Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HLA-A Gene

Aliases for HLA-A Gene

  • Major Histocompatibility Complex, Class I, A 2 3 5
  • HLA Class I Histocompatibility Antigen, A-1 Alpha Chain 3 4
  • HLAA 3 4
  • HLA Class I Histocompatibility Antigen, A-10 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-28 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, A-9 Alpha Chain 4
  • MHC Class I Antigen HLA-A Heavy Chain 3
  • Leukocyte Antigen Class I-A 3
  • MHC Class I Antigen A*11 4
  • MHC Class I Antigen A*23 4
  • MHC Class I Antigen A*24 4
  • MHC Class I Antigen A*25 4
  • MHC Class I Antigen A*26 4
  • MHC Class I Antigen A*29 4
  • MHC Class I Antigen A*30 4
  • MHC Class I Antigen A*31 4
  • MHC Class I Antigen A*32 4
  • MHC Class I Antigen A*33 4
  • MHC Class I Antigen A*34 4
  • MHC Class I Antigen A*36 4
  • MHC Class I Antigen A*43 4
  • MHC Class I Antigen A*66 4
  • MHC Class I Antigen A*68 4
  • MHC Class I Antigen A*69 4
  • MHC Class I Antigen A*74 4
  • MHC Class I Antigen A*80 4
  • MHC Class I Antigen A*1 4
  • MHC Class I Antigen A*2 4
  • MHC Class I Antigen A*3 4
  • Aw-19 4
  • Aw-24 4
  • Aw-33 4
  • Aw-34 4
  • Aw-36 4
  • Aw-43 4
  • Aw-66 4
  • Aw-68 4
  • Aw-69 4
  • Aw-74 4
  • Aw-80 4

External Ids for HLA-A Gene

Previous GeneCards Identifiers for HLA-A Gene

  • GC06P029953
  • GC06P029626
  • GC06P029902
  • GC06P030016
  • GC06P030019
  • GC06P030020
  • GC06P029916
  • GC06P029918
  • GC06P029921
  • GC06P029933
  • GC06P029949
  • GC06P030186
  • GC06P030205
  • GC06P030244
  • GC06P030355
  • GC06P030504
  • GC06P030707

Summaries for HLA-A Gene

Entrez Gene Summary for HLA-A Gene

  • HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-A Gene

HLA-A (Major Histocompatibility Complex, Class I, A) is a Protein Coding gene. Diseases associated with HLA-A include Hypersensitivity Syndrome, Carbamazepine-Induced and Hla-A-Related Altered Drug Metabolism. Among its related pathways are Allograft rejection and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include poly(A) RNA binding and peptide antigen binding. An important paralog of this gene is HLA-B.

Gene Wiki entry for HLA-A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-A Gene

Genomics for HLA-A Gene

Regulatory Elements for HLA-A Gene

Enhancers for HLA-A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G029963 2 FANTOM5 Ensembl ENCODE dbSUPER 40.6 +25.0 24990 4.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 HLA-A HLA-K HLA-W HLA-H HLA-J HCG4P5 MICD HCG4 IFITM4P HLA-F
GH06G029940 1.3 ENCODE dbSUPER 40.2 +1.0 1001 3.7 HDGF PKNOX1 FOXA2 WRNIP1 ZFP64 ARID4B DMAP1 ZNF2 YY1 ZNF143 HLA-J HLA-T HLA-G HLA-H HLA-W HLA-K HLA-A HCG4P3 ZFP57 HLA-U
GH06G029924 1.1 ENCODE dbSUPER 32.6 -15.2 -15188 3.6 TBP MLX ARID4B DMAP1 RFX5 YY1 PCBP1 KLF11 SMAD5 CEBPB HLA-A MICD ZFP57 HLA-J HLA-H HLA-K HCG4P3 RPL23AP1 ZNRD1 HCG4
GH06G029949 0.8 ENCODE dbSUPER 41 +4.3 4259 0.2 SOX5 ELF3 NFIL3 POLR2A SMAD4 TEAD3 HLA-A ZNRD1 PIR61557 HCG4P4
GH06G029976 1.3 ENCODE dbSUPER 23.7 +35.7 35695 1.7 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 HLA-J HCG4P3 HLA-K ZFP57 HLA-H ZNRD1 HLA-A HCG4P7 MICD HCG4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HLA-A on UCSC Golden Path with GeneCards custom track

Promoters for HLA-A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195346 1540 2001 HDGF FOXA2 ATF1 WRNIP1 ARID4B DMAP1 ZNF2 YY1 GLIS2 ZNF143

Genomic Location for HLA-A Gene

Chromosome:
6
Start:
29,941,260 bp from pter
End:
29,945,884 bp from pter
Size:
4,625 bases
Orientation:
Plus strand

Genomic View for HLA-A Gene

Genes around HLA-A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-A Gene

  • Protein details for HLA-A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01891-1A68_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, A-68 alpha chain
    Protein Accession:
    P01891
    Secondary Accessions:
    • O19673
    • O19695
    • O19794
    • O19795
    • O43907
    • O77938
    • O98010
    • P10315
    • P79505
    • Q9MYA5
    • Q9MYC4
    • Q9TQG7
    • Q9TQN5
    • Q9UIN2

    Protein attributes for HLA-A Gene

    Size:
    365 amino acids
    Molecular mass:
    40909 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).

    Three dimensional structures from OCA and Proteopedia for HLA-A Gene

neXtProt entry for HLA-A Gene

Post-translational modifications for HLA-A Gene

No data available for DME Specific Peptides for HLA-A Gene

Domains & Families for HLA-A Gene

Graphical View of Domain Structure for InterPro Entry

P30443

UniProtKB/Swiss-Prot:

1A80_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-A: view

Function for HLA-A Gene

Molecular function for HLA-A Gene

GENATLAS Biochemistry:
HLA-A,alpha chain,44kDa,class Ia ,ubiquitously expressed,except central nervous system,placenta,sperm cells (see MHC1)
UniProtKB/Swiss-Prot Function:
Involved in the presentation of foreign antigens to the immune system.

Gene Ontology (GO) - Molecular Function for HLA-A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 23401559
GO:0030881 beta-2-microglobulin binding ISS --
GO:0042605 peptide antigen binding IDA,ISS --
genes like me logo Genes that share ontologies with HLA-A: view

Phenotypes for HLA-A Gene

genes like me logo Genes that share phenotypes with HLA-A: view

Human Phenotype Ontology for HLA-A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-A Gene

Localization for HLA-A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-A gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 4
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HLA-A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS --
genes like me logo Genes that share ontologies with HLA-A: view

Pathways & Interactions for HLA-A Gene

genes like me logo Genes that share pathways with HLA-A: view

Interacting Proteins for HLA-A Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366005%0d%0a9606.ENSP00000452780%0d%0a9606.ENSP00000329411%0d%0a9606.ENSP00000358165%0d%0a9606.ENSP00000369440%0d%0a9606.ENSP00000318472%0d%0a

Symbol External ID(s) Details
HLA-B