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Aliases for CXCR4 Gene

Aliases for CXCR4 Gene

  • Chemokine (C-X-C Motif) Receptor 4 2 3
  • Leukocyte-Derived Seven Transmembrane Domain Receptor 3 4
  • Lipopolysaccharide-Associated Protein 3 3 4
  • Stromal Cell-Derived Factor 1 Receptor 3 4
  • LPS-Associated Protein 3 3 4
  • SDF-1 Receptor 3 4
  • CD184 Antigen 3 4
  • D2S201E 3 6
  • Fusin 3 4
  • NPY3R 3 6
  • LAP-3 3 4
  • LESTR 3 4
  • NPYRL 3 4
  • WHIM 3 6
  • FB22 3 4
  • HM89 3 4
  • LCR1 3 4
  • Seven-Transmembrane-Segment Receptor, Spleen 3
  • Chemokine (C-X-C Motif), Receptor 4 (Fusin) 2
  • Seven Transmembrane Helix Receptor 3
  • C-X-C Chemokine Receptor Type 4 3
  • Neuropeptide Y Receptor Y3 3
  • HSY3RR 3
  • NPYY3R 3
  • CXC-R4 4
  • CXCR-4 4
  • CD184 3
  • WHIMS 3
  • NPYR 3
  • LAP3 3

External Ids for CXCR4 Gene

Previous GeneCards Identifiers for CXCR4 Gene

  • GC02M134526
  • GC02M135169
  • GC02M136894
  • GC02M137082
  • GC02M136705
  • GC02M136588
  • GC02M128864
  • GC02M136871

Summaries for CXCR4 Gene

Entrez Gene Summary for CXCR4 Gene

  • This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for CXCR4 Gene

CXCR4 (Chemokine (C-X-C Motif) Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include whim syndrome and intraocular lymphoma. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include G-protein coupled receptor activity and ubiquitin protein ligase binding. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CXCR4 Gene

  • Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Tocris Summary for CXCR4 Gene

  • Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorised into four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are classified according to the class of chemokines that they bind. The major function of chemokines is to regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by cytotoxic T-cells and macrophages.

Gene Wiki entry for CXCR4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXCR4 Gene

Genomics for CXCR4 Gene

Regulatory Elements for CXCR4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CXCR4 Gene

Start:
136,114,349 bp from pter
End:
136,118,165 bp from pter
Size:
3,817 bases
Orientation:
Minus strand

Genomic View for CXCR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CXCR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXCR4 Gene

Proteins for CXCR4 Gene

  • Protein details for CXCR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61073-CXCR4_HUMAN
    Recommended name:
    C-X-C chemokine receptor type 4
    Protein Accession:
    P61073
    Secondary Accessions:
    • B2R5N0
    • O60835
    • P30991
    • P56438
    • Q53S69
    • Q9BXA0
    • Q9UKN2

    Protein attributes for CXCR4 Gene

    Size:
    352 amino acids
    Molecular mass:
    39746 Da
    Quaternary structure:
    • Monomer. Can form dimers. Interacts with CD164. Interacts with HIV-1 surface protein gp120 and Tat. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin. Interacts with human cytomegalovirus/HHV-5 protein UL78. Interacts with DBN1; this interaction is enhanced by antigenic stimulation. Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
    Miscellaneous:
    • Plerixafor (AMD3100), an antagonist of CXCR4 activity, blocks HIV-1 entry, interaction with CXCL12 and subsequent CXCR4 signaling
    SequenceCaution:
    • Sequence=CAA12166.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CXCR4 Gene

    Alternative splice isoforms for CXCR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXCR4 Gene

Proteomics data for CXCR4 Gene at MOPED

Post-translational modifications for CXCR4 Gene

  • O- and N-glycosylated. Asn-11 is the principal site of N-glycosylation. There appears to be very little or no glycosylation on Asn-176. N-glycosylation masks coreceptor function in both X4 and R5 laboratory-adapted and primary HIV-1 strains through inhibiting interaction with their Env glycoproteins. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity.
  • Phosphorylated on agonist stimulation. Rapidly phosphorylated on serine and threonine residues in the C-terminal. Phosphorylation at Ser-324 and Ser-325 leads to recruitment of ITCH, ubiquitination and protein degradation.
  • Sulfation on Tyr-21 is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization. Tyr-7 and Tyr-12 are sulfated in a sequential manner after Tyr-21 is almost fully sulfated, with the binding affinity for CXCL12/SDF-1alpha increasing with the number of sulfotyrosines present. Sulfotyrosines Tyr-7 and Tyr-12 occupy clefts on opposing CXCL12 subunits, thus bridging the CXCL12 dimer interface and promoting CXCL12 dimerization.
  • Ubiquitinated by ITCH at the cell membrane on agonist stimulation. The ubiquitin-dependent mechanism, endosomal sorting complex required for transport (ESCRT), then targets CXCR4 for lysosomal degradation. This process is dependent also on prior Ser-/Thr-phosphorylation in the C-terminal of CXCR4. Also binding of ARRB1 to STAM negatively regulates CXCR4 sorting to lysosomes though modulating ubiquitination of SFR5S.
  • Ubiquitination at Lys310 and Lys327
  • Glycosylation at Asn11, Ser18, and Asn176
  • Modification sites at PhosphoSitePlus

