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Aliases for AGRN Gene

Aliases for AGRN Gene

  • Agrin 2 3
  • Agrin Proteoglycan 2 3
  • CMSPPD 3
  • AGRIN 4

External Ids for AGRN Gene

Summaries for AGRN Gene

Entrez Gene Summary for AGRN Gene

  • This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

GeneCards Summary for AGRN Gene

AGRN (Agrin) is a Protein Coding gene. Diseases associated with AGRN include agrn-related congenital myasthenic syndrome and presynaptic congenital myasthenic syndromes. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include calcium ion binding and laminin binding. An important paralog of this gene is EGFLAM.

UniProtKB/Swiss-Prot for AGRN Gene

  • Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain

  • Isoform 2: transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases

  • Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the z isoforms

  • Isoform 3 and isoform 6: lack any z insert, are muscle-specific and may be involved in endothelial cell differentiation

  • Agrin N-terminal 110 kDa subunit: is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity).

  • Agrin C-terminal 22 kDa fragment: this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All z splice variants (z+) of this fragment also show an increase in the number of filopodia

Gene Wiki entry for AGRN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AGRN Gene

Genomics for AGRN Gene

Genomic Location for AGRN Gene

Start:
1,020,123 bp from pter
End:
1,056,119 bp from pter
Size:
35,997 bases
Orientation:
Plus strand

Genomic View for AGRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AGRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AGRN Gene

Regulatory Elements for AGRN Gene

Proteins for AGRN Gene

  • Protein details for AGRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00468-AGRIN_HUMAN
    Recommended name:
    Agrin
    Protein Accession:
    O00468
    Secondary Accessions:
    • Q5SVA1
    • Q5SVA2
    • Q60FE1
    • Q7KYS8
    • Q8N4J5
    • Q96IC1
    • Q9BTD4

    Protein attributes for AGRN Gene

    Size:
    2067 amino acids
    Molecular mass:
    217232 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts (N-terminal subunit) with TGF-beta family members, BMP2 AND BMP4; the interactions inhibit the activity of these growth factors. Interacts with TGFB1; the interaction enhances the activity of TGFB1 (By similarity). Component of the AGRN-LRP4 complex that consists of a tetramer of two AGRN-LRP4 heterodimers. Interacts (via the laminin G-like 3 domain) directly with LRP4; the interaction is required for activation of MUSK and clustering of AChR and requires the z8 insert present in the z(+8) isoforms. Interacts with DAG1; the interaction is influenced by cell surface glycosaminoglycans and by alternative splicing of AGRN.
    Miscellaneous:
    • Cleaved C-terminal fragments may be used as a biomarker for sarcopenia, age-related progressive loss of skeletal muscle.

    Alternative splice isoforms for AGRN Gene

neXtProt entry for AGRN Gene

Proteomics data for AGRN Gene at MOPED

Post-translational modifications for AGRN Gene

  • At synaptic junctions, cleaved at two conserved sites, alpha and beta, by neurotrypsin. Cleavage at the alpha-site produces the agrin N-terminal 110-kDa subunit and the agrin C-terminal 110-kDa subunit. Further cleavage of agrin C-terminal 110-kDa subunit at the beta site produces the C-terminal fragments, agrin C-terminal 90 kDa fragment and agrin C-terminal 22 kDa fragment. Excessive cleavage at the beta-site releases large amounts of the agrin C-terminal 22 kDa fragment leading to destabilization at the neuromuscular junction (NMJ)
  • Contains heparan and chondroitin sulfate chains and alpha-dystroglycan as well as N-linked and O-linked oligosaccharides. Glycosaminoglycans (GAGs), present in the N-terminal 110 kDa fragment, are required for induction of filopodia in hippocampal neurons. The first cluster (Gly/Ser-rich) for GAG attachment contains heparan sulfate (HS) chains and the second cluster (Ser/Thr-rich), contains chondroitin sulfate (CS) chains. Heparin and heparin sulfate binding in the G3 domain is independent of calcium ions. Binds heparin with a stoichiometry of 2:1. Binds sialic acid with a stoichiometry of 1:1 and binding requires calcium ions (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn135, Thr159, Thr162, Thr167, Asn250, Thr754, Asn777, Asn932, Thr1274, Thr1275, Ser1277, Ser1281, Ser1282, Thr1285, Ser1292, Thr1294, Ser1295, Thr1301, Thr1302, Thr1306, Thr1307, Thr1312, Thr1313, Ser1316, Thr1540, Thr1584, Thr1720, Thr1725, Thr1815, Ser1835, Ser1912, Ser1918, Thr1921, Thr1924, Ser1931, Thr1886, and Ser1750

