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Aliases for IL10 Gene

Aliases for IL10 Gene

  • Interleukin 10 2 3 5
  • Cytokine Synthesis Inhibitory Factor 2 3 4
  • T-Cell Growth Inhibitory Factor 2 3
  • IL-10 3 4
  • CSIF 3 4
  • Interleukin-10 3
  • GVHDS 3
  • IL10A 3
  • TGIF 3

External Ids for IL10 Gene

Previous GeneCards Identifiers for IL10 Gene

  • GC01M205600
  • GC01M202651
  • GC01M203584
  • GC01M204024
  • GC01M203329
  • GC01M205007
  • GC01M206940
  • GC01M177639

Summaries for IL10 Gene

Entrez Gene Summary for IL10 Gene

  • The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

GeneCards Summary for IL10 Gene

IL10 (Interleukin 10) is a Protein Coding gene. Diseases associated with IL10 include Graft-Versus-Host Disease, Protection Against and Rheumatoid Arthritis. Among its related pathways are Allograft rejection and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and interleukin-10 receptor binding.

UniProtKB/Swiss-Prot for IL10 Gene

  • Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Gene Wiki entry for IL10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL10 Gene

Genomics for IL10 Gene

Regulatory Elements for IL10 Gene

Enhancers for IL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G206782 1.7 FANTOM5 Ensembl ENCODE dbSUPER 43.1 -7.9 -7923 0.7 PKNOX1 CREB3L1 YY1 ZNF766 GATA2 ZNF143 ZNF207 JUNB TBX21 ZNF592 IL10 IL19
GH01G206722 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +50.9 50920 2.2 TBP SIN3A BRCA1 RAD21 RFX5 YY1 RCOR1 FOS ZHX1 DEK MAPKAPK2 IL19 IL10 FCMR PIGR IL24 IL20 DYRK3 RASSF5 PIR58159
GH01G206802 1.4 Ensembl ENCODE dbSUPER 11.7 -29.1 -29131 2.1 HDGF PKNOX1 TBL1XR1 WRNIP1 BMI1 EGR1 CBX5 ELK1 ZNF143 ZNF207 IL10 IL19 LOC105372878
GH01G206690 1.4 Ensembl ENCODE dbSUPER 10.4 +81.6 81587 5.1 PKNOX1 ARID4B SIN3A FEZF1 TCF12 ZNF143 DEK REST ZNF662 ZNF592 IKBKE FCMR PIGR IL10 IL19 EIF2D DYRK3 MAPKAPK2 GC01M206696
GH01G206966 1.4 Ensembl ENCODE dbSUPER 10.1 -196.3 -196251 7.9 HDGF HDAC1 RAD21 YY1 GATA2 FOS RELB ETV6 IKZF2 ELF4 PIGR FCMR IL20 IL24 IL10 IL19 MAPKAPK2 ENSG00000271680 C1orf116 FCAMR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL10 on UCSC Golden Path with GeneCards custom track

Genomic Location for IL10 Gene

Chromosome:
1
Start:
206,767,602 bp from pter
End:
206,774,607 bp from pter
Size:
7,006 bases
Orientation:
Minus strand

Genomic View for IL10 Gene

Genes around IL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL10 Gene

Proteins for IL10 Gene

  • Protein details for IL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22301-IL10_HUMAN
    Recommended name:
    Interleukin-10
    Protein Accession:
    P22301

    Protein attributes for IL10 Gene

    Size:
    178 amino acids
    Molecular mass:
    20517 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IL10 Gene

neXtProt entry for IL10 Gene

Post-translational modifications for IL10 Gene

Other Protein References for IL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IL10 (IL10)
  • Abcam antibodies for IL10

No data available for DME Specific Peptides for IL10 Gene

Domains & Families for IL10 Gene

Gene Families for IL10 Gene

Graphical View of Domain Structure for InterPro Entry

P22301

UniProtKB/Swiss-Prot:

IL10_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL10: view

Function for IL10 Gene

Molecular function for IL10 Gene

GENATLAS Biochemistry:
interleukin 10,20.5kDa,cytokine synthesis inhibitory factor,costimulator of proliferation and differentiation of B,T,mast cell
UniProtKB/Swiss-Prot Function:
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Gene Ontology (GO) - Molecular Function for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 10443688
GO:0005141 interleukin-10 receptor binding NAS 1847510
GO:0005515 protein binding IPI 11485736
GO:0008083 growth factor activity NAS 1371884
genes like me logo Genes that share ontologies with IL10: view
genes like me logo Genes that share phenotypes with IL10: view

Human Phenotype Ontology for IL10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL10 Gene

MGI Knock Outs for IL10:

Animal Model Products

Transcription Factor Targets for IL10 Gene

Selected GeneGlobe predicted Target genes for IL10

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for IL10 Gene

Localization for IL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL10 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 1

Gene Ontology (GO) - Cellular Components for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10443688
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IL10: view

Pathways & Interactions for IL10 Gene

genes like me logo Genes that share pathways with IL10: view

SIGNOR curated interactions for IL10 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0002237 response to molecule of bacterial origin IDA 17449476
GO:0002740 negative regulation of cytokine secretion involved in immune response IDA 10443688
GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus IEA --
GO:0002904 positive regulation of B cell apoptotic process IDA 9184696
genes like me logo Genes that share ontologies with IL10: view

