Aliases for STRA6 Gene
Aliases for STRA6 Gene
- Stimulated By Retinoic Acid 6 2 3 5
- Stimulated By Retinoic Acid Gene 6 Protein Homolog 3 4
- Retinol-Binding Protein Receptor STRA6 3 4
- Retinol Binding Protein 4 Receptor 2 3
- Stimulated By Retinoic Acid Gene 6 Homolog (Mouse) 2
- Stimulated By Retinoic Acid 6 Homolog (Mouse) 2
- Stimulated By Retinoic Acid Gene 6 Homolog 3
External Ids for STRA6 Gene
- HGNC: 30650
- Entrez Gene: 64220
- Ensembl: ENSG00000137868
- OMIM: 610745
- UniProtKB: Q9BX79
Previous GeneCards Identifiers for STRA6 Gene
- GC15M072260
- GC15M074471
- GC15M051265
Summaries for STRA6 Gene
-
The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
GeneCards Summary for STRA6 Gene
STRA6 (Stimulated By Retinoic Acid 6) is a Protein Coding gene. Diseases associated with STRA6 include Microphthalmia, Syndromic 9 and Colobomatous Microphthalmia. Among its related pathways are Diseases associated with visual transduction and the visual cycle I (vertebrates). Gene Ontology (GO) annotations related to this gene include receptor activity.
UniProtKB/Swiss-Prot for STRA6 Gene
-
Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031).
Additional gene information for STRA6 Gene
- Monarch Initiative
- Search for STRA6 at DataMed
- Search for STRA6 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRA6 Gene
Genomics for STRA6 Gene
GeneHancer (GH) Regulatory Elements for STRA6 Gene
- Top Transcription factor binding sites by QIAGEN in the STRA6 gene promoter:
Regulatory Element Products
Genomic Locations for STRA6 Gene
- chr15:74,179,466-74,212,267
- (GRCh38/hg38)
- Size:
- 32,802 bases
- Orientation:
- Minus strand
- chr15:74,471,807-74,504,608
- (GRCh37/hg19)
Genomic View for STRA6 Gene
- Cytogenetic band:
-
- 15q24.1 by Ensembl
- 15q24.1 by Entrez Gene
- 15q24.1 by HGNC


RefSeq DNA sequence for STRA6 Gene
Proteins for STRA6 Gene
-
Protein details for STRA6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BX79-STRA6_HUMAN
- Recommended name:
- Receptor for retinol uptake STRA6
- Protein Accession:
- Q9BX79
- A8K7F1
- B7Z5M9
- B7Z862
- D3DW54
- F5GYI8
- I3L1G8
- Q6PJF8
- Q71RB9
- Q7L9G1
- Q7Z3U9
- Q8TB21
- Q9BX78
- Q9H9U8
Protein attributes for STRA6 Gene
- Size:
- 667 amino acids
- Molecular mass:
- 73503 Da
- Quaternary structure:
-
- Homodimer (By similarity). Interacts with JAK2 and STAT5 (PubMed:21368206). Interacts (via extracellular domains) with RBP4 (PubMed:22665496). Interacts (via cytoplasmic domains) with RBP1 (PubMed:22665496).
- SequenceCaution:
-
- Sequence=BAB14122.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAH13848.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97655.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for STRA6 Gene
Post-translational modifications for STRA6 Gene
- Phosphorylated on tyrosine residues in response to RBP4 binding (PubMed:21368206, PubMed:22665496). Phosphorylation requires the presence of LRAT, suggesting it may be triggered by the uptake of retinol that is then metabolized within the cell to retinoids that function as signaling molecules (PubMed:22665496).
