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Aliases for SUMO4 Gene

Aliases for SUMO4 Gene

  • Small Ubiquitin-Like Modifier 4 2 3 5
  • Insulin-Dependent Diabetes Mellitus 5 2 3
  • SMT3H4 3 4
  • SUMO-4 3 4
  • SMT3 Suppressor Of Mif Two 3 Homolog 4 (S. Cerevisiae) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 4 (Yeast) 2
  • Small Ubiquitin-Like Modifier 4 Protein 3
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 3
  • SMT3 Suppressor Of Mif Two 3 Homolog 4 3
  • Small Ubiquitin-Related Modifier 4 3
  • Small Ubiquitin-Like Protein 4 4
  • DJ281H8.4 3
  • IDDM5 3

External Ids for SUMO4 Gene

Previous HGNC Symbols for SUMO4 Gene

  • SMT3H4
  • IDDM5

Previous GeneCards Identifiers for SUMO4 Gene

  • GC06U900642
  • GC0XM114776
  • GC06P149763
  • GC06P147288

Summaries for SUMO4 Gene

Entrez Gene Summary for SUMO4 Gene

  • This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUMO4 Gene

SUMO4 (Small Ubiquitin-Like Modifier 4) is a Protein Coding gene. Diseases associated with SUMO4 include Diabetes Mellitus, Insulin-Dependent, 5 and Diabetes Mellitus, Insulin-Dependent. Among its related pathways are RNA transport and NF-kB (NFkB) Pathway. An important paralog of this gene is SUMO2.

UniProtKB/Swiss-Prot for SUMO4 Gene

  • Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.

Gene Wiki entry for SUMO4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMO4 Gene

Genomics for SUMO4 Gene

Regulatory Elements for SUMO4 Gene

Enhancers for SUMO4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G149333 1.4 Ensembl ENCODE dbSUPER 11.9 -64.2 -64229 4.4 PKNOX1 INSM2 ZEB1 ZNF121 GATA2 ZNF366 FOS IKZF2 EGR2 ZNF263 TAB2 SUMO4 LOC105378047 TAB2-AS1 ENSG00000231760 FABP12P1 GC06P149383
GH06G149431 1.2 Ensembl ENCODE 12 +32.1 32125 0.9 HDGF WRNIP1 ARID4B SIN3A ZNF2 ZNF48 ZNF143 ZNF207 SP5 REST SUMO4 LOC105378047 TAB2 TAB2-AS1 ENSG00000231760 ZC3H12D
GH06G149365 0.8 ENCODE dbSUPER 13 -34.0 -34032 1.5 PKNOX1 PRDM6 CBFB ZNF512 IKZF1 JUNB CREM TAB2 SUMO4 RNU7-3P PPIL4 TAB2-AS1 GC06P149383 FABP12P1
GH06G149334 0.8 Ensembl dbSUPER 11.9 -66.9 -66927 0.2 GATAD2A FOXA3 ZSCAN5C FEZF1 SUMO4 TAB2 TAB2-AS1 FABP12P1 GC06P149383
GH06G149359 0.7 dbSUPER 13.4 -40.2 -40152 2.0 TAL1 ZKSCAN1 CHAMP1 TCF12 ZNF316 NCOR1 TRIM24 SMARCE1 MTA2 RNF2 SUMO4 TAB2 ENSG00000228408 TAB2-AS1 RNU7-3P PPIL4 GC06P149383 FABP12P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SUMO4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SUMO4 Gene

Chromosome:
6
Start:
149,400,227 bp from pter
End:
149,401,292 bp from pter
Size:
1,066 bases
Orientation:
Plus strand

Genomic View for SUMO4 Gene

Genes around SUMO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SUMO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SUMO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMO4 Gene

Proteins for SUMO4 Gene

  • Protein details for SUMO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EEV6-SUMO4_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 4
    Protein Accession:
    Q6EEV6
    Secondary Accessions:
    • A1L3W5

    Protein attributes for SUMO4 Gene

    Size:
    95 amino acids
    Molecular mass:
    10685 Da
    Quaternary structure:
    • Interacts with SAE2. Covalently attached to a number of proteins (Probable).

neXtProt entry for SUMO4 Gene

Post-translational modifications for SUMO4 Gene

  • In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SUMO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SUMO4 Gene

Domains & Families for SUMO4 Gene

Protein Domains for SUMO4 Gene

Suggested Antigen Peptide Sequences for SUMO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6EEV6

UniProtKB/Swiss-Prot:

SUMO4_HUMAN :
  • Belongs to the ubiquitin family. SUMO subfamily.
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.
genes like me logo Genes that share domains with SUMO4: view

No data available for Gene Families for SUMO4 Gene

Function for SUMO4 Gene

Molecular function for SUMO4 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.

