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Aliases for ABCB1 Gene

Aliases for ABCB1 Gene

  • ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 2 3
  • MDR1 3 4 6
  • PGY1 3 4 6
  • Multidrug Resistance Protein 1 2 3
  • Colchicin Sensitivity 2 3
  • P-Glycoprotein 1 3 4
  • EC 3.6.3.44 4 64
  • CLCS 3 6
  • ATP-Binding Cassette Sub-Family B Member 1 4
  • Doxorubicin Resistance 3
  • CD243 Antigen 4
  • EC 3.6.3 64
  • ABC20 3
  • CD243 3
  • GP170 3
  • IBD13 6
  • P-GP 3

External Ids for ABCB1 Gene

Previous Symbols for ABCB1 Gene

  • PGY1
  • MDR1
  • CLCS

Summaries for ABCB1 Gene

Entrez Gene Summary for ABCB1 Gene

  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCB1 Gene

ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1) is a Protein Coding gene. Diseases associated with ABCB1 include inflammatory bowel disease 13 and acute non lymphoblastic leukemia. Among its related pathways are MicroRNAs in cancer and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include transporter activity and xenobiotic-transporting ATPase activity. An important paralog of this gene is ABCB11.

UniProtKB/Swiss-Prot for ABCB1 Gene

  • Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells

Tocris Summary for ABCB1 Gene

  • P-glycoprotein (ABCB1, MDR1) is a well-characterized human ABC transporter that was the first ABC transporter implicated in multidrug resistance. Normal physiological expression of P-glycoprotein has been found to prevent uptake of some lipophilic drugs into the brain and other key organs. P-glycoprotein is frequently overexpressed in cancer cells resulting in drugs being pumped out of the cells faster than they can enter. This causes a lower concentration of the drug in the cell and reduces the effectiveness of the drugs in killing cancer cells. Drugs that are affected by classical multidrug resistance include the vinca alkaloids (vinblastine and vincristine), the anthracyclines (doxorubicin and daunorubicin), the RNA transcription inhibitor actinomycin D and the microtubule-stabilizing drug taxol.

Gene Wiki entry for ABCB1 Gene

PharmGKB "VIP" Summary for ABCB1 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for ABCB1 Gene

Genomics for ABCB1 Gene

Genomic Location for ABCB1 Gene

Start:
87,503,633 bp from pter
End:
87,713,323 bp from pter
Size:
209,691 bases
Orientation:
Minus strand

Genomic View for ABCB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ABCB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCB1 Gene

Regulatory Elements for ABCB1 Gene

Proteins for ABCB1 Gene

  • Protein details for ABCB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08183-MDR1_HUMAN
    Recommended name:
    Multidrug resistance protein 1
    Protein Accession:
    P08183
    Secondary Accessions:
    • A8K294
    • B5AK60
    • Q12755
    • Q14812

    Protein attributes for ABCB1 Gene

    Size:
    1280 amino acids
    Molecular mass:
    141479 Da
    Quaternary structure:
    • Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
    SequenceCaution:
    • Sequence=AAM49149.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ABCB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCB1 Gene

Proteomics data for ABCB1 Gene at MOPED

Post-translational modifications for ABCB1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys279, Lys367, Lys515, Lys519, Lys915, Lys1093, and Lys1164
  • Glycosylation at Asn91, Asn94, and Asn99

Other Protein References for ABCB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ABCB1 Gene

Gene Families for ABCB1 Gene

HGNC:
  • CD :CD molecules
  • ABCB :ATP binding cassette transporters / subfamily B
IUPHAR :

Protein Domains for ABCB1 Gene

UniProtKB/Swiss-Prot:

MDR1_HUMAN
Domain:
  • Contains 2 ABC transmembrane type-1 domains.:
    • P08183
  • Contains 2 ABC transporter domains.:
    • P08183
Family:
  • Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.:
    • P08183
genes like me logo Genes that share domains with ABCB1: view

Function for ABCB1 Gene

Molecular function for ABCB1 Gene

GENATLAS Biochemistry: ATP binding cassette superfamily,subfamily B (MDR/TAP),member 1,putatively activated by random chromosomal rearrangements,and overexpressed in acute myeloid leukemia and cancer cell lines,by hypomethylation of the promoter and altered chromatin structure,up-regulated by P/CAF
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out)
UniProtKB/Swiss-Prot Function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells

