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Aliases for ITPR3 Gene

Aliases for ITPR3 Gene

  • Inositol 1,4,5-Trisphosphate Receptor, Type 3 2 3
  • Inositol 1,4,5-Triphosphate Receptor, Type 3 2 3
  • Type 3 InsP3 Receptor 3 4
  • InsP3R3 3 4
  • Inositol 1,4,5-Trisphosphate Receptor Type 3 3
  • Type 3 Inositol 1,4,5-Trisphosphate Receptor 4
  • IP3 Receptor Isoform 3 4
  • IP3 Receptor 3
  • IP3R 3 4
  • IP3R3 3
  • IP3R 3

External Ids for ITPR3 Gene

Previous GeneCards Identifiers for ITPR3 Gene

  • GC06P033591
  • GC06P033636
  • GC06P033697
  • GC06P033330

Summaries for ITPR3 Gene

Entrez Gene Summary for ITPR3 Gene

  • This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

GeneCards Summary for ITPR3 Gene

ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3) is a Protein Coding gene. Diseases associated with ITPR3 include diabetes mellitus, insulin-dependent. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include phosphatidylinositol binding and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. An important paralog of this gene is RYR1.

UniProtKB/Swiss-Prot for ITPR3 Gene

  • Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium

Tocris Summary for ITPR3 Gene

  • Inositol 1,4,5-triphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores. IP3 receptors play an important role in intracellular Ca2+ signaling in a variety of cell types. There are three IP3 receptor subtypes; IP3R1, IP3R2 and IP3R3, which exist as homo- and heterotetramers. All subtypes are closely associated with calmodulin and FK506-binding protein and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.

Gene Wiki entry for ITPR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITPR3 Gene

Genomics for ITPR3 Gene

Regulatory Elements for ITPR3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITPR3 Gene

33,620,365 bp from pter
33,696,574 bp from pter
76,210 bases
Plus strand

Genomic View for ITPR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITPR3 Gene

Proteins for ITPR3 Gene

  • Protein details for ITPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol 1,4,5-trisphosphate receptor type 3
    Protein Accession:
    Secondary Accessions:
    • Q14649
    • Q5TAQ2

    Protein attributes for ITPR3 Gene

    2671 amino acids
    Molecular mass:
    304106 Da
    Quaternary structure:
    • Homotetramer. Interacts with SIGMAR1, PML, AKT1, TRPC1, TRPC3 and TRPC4 (By similarity). Interacts with LRMP (via coiled-coil domain) (By similarity). Interacts with CABP1. Interacts with TMBIM4/LFG4. Interacts with CEMIP. Interacts with TESPA1 (By similarity).

neXtProt entry for ITPR3 Gene

Proteomics data for ITPR3 Gene at MOPED

Post-translational modifications for ITPR3 Gene

  • Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity).
  • Ubiquitination at Lys1589
  • Glycosylation at Asn2405
  • Modification sites at PhosphoSitePlus

Other Protein References for ITPR3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ITPR3 Gene

Domains for ITPR3 Gene

Gene Families for ITPR3 Gene

  • ITPR :Ion channels / Inositol triphosphate receptors

Suggested Antigen Peptide Sequences for ITPR3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q14573
  • The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region
  • Contains 5 MIR domains.
  • Belongs to the InsP3 receptor family.
genes like me logo Genes that share domains with ITPR3: view

Function for ITPR3 Gene

Molecular function for ITPR3 Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate receptor,type 3,coexpressed with RYR3 in neurons and smooth muscle cells forming heterotetrameric channel with ITPR1 and ITPR2,involved in Ca++ mobilization from the endoplastic reticulum,poorly sensitive to IP3 and CA++,mediating monophasic Ca++ transients
UniProtKB/Swiss-Prot Function:
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium

Gene Ontology (GO) - Molecular Function for ITPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000822 inositol hexakisphosphate binding ISS --
GO:0005216 ion channel activity --
GO:0005218 intracellular ligand-gated calcium channel activity ISS --
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISS --
GO:0005262 calcium channel activity --
genes like me logo Genes that share ontologies with ITPR3: view
genes like me logo Genes that share phenotypes with ITPR3: view

Animal Models for ITPR3 Gene

MGI Knock Outs for ITPR3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITPR3 Gene

Localization for ITPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITPR3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ITPR3 Gene COMPARTMENTS Subcellular localization image for ITPR3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
nucleus 3
mitochondrion 2
cytoskeleton 1
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ITPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005640 nuclear outer membrane ISS --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with ITPR3: view

Pathways for ITPR3 Gene

SuperPathways for ITPR3 Gene

Superpath Contained pathways
1 Signaling by FGFR
2 Ca-dependent events
3 Development Angiotensin activation of ERK
4 fMLP Pathway
5 Development Endothelin-1/EDNRA signaling
genes like me logo Genes that share pathways with ITPR3: view

Gene Ontology (GO) - Biological Process for ITPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006811 ion transport --
GO:0006816 calcium ion transport --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with ITPR3: view

Compounds for ITPR3 Gene

(2) Tocris Compounds for ITPR3 Gene

Compound Action Cas Number
(-)-Xestospongin C Inhibits IP3-mediated Ca2+ release [88903-69-9]
2-APB IP3 receptor antagonist. Also TRP channel modulator [524-95-8]

(2) HMDB Compounds for ITPR3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
Inositol 1,4,5-trisphosphate
  • 1D-myo-Inositol 1,4,5-trisphosphate

(4) IUPHAR Ligand for ITPR3 Gene

Ligand Type Action Affinity Pubmed IDs
IP3 Activator None
decavanadate Activator None
Ca2+ Antagonist Antagonist
heparin Antagonist Antagonist

