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Aliases for MT-ND2 Gene

Aliases for MT-ND2 Gene

  • Mitochondrially Encoded NADH Dehydrogenase 2 2
  • MTND2 3 3 4
  • NADH Dehydrogenase Subunit 2 3 4
  • EC 1.6.5.3 4 63
  • ND2 3 4
  • NADH-Ubiquinone Oxidoreductase Chain 2 2
  • Complex I ND2 Subunit 2
  • NADH Dehydrogenase 2 2
  • NADH2 4

External Ids for MT-ND2 Gene

Previous Symbols for MT-ND2 Gene

  • MTND2

Summaries for MT-ND2 Gene

GeneCards Summary for MT-ND2 Gene

MT-ND2 (Mitochondrially Encoded NADH Dehydrogenase 2) is a Protein Coding gene. Diseases associated with MT-ND2 include alzheimer disease mitochondrial and maternally inherited leigh syndrome. Among its related pathways are Metabolism and Metabolism.

UniProtKB/Swiss-Prot for MT-ND2 Gene

  • Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Gene Wiki entry for MT-ND2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-ND2 Gene

Genomics for MT-ND2 Gene

Genomic Location for MT-ND2 Gene

Start:
4,470 bp from pter
End:
5,511 bp from pter
Size:
1,042 bases
Orientation:
Plus strand

Genomic View for MT-ND2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for MT-ND2 Gene

No data available for Regulatory Elements for MT-ND2 Gene

Proteins for MT-ND2 Gene

  • Protein details for MT-ND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P03891-NU2M_HUMAN
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 2
    Protein Accession:
    P03891
    Secondary Accessions:
    • Q34769
    • Q9TGI0
    • Q9TGI1
    • Q9TGI2
    • Q9TGI3
    • Q9TGI4

    Protein attributes for MT-ND2 Gene

    Size:
    347 amino acids
    Molecular mass:
    38961 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA65502.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MT-ND2 Gene

Proteomics data for MT-ND2 Gene at MOPED

Post-translational modifications for MT-ND2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT-ND2 Gene

ENSEMBL proteins:
Reactome Protein details:

Domains for MT-ND2 Gene

Gene Families for MT-ND2 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Suggested Antigen Peptide Sequences for MT-ND2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P03891

UniProtKB/Swiss-Prot:

NU2M_HUMAN
Family:
  • Belongs to the complex I subunit 2 family.:
    • P03891
genes like me logo Genes that share domains with MT-ND2: view

Function for MT-ND2 Gene

Molecular function for MT-ND2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out)
UniProtKB/Swiss-Prot Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Enzyme Numbers (IUBMB) for MT-ND2 Gene

Gene Ontology (GO) - Molecular Function for MT-ND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity --
genes like me logo Genes that share ontologies with MT-ND2: view

Phenotypes for MT-ND2 Gene

genes like me logo Genes that share phenotypes with MT-ND2: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MT-ND2 Gene

Localization for MT-ND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MT-ND2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT-ND2 Gene COMPARTMENTS Subcellular localization image for MT-ND2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MT-ND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane --
GO:0005747 mitochondrial respiratory chain complex I --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with MT-ND2: view

Pathways for MT-ND2 Gene

genes like me logo Genes that share pathways with MT-ND2: view

Interacting Proteins for MT-ND2 Gene

Gene Ontology (GO) - Biological Process for MT-ND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone --
GO:0022904 respiratory electron transport chain --
GO:0044237 cellular metabolic process --
GO:0044281 small molecule metabolic process --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with MT-ND2: view

Compounds for MT-ND2 Gene

(9) HMDB Compounds for MT-ND2 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for MT-ND2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target binder

(7) Novoseek inferred chemical compound relationships for MT-ND2 Gene

Compound -log(P) Hits PubMed IDs
nadh 83.8 28
valine 30.9 1
methionine 18.3 1
threonine 16.9 1
alanine 5.96 1
genes like me logo Genes that share compounds with MT-ND2: view

Transcripts for MT-ND2 Gene

mRNA/cDNA for MT-ND2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-ND2 Gene

No ASD Table

Relevant External Links for MT-ND2 Gene

GeneLoc Exon Structure for
MT-ND2
ECgene alternative splicing isoforms for
MT-ND2