Enzyme Numbers (IUBMB) for ABCB1 Gene

Gene Ontology (GO) - Molecular Function for ABCB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 3022150
GO:0005515 protein binding IPI 17088979
GO:0005524 ATP binding IEA --
GO:0008559 xenobiotic-transporting ATPase activity IEA --
GO:0016887 ATPase activity --
genes like me logo Genes that share ontologies with ABCB1: view
genes like me logo Genes that share phenotypes with ABCB1: view

Animal Models for ABCB1 Gene

MGI Knock Outs for ABCB1:

miRNA for ABCB1 Gene

miRTarBase miRNAs that target ABCB1

No data available for Transcription Factor Targeting and HOMER Transcription for ABCB1 Gene

Localization for ABCB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCB1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ABCB1 Gene COMPARTMENTS Subcellular localization image for ABCB1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
nucleus 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ABCB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 19384922
GO:0016020 membrane TAS 3022150
GO:0016021 integral component of membrane IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ABCB1: view

Pathways for ABCB1 Gene

genes like me logo Genes that share pathways with ABCB1: view

Gene Ontology (GO) - Biological Process for ABCB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 19384922
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport TAS 3022150
GO:0006855 drug transmembrane transport TAS --
GO:0042493 response to drug TAS 3022150
genes like me logo Genes that share ontologies with ABCB1: view

Compounds for ABCB1 Gene

(5) Tocris Compounds for ABCB1 Gene

Compound Action Cas Number
Elacridar hydrochloride P-gp inhibitor [143851-98-3]
Ko 143 Potent and selective BCRP inhibitor [461054-93-3]
Probenecid MRP inhibitor [57-66-9]
PSC 833 Inhibitor of P-gp-mediated MDR [121584-18-7]
XR 9051 HCl Potent modulator of P-gp-mediated MDR [180422-22-4]

(294) Drugbank Compounds for ABCB1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acebutolol
  • Acebutolol HCL
37517-30-9 transporter substrate
Acetaminophen
  • Acetaminofen
103-90-2 transporter substrate inhibitor
Acetylsalicylic acid
  • 2-Acetoxybenzenecarboxylic acid
50-78-2 transporter substrate
Adenosine triphosphate
  • 5'-ATP
56-65-5 target
ado-trastuzumab emtansine
  • RG-3502
1018448-65- transporter substrate

(131) Novoseek inferred chemical compound relationships for ABCB1 Gene

Compound -log(P) Hits PubMed IDs
rhodamine 123 94.9 221
verapamil 91.7 225
daunorubicin 91.4 198
psc-833 91.1 113
doxorubicin 90.8 251
genes like me logo Genes that share compounds with ABCB1: view

Transcripts for ABCB1 Gene

Unigene Clusters for ABCB1 Gene

ATP-binding cassette, sub-family B (MDR/TAP), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ABCB1 Gene

No ASD Table

Relevant External Links for ABCB1 Gene

GeneLoc Exon Structure for
ABCB1
ECgene alternative splicing isoforms for
ABCB1

Expression for ABCB1 Gene

mRNA expression in normal human tissues for ABCB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCB1 Gene

This gene is overexpressed in Adrenal Gland (18.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ABCB1 Gene

SOURCE GeneReport for Unigene cluster for ABCB1 Gene Hs.489033

mRNA Expression by UniProt/SwissProt for ABCB1 Gene

P08183-MDR1_HUMAN
Tissue specificity: Expressed in liver, kidney, small intestine and brain
genes like me logo Genes that share expressions with ABCB1: view

Orthologs for ABCB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCB1 36
  • 99.56 (n)
  • 99.53 (a)
ABCB1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 66 (a)
OneToMany
ABCB1 36
  • 85.86 (n)
  • 86.43 (a)
ABCB1 37
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ABCB1 36
  • 90.06 (n)
  • 90.61 (a)
MDR1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Abcb1a 36
  • 86.07 (n)
  • 87.61 (a)
Abcb1a 16
Abcb1a 37
  • 88 (a)
OneToMany
Abcb1b 37
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 73 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 68 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Abcb1a 36
  • 85.73 (n)
  • 87.57 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 65 (a)
ManyToMany
ABCB1LB 37
  • 64 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia abcb1 36
  • 67.99 (n)
  • 69.98 (a)
MGC76216 36
zebrafish
(Danio rerio)
Actinopterygii abcb4 37
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10226 37
  • 39 (a)
ManyToMany
Mdr49 37
  • 42 (a)
ManyToMany
Mdr50 36
  • 51.39 (n)
  • 45.26 (a)
Mdr50 37
  • 42 (a)
ManyToMany
Mdr65 37
  • 41 (a)
ManyToMany
Mdr50 38
  • 44 (a)
Mdr65 38
  • 41 (a)
CG10226 38
  • 65 (a)
Mdr49 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea pgp-1 37
  • 43 (a)
ManyToMany
pgp-9 36
  • 52.1 (n)
  • 47.2 (a)
pgp-5 38
  • 36 (a)
pgp-11 38
  • 33 (a)
pgp-14 38
  • 38 (a)
pgp-2 38
  • 45 (a)
pgp-4 38
  • 40 (a)
pgp-7 38
  • 36 (a)
pgp-13 38
  • 36 (a)
pgp-1 38
  • 45 (a)
pgp-6 38
  • 36 (a)
pgp-12 38
  • 38 (a)
pgp-15 38
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE6 37
  • 26 (a)
OneToMany
STE6 39
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1243 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ABCB4 36
  • 51.91 (n)
  • 44.53 (a)
corn
(Zea mays)
Liliopsida Zm.4341 36
rice
(Oryza sativa)
Liliopsida Os.20120 36
Os01g0695700 36
  • 51.8 (n)
  • 44.27 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07546 36
  • 49.85 (n)
  • 43.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pmd1 36
  • 48.59 (n)
  • 41.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7248 37
  • 52 (a)
ManyToMany
Species with no ortholog for ABCB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCB1 Gene

