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Aliases for ZIC1 Gene

Aliases for ZIC1 Gene

  • Zic Family Member 1 2 3
  • Zic Family Member 1 (Odd-Paired Homolog, Drosophila) 2 3
  • Zinc Finger Protein Of The Cerebellum 1 3 4
  • Zinc Finger Protein 201 3 4
  • ZNF201 3 4
  • ZIC 3 4
  • Zic Family Member 1 (Odd-Paired Drosophila Homolog) 2
  • Zinc Finger Protein ZIC 1 3

External Ids for ZIC1 Gene

Summaries for ZIC1 Gene

Entrez Gene Summary for ZIC1 Gene

  • This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZIC1 Gene

ZIC1 (Zic Family Member 1) is a Protein Coding gene. Diseases associated with ZIC1 include isolated dandy-walker malformation without hydrocephalus and isolated dandy-walker malformation with hydrocephalus. Among its related pathways are Neural Crest Differentiation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZIC4.

UniProtKB/Swiss-Prot for ZIC1 Gene

  • Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5-TGGGTGGTC-3 (By similarity).

Gene Wiki entry for ZIC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZIC1 Gene

Genomics for ZIC1 Gene

Genomic Location for ZIC1 Gene

Start:
147,393,422 bp from pter
End:
147,510,293 bp from pter
Size:
116,872 bases
Orientation:
Plus strand

Genomic View for ZIC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZIC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZIC1 Gene

Regulatory Elements for ZIC1 Gene

Proteins for ZIC1 Gene

  • Protein details for ZIC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15915-ZIC1_HUMAN
    Recommended name:
    Zinc finger protein ZIC 1
    Protein Accession:
    Q15915
    Secondary Accessions:
    • Q2M3N1

    Protein attributes for ZIC1 Gene

    Size:
    447 amino acids
    Molecular mass:
    48309 Da
    Quaternary structure:
    • Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation (By similarity).

neXtProt entry for ZIC1 Gene

Proteomics data for ZIC1 Gene at MOPED

Post-translational modifications for ZIC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZIC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZIC1 Gene

Domains for ZIC1 Gene

Gene Families for ZIC1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZIC1 Gene

Suggested Antigen Peptide Sequences for ZIC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15915

UniProtKB/Swiss-Prot:

ZIC1_HUMAN
Domain:
  • The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.:
    • Q15915
Family:
  • Belongs to the GLI C2H2-type zinc-finger protein family.:
    • Q15915
Similarity:
  • Contains 5 C2H2-type zinc fingers.:
    • Q15915
genes like me logo Genes that share domains with ZIC1: view

Function for ZIC1 Gene

Molecular function for ZIC1 Gene

GENATLAS Biochemistry: zinc finger protein of the cerebellum,mouse Zic homolog,potential marker for medulloblastoma and cellular granular cell lineage
UniProtKB/Swiss-Prot Function: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5-TGGGTGGTC-3 (By similarity).

Gene Ontology (GO) - Molecular Function for ZIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8542595
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZIC1: view
genes like me logo Genes that share phenotypes with ZIC1: view

Animal Models for ZIC1 Gene

MGI Knock Outs for ZIC1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZIC1 Gene

Localization for ZIC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZIC1 Gene

Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZIC1 Gene COMPARTMENTS Subcellular localization image for ZIC1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8542595
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZIC1: view

Pathways for ZIC1 Gene

SuperPathways for ZIC1 Gene

genes like me logo Genes that share pathways with ZIC1: view

Pathways by source for ZIC1 Gene

1 BioSystems pathway for ZIC1 Gene

Gene Ontology (GO) - Biological Process for ZIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007389 pattern specification process ISS --
GO:0007417 central nervous system development --
GO:0007420 brain development IDA 8542595
GO:0007628 adult walking behavior IEA --
genes like me logo Genes that share ontologies with ZIC1: view

Compounds for ZIC1 Gene

(1) Novoseek inferred chemical compound relationships for ZIC1 Gene

Compound -log(P) Hits PubMed IDs
zinc 53.8 19
genes like me logo Genes that share compounds with ZIC1: view

Transcripts for ZIC1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZIC1 Gene