Expression for MT-ND2 Gene

mRNA expression in normal human tissues for MT-ND2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MT-ND2 Gene

genes like me logo Genes that share expressions with MT-ND2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MT-ND2 Gene

Orthologs for MT-ND2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MT-ND2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT-ND2 36
  • 96 (a)
OneToOne
ND2 35
  • 90.39 (n)
  • 95.39 (a)
cow
(Bos Taurus)
Mammalia ND2 35
  • 66.08 (n)
  • 63.93 (a)
ND2 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MT-ND2 36
  • 59 (a)
OneToOne
ND2 35
  • 64.53 (n)
  • 59.77 (a)
mouse
(Mus musculus)
Mammalia mt-Nd2 16
mt-Nd2 36
  • 57 (a)
OneToOne
ND2 35
  • 62.84 (n)
  • 59.94 (a)
oppossum
(Monodelphis domestica)
Mammalia NADH2 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ND2 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia ND2 35
  • 63.2 (n)
  • 57.41 (a)
chicken
(Gallus gallus)
Aves MT-ND2 36
  • 48 (a)
OneToOne
ND2 35
  • 60.04 (n)
  • 51.24 (a)
lizard
(Anolis carolinensis)
Reptilia ND2 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ND2 35
  • 57.95 (n)
  • 52.03 (a)
zebrafish
(Danio rerio)
Actinopterygii mt-nd2 36
  • 45 (a)
OneToOne
ND2 35
  • 53.48 (n)
  • 46.11 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta ND2 35
  • 48.42 (n)
  • 41.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta mt:ND2 36
  • 35 (a)
OneToOne
ND2 35
  • 50.13 (n)
  • 44.7 (a)
Species with no ortholog for MT-ND2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MT-ND2 Gene

ENSEMBL:
Gene Tree for MT-ND2 (if available)
TreeFam:
Gene Tree for MT-ND2 (if available)

Paralogs for MT-ND2 Gene

Selected SIMAP similar genes for MT-ND2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT-ND2: view

No data available for Paralogs for MT-ND2 Gene

Variants for MT-ND2 Gene

Sequence variations from dbSNP and Humsavar for MT-ND2 Gene

SNP ID Clin Chr MT pos Sequence Context AA Info Type MAF
VAR_004755 Leber hereditary optic neuropathy (LHON)
VAR_004756 Leber hereditary optic neuropathy (LHON)
VAR_004757 -
VAR_004758 Alzheimer disease mitochondrial (AD-MT)
VAR_008590 -

Relevant External Links for MT-ND2 Gene

HapMap Linkage Disequilibrium report
MT-ND2
Human Gene Mutation Database (HGMD)
MT-ND2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MT-ND2 Gene

Disorders for MT-ND2 Gene

UniProtKB/Swiss-Prot

NU2M_HUMAN
  • Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. {ECO:0000269 PubMed:1732158, ECO:0000269 PubMed:1900003}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Alzheimer disease mitochondrial (AD-MT) [MIM:502500]: Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for MT-ND2 Gene

Disease -log(P) Hits PubMed IDs
somatic mutations 34.3 1
cancer 0 1

Relevant External Links for MT-ND2

GeneTests
MT-ND2
GeneReviews
MT-ND2
Genetic Association Database (GAD)
MT-ND2
genes like me logo Genes that share disorders with MT-ND2: view

Publications for MT-ND2 Gene

  1. The association of mitochondrial DNA 5178 C > a polymorphism with plasma lipid levels among three ethnic groups. (PMID: 16266403) Lal S. … Heng C.K. (Ann. Hum. Genet. 2005) 3 23 48
  2. Association of a 5178C-->A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals. (PMID: 15262184) Takagi K. … Tanaka M. (Atherosclerosis 2004) 3 23 48
  3. Longevity-associated NADH dehydrogenase subunit-2 polymorphism and serum electrolyte levels in middle-aged obese Japanese men. (PMID: 15888325) Kokaze A. … Takashima Y. (Mech. Ageing Dev. 2005) 3 23 48
  4. Sequence and organization of the human mitochondrial genome. (PMID: 7219534) Anderson S. … Young I.G. (Nature 1981) 3 4
  5. Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. (PMID: 15069201) Gingrich J.R. … Salter M.W. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23

Products for MT-ND2 Gene

Sources for MT-ND2 Gene

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