Drugs & Compounds for IL10 Gene

(104) Drugs for IL10 Gene - From: DrugBank, PharmGKB, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 922
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1551
Mycophenolate mofetil Approved, Investigational Pharma IMPDH inhibitor 952
Tacrolimus Approved, Investigational Pharma 1102
Efavirenz Approved, Investigational Pharma Reverse transcriptase inhibitor 409

(53) Additional Compounds for IL10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL10: view

Transcripts for IL10 Gene

mRNA/cDNA for IL10 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL10 Gene

Interleukin 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL10 Gene

No ASD Table

Relevant External Links for IL10 Gene

GeneLoc Exon Structure for
IL10
ECgene alternative splicing isoforms for
IL10

Expression for IL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL10 Gene

mRNA differential expression in normal tissues according to GTEx for IL10 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.3), Whole Blood (x6.1), and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for IL10 Gene

This gene is overexpressed in Tlymphocyte (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL10 Gene



Protein tissue co-expression partners for IL10 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL10 Gene:

IL10

SOURCE GeneReport for Unigene cluster for IL10 Gene:

Hs.193717

mRNA Expression by UniProt/SwissProt for IL10 Gene:

P22301-IL10_HUMAN
Tissue specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

Evidence on tissue expression from TISSUES for IL10 Gene

  • Blood(4.8)
  • Spleen(3.7)
  • Lymph node(3.6)
  • Intestine(3.3)
  • Lung(3)
  • Nervous system(2.9)
  • Bone marrow(2.8)
  • Liver(2.8)
  • Skin(2.7)
  • Heart(2.6)
  • Kidney(2.6)
  • Pancreas(2.6)
  • Muscle(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • face
  • head
  • meninges
  • mouth
  • neck
Thorax:
  • esophagus
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • anus
  • penis
  • rectum
  • testicle
  • vagina
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with IL10: view

Primer Products

Orthologs for IL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL10 35 34
  • 99.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL10 35 34
  • 84.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL10 34 35
  • 83.43 (n)
rat
(Rattus norvegicus)
Mammalia Il10 34
  • 82.21 (n)
mouse
(Mus musculus)
Mammalia Il10 34 16 35
  • 81.09 (n)
oppossum
(Monodelphis domestica)
Mammalia IL10 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL10 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL10 34 35
  • 57.89 (n)
lizard
(Anolis carolinensis)
Reptilia IL10 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il10 34
  • 59.1 (n)
zebrafish
(Danio rerio)
Actinopterygii il10 34 35
  • 47.78 (n)
Species where no ortholog for IL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL10 Gene

ENSEMBL:
Gene Tree for IL10 (if available)
TreeFam:
Gene Tree for IL10 (if available)

Paralogs for IL10 Gene

No data available for Paralogs for IL10 Gene

Variants for IL10 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IL10 Gene

IL10_HUMAN-P22301
A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS) [MIM:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease.

Sequence variations from dbSNP and Humsavar for IL10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000660306 -- 206,771,802(+) TTAGC(C/T)TGGAA intron-variant
rs1000968106 -- 206,773,654(+) AGTTG(C/G)GTTGC upstream-variant-2KB
rs1001055509 -- 206,767,177(+) GGAGG(C/T)GGAGG downstream-variant-500B
rs1001440172 -- 206,773,941(+) CCTGT(C/T)CTCCT upstream-variant-2KB
rs1001662384 -- 206,770,319(+) CACCA(A/G)CTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL10 Gene

Variant ID Type Subtype PubMed ID
esv3578391 CNV loss 25503493

Variation tolerance for IL10 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL10 Gene

Human Gene Mutation Database (HGMD)
IL10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL10

Disorders for IL10 Gene

MalaCards: The human disease database

(242) MalaCards diseases for IL10 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
graft-versus-host disease, protection against
  • graft-versus-host disease, susceptibility to
rheumatoid arthritis
  • rheumatoid arthritis, progression of
hiv-1
  • aids, slow progression to
inflammatory bowel disease 25, early onset, autosomal recessive
  • inflammatory bowel disease 25
leishmaniasis
  • post kala-azar dermal leishmaniasis
- elite association - COSMIC cancer census association via MalaCards
Search IL10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IL10

Genetic Association Database (GAD)
IL10
Human Genome Epidemiology (HuGE) Navigator
IL10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL10
genes like me logo Genes that share disorders with IL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL10 Gene

Publications for IL10 Gene

  1. Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart. (PMID: 20388088) Licastro F. … Ferrari R. (Curr. Pharm. Des. 2010) 3 22 46 64
  2. Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study. (PMID: 19700159) Heiskanen M. … Hulkkonen J. (Atherosclerosis 2010) 3 22 46 64
  3. Interaction among variant vascular endothelial growth factor (VEGF) and its receptor in relation to prostate cancer risk. (PMID: 19908237) VanCleave T.T. … Kidd L.C. (Prostate 2010) 3 22 46 64
  4. Interleukin 10 gene promoter polymorphisms in women with pregnancy loss: preferential association with embryonic wastage. (PMID: 19208551) Cochery-Nouvellon E. … Gris J.C. (Biol. Reprod. 2009) 3 22 46 64
  5. Interaction between BCL2 and interleukin-10 gene polymorphisms alter outcomes of diffuse large B-cell lymphoma following rituximab plus CHOP chemotherapy. (PMID: 19276283) Park Y.H. … Kim D.H. (Clin. Cancer Res. 2009) 3 22 46 64

Products for IL10 Gene

Sources for IL10 Gene

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