Aliases for SUMO4 Gene
External Ids for SUMO4 Gene
Previous HGNC Symbols for SUMO4 Gene
Previous GeneCards Identifiers for SUMO4 Gene
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]
GeneCards Summary for SUMO4 Gene
SUMO4 (Small Ubiquitin-Like Modifier 4) is a Protein Coding gene. Diseases associated with SUMO4 include Diabetes Mellitus, Insulin-Dependent, 5 and Diabetes Mellitus, Insulin-Dependent, 12. Among its related pathways are NF-kB (NFkB) Pathway and HIF Repressor Pathways. An important paralog of this gene is SUMO2.
UniProtKB/Swiss-Prot for SUMO4 Gene
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.