders for RBM10 Gene

(1) OMIM Diseases for RBM10 Gene (300080)

UniProtKB/Swiss-Prot

RBM10_HUMAN
  • TARP syndrome (TARPS) [MIM:311900]: A disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects. {ECO:0000269 PubMed:20451169}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RBM10 Gene

genes like me logo Genes that share disorders with RBM10: view

Publications for RBM10 Gene

  1. A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. (PMID: 8808293) Coleman M.P. … Davies K.E. (Genomics 1996) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PMID: 11944989) Thiselton D.L. … Meindl A. (Genomics 2002) 3 23
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for RBM10 Gene

Sources for RBM10 Gene

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