- Glycosylation at posLast=88
Other Protein References for STRA6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for STRA6 (STRA6)
- Novus Biologicals Antibodies for STRA6
-
Abcam antibodies for STRA6
- Invitrogen Antibodies for STRA6
- antibodies-online: Search results for 100 available STRA6 Antibodies ranked by validation data
- Compare Top STRA6 Antibodies
-
Recommended
- 39 WB Antibodies (anti-human)
- 15 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 WB Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 41 WB Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- GeneTex STRA6 antibody for STRA6
Protein Products
-
OriGene Purified Proteins for STRA6
- Search Origene for MassSpec and Protein Over-expression Lysates for STRA6
- Origene Custom Protein Services for STRA6
- Search GeneTex for Proteins for STRA6
-
Abcam proteins for STRA6
Assay Products
- antibodies-online: Search results for 1 available STRA6 Elisa Kits ranked by validation data
- Compare Top STRA6 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for STRA6 Gene
Domains & Families for STRA6 Gene
Gene Families for STRA6 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Potential drug targets
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for STRA6 Gene
Graphical View of Domain Structure for InterPro Entry
Q9BX79UniProtKB/Swiss-Prot:
STRA6_HUMAN :- Contrary to predictions, contains nine transmembrane helices, with an extracellular N-terminus and a cytoplasmic C-terminus (By similarity). Besides, contains one long helix that dips into the membrane and then runs more or less parallel to the membrane surface (By similarity).
- Domain:
-
- Contrary to predictions, contains nine transmembrane helices, with an extracellular N-terminus and a cytoplasmic C-terminus (By similarity). Besides, contains one long helix that dips into the membrane and then runs more or less parallel to the membrane surface (By similarity).
Function for STRA6 Gene
Molecular function for STRA6 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in the colorectal cancer cell line WiDr by the administration of retinoic acid and in tumors with frequent defects in Wnt-1 signaling.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004872 | receptor activity | IEA | -- |
GO:0016918 | retinal binding | IEA | -- |
GO:0019841 | retinol binding | IEA | -- |
GO:0034632 | retinol transmembrane transporter activity | IDA | 21901792 |
Phenotypes for STRA6 Gene
- MGI mutant phenotypes for STRA6:
-
inferred from 6 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- growth/size/body region phenotype
- vision/eye phenotype
- embryo phenotype
- skeleton phenotype
- pigmentation phenotype
- craniofacial phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for STRA6:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Lamellipodia cells
- Decreased ionizing radiation sensitivity
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- FOXO1 nuclear localization
- Decreased viability with paclitaxel
Animal Models for STRA6 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for STRA6
-
- Search ViGene Biosciences for STRA6
CRISPR Products
-
OriGene CRISPR knockouts for STRA6
- genomics-online: gRNA clones - Search results for 134 available STRA6 gene related products
- Overview of 134 available STRA6 gene related products
-
Recommended
- Applied Biological Materials CRISPR for STRA6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STRA6
- GenScript: Design CRISPR guide RNA sequences for STRA6
miRNA Products
- Search ViGene Biosciences for STRA6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for STRA6
- Browse OriGene Inhibitory RNA Products For STRA6
- genomics-online: shRNA clones - Search results for 134 available STRA6 gene related products
- Overview of 134 available STRA6 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for STRA6
- RG206826
- RC206826L2
- RC206826L1
- RC206826
- RG231385
- RC231385L2
- RC231385L1
- RC231385
- RG231373
- RC231373L2
- RC231373L1
- RC231373
- RG231384
- RC231384L2
- RC231384L1
- RC231384
- RG227536
- RC227536L2
- RC227536L1
- RC227536
- RG227505
- RC227505L2
- RC227505L1
- RC227505
- RG227472
- RC227472L2
- RC227472L1
- RC227472
- RG227393
- RC227393L2
- RC227393L1
- RC227393
- RC206826L2V
- RC206826L1V
- RC231385L2V
- RC231385L1V
- RC231373L2V
- RC231373L1V
- RC231384L2V
- RC231384L1V
- RC227536L2V
- RC227536L1V
- RC227505L2V
- RC227505L1V
- RC227472L2V
- RC227472L1V
- RC227393L2V
- RC227393L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for STRA6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STRA6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 134 available STRA6 gene related products
- Overview of 134 available STRA6 gene related products
-
Recommended
- orf clones - Search results for 134 available STRA6 gene related products
- Overview of 134 available STRA6 gene related products
-
Recommended
- Applied Biological Materials Clones for STRA6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for STRA6
Cell Line Products
-
Horizon Cell Lines for STRA6
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , miRNA , Transcription Factor Targets and HOMER Transcription for STRA6 Gene
Localization for STRA6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for STRA6 Gene
- Cell membrane; Multi-pass membrane protein. Note=In the retinal pigment epithelium localizes to the basolateral membrane. {ECO:0000250 UniProtKB:Q0V8E7}.