(7) Novoseek inferred chemical compound relationships for ITPR3 Gene

Compound -log(P) Hits PubMed IDs
inositol 1,4,5 trisphosphate 87.3 25
cyclic adp-ribose 55 1
thimerosal 54.1 1
calcium 53.1 22
inositol 26.6 1
genes like me logo Genes that share compounds with ITPR3: view

Transcripts for ITPR3 Gene

mRNA/cDNA for ITPR3 Gene

Unigene Clusters for ITPR3 Gene

Inositol 1,4,5-trisphosphate receptor, type 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITPR3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITPR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - -
SP2: -

ExUns: 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40a · 40b ^ 41 ^ 42a · 42b ·
SP1: - -
SP2: - - -
SP3: -

ExUns: 42c ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49a · 49b · 49c ^ 50 ^ 51 ^ 52 ^ 53a · 53b · 53c ^ 54a · 54b ^ 55a · 55b · 55c ^ 56 ^ 57a · 57b ^ 58 ^ 59a ·
SP1: - - -
SP4: - -
SP5: -
SP9: -

Relevant External Links for ITPR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITPR3 Gene

mRNA expression in normal human tissues for ITPR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ITPR3 Gene

This gene is overexpressed in Nasal epithelium (47.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITPR3 Gene

SOURCE GeneReport for Unigene cluster for ITPR3 Gene Hs.65758

mRNA Expression by UniProt/SwissProt for ITPR3 Gene

Tissue specificity: Expressed in intestinal crypt and villus epithelial cells
genes like me logo Genes that share expressions with ITPR3: view

Expression partners for ITPR3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ITPR3 Gene

Orthologs for ITPR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITPR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ITPR3 35
  • 92.77 (n)
  • 96.85 (a)
ITPR3 36
  • 97 (a)
(Canis familiaris)
Mammalia ITPR3 35
  • 92.61 (n)
  • 97.42 (a)
ITPR3 36
  • 97 (a)
(Mus musculus)
Mammalia Itpr3 35
  • 89.41 (n)
  • 95.36 (a)
Itpr3 16
Itpr3 36
  • 95 (a)
(Pan troglodytes)
Mammalia ITPR3 35
  • 98.45 (n)
  • 98.34 (a)
ITPR3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Itpr3 35
  • 89.7 (n)
  • 95.28 (a)
(Monodelphis domestica)
Mammalia ITPR3 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ITPR3 36
  • 66 (a)
(Gallus gallus)
Aves ITPR3 35
  • 83.53 (n)
  • 90.08 (a)
ITPR3 36
  • 90 (a)
(Anolis carolinensis)
Reptilia ITPR3 36
  • 88 (a)
(Danio rerio)
Actinopterygii Dr.23369 35
itpr3 36
  • 73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.660 35
fruit fly
(Drosophila melanogaster)
Insecta Itp-r83A 37
  • 51 (a)
Itp-r83A 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea itr-1 37
  • 36 (a)
itr-1 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for ITPR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ITPR3 Gene

Gene Tree for ITPR3 (if available)
Gene Tree for ITPR3 (if available)

Paralogs for ITPR3 Gene

Paralogs for ITPR3 Gene

Selected SIMAP similar genes for ITPR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ITPR3: view

Variants for ITPR3 Gene

Sequence variations from dbSNP and Humsavar for ITPR3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3227 -- 33,694,518(+) GACTC(C/G)CGTCT intron-variant
rs10672 -- 33,694,488(+) CCTCC(C/T)GATCC intron-variant
rs653536 -- 33,692,634(+) GGTCC(C/T)CAATA intron-variant
rs684119 -- 33,694,890(+) GGGCC(C/T)ACGCC intron-variant
rs729424 -- 33,676,256(+) CTGAG(C/T)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITPR3 Gene

Variant ID Type Subtype PubMed ID
nsv885770 CNV Loss 21882294
dgv85n68 CNV Loss 17160897
nsv5250 CNV Loss 18451855
nsv470811 CNV Loss 18288195
nsv885771 CNV Loss 21882294
nsv522906 CNV Loss 19592680
nsv885772 CNV Loss 21882294
esv8764 CNV Gain 19470904

Relevant External Links for ITPR3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITPR3 Gene

Disorders for ITPR3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ITPR3 Gene in MalaCards »

(1) Diseases for ITPR3 Gene including...

(1) OMIM Diseases for ITPR3 Gene (147267)

(4) Novoseek inferred disease relationships for ITPR3 Gene

Disease -log(P) Hits PubMed IDs
peritoneal cancer 63.2 2
malignant ascites 58.5 2
primary tumor 6.95 2
gastric cancer 6.11 8

Relevant External Links for ITPR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ITPR3: view

No data available for UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for ITPR3 Gene

Publications for ITPR3 Gene

  1. Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors. (PMID: 8081734) Yamamoto-Hino M. … Mikoshiba K. (Recept. Channels 1994) 2 3 4 23
  2. Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium. (PMID: 8288584) Maranto A.R. (J. Biol. Chem. 1994) 2 3 4 23
  3. Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden. (PMID: 16960798) Roach J.C. … . (Am. J. Hum. Genet. 2006) 3 23 48
  4. A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population. (PMID: 18219441) Oishi T. … Matsuda K. (J. Hum. Genet. 2008) 3 23 48
  5. Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with SjAPgren's syndrome and other systemic rheumatic diseases. (PMID: 17437169) Miyachi K. … Mikoshiba K. (Mod Rheumatol 2007) 3 23

Products for ITPR3 Gene

Sources for ITPR3 Gene

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