ENSEMBL:
Gene Tree for ABCB1 (if available)
TreeFam:
Gene Tree for ABCB1 (if available)

Paralogs for ABCB1 Gene

Paralogs for ABCB1 Gene

genes like me logo Genes that share paralogs with ABCB1: view

Variants for ABCB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ABCB1 Gene

P08183-MDR1_HUMAN
Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment

Sequence variations from dbSNP and Humsavar for ABCB1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3842 -- 87,504,050(-) AAATC(A/G)TAGTT utr-variant-3-prime
rs16706 -- 87,586,903(+) AAAAG(-/AG)TATCT intron-variant
rs17064 -- 87,504,154(-) GAATT(A/T)TGAAG utr-variant-3-prime
rs868755 -- 87,560,614(-) ATATA(A/C)ATATC intron-variant
rs955000 -- 87,562,930(-) GTAGA(C/G)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ABCB1 Gene

Variant ID Type Subtype PubMed ID
nsv888677 CNV Gain 21882294
nsv464622 CNV Gain 19166990
nsv464623 CNV Gain 19166990
nsv888691 CNV Gain 21882294
esv2734775 CNV Deletion 23290073
nsv888692 CNV Loss 21882294
esv2734776 CNV Deletion 23290073
esv7655 CNV Loss 19470904
esv2666273 CNV Deletion 23128226
esv28195 CNV Loss 19812545
dgv7384n71 CNV Loss 21882294
nsv888695 CNV Loss 21882294

Relevant External Links for ABCB1 Gene

HapMap Linkage Disequilibrium report
ABCB1
Human Gene Mutation Database (HGMD)
ABCB1

Disorders for ABCB1 Gene

(2) OMIM Diseases for ABCB1 Gene (171050)

UniProtKB/Swiss-Prot

MDR1_HUMAN
  • Inflammatory bowel disease 13 (IBD13) [MIM:612244]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(89) Novoseek inferred disease relationships for ABCB1 Gene

Disease -log(P) Hits PubMed IDs
cancer 75.3 221
leukemia 75.2 169
tumors 72.3 326
breast cancer 70.3 217
colchicine resistance 69.4 5

Relevant External Links for ABCB1

Genetic Association Database (GAD)
ABCB1
Human Genome Epidemiology (HuGE) Navigator
ABCB1
genes like me logo Genes that share disorders with ABCB1: view

Publications for ABCB1 Gene

  1. Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. (PMID: 16791115) Anderson P.L. … Fletcher C.V. (J. Acquir. Immune Defic. Syndr. 2006) 3 23 25 49
  2. Adenosine triphosphate-binding cassette B1 (ABCB1) (multidrug resistance 1) G2677T/A gene polymorphism is associated with high risk of lung cancer. (PMID: 17120199) Gervasini G. … Benitez J. (Cancer 2006) 3 23 25 49
  3. Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. (PMID: 20179710) Bray J. … Boddy A.V. (Br. J. Cancer 2010) 3 23 25 49
  4. Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors. (PMID: 9473242) Mickley L.A. … Fojo T. (Blood 1998) 3 4 23
  5. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P- glycoprotein expression and activity in vivo. (PMID: 10716719) Hoffmeyer S. … Brinkmann U. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23

Products for ABCB1 Gene

  • Addgene plasmids for ABCB1

Sources for ABCB1 Gene

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