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Aliases for HLA-A Gene

Aliases for HLA-A Gene

  • Major Histocompatibility Complex, Class I, A 2 3
  • HLA Class I Histocompatibility Antigen, A-1 Alpha Chain 3 4
  • HLAA 3 4
  • HLA Class I Histocompatibility Antigen, A-10 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-28 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-9 Alpha Chain 4
  • MHC Class I Antigen HLA-A Heavy Chain 3
  • Antigen Presenting Molecule 3
  • Leukocyte Antigen Class I-A 3
  • MHC Class I Antigen A*11 4
  • MHC Class I Antigen A*23 4
  • MHC Class I Antigen A*24 4
  • MHC Class I Antigen A*25 4
  • MHC Class I Antigen A*26 4
  • MHC Class I Antigen A*29 4
  • MHC Class I Antigen A*30 4
  • MHC Class I Antigen A*31 4
  • MHC Class I Antigen A*32 4
  • MHC Class I Antigen A*33 4
  • MHC Class I Antigen A*34 4
  • MHC Class I Antigen A*36 4
  • MHC Class I Antigen A*43 4
  • MHC Class I Antigen A*66 4
  • MHC Class I Antigen A*68 4
  • MHC Class I Antigen A*69 4
  • MHC Class I Antigen A*74 4
  • MHC Class I Antigen A*80 4
  • MHC Class I Antigen A*1 4
  • MHC Class I Antigen A*2 4
  • MHC Class I Antigen A*3 4
  • Aw-19 4
  • Aw-24 4
  • Aw-33 4
  • Aw-34 4
  • Aw-36 4
  • Aw-43 4
  • Aw-66 4
  • Aw-68 4
  • Aw-69 4
  • Aw-74 4
  • Aw-80 4

External Ids for HLA-A Gene

Previous GeneCards Identifiers for HLA-A Gene

  • GC06P029953
  • GC06P029626
  • GC06P029902
  • GC06P030016
  • GC06P030019
  • GC06P030020
  • GC06P029916
  • GC06P029918
  • GC06P029921
  • GC06P029933
  • GC06P029949
  • GC06P030186

Summaries for HLA-A Gene

Entrez Gene Summary for HLA-A Gene

  • HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-A Gene

HLA-A (Major Histocompatibility Complex, Class I, A) is a Protein Coding gene. Diseases associated with HLA-A include hypersensitivity syndrome, carbamazepine-induced and birdshot chorioretinopathy. Among its related pathways are Disease and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include receptor binding and peptide antigen binding. An important paralog of this gene is MR1.

Gene Wiki entry for HLA-A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-A Gene

Genomics for HLA-A Gene

Regulatory Elements for HLA-A Gene

Genomic Location for HLA-A Gene

Start:
29,941,260 bp from pter
End:
29,945,884 bp from pter
Size:
4,625 bases
Orientation:
Plus strand

Genomic View for HLA-A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HLA-A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-A Gene

  • Protein details for HLA-A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01891-1A68_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, A-68 alpha chain
    Protein Accession:
    P01891
    Secondary Accessions:
    • O19673
    • O19695
    • O19794
    • O19795
    • O43907
    • O77938
    • O98010
    • P10315
    • P79505
    • Q9MYA5
    • Q9MYC4
    • Q9TQG7
    • Q9TQN5
    • Q9UIN2

    Protein attributes for HLA-A Gene

    Size:
    365 amino acids
    Molecular mass:
    40909 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).

    Three dimensional structures from OCA and Proteopedia for HLA-A Gene

neXtProt entry for HLA-A Gene

Proteomics data for HLA-A Gene at MOPED

Post-translational modifications for HLA-A Gene

No data available for DME Specific Peptides for HLA-A Gene

Domains for HLA-A Gene

Gene Families for HLA-A Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing
  • HLA :Histocompatibility complex

Graphical View of Domain Structure for InterPro Entry

P30443

UniProtKB/Swiss-Prot:

1A80_HUMAN :
  • P30443
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-A: view

Function for HLA-A Gene

Molecular function for HLA-A Gene

GENATLAS Biochemistry: HLA-A,alpha chain,44kDa,class Ia ,ubiquitously expressed,except central nervous system,placenta,sperm cells (see MHC1)

Gene Ontology (GO) - Molecular Function for HLA-A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 19124746
GO:0005515 protein binding IPI 23401559
GO:0030881 beta-2-microglobulin binding ISS --
GO:0042605 peptide antigen binding ISS --
GO:0042608 T cell receptor binding IDA 8955188
genes like me logo Genes that share ontologies with HLA-A: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HLA-A Gene

Localization for HLA-A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-A Gene COMPARTMENTS Subcellular localization image for HLA-A gene
Compartment Confidence
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
plasma membrane 4
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HLA-A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005797 Golgi medial cisterna IDA 8805302
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with HLA-A: view

Pathways for HLA-A Gene

genes like me logo Genes that share pathways with HLA-A: view

Gene Ontology (GO) - Biological Process for HLA-A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS --
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IDA 22031944
genes like me logo Genes that share ontologies with HLA-A: view

Compounds for HLA-A Gene

(1) Drugbank Compounds for HLA-A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-Indolebutyric Acid
133-32-4 target

(15) Novoseek inferred chemical compound relationships for HLA-A Gene

Compound -log(P) Hits PubMed IDs
dr-10 61.2 2
5-aza-2deoxycytidine 30.7 3
levamisole 6.25 2
zinc 5.4 1
tyrosine 4.43 1

(3) PharmGKB related drug/compound annotations for HLA-A Gene

Drug/compound Annotation
allopurinol CA
carbamazepine CA
zonisamide CA
genes like me logo Genes that share compounds with HLA-A: view

Transcripts for HLA-A Gene

Unigene Clusters for HLA-A Gene

Major histocompatibility complex, class I, A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-A Gene

No ASD Table

Relevant External Links for HLA-A Gene

GeneLoc Exon Structure for
HLA-A
ECgene alternative splicing isoforms for
HLA-A

Expression for HLA-A Gene

mRNA expression in normal human tissues for HLA-A Gene

mRNA differential expression in normal tissues according to GTEx for HLA-A Gene

This gene is overexpressed in Whole Blood (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HLA-A Gene

SOURCE GeneReport for Unigene cluster for HLA-A Gene Hs.181244

genes like me logo Genes that share expressions with HLA-A: view

No data available for mRNA Expression by UniProt/SwissProt for HLA-A Gene

Orthologs for HLA-A Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 93 (a)
OneToMany
PATR-A 35
  • 96.26 (n)
  • 93.15 (a)
PATR-A 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia H2-Q10 35
  • 80.85 (n)
  • 75.24 (a)
H2-Q10 16
rat
(Rattus norvegicus)
Mammalia LOC100364500 35
  • 78.5 (n)
  • 67.6 (a)
chicken
(Gallus gallus)
Aves LOC100858733 35
  • 54.53 (n)
  • 43.69 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC563036 35
  • 46.79 (n)
  • 34.34 (a)
Species with no ortholog for HLA-A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLA-A Gene

ENSEMBL:
Gene Tree for HLA-A (if available)
TreeFam:
Gene Tree for HLA-A (if available)

Paralogs for HLA-A Gene

Paralogs for HLA-A Gene

Selected SIMAP similar genes for HLA-A Gene using alignment to 5215 proteins: