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Aliases for ZFPM2 Gene

Aliases for ZFPM2 Gene

  • Zinc Finger Protein, FOG Family Member 2 2 3
  • FOG2 3 4 6
  • Zinc Finger Protein, Multitype 2 2 3
  • Friend Of GATA Protein 2 3 4
  • Zinc Finger Protein 89B 3 4
  • Friend Of GATA 2 3 4
  • ZNF89B 3 4
  • HFOG-2 3 4
  • FOG-2 3 4
  • DIH3 3 6
  • Transcription Factor GATA4, Modulator Of 3
  • Zinc Finger Protein Multitype 2 4
  • Zinc Finger Protein ZFPM2 3
  • Friend Of GATA2 3
  • ZC2HC11B 3
  • SRXY9 3

External Ids for ZFPM2 Gene

Summaries for ZFPM2 Gene

Entrez Gene Summary for ZFPM2 Gene

  • The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZFPM2 Gene

ZFPM2 (Zinc Finger Protein, FOG Family Member 2) is a Protein Coding gene. Diseases associated with ZFPM2 include diaphragmatic hernia 3 and 46,xy sex reversal 9. Among its related pathways are MicroRNAs in cancer and Hemostasis. GO annotations related to this gene include transcription factor binding and RNA polymerase II transcription coactivator activity. An important paralog of this gene is ZFPM1.

UniProtKB/Swiss-Prot for ZFPM2 Gene

  • Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity).

Gene Wiki entry for ZFPM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFPM2 Gene

Genomics for ZFPM2 Gene

Genomic Location for ZFPM2 Gene

Start:
104,590,733 bp from pter
End:
105,804,539 bp from pter
Size:
1,213,807 bases
Orientation:
Plus strand

Genomic View for ZFPM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFPM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFPM2 Gene

Regulatory Elements for ZFPM2 Gene

Proteins for ZFPM2 Gene

  • Protein details for ZFPM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW38-FOG2_HUMAN
    Recommended name:
    Zinc finger protein ZFPM2
    Protein Accession:
    Q8WW38
    Secondary Accessions:
    • Q32MA6
    • Q9NPL7
    • Q9NPS4
    • Q9UNI5

    Protein attributes for ZFPM2 Gene

    Size:
    1151 amino acids
    Molecular mass:
    128159 Da
    Quaternary structure:
    • Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid nuclear receptor RXRA when ligand bound (By similarity). Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity. Able to bind GATA1 in vitro. Interacts with NR2F2 and NR2F6 (By similarity).

    Alternative splice isoforms for ZFPM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFPM2 Gene

Proteomics data for ZFPM2 Gene at MOPED

Post-translational modifications for ZFPM2 Gene

  • Sumoylation reduces transcriptional repression activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFPM2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFPM2 Gene

Domains for ZFPM2 Gene

Gene Families for ZFPM2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • ZC2HC :Zinc fingers, C2HC-type containing

Protein Domains for ZFPM2 Gene

Suggested Antigen Peptide Sequences for ZFPM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WW38

UniProtKB/Swiss-Prot:

FOG2_HUMAN
Domain:
  • The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).:
    • Q8WW38
Family:
  • Belongs to the FOG (Friend of GATA) family.:
    • Q8WW38
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q8WW38
  • Contains 5 C2HC-type zinc fingers.:
    • Q8WW38
genes like me logo Genes that share domains with ZFPM2: view

Function for ZFPM2 Gene

Molecular function for ZFPM2 Gene

UniProtKB/Swiss-Prot Function: Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity).

