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Aliases for SUMO4 Gene

Aliases for SUMO4 Gene

  • Small Ubiquitin-Like Modifier 4 2 3
  • Insulin-Dependent Diabetes Mellitus 5 2 3
  • SMT3H4 3 4
  • SUMO-4 3 4
  • IDDM5 3 6
  • SMT3 Suppressor Of Mif Two 3 Homolog 4 (S. Cerevisiae) 2
  • SMT3 Suppressor Of Mif Two 3 Homolog 4 (Yeast) 2
  • Small Ubiquitin-Like Modifier 4 Protein 3
  • SMT3 Suppressor Of Mif Two 3 Homolog 2 3
  • SMT3 Suppressor Of Mif Two 3 Homolog 4 3
  • Small Ubiquitin-Related Modifier 4 3
  • Small Ubiquitin-Like Protein 4 4
  • DJ281H8.4 3

External Ids for SUMO4 Gene

Previous HGNC Symbols for SUMO4 Gene

  • SMT3H4
  • IDDM5

Previous GeneCards Identifiers for SUMO4 Gene

  • GC06U900642
  • GC0XM114776
  • GC06P149763
  • GC06P147288

Summaries for SUMO4 Gene

Entrez Gene Summary for SUMO4 Gene

  • This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

GeneCards Summary for SUMO4 Gene

SUMO4 (Small Ubiquitin-Like Modifier 4) is a Protein Coding gene. Diseases associated with SUMO4 include diabetes mellitus, insulin-dependent, 5. Among its related pathways are RNA transport. An important paralog of this gene is SUMO3.

UniProtKB/Swiss-Prot for SUMO4 Gene

  • Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.

Gene Wiki entry for SUMO4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUMO4 Gene

Genomics for SUMO4 Gene

Genomic Location for SUMO4 Gene

Start:
149,400,227 bp from pter
End:
149,401,292 bp from pter
Size:
1,066 bases
Orientation:
Plus strand

Genomic View for SUMO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SUMO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SUMO4 Gene

Proteins for SUMO4 Gene

  • Protein details for SUMO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6EEV6-SUMO4_HUMAN
    Recommended name:
    Small ubiquitin-related modifier 4
    Protein Accession:
    Q6EEV6
    Secondary Accessions:
    • A1L3W5

    Protein attributes for SUMO4 Gene

    Size:
    95 amino acids
    Molecular mass:
    10685 Da
    Quaternary structure:
    • Interacts with SAE2. Covalently attached to a number of proteins (Probable).

neXtProt entry for SUMO4 Gene

Proteomics data for SUMO4 Gene at MOPED

Post-translational modifications for SUMO4 Gene

  • In contrast to SUMO1, SUMO2 and SUMO3, seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates
  • Ubiquitination at Lys33 and Lys35
  • Modification sites at PhosphoSitePlus

Other Protein References for SUMO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SUMO4 Gene

Domains for SUMO4 Gene

Protein Domains for SUMO4 Gene

Suggested Antigen Peptide Sequences for SUMO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6EEV6

UniProtKB/Swiss-Prot:

SUMO4_HUMAN :
  • Q6EEV6
Domain:
  • Contains 1 ubiquitin-like domain.
Family:
  • Belongs to the ubiquitin family. SUMO subfamily.
genes like me logo Genes that share domains with SUMO4: view

No data available for Gene Families for SUMO4 Gene

Function for SUMO4 Gene

Molecular function for SUMO4 Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.

Gene Ontology (GO) - Molecular Function for SUMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SUMO4: view

Phenotypes for SUMO4 Gene

genes like me logo Genes that share phenotypes with SUMO4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SUMO4 Gene

Localization for SUMO4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SUMO4 Gene COMPARTMENTS Subcellular localization image for SUMO4 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SUMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SUMO4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SUMO4 Gene

Pathways for SUMO4 Gene

SuperPathways for SUMO4 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with SUMO4: view

Pathways by source for SUMO4 Gene

1 KEGG pathway for SUMO4 Gene

Gene Ontology (GO) - Biological Process for SUMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016925 protein sumoylation IEA --
genes like me logo Genes that share ontologies with SUMO4: view