- Cytosol (2)
- Nucleus (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IDA | 21901792 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0043234 | protein complex | IDA | -- |
Pathways & Interactions for STRA6 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | HIV Life Cycle |
.45
|
|
2 | Diseases associated with visual transduction | ||
3 | Signaling by GPCR | ||
4 | the visual cycle I (vertebrates) | ||
5 | Metabolism of fat-soluble vitamins |
Pathways by source for STRA6 Gene
7 Reactome pathways for STRA6 Gene
Interacting Proteins for STRA6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001523 | retinoid metabolic process | TAS | -- |
GO:0001568 | blood vessel development | IMP | 17273977 |
GO:0001822 | kidney development | IMP | 17273977 |
GO:0003184 | pulmonary valve morphogenesis | IMP | 17273977 |
GO:0003281 | ventricular septum development | IMP | 17273977 |
No data available for SIGNOR curated interactions for STRA6 Gene
Transcripts for STRA6 Gene
mRNA/cDNA for STRA6 Gene
- (14) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (120) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for STRA6 Gene
- Stimulated by retinoic acid 6:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for STRA6
- genomics-online: gRNA clones - Search results for 134 available STRA6 gene related products
- Overview of 134 available STRA6 gene related products
-
Recommended
- Applied Biological Materials CRISPR for STRA6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for STRA6
- GenScript: Design CRISPR guide RNA sequences for STRA6
miRNA Products
- Search ViGene Biosciences for STRA6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for STRA6
- Browse OriGene Inhibitory RNA Products For STRA6
- genomics-online: shRNA clones - Search results for 134 available STRA6 gene related products
- Overview of 134 available STRA6 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for STRA6
- RG206826
- RC206826L2
- RC206826L1
- RC206826
- RG231385
- RC231385L2
- RC231385L1
- RC231385
- RG231373
- RC231373L2
- RC231373L1
- RC231373
- RG231384
- RC231384L2
- RC231384L1
- RC231384
- RG227536
- RC227536L2
- RC227536L1
- RC227536
- RG227505
- RC227505L2
- RC227505L1
- RC227505
- RG227472
- RC227472L2
- RC227472L1
- RC227472
- RG227393
- RC227393L2
- RC227393L1
- RC227393
- RC206826L2V
- RC206826L1V
- RC231385L2V
- RC231385L1V
- RC231373L2V
- RC231373L1V
- RC231384L2V
- RC231384L1V
- RC227536L2V
- RC227536L1V
- RC227505L2V
- RC227505L1V
- RC227472L2V
- RC227472L1V
- RC227393L2V
- RC227393L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for STRA6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for STRA6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 134 available STRA6 gene related products
- Overview of 134 available STRA6 gene related products
-
Recommended
- orf clones - Search results for 134 available STRA6 gene related products
- Overview of 134 available STRA6 gene related products
-
Recommended
- Applied Biological Materials Clones for STRA6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for STRA6
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP17: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP18: | - | - |
ExUns: | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||
SP12: | |||||||||||||||||||||||||||||
SP13: | |||||||||||||||||||||||||||||
SP14: | |||||||||||||||||||||||||||||
SP15: | |||||||||||||||||||||||||||||
SP16: | |||||||||||||||||||||||||||||
SP17: | |||||||||||||||||||||||||||||
SP18: |
Expression for STRA6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Granulosa Cells Primary Follicle
- Neural Tube (Nervous System)
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
-
Eye (Sensory Organs)
- Lens Vesicle Cells Lens Vesicle
- Head Mesenchyme (Muscoskeletal System)
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Extraembryonic Tissues (Extraembryonic Tissues)
- Uncategorized
- Endothelium (Cardiovascular System)
- Brain (Nervous System)
- NULL (Uncategorized)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for STRA6 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STRA6 Gene
NURSA nuclear receptor signaling pathways regulating expression of STRA6 Gene:
STRA6SOURCE GeneReport for Unigene cluster for STRA6 Gene:
Hs.24553mRNA Expression by UniProt/SwissProt for STRA6 Gene:
Q9BX79-STRA6_HUMANEvidence on tissue expression from TISSUES for STRA6 Gene
- Nervous system(4.7)
- Muscle(4.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for STRA6 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
- brain
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- head
- jaw
- mandible
- maxilla
- mouth
- nose
- skull
- aorta
- diaphragm
