Aliases for IL10 Gene
External Ids for IL10 Gene
Previous GeneCards Identifiers for IL10 Gene
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
GeneCards Summary for IL10 Gene
IL10 (Interleukin 10) is a Protein Coding gene. Diseases associated with IL10 include Rheumatoid Arthritis and Graft-Versus-Host Disease, Protection Against. Among its related pathways are RANK Signaling in Osteoclasts and Allograft rejection. GO annotations related to this gene include cytokine activity and interleukin-10 receptor binding.
UniProtKB/Swiss-Prot for IL10 Gene
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.