Compounds for SUMO4 Gene

(2) Novoseek inferred chemical compound relationships for SUMO4 Gene

Compound -log(P) Hits PubMed IDs
valine 36.4 4
methionine 24.2 2
genes like me logo Genes that share compounds with SUMO4: view

Transcripts for SUMO4 Gene

mRNA/cDNA for SUMO4 Gene

(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SUMO4 Gene

SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SUMO4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SUMO4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SUMO4 Gene

No ASD Table

Relevant External Links for SUMO4 Gene

GeneLoc Exon Structure for
SUMO4
ECgene alternative splicing isoforms for
SUMO4

Expression for SUMO4 Gene

mRNA expression in normal human tissues for SUMO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SUMO4 Gene

SOURCE GeneReport for Unigene cluster for SUMO4 Gene Hs.657168

mRNA Expression by UniProt/SwissProt for SUMO4 Gene

Q6EEV6-SUMO4_HUMAN
Tissue specificity: Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen.
genes like me logo Genes that share expressions with SUMO4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SUMO4 Gene

Orthologs for SUMO4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SUMO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 39 (a)
ManyToMany
SUMO4 35
  • 98.95 (n)
  • 97.89 (a)
cow
(Bos Taurus)
Mammalia SUMO3 36
  • 74 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SUMO2 36
  • 85 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Sumo3 36
  • 70 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves SUMO2 36
  • 85 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 85 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii sumo2b 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta smt3 36
  • 62 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMT3 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11356 36
  • 62 (a)
OneToMany
Species with no ortholog for SUMO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SUMO4 Gene

ENSEMBL:
Gene Tree for SUMO4 (if available)
TreeFam:
Gene Tree for SUMO4 (if available)

Paralogs for SUMO4 Gene

Paralogs for SUMO4 Gene

Selected SIMAP similar genes for SUMO4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SUMO4: view

Variants for SUMO4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SUMO4 Gene

Q6EEV6-SUMO4_HUMAN
Variant Val-55 could be associated with insulin-dependent diabetes mellitus 5 (IDDM5) [MIM:600320]

Sequence variations from dbSNP and Humsavar for SUMO4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_023740 -

Structural Variations from Database of Genomic Variants (DGV) for SUMO4 Gene

Variant ID Type Subtype PubMed ID
nsv522875 CNV Loss 19592680

Relevant External Links for SUMO4 Gene

HapMap Linkage Disequilibrium report
SUMO4
Human Gene Mutation Database (HGMD)
SUMO4

Disorders for SUMO4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SUMO4 Gene including...

Search for SUMO4 Gene in MalaCards »

(1) OMIM Diseases for SUMO4 Gene (608829)

(1) University of Copenhagen DISEASES for SUMO4 Gene

(7) Novoseek inferred disease relationships for SUMO4 Gene

Disease -log(P) Hits PubMed IDs
autoimmune thyroid disease 62.7 1
diabetes autoimmune 53.2 1
autoimmunity 50.7 1
diabetes mellitus insulin-dependent 46.9 3
autoimmune diseases 46.3 5

Relevant External Links for SUMO4

Genetic Association Database (GAD)
SUMO4
Human Genome Epidemiology (HuGE) Navigator
SUMO4
genes like me logo Genes that share disorders with SUMO4: view

No data available for UniProtKB/Swiss-Prot for SUMO4 Gene

Publications for SUMO4 Gene

  1. A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. (PMID: 15123604) Bohren K.M. … Owerbach D. (J. Biol. Chem. 2004) 2 3 4 23 48
  2. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. (PMID: 15247916) Guo D. … Wang C.-Y. (Nat. Genet. 2004) 3 4 23 48
  3. No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' disease. (PMID: 15730420) Jennings C.E. … Pearce S.H. (Clin. Endocrinol. (Oxf) 2005) 3 23 48
  4. The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis. (PMID: 16159953) Gibbons L.J. … Hinks A. (Rheumatology (Oxford) 2005) 3 23 48
  5. Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes. (PMID: 16306380) Noso S. … Ogihara T. (Diabetes 2005) 3 23 48

Products for SUMO4 Gene

Sources for SUMO4 Gene

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