- heart
- heart valve
- lung
- abdominal wall
- intestine
- kidney
- large intestine
- liver
- small intestine
- spleen
- stomach
- testicle
- ureter
- uterus
- blood
- blood vessel
- peripheral nervous system
- skin
Primer Products
-
OriGene qPCR primer pairs for STRA6
-
OriGene qPCR primer pairs and template standards for STRA6
- genomics-online: primer clones - Search results for 134 available STRA6 gene related products
- Overview of 134 available STRA6 gene related products
-
Recommended
Orthologs for STRA6 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | STRA6 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | STRA6 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | STRA6 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Stra6 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Stra6 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | STRA6 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | STRA6 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | STRA6 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | STRA6 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | stra6 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | stra6 33 34 |
|
- Species where no ortholog for STRA6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for STRA6 Gene
No data available for Paralogs for STRA6 Gene
Variants for STRA6 Gene
SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10910 | benign, Syndromic Microphthalmia, Recessive | 74,179,858(-) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
rs111489755 | uncertain-significance, Syndromic Microphthalmia, Recessive | 74,202,177(-) | C/G/T | 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs115067613 | benign, Microphthalmia syndromic 9 | 74,196,047(-) | C/G/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs115331762 | uncertain-significance, likely-benign, Syndromic Microphthalmia, Recessive, not provided | 74,180,851(-) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
rs11631944 | likely-benign, Syndromic Microphthalmia, Recessive | 74,179,953(-) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant |
Additional Variant Information for STRA6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRA6 Gene
Disorders for STRA6 Gene

(8) MalaCards diseases for STRA6 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
microphthalmia, syndromic 9 |
|
|
colobomatous microphthalmia |
|
|
diaphragmatic eventration |
|
|
microphthalmia |
|
|
alveolar capillary dysplasia |
|
|
UniProtKB/Swiss-Prot
STRA6_HUMAN- Microphthalmia, syndromic, 9 (MCOPS9) [MIM:601186]: A rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. {ECO:0000269 PubMed:17273977, ECO:0000269 PubMed:17503335, ECO:0000269 PubMed:21368206, ECO:0000269 PubMed:21901792}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. {ECO:0000269 PubMed:21901792}.
Additional Disease Information for STRA6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for STRA6 Gene
Publications for STRA6 Gene
- Identification of STRA6 and SKI sequence variants in patients with anophthalmia/microphthalmia. (PMID: 19112531) White T … Young TL (Molecular vision 2008) 3 4 44 58
- Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. (PMID: 17273977) Pasutto F … Rauch A (American journal of human genetics 2007) 2 3 4 58
- Structure of the STRA6 receptor for retinol uptake. (PMID: 27563101) Chen Y … Mancia F (Science (New York, N.Y.) 2016) 2 3 58
- Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6. (PMID: 22665496) Berry DC … Noy N (Molecular and cellular biology 2012) 3 4 58
- First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype. (PMID: 21901792) Casey J … Ennis S (Human mutation 2011) 3 4 58
Products for STRA6 Gene
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- Invitrogen Antibodies for STRA6
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- Yeast expression
- antibodies-online: Search results for 100 available STRA6 Antibodies ranked by validation data
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- 41 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 10 WB Antibodies (anti-rat)
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Sources for STRA6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
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- (96) Addgene
- (97) antibodies-online
- (98) CYP
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- (101) TreeFam
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- (103) GeneReviews
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- (138) Cyagen
- (139) VectorBuilder
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- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew