Aliases for SLC22A4 Gene
External Ids for SLC22A4 Gene
Previous GeneCards Identifiers for SLC22A4 Gene
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC22A4 Gene
SLC22A4 (Solute Carrier Family 22 Member 4) is a Protein Coding gene. Diseases associated with SLC22A4 include rheumatoid arthritis and tracheal disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Phospholipase D signaling pathway. GO annotations related to this gene include nucleotide binding and transmembrane transporter activity. An important paralog of this gene is SLC22A12.
UniProtKB/Swiss-Prot for SLC22A4 Gene
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).