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Aliases for MIF Gene

Aliases for MIF Gene

  • Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) 2 3
  • Phenylpyruvate Tautomerase 3 4
  • L-Dopachrome Tautomerase 3 4
  • L-Dopachrome Isomerase 3 4
  • GLIF 3 4
  • MMIF 3 4
  • GIF 3 4
  • Macrophage Migration Inhibitory Factor 3
  • Glycosylation-Inhibiting Factor 4
  • EC 5.3.3.12 4
  • EC 5.3.2.1 4

External Ids for MIF Gene

Previous Symbols for MIF Gene

  • GLIF

Summaries for MIF Gene

Entrez Gene Summary for MIF Gene

  • This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

GeneCards Summary for MIF Gene

MIF (Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor)) is a Protein Coding gene. Diseases associated with MIF include malaria and rheumatoid arthritis, systemic juvenile. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include receptor binding and chemoattractant activity.

UniProtKB/Swiss-Prot for MIF Gene

  • Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

Gene Wiki entry for MIF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIF Gene

Genomics for MIF Gene

Genomic Location for MIF Gene

Start:
23,894,004 bp from pter
End:
23,895,227 bp from pter
Size:
1,224 bases
Orientation:
Plus strand

Genomic View for MIF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIF Gene

Regulatory Elements for MIF Gene

Proteins for MIF Gene

  • Protein details for MIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14174-MIF_HUMAN
    Recommended name:
    Macrophage migration inhibitory factor
    Protein Accession:
    P14174
    Secondary Accessions:
    • A5Z1R8
    • B2R4S3
    • Q2V4Y5
    • Q6FHV0

    Protein attributes for MIF Gene

    Size:
    115 amino acids
    Molecular mass:
    12476 Da
    Quaternary structure:
    • Homotrimer. Interacts with CXCR2 extracellular domain (By similarity). Interacts with the CD74 extracellular domain, COPS5 and BNIPL.
    Miscellaneous:
    • Serum levels of MIF are elevated in patients with severe sepsis or septic shock. High levels of MIF are correlated with low survival. Drugs that inhibit tautomerase activity protect against death due to sepsis

    Three dimensional structures from OCA and Proteopedia for MIF Gene

neXtProt entry for MIF Gene

Proteomics data for MIF Gene at MOPED

Post-translational modifications for MIF Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys78

Other Protein References for MIF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MIF Gene

Domains for MIF Gene

UniProtKB/Swiss-Prot:

MIF_HUMAN
Family:
  • Belongs to the MIF family.:
    • P14174
genes like me logo Genes that share domains with MIF: view

No data available for Gene Families for MIF Gene

Function for MIF Gene

Molecular function for MIF Gene

GENATLAS Biochemistry: macrophage migration inhibitory factor,12.3kDa,expressed in T cells and various tissues,including immunologically privileged lens and brain,also involved in mitogenic response and the control of cell cycle progression,maybe the same as DDT
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=249 uM for phenylpyruvate {ECO:0000269 PubMed:11439086}; KM=168 uM for p-hydroxyphenylpyruvate {ECO:0000269 PubMed:11439086}; Vmax=2113 umol/min/mg enzyme toward phenylpyruvate {ECO:0000269 PubMed:11439086}; Vmax=524 umol/min/mg enzyme toward p-hydroxyphenylpyruvate {ECO:0000269 PubMed:11439086};
UniProtKB/Swiss-Prot CatalyticActivity: Keto-phenylpyruvate = enol-phenylpyruvate
UniProtKB/Swiss-Prot CatalyticActivity: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate
UniProtKB/Swiss-Prot Function: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
UniProtKB/Swiss-Prot Induction: Up-regulated in concanavalin-A-treated lymphocytes. Up-regulated in macrophages upon exposure to M.tuberculosis antigens.

Enzyme Numbers (IUBMB) for MIF Gene

Gene Ontology (GO) - Molecular Function for MIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004167 dopachrome isomerase activity IDA 17526494
GO:0005102 receptor binding IPI 12782713
GO:0005125 cytokine activity IDA 12782713
GO:0005126 cytokine receptor binding IPI 17045821
GO:0005515 protein binding IPI 12681488
genes like me logo Genes that share ontologies with MIF: view
genes like me logo Genes that share phenotypes with MIF: view

Animal Models for MIF Gene

MGI Knock Outs for MIF:

miRNA for MIF Gene

No data available for Transcription Factor Targeting and HOMER Transcription for MIF Gene

Localization for MIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIF Gene

Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MIF Gene COMPARTMENTS Subcellular localization image for MIF gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 12782713
GO:0005615 extracellular space IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0009986 cell surface IDA 12782713
genes like me logo Genes that share ontologies with MIF: view

Pathways for MIF Gene

SuperPathways for MIF Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 PEDF Induced Signaling
3 Phenylalanine metabolism
4 Disease
5 Metabolism
genes like me logo Genes that share pathways with MIF: view

Gene Ontology (GO) - Biological Process for MIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001516 prostaglandin biosynthetic process IDA 12782713
GO:0001934 positive regulation of protein phosphorylation --
GO:0002906 negative regulation of mature B cell apoptotic process IEA --
GO:0006954 inflammatory response IEA --
GO:0007166 cell surface receptor signaling pathway IDA 12782713
genes like me logo Genes that share ontologies with MIF: view