Other Protein References for AGRN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AGRN Gene

Domains for AGRN Gene

Gene Families for AGRN Gene

HGNC:
  • ECMPG :Proteoglycans / Extracellular Matrix : Other

UniProtKB/Swiss-Prot:

AGRIN_HUMAN
Domain:
  • The NtA domain, absent in TM-agrin, is required for binding laminin and connecting to basal lamina:
    • O00468
  • Both laminin G-like 2 (G2) and laminin G-like 3 (G3) domains are required for alpha-dystroglycan/DAG1 binding. G3 domain is required for C-terminal heparin, heparan sulfate and sialic acid binding (By similarity).:
    • O00468
  • Contains 4 EGF-like domains.:
    • O00468
  • Contains 9 Kazal-like domains.:
    • O00468
  • Contains 2 laminin EGF-like domains.:
    • O00468
  • Contains 3 laminin G-like domains.:
    • O00468
  • Contains 1 NtA (N-terminal agrin) domain.:
    • O00468
  • Contains 1 SEA domain.:
    • O00468
genes like me logo Genes that share domains with AGRN: view

Function for AGRN Gene

Molecular function for AGRN Gene

GENATLAS Biochemistry: acetylcholine receptor aggregating factor,agrin,component of synaptic basal lamina on the surface of muscle fibers
UniProtKB/Swiss-Prot Function: Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain
UniProtKB/Swiss-Prot Function: Isoform 2: transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases
UniProtKB/Swiss-Prot Function: Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the z isoforms
UniProtKB/Swiss-Prot Function: Isoform 3 and isoform 6: lack any z insert, are muscle-specific and may be involved in endothelial cell differentiation
UniProtKB/Swiss-Prot Function: Agrin N-terminal 110 kDa subunit: is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity).
UniProtKB/Swiss-Prot Function: Agrin C-terminal 22 kDa fragment: this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All z splice variants (z+) of this fragment also show an increase in the number of filopodia

Gene Ontology (GO) - Molecular Function for AGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002162 dystroglycan binding ISS --
GO:0005200 structural constituent of cytoskeleton TAS 9652404
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding IPI 21078624
GO:0030548 acetylcholine receptor regulator activity IEA --
genes like me logo Genes that share ontologies with AGRN: view
genes like me logo Genes that share phenotypes with AGRN: view

Animal Models for AGRN Gene

MGI Knock Outs for AGRN:

miRNA for AGRN Gene

miRTarBase miRNAs that target AGRN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AGRN Gene

Localization for AGRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for AGRN Gene

Isoform 1: Secreted, extracellular space, extracellular matrix. Note=Synaptic basal lamina at the neuromuscular junction. {ECO:0000250}.
Isoform 2: Cell junction, synapse. Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AGRN Gene COMPARTMENTS Subcellular localization image for AGRN gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 4
lysosome 4
vacuole 4
cytosol 1

Gene Ontology (GO) - Cellular Components for AGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005604 basement membrane --
GO:0005605 basal lamina IDA 9405491
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with AGRN: view

Pathways for AGRN Gene

genes like me logo Genes that share pathways with AGRN: view

Gene Ontology (GO) - Biological Process for AGRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0006027 glycosaminoglycan catabolic process TAS --
GO:0007009 plasma membrane organization IEA --
genes like me logo Genes that share ontologies with AGRN: view

Compounds for AGRN Gene

(19) Novoseek inferred chemical compound relationships for AGRN Gene

Compound -log(P) Hits PubMed IDs
acetylcholine 84.8 117
tyrosine 66.2 75
heparan sulfate 63.4 5
heparin 34.7 20
alpha-bungarotoxin 29.6 1
genes like me logo Genes that share compounds with AGRN: view

Transcripts for AGRN Gene

Unigene Clusters for AGRN Gene

Agrin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AGRN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1:
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SP6: -
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SP9: - - - - - - - - - - - - - - - - -
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SP15: -
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SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36a · 36b ·
SP1: -
SP2:
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SP9: - - - - - - -
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SP18:
SP19:
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SP23:
SP24:
SP25:

ExUns: 36c ^ 37a · 37b · 37c ^ 38 ^ 39a · 39b ^ 40a · 40b · 40c ^ 41 ^ 42a · 42b ^ 43 ^ 44a · 44b
SP1: - - - - -
SP2:
SP3:
SP4: - - - -
SP5:
SP6:
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SP8: - - - - -
SP9:
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SP12:
SP13:
SP14:
SP15:
SP16: - - - -
SP17:
SP18:
SP19:
SP20:
SP21: - - -
SP22:
SP23:
SP24: -
SP25:

Relevant External Links for AGRN Gene

GeneLoc Exon Structure for
AGRN
ECgene alternative splicing isoforms for
AGRN

Expression for AGRN Gene

mRNA expression in normal human tissues for AGRN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AGRN Gene

SOURCE GeneReport for Unigene cluster for AGRN Gene Hs.273330

mRNA Expression by UniProt/SwissProt for AGRN Gene

O00468-AGRIN_HUMAN
Tissue specificity: Expressed in basement membranes of lung and kidney. Muscle- and neuron-specific isoforms are found. Isoforms (y+) with the 4 AA insert and (z+8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z+11) are found in both neuronal and non-neuronal tissues.
genes like me logo Genes that share expressions with AGRN: view

Orthologs for AGRN Gene

This gene was present in the common ancestor of animals.

Orthologs for AGRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGRN 37
  • 99 (a)
OneToOne
LOC100609326 36
  • 99.01 (n)
  • 99.02 (a)
cow
(Bos Taurus)
Mammalia AGRN 36
  • 84.17 (n)
  • 86.24 (a)
AGRN 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AGRN 36
  • 83.45 (n)
  • 85.62 (a)
AGRN 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agrn 36
  • 80.3 (n)
  • 82.57 (a)
Agrn 16
Agrn 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 70 (a)
OneToMany
-- 37
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia AGRN 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Agrn 36
  • 79.45 (n)
  • 81.61 (a)
chicken
(Gallus gallus)
Aves AGRN 36
  • 67.82 (n)
  • 64.17 (a)
AGRN 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AGRN 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia agrn 36
  • 61.39 (n)
  • 62.66 (a)
zebrafish
(Danio rerio)
Actinopterygii agrn 37
  • 54 (a)
OneToOne
hm:gc12 36
  • 60.96 (n)
  • 58.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta SP2353 38
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea agr-1 36
  • 41.94 (n)
  • 34.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToOne
Species with no ortholog for AGRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AGRN Gene

ENSEMBL:
Gene Tree for AGRN (if available)
TreeFam:
Gene Tree for AGRN (if available)

Paralogs for AGRN Gene

Paralogs for AGRN Gene

genes like me logo Genes that share paralogs with AGRN: view

Variants for AGRN Gene

Sequence variations from dbSNP and Humsavar for AGRN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8014 -- 1,055,604(+) TGGAC(A/G)TGACC utr-variant-3-prime
rs10267 Benign 1,047,614(+) GATTT(C/T)CGGAG synonymous-codon, reference
rs13129 -- 1,055,459(+) TGTGA(C/T)TTCCA utr-variant-3-prime
rs1105349 -- 1,044,826(+) CGGTT(C/T)GGAGG intron-variant
rs1806805 -- 1,023,084(+) GAATG(C/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AGRN Gene

