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Aliases for PRKAB2 Gene

Aliases for PRKAB2 Gene

  • Protein Kinase, AMP-Activated, Beta 2 Non-Catalytic Subunit 2 3
  • AMPK Subunit Beta-2 4
  • AMPK Beta 2 2

External Ids for PRKAB2 Gene

Previous GeneCards Identifiers for PRKAB2 Gene

  • GC01M144845
  • GC01M143356
  • GC01M143971
  • GC01M144138
  • GC01M144133
  • GC01M143851
  • GC01M145093
  • GC01M146627
  • GC01M120041

Summaries for PRKAB2 Gene

Entrez Gene Summary for PRKAB2 Gene

  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for PRKAB2 Gene

PRKAB2 (Protein Kinase, AMP-Activated, Beta 2 Non-Catalytic Subunit) is a Protein Coding gene. Diseases associated with PRKAB2 include atrioventricular septal defect. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include identical protein binding and AMP-activated protein kinase activity. An important paralog of this gene is PRKAB1.

UniProtKB/Swiss-Prot for PRKAB2 Gene

  • Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)

Gene Wiki entry for PRKAB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAB2 Gene

Genomics for PRKAB2 Gene

Regulatory Elements for PRKAB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKAB2 Gene

Start:
147,155,106 bp from pter
End:
147,172,589 bp from pter
Size:
17,484 bases
Orientation:
Minus strand

Genomic View for PRKAB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKAB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAB2 Gene

Proteins for PRKAB2 Gene

  • Protein details for PRKAB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43741-AAKB2_HUMAN
    Recommended name:
    5-AMP-activated protein kinase subunit beta-2
    Protein Accession:
    O43741
    Secondary Accessions:
    • A8K9V5
    • B4DH06
    • Q5VXY0

    Protein attributes for PRKAB2 Gene

    Size:
    272 amino acids
    Molecular mass:
    30302 Da
    Quaternary structure:
    • AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3).

    Three dimensional structures from OCA and Proteopedia for PRKAB2 Gene

    Alternative splice isoforms for PRKAB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKAB2 Gene

Proteomics data for PRKAB2 Gene at MOPED

Post-translational modifications for PRKAB2 Gene

  • Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.
  • Ubiquitination at Lys270
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKAB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKAB2 (AMPKB2)

No data available for DME Specific Peptides for PRKAB2 Gene

Domains for PRKAB2 Gene

Graphical View of Domain Structure for InterPro Entry

O43741

UniProtKB/Swiss-Prot:

AAKB2_HUMAN :
  • O43741
Family:
  • Belongs to the 5-AMP-activated protein kinase beta subunit family.
genes like me logo Genes that share domains with PRKAB2: view

Function for PRKAB2 Gene

Molecular function for PRKAB2 Gene

GENATLAS Biochemistry: protein kinase,cAMP activated,beta 2 non catalytic subunit,highly expressed in skeletal and cardiac muscle,complexing with alpha 2 and gamma 1
UniProtKB/Swiss-Prot Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)

Gene Ontology (GO) - Molecular Function for PRKAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004679 contributes_to AMP-activated protein kinase activity IDA 21399626
GO:0005515 protein binding IPI 16306228
GO:0042802 identical protein binding IPI 20562859
genes like me logo Genes that share ontologies with PRKAB2: view
genes like me logo Genes that share phenotypes with PRKAB2: view

Animal Models for PRKAB2 Gene

MGI Knock Outs for PRKAB2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKAB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PRKAB2 Gene

Localization for PRKAB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKAB2 Gene COMPARTMENTS Subcellular localization image for PRKAB2 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for PRKAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0031588 AMP-activated protein kinase complex IDA 17851531
genes like me logo Genes that share ontologies with PRKAB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRKAB2 Gene

Pathways for PRKAB2 Gene

genes like me logo Genes that share pathways with PRKAB2: view

Pathways by source for PRKAB2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for PRKAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IDA 21399626
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006853 carnitine shuttle TAS --
genes like me logo Genes that share ontologies with PRKAB2: view

Compounds for PRKAB2 Gene

(1) Drugbank Compounds for PRKAB2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
61-19-8 target activator
genes like me logo Genes that share compounds with PRKAB2: view

Transcripts for PRKAB2 Gene

Unigene Clusters for PRKAB2 Gene

Protein kinase, AMP-activated, beta 2 non-catalytic subunit:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKAB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for PRKAB2 Gene

GeneLoc Exon Structure for
PRKAB2
ECgene alternative splicing isoforms for
PRKAB2