Gene Ontology (GO) - Molecular Function for SUMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031386 protein tag IBA --
genes like me logo Genes that share ontologies with SUMO4: view
genes like me logo Genes that share phenotypes with SUMO4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SUMO4 Gene

Localization for SUMO4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SUMO4 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SUMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SUMO4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SUMO4 Gene

Pathways & Interactions for SUMO4 Gene

genes like me logo Genes that share pathways with SUMO4: view

Pathways by source for SUMO4 Gene

1 Sino Biological pathway for SUMO4 Gene
1 GeneTex pathway for SUMO4 Gene
2 KEGG pathways for SUMO4 Gene
2 R&D Systems pathways for SUMO4 Gene

Gene Ontology (GO) - Biological Process for SUMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation IBA --
genes like me logo Genes that share ontologies with SUMO4: view

No data available for SIGNOR curated interactions for SUMO4 Gene

Drugs & Compounds for SUMO4 Gene

(2) Drugs for SUMO4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SUMO4: view

Transcripts for SUMO4 Gene

mRNA/cDNA for SUMO4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SUMO4 Gene

SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO4 Gene

No ASD Table

Relevant External Links for SUMO4 Gene

GeneLoc Exon Structure for
SUMO4
ECgene alternative splicing isoforms for
SUMO4

Expression for SUMO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SUMO4 Gene

Protein differential expression in normal tissues from HIPED for SUMO4 Gene

This gene is overexpressed in Skin (53.8), Heart (7.7), and Brain (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SUMO4 Gene



Protein tissue co-expression partners for SUMO4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SUMO4 Gene:

SUMO4

SOURCE GeneReport for Unigene cluster for SUMO4 Gene:

Hs.657168

mRNA Expression by UniProt/SwissProt for SUMO4 Gene:

Q6EEV6-SUMO4_HUMAN
Tissue specificity: Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
genes like me logo Genes that share expression patterns with SUMO4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SUMO4 Gene

Orthologs for SUMO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUMO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SUMO4 34
  • 98.95 (n)
-- 35
  • 39 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SUMO2 35
  • 85 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SUMO3 35
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Sumo3 35
  • 70 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves SUMO2 35
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 85 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii sumo2b 35
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta smt3 35
  • 62 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMT3 35
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11356 35
  • 62 (a)
OneToMany
Species where no ortholog for SUMO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUMO4 Gene

ENSEMBL:
Gene Tree for SUMO4 (if available)
TreeFam:
Gene Tree for SUMO4 (if available)

Paralogs for SUMO4 Gene

Paralogs for SUMO4 Gene

(4) SIMAP similar genes for SUMO4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SUMO4: view

Variants for SUMO4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO4 Gene

SUMO4_HUMAN-Q6EEV6
Variant Val-55 could be associated with insulin-dependent diabetes mellitus 5 (IDDM5) [MIM:600320].

Sequence variations from dbSNP and Humsavar for SUMO4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs237025 other 149,400,554(-) CTTCA(C/T)TGACA intron-variant, reference, missense
rs1000725887 -- 149,399,832(+) AAAGT(G/T)AAAAG intron-variant, upstream-variant-2KB
rs1000954908 -- 149,401,430(+) CAGAA(A/T)CAATA intron-variant, downstream-variant-500B
rs1004064088 -- 149,399,382(+) TTAGC(A/T)TTTTA intron-variant, upstream-variant-2KB
rs1005286707 -- 149,399,468(+) ACTAA(A/G)TACAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SUMO4 Gene

Variant ID Type Subtype PubMed ID
nsv522875 CNV loss 19592680
nsv969455 CNV duplication 23825009

Variation tolerance for SUMO4 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SUMO4 Gene

Human Gene Mutation Database (HGMD)
SUMO4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SUMO4

Disorders for SUMO4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SUMO4 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent, 5
  • type 1 diabetes mellitus 5
diabetes mellitus, insulin-dependent
  • diabetes, type 1
erythema infectiosum
  • fifth disease
viral exanthem
diabetes mellitus, insulin-dependent, 12
  • type 1 diabetes mellitus 12
- elite association - COSMIC cancer census association via MalaCards
Search SUMO4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SUMO4

Genetic Association Database (GAD)
SUMO4
Human Genome Epidemiology (HuGE) Navigator
SUMO4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SUMO4
genes like me logo Genes that share disorders with SUMO4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SUMO4 Gene

Publications for SUMO4 Gene

  1. A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. (PMID: 15123604) Bohren K.M. … Owerbach D. (J. Biol. Chem. 2004) 2 3 4 22 46 64
  2. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. (PMID: 15247916) Guo D. … Wang C.-Y. (Nat. Genet. 2004) 3 4 22 46 64
  3. A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes. (PMID: 17926234) Rudofsky G. … Hamann A. (Exp. Clin. Endocrinol. Diabetes 2008) 3 22 46 64
  4. SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes. (PMID: 17229939) Lin H.Y. … Shin S.J. (Diabetes 2007) 3 22 46 64
  5. No association of SUMO4 M55V with autoimmune diabetes in Asian-Indian patients. (PMID: 17373940) Sedimbi S.K. … Sanjeevi C.B. (Int. J. Immunogenet. 2007) 3 22 46 64

Products for SUMO4 Gene

Sources for SUMO4 Gene

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