Compounds for MIF Gene

(5) Tocris Compounds for MIF Gene

Compound Action Cas Number
4-IPP Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate [41270-96-6]
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release [106566-58-9]
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines [6501-72-0]
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo [53179-13-8]
Thalidomide TNF-alpha synthesis inhibitor [50-35-1]

(4) HMDB Compounds for MIF Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxy-3-(4-hydroxyphenyl)propenoic acid
  • 2-Hydroxy-3-(4-hydroxyphenyl)propenoate
Not Available
4-Hydroxyphenylpyruvic acid
  • (p-Hydroxyphenyl)pyruvate
156-39-8
Enol-phenylpyruvate
  • 2-Hydroxy-3-phenylpropenoate
5801-57-0
Phenylpyruvic acid
  • 2-Oxo-3-phenylpropanoate
156-06-9

(76) Novoseek inferred chemical compound relationships for MIF Gene

Compound -log(P) Hits PubMed IDs
d-dopachrome 94 22
5-carboxymethyl-2-hydroxymuconate 90.2 6
l-dopachrome 85.2 5
(e)-2-fluoro-p-hydroxycinnamate 84.4 2
chmi 84.3 4
genes like me logo Genes that share compounds with MIF: view

Transcripts for MIF Gene

mRNA/cDNA for MIF Gene

Unigene Clusters for MIF Gene

Macrophage migration inhibitory factor (glycosylation-inhibiting factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIF Gene

No ASD Table

Relevant External Links for MIF Gene

GeneLoc Exon Structure for
MIF
ECgene alternative splicing isoforms for
MIF

Expression for MIF Gene

mRNA expression in normal human tissues for MIF Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MIF Gene

SOURCE GeneReport for Unigene cluster for MIF Gene Hs.407995

genes like me logo Genes that share expressions with MIF: view

Orthologs for MIF Gene

This gene was present in the common ancestor of animals.

Orthologs for MIF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIF 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIF 36
  • 93.62 (n)
  • 92.17 (a)
MIF 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mif 36
  • 88.7 (n)
  • 89.57 (a)
Mif 16
Mif 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIF 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MIF 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mif 36
  • 89.86 (n)
  • 90.43 (a)
chicken
(Gallus gallus)
Aves MIF 36
  • 75.07 (n)
  • 71.3 (a)
MIF 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MIF 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mif 36
  • 65.51 (n)
  • 64.35 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.7856 36
mif 36
  • 67.54 (n)
  • 69.3 (a)
mif 37
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mif-1 37
  • 33 (a)
OneToMany
mif-2 37
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToOne
Species with no ortholog for MIF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MIF Gene

ENSEMBL:
Gene Tree for MIF (if available)
TreeFam:
Gene Tree for MIF (if available)

Paralogs for MIF Gene

Selected SIMAP similar genes for MIF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MIF: view

No data available for Paralogs for MIF Gene

Variants for MIF Gene

Sequence variations from dbSNP and Humsavar for MIF Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2012124 -- 23,892,477(+) GGTTC(C/T)GAATG upstream-variant-2KB
rs2012133 -- 23,892,547(+) GTCTC(C/G)GGGTT upstream-variant-2KB
rs4822443 -- 23,893,011(+) GTCCA(A/G)GCCAA upstream-variant-2KB
rs4822444 -- 23,893,116(+) GTGAT(C/G)AGGTG upstream-variant-2KB
rs4822445 -- 23,893,119(+) ATGAG(A/G)TGTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIF Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv3577 CNV Insertion 18451855
nsv914604 CNV Loss 21882294

Relevant External Links for MIF Gene

HapMap Linkage Disequilibrium report
MIF
Human Gene Mutation Database (HGMD)
MIF

Disorders for MIF Gene

(1) OMIM Diseases for MIF Gene (153620)

UniProtKB/Swiss-Prot

MIF_HUMAN
  • Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for MIF Gene

(93) Novoseek inferred disease relationships for MIF Gene

Disease -log(P) Hits PubMed IDs
shock septic 59.1 42
inflammation 57.3 76
sepsis 54.1 83
rheumatoid arthritis 52.8 38
necrosis 49.2 56

Relevant External Links for MIF

Genetic Association Database (GAD)
MIF
Human Genome Epidemiology (HuGE) Navigator
MIF
genes like me logo Genes that share disorders with MIF: view

Publications for MIF Gene

  1. A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. (PMID: 11508429) Donn R.P. … Thomson W. (Arthritis Rheum. 2001) 3 4 23 49
  2. Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. (PMID: 11170644) Orita M. … Tanaka A. (J. Med. Chem. 2001) 3 4 23
  3. Macrophage migration inhibitory factor gene polymorphism is associated with sarcoidosis in biopsy proven erythema nodosum. (PMID: 12180727) Amoli M.M. … Gonzalez-Gay M.A. (J. Rheumatol. 2002) 3 23 49
  4. Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis. (PMID: 12355488) Donn R. … Ray D. (Arthritis Rheum. 2002) 3 23 49
  5. MIF signal transduction initiated by binding to CD74. (PMID: 12782713) Leng L. … Bucala R. (J. Exp. Med. 2003) 3 4 23

Products for MIF Gene

Sources for MIF Gene

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