Expression for PRKAB2 Gene

mRNA expression in normal human tissues for PRKAB2 Gene

mRNA differential expression in normal tissues according to GTEx for PRKAB2 Gene

This gene is overexpressed in Muscle - Skeletal (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKAB2 Gene

SOURCE GeneReport for Unigene cluster for PRKAB2 Gene Hs.50732

genes like me logo Genes that share expressions with PRKAB2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRKAB2 Gene

Orthologs for PRKAB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKAB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKAB2 35
  • 99.63 (n)
  • 99.26 (a)
PRKAB2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKAB2 35
  • 94.73 (n)
  • 98.9 (a)
PRKAB2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKAB2 35
  • 90.81 (n)
  • 93.75 (a)
PRKAB2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkab2 35
  • 91.27 (n)
  • 97.42 (a)
Prkab2 16
Prkab2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKAB2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAB2 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkab2 35
  • 92.13 (n)
  • 97.42 (a)
chicken
(Gallus gallus)
Aves PRKAB2 35
  • 79.53 (n)
  • 90.44 (a)
PRKAB2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKAB2 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia prkab2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prkab2 35
  • 76.12 (n)
  • 85.07 (a)
zebrafish
(Danio rerio)
Actinopterygii prkab2 35
  • 71.72 (n)
  • 76.89 (a)
PRKAB2 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alc 36
  • 38 (a)
OneToMany
CG8057 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea aakb-1 35
  • 55.09 (n)
  • 55.96 (a)
aakb-1 36
  • 44 (a)
ManyToMany
aakb-2 36
  • 42 (a)
ManyToMany
F55F3.1 37
  • 50 (a)
Y47D3A.15 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GAL83 36
  • 19 (a)
ManyToMany
SIP2 35
  • 49.74 (n)
  • 41.03 (a)
SIP2 36
  • 20 (a)
ManyToMany
SIP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AKINBETA1 35
  • 49.31 (n)
  • 35.57 (a)
rice
(Oryza sativa)
Liliopsida Os05g0491200 35
  • 49.07 (n)
  • 39.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10258 36
  • 51 (a)
OneToMany
Species with no ortholog for PRKAB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKAB2 Gene

ENSEMBL:
Gene Tree for PRKAB2 (if available)
TreeFam:
Gene Tree for PRKAB2 (if available)

Paralogs for PRKAB2 Gene

Paralogs for PRKAB2 Gene

Selected SIMAP similar genes for PRKAB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRKAB2: view

Variants for PRKAB2 Gene

Sequence variations from dbSNP and Humsavar for PRKAB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6937 -- 147,155,343(-) AAGGG(A/C/G/T)ATTAA utr-variant-3-prime, nc-transcript-variant
rs15722 -- 147,156,217(-) GTTTG(A/G)AATAC utr-variant-3-prime, nc-transcript-variant
rs930495 -- 147,162,935(+) TGATG(G/T)TTTTA intron-variant
rs1036850 -- 147,162,160(+) GTACA(A/C)CCCCA intron-variant
rs1036851 -- 147,162,171(+) AATGA(C/T)AACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKAB2 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
esv529 CNV CNV 17122850
dgv114e1 CNV Complex 17122850
nsv872251 CNV Gain 21882294
nsv872255 CNV Gain 21882294
nsv8169 CNV Gain 18304495
nsv872257 CNV Gain 21882294
nsv437047 CNV Loss 16327808

Relevant External Links for PRKAB2 Gene

HapMap Linkage Disequilibrium report
PRKAB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKAB2 Gene

Disorders for PRKAB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PRKAB2 Gene including...

Search for PRKAB2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PRKAB2 Gene

Relevant External Links for PRKAB2

Genetic Association Database (GAD)
PRKAB2
Human Genome Epidemiology (HuGE) Navigator
PRKAB2
genes like me logo Genes that share disorders with PRKAB2: view

No data available for UniProtKB/Swiss-Prot for PRKAB2 Gene

Publications for PRKAB2 Gene

  1. Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians. (PMID: 12490143) Prochazka M. … Bogardus C. (Mol. Cell. Probes 2002) 3 4 23 48
  2. Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes. (PMID: 16505254) Sun M.W. … Florez J.C. (Diabetes 2006) 3 23 48
  3. Mammalian AMP-activated protein kinase subfamily. (PMID: 8557660) Stapleton D. … Kemp B.E. (J. Biol. Chem. 1996) 2 3
  4. Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. (PMID: 9575201) Thornton C. … Carling D. (J. Biol. Chem. 1998) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for PRKAB2 Gene

Sources for PRKAB2 Gene

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