No ASD Table

Relevant External Links for ZIC1 Gene

GeneLoc Exon Structure for
ZIC1
ECgene alternative splicing isoforms for
ZIC1

Expression for ZIC1 Gene

mRNA expression in normal human tissues for ZIC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZIC1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (24.4) and Brain - Cerebellum (18.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZIC1 Gene

SOURCE GeneReport for Unigene cluster for ZIC1 Gene Hs.598590

mRNA Expression by UniProt/SwissProt for ZIC1 Gene

Q15915-ZIC1_HUMAN
Tissue specificity: CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.
genes like me logo Genes that share expressions with ZIC1: view

Orthologs for ZIC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZIC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZIC1 35
  • 99.85 (n)
  • 100 (a)
ZIC1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZIC1 35
  • 93.3 (n)
  • 99.74 (a)
ZIC1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zic1 35
  • 90.83 (n)
  • 99.33 (a)
Zic1 16
Zic1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZIC1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZIC1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zic1 35
  • 91.2 (n)
  • 99.33 (a)
chicken
(Gallus gallus)
Aves ZIC1 35
  • 81.98 (n)
  • 91.89 (a)
ZIC1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZIC1 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1796 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17224 35
zic1 35
  • 78.81 (n)
  • 91.4 (a)
zebrafish
(Danio rerio)
Actinopterygii zic1 35
  • 76.32 (n)
  • 87.93 (a)
zic1 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta opa 36
  • 34 (a)
OneToMany
opa 37
  • 66 (a)
lmd 37
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
Species with no ortholog for ZIC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZIC1 Gene

ENSEMBL:
Gene Tree for ZIC1 (if available)
TreeFam:
Gene Tree for ZIC1 (if available)

Paralogs for ZIC1 Gene

Paralogs for ZIC1 Gene

genes like me logo Genes that share paralogs with ZIC1: view

Variants for ZIC1 Gene

Sequence variations from dbSNP and Humsavar for ZIC1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3832180 -- 147,411,286(-) GTGTG(-/TG)TTTTC intron-variant
rs4467417 -- 147,413,715(+) AGGAA(A/G)CATCA utr-variant-3-prime
rs6786925 -- 147,409,847(+) CGGCA(A/G)AATCT utr-variant-5-prime
rs9833875 -- 147,416,245(+) ACACC(A/G)CAATT utr-variant-3-prime
rs10662843 -- 147,415,880(+) CTGTT(-/AG)TCAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZIC1 Gene

Variant ID Type Subtype PubMed ID
nsv822285 CNV Gain 20364138

Relevant External Links for ZIC1 Gene

HapMap Linkage Disequilibrium report
ZIC1
Human Gene Mutation Database (HGMD)
ZIC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZIC1 Gene

Disorders for ZIC1 Gene

(9) Novoseek inferred disease relationships for ZIC1 Gene

Disease -log(P) Hits PubMed IDs
holoprosencephaly 78.1 5
neural tube defects 57.8 2
cerebellar dysfunction 57.1 1
medulloblastoma 52.1 7
spina bifida 35.3 1

Relevant External Links for ZIC1

Genetic Association Database (GAD)
ZIC1
Human Genome Epidemiology (HuGE) Navigator
ZIC1
genes like me logo Genes that share disorders with ZIC1: view

No data available for UniProtKB/Swiss-Prot for ZIC1 Gene

Publications for ZIC1 Gene

  1. Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma. (PMID: 8542595) Yokota N. … Mikoshiba K. (Cancer Res. 1996) 2 3 4 23
  2. Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans. (PMID: 14679585) Klootwijk R. … Franke B. (Am. J. Med. Genet. A 2004) 3 23 48
  3. Physical and functional interactions between Zic and Gli proteins. (PMID: 11238441) Koyabu Y. … Mikoshiba K. (J. Biol. Chem. 2001) 3 23
  4. The ZIC gene family in development and disease. (PMID: 15733262) Grinberg I. … Millen K.J. (Clin. Genet. 2005) 3 23
  5. Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter. (PMID: 11038359) Salero E. … Zafra F. (J. Biol. Chem. 2001) 3 23

Products for ZIC1 Gene

Sources for ZIC1 Gene

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