Aliases for GATA4 Gene
External Ids for GATA4 Gene
Previous GeneCards Identifiers for GATA4 Gene
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008]
GeneCards Summary for GATA4 Gene
GATA4 (GATA Binding Protein 4) is a Protein Coding gene. Diseases associated with GATA4 include atrial septal defect 2 and ventricular septal defect 1. Among its related pathways are GPCR Pathway and Heart Development. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is GATA5.
UniProtKB/Swiss-Prot for GATA4 Gene
Transcriptional activator that binds to the consensus sequence 5-AGATAG-3 and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development.