Other Protein References for CXCR4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CXCR4 Gene

Domains for CXCR4 Gene

Gene Families for CXCR4 Gene

HGNC:
  • CD :CD molecules
  • CXCR :GPCR / Class A : Chemokine receptors : C-X-C motif
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P61073

UniProtKB/Swiss-Prot:

CXCR4_HUMAN :
  • P61073
Domain:
  • The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CXCR4: view

Function for CXCR4 Gene

Molecular function for CXCR4 Gene

GENATLAS Biochemistry:
fusin,chemokine (CXC) motif,receptor 4,preferentially expressed on the more immature CD34+ hematopoietic stem cells,G protein coupled receptor superfamily,required for entry of T cell line-tropic strains HIV-1 into CD4 cells,bovine locus coeruleus homolog
UniProtKB/Swiss-Prot Function:
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Gene Ontology (GO) - Molecular Function for CXCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0003779 actin binding IDA 12421915
GO:0004930 G-protein coupled receptor activity TAS 8276799
GO:0005515 protein binding IPI 10644702
GO:0015026 coreceptor activity TAS 10754293
genes like me logo Genes that share ontologies with CXCR4: view
genes like me logo Genes that share phenotypes with CXCR4: view

Animal Models for CXCR4 Gene

MGI Knock Outs for CXCR4:

Animal Model Products

miRNA for CXCR4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCR4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CXCR4 Gene

Localization for CXCR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CXCR4 Gene

Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CXCR4 Gene COMPARTMENTS Subcellular localization image for CXCR4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
endosome 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CXCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10415069
GO:0005764 lysosome IDA 21540189
GO:0005769 early endosome IDA 21540189
GO:0005770 late endosome IDA 21540189
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CXCR4: view

Pathways for CXCR4 Gene

genes like me logo Genes that share pathways with CXCR4: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CXCR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10570282
GO:0001569 patterning of blood vessels IEA --
GO:0001666 response to hypoxia IEP 15174142
GO:0001667 ameboidal-type cell migration IEA --
GO:0001764 neuron migration IEA --
genes like me logo Genes that share ontologies with CXCR4: view

Compounds for CXCR4 Gene

(5) Tocris Compounds for CXCR4 Gene

Compound Action Cas Number
AMD 3100 octahydrochloride Highly selective CXCR4 antagonist [155148-31-5]
AMD 3465 hexahydrobromide Potent, selective CXCR4 antagonist [185991-07-5]
RS 504393 Highly selective CCR2 chemokine receptor antagonist [300816-15-3]
SB 225002 Potent and selective CXCR2 antagonist [182498-32-4]
SB 328437 Potent and selective CCR3 antagonist [247580-43-4]

(3) ApexBio Compounds for CXCR4 Gene

Compound Action Cas Number
Plerixafor (AMD3100) CXCR4 chemokine receptor antagonist [110078-46-1]
Plerixafor 8HCl (AMD3100 8HCl) CXCR4 antagonist [155148-31-5]
WZ811 "Competitive CXR4 antagonist,highly potent" [55778-02-4]

(1) HMDB Compounds for CXCR4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) Drugbank Compounds for CXCR4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Framycetin
  • Framycetinum [INN-Latin]
119-04-0 target antagonist
Plerixafor
  • AMD3100
110078-46-1 target antagonist

(18) IUPHAR Ligand for CXCR4 Gene

Ligand Type Action Affinity Pubmed IDs
T140 Antagonist Inverse agonist 8.6
[125I]SDF-1alpha (human) Agonist Full agonist 8.4
T134 Antagonist Antagonist 8.4
vMIP-II Antagonist Antagonist 8.1
isothiourea-1t Agonist Agonist 8.1
isothiourea-1a Agonist Agonist 7.96
SDF-1alpha Agonist Agonist 7.9
[125I]SDF-1beta (human) Agonist Full agonist 7.9
SDF-1beta Agonist Full agonist 7.86
T22 Antagonist Antagonist 7.3
HIV-Tat Agonist Full agonist 7.2
plerixafor Agonist Agonist 6.85
ALX40-4C Agonist Partial agonist 6.1
CXCL12-(1-9) dimer Agonist Full agonist 6.1
CXCL12-(1-17) Agonist Full agonist 6.1
SDF-1, 1-9[P2G] dimer Antagonist Antagonist 5.6
CXCL12-(1-9) Agonist Full agonist 4.9
X4-HIV-1 gp120 Agonist Agonist

(86) Novoseek inferred chemical compound relationships for CXCR4 Gene

Compound -log(P) Hits PubMed IDs
bicyclam 87 14
sdf 1 85.2 59
rantes 82.9 59
c-d4i 66.7 1
enfuvirtide 64.7 1
genes like me logo Genes that share compounds with CXCR4: view

Transcripts for CXCR4 Gene

mRNA/cDNA for CXCR4 Gene

Unigene Clusters for CXCR4 Gene

Chemokine (C-X-C motif) receptor 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CXCR4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CXCR4 Gene

No ASD Table

Relevant External Links for CXCR4 Gene

GeneLoc Exon Structure for
CXCR4
ECgene alternative splicing isoforms for
CXCR4

Expression for CXCR4 Gene

mRNA expression in normal human tissues for CXCR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CXCR4 Gene

This gene is overexpressed in Whole Blood (25.3) and Spleen (5.1).

