Aliases for CXCR4 Gene
- Chemokine (C-X-C Motif) Receptor 4 2 3
- Leukocyte-Derived Seven Transmembrane Domain Receptor 3 4
- Lipopolysaccharide-Associated Protein 3 3 4
- Stromal Cell-Derived Factor 1 Receptor 3 4
- LPS-Associated Protein 3 3 4
- SDF-1 Receptor 3 4
- CD184 Antigen 3 4
- D2S201E 3 6
- Fusin 3 4
- NPY3R 3 6
- LAP-3 3 4
- LESTR 3 4
- NPYRL 3 4
- WHIM 3 6
- FB22 3 4
- HM89 3 4
External Ids for CXCR4 Gene
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for CXCR4 Gene
CXCR4 (Chemokine (C-X-C Motif) Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include whim syndrome and intraocular lymphoma. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include G-protein coupled receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is CCR7.
UniProtKB/Swiss-Prot for CXCR4 Gene
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorised into four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are classified according to the class of chemokines that they bind. The major function of chemokines is to regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by cytotoxic T-cells and macrophages.