Gene Ontology (GO) - Molecular Function for ZFPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IBA --
GO:0001085 RNA polymerase II transcription factor binding IBA --
GO:0001105 RNA polymerase II transcription coactivator activity NAS 10438528
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZFPM2: view
genes like me logo Genes that share phenotypes with ZFPM2: view

Animal Models for ZFPM2 Gene

MGI Knock Outs for ZFPM2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZFPM2 Gene

Localization for ZFPM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFPM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFPM2 Gene COMPARTMENTS Subcellular localization image for ZFPM2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZFPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZFPM2: view

Pathways for ZFPM2 Gene

genes like me logo Genes that share pathways with ZFPM2: view

Pathways by source for ZFPM2 Gene

1 KEGG pathway for ZFPM2 Gene

Gene Ontology (GO) - Biological Process for ZFPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0001570 vasculogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0003148 outflow tract septum morphogenesis IMP 20807224
GO:0003221 right ventricular cardiac muscle tissue morphogenesis IMP 20807224
genes like me logo Genes that share ontologies with ZFPM2: view

Compounds for ZFPM2 Gene

(1) Novoseek inferred chemical compound relationships for ZFPM2 Gene

Compound -log(P) Hits PubMed IDs
zinc 55.7 2
genes like me logo Genes that share compounds with ZFPM2: view

Transcripts for ZFPM2 Gene

Unigene Clusters for ZFPM2 Gene

Zinc finger protein, FOG family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFPM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2:

Relevant External Links for ZFPM2 Gene

GeneLoc Exon Structure for
ZFPM2
ECgene alternative splicing isoforms for
ZFPM2

Expression for ZFPM2 Gene

mRNA expression in normal human tissues for ZFPM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFPM2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.5) and Brain - Cerebellum (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZFPM2 Gene

SOURCE GeneReport for Unigene cluster for ZFPM2 Gene Hs.431009

mRNA Expression by UniProt/SwissProt for ZFPM2 Gene

Q8WW38-FOG2_HUMAN
Tissue specificity: Widely expressed at low level.
genes like me logo Genes that share expressions with ZFPM2: view

Orthologs for ZFPM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZFPM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFPM2 35
  • 99.54 (n)
  • 99.65 (a)
ZFPM2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFPM2 35
  • 91.6 (n)
  • 95.48 (a)
ZFPM2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFPM2 35
  • 90.86 (n)
  • 95.8 (a)
ZFPM2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfpm2 35
  • 89.08 (n)
  • 93.92 (a)
Zfpm2 16
Zfpm2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFPM2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFPM2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfpm2 35
  • 89.57 (n)
  • 94.35 (a)
chicken
(Gallus gallus)
Aves ZFPM2 35
  • 83.52 (n)
  • 90.01 (a)
ZFPM2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFPM2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zfpm2 35
  • 75.18 (n)
  • 77.59 (a)
zebrafish
(Danio rerio)
Actinopterygii zfpm2a 35
  • 66.46 (n)
  • 64.2 (a)
zfpm2a 36
  • 64 (a)
OneToMany
zfpm2b 36
  • 45 (a)
OneToMany
Species with no ortholog for ZFPM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZFPM2 Gene

ENSEMBL:
Gene Tree for ZFPM2 (if available)
TreeFam:
Gene Tree for ZFPM2 (if available)

Paralogs for ZFPM2 Gene

Paralogs for ZFPM2 Gene

genes like me logo Genes that share paralogs with ZFPM2: view

Variants for ZFPM2 Gene

Sequence variations from dbSNP and Humsavar for ZFPM2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs215400 -- 105,506,982(+) GACTC(C/T)GTCTC intron-variant
rs302953 -- 105,500,253(-) ATGCC(A/G)ATATT intron-variant
rs302954 -- 105,499,462(-) TGTTT(A/G)TTTTG intron-variant
rs302955 -- 105,488,928(-) CTAAA(A/T)TACAT intron-variant
rs302956 -- 105,487,896(-) ataga(C/T)agaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFPM2 Gene

Variant ID Type Subtype PubMed ID
nsv521187 CNV Loss 19592680
esv2674317 CNV Deletion 23128226
esv1637363 CNV Insertion 17803354
esv270944 CNV Insertion 20981092
nsv510163 CNV Loss 20534489
nsv891258 CNV Loss 21882294
nsv525601 CNV Gain 19592680
nsv395924 CNV Loss 16902084
esv2670397 CNV Deletion 23128226
esv23851 CNV Loss 19812545
nsv831418 CNV Gain 17160897
nsv891259 CNV Gain 