Protein differential expression in normal tissues for CXCR4 Gene

This gene is overexpressed in CD8 Tcells (22.0), Platelet (19.1), Tlymphocyte (8.6), Peripheral blood mononuclear cells (8.3), and Blymphocyte (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CXCR4 Gene

SOURCE GeneReport for Unigene cluster for CXCR4 Gene Hs.593413

mRNA Expression by UniProt/SwissProt for CXCR4 Gene

P61073-CXCR4_HUMAN
Tissue specificity: Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.
genes like me logo Genes that share expressions with CXCR4: view

Expression partners for CXCR4 Gene

In Situ Assay Products

Orthologs for CXCR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXCR4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CXCR4 35
  • 90.28 (n)
  • 92.26 (a)
CXCR4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CXCR4 35
  • 91.27 (n)
  • 95.54 (a)
CXCR4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cxcr4 35
  • 86.89 (n)
  • 90.69 (a)
Cxcr4 16
Cxcr4 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CXCR4 35
  • 99.81 (n)
  • 100 (a)
CXCR4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cxcr4 35
  • 85.59 (n)
  • 90.99 (a)
oppossum
(Monodelphis domestica)
Mammalia CXCR4 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CXCR4 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CXCR4 35
  • 74.03 (n)
  • 81.49 (a)
CXCR4 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CXCR4 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cxcr4 35
  • 71.67 (n)
  • 74.77 (a)
Str.266 35
African clawed frog
(Xenopus laevis)
Amphibia cxcr4-prov 35
zebrafish
(Danio rerio)
Actinopterygii cxcr4a 35
  • 66.67 (n)
  • 68.4 (a)
cxcr4a 36
  • 66 (a)
OneToMany
cxcr4b 36
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11892 35
Species with no ortholog for CXCR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXCR4 Gene

ENSEMBL:
Gene Tree for CXCR4 (if available)
TreeFam:
Gene Tree for CXCR4 (if available)

Paralogs for CXCR4 Gene

genes like me logo Genes that share paralogs with CXCR4: view

Variants for CXCR4 Gene

Sequence variations from dbSNP and Humsavar for CXCR4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1051557 -- 136,115,583(-) GTCAT(C/T)TACAC reference, synonymous-codon
rs1112156 -- 136,119,144(-) GGGGA(A/C)CGAAG upstream-variant-2KB
rs1804029 -- 136,114,803(-) TCAGA(G/T)ATAAA utr-variant-3-prime
rs2228014 -- 136,115,514(-) GCCAT(C/T)GTCCA reference, synonymous-codon
rs2471859 -- 136,116,434(-) TGCGC(C/T)TTAGG upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CXCR4 Gene

Variant ID Type Subtype PubMed ID
nsv523997 CNV Gain 19592680

Relevant External Links for CXCR4 Gene

HapMap Linkage Disequilibrium report
CXCR4
Human Gene Mutation Database (HGMD)
CXCR4
Locus Specific Mutation Databases (LSDB)
CXCR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CXCR4 Gene

Disorders for CXCR4 Gene

(1) OMIM Diseases for CXCR4 Gene (162643)

UniProtKB/Swiss-Prot

CXCR4_HUMAN
  • WHIM syndrome (WHIMS) [MIM:193670]: Immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis. {ECO:0000269 PubMed:12692554}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(93) Novoseek inferred disease relationships for CXCR4 Gene

Disease -log(P) Hits PubMed IDs
whim syndrome 87.5 26
immunodeficiency 84.1 148
metastasis 71 282
hiv infections 69.4 68
aids 56.6 59

Relevant External Links for CXCR4

Genetic Association Database (GAD)
CXCR4
Human Genome Epidemiology (HuGE) Navigator
CXCR4
genes like me logo Genes that share disorders with CXCR4: view

No data available for Genatlas for CXCR4 Gene

Publications for CXCR4 Gene

  1. Genomic organization and promoter characterization of human CXCR4 gene. (PMID: 9599023) Caruz A. … Arenzana-Seisdedos F. (FEBS Lett. 1998) 2 3 4 23
  2. Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. (PMID: 9468539) Wegner S.A. … Michael N.L. (J. Biol. Chem. 1998) 3 4 23
  3. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. (PMID: 8752281) Oberlin E. … Moser B. (Nature 1996) 3 4 23
  4. Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines. (PMID: 8849450) Lapham C.K. … Golding H. (Science 1996) 3 4 23
  5. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. (PMID: 8276799) Loetscher M. … Moser B. (J. Biol. Chem. 1994) 3 4 23

Products for CXCR4 Gene

  • Addgene plasmids for CXCR4

Sources for CXCR4 Gene

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