Variant ID Type Subtype PubMed ID
dgv3e1 CNV Complex 17122850
essv4734 CNV CNV 17122850
nsv10161 CNV Gain+Loss 18304495
essv2408 CNV CNV 17122850
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871883 CNV Gain+Loss 21882294
dgv9n71 CNV Loss 21882294
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv13n71 CNV Loss 21882294
nsv871483 CNV Loss 21882294
nsv509146 CNV Insertion 20534489
dgv14n71 CNV Loss 21882294
dgv15n71 CNV Loss 21882294
nsv871424 CNV Loss 21882294
dgv16n71 CNV Loss 21882294
nsv871557 CNV Gain 21882294
esv29017 CNV Loss 19812545
esv987912 CNV Loss 20482838
esv4415 CNV Deletion 18987735
esv2674475 CNV Deletion 23128226
esv2733916 CNV Deletion 23290073
dgv2e201 CNV Deletion 23290073
esv2736139 CNV Deletion 23290073
esv6517 CNV Loss 19470904
esv2738361 CNV Deletion 23290073
esv2740583 CNV Deletion 23290073
esv2741694 CNV Deletion 23290073
esv1064309 CNV Insertion 17803354
esv2742805 CNV Deletion 23290073
esv2743474 CNV Deletion 23290073
nsv870874 CNV Loss 21882294
nsv871349 CNV Loss 21882294
nsv829425 CNV Loss 20364138

Relevant External Links for AGRN Gene

HapMap Linkage Disequilibrium report
AGRN
Human Gene Mutation Database (HGMD)
AGRN
Locus Specific Mutation Databases (LSDB)
AGRN

Disorders for AGRN Gene

(1) OMIM Diseases for AGRN Gene (103320)

UniProtKB/Swiss-Prot

AGRIN_HUMAN
  • Myasthenic syndrome, congenital, with pre- and postsynaptic defects (CMSPPD) [MIM:615120]: A form of congenital myasthenic syndrome, a group of genetic disorders characterized by failure of neuromuscular transmission, weakness and easy fatigability. CMSPPD is an autosomal recessive disease characterized by prominent defects of both the pre- and postsynaptic regions. Affected individuals have onset of muscle weakness in early childhood; the severity of the weakness and muscles affected is variable. {ECO:0000269 PubMed:19631309, ECO:0000269 PubMed:22205389, ECO:0000269 PubMed:24951643}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for AGRN Gene

(14) Novoseek inferred disease relationships for AGRN Gene

Disease -log(P) Hits PubMed IDs
muscular dystrophies 58.5 3
myasthenia gravis 33.8 1
senile plaques 32.4 5
diabetic nephropathies 21.6 2
brain diseases 19.1 4

Relevant External Links for AGRN

Genetic Association Database (GAD)
AGRN
Human Genome Epidemiology (HuGE) Navigator
AGRN
genes like me logo Genes that share disorders with AGRN: view

Publications for AGRN Gene

  1. Primary structure and high expression of human agrin in basement membranes of adult lung and kidney. (PMID: 9652404) Groffen A.J.A. … Van den Heuvel L.P.W.J. (Eur. J. Biochem. 1998) 3 4 23
  2. Agrin binds to the nerve-muscle basal lamina via laminin. (PMID: 9151673) Denzer A.J. … Ruegg M.A. (J. Cell Biol. 1997) 3 4 23
  3. Agrin in the developing CNS: new roles for a synapse organizer. (PMID: 12270958) KrAPger S. … SchrAPder J.E. (News Physiol. Sci. 2002) 2 3 23
  4. Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. (PMID: 19631309) Huze C. … Hantai D. (Am. J. Hum. Genet. 2009) 3 4 23
  5. Amyloid beta induces cellular relocalization and production of agrin and glypican-1. (PMID: 19166823) Timmer N.M. … Verbeek M.M. (Brain Res. 2009) 3 23

Products for AGRN Gene

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