Aliases for FASN Gene
External Ids for FASN Gene
Previous GeneCards Identifiers for FASN Gene
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
GeneCards Summary for FASN Gene
FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with FASN include Partial Fetal Alcohol Syndrome and Obesity. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include poly(A) RNA binding and identical protein binding. An important paralog of this gene is OXSM.
UniProtKB/Swiss-Prot for FASN Gene
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
Fatty acid synthase (FASN), EC 220.127.116.11, is a multienzyme that catalyzes the conversion of acetyl-CoA and malonyl-CoA to the 16-carbon fatty acid palmitate. FASN overexpression and hyperactivity is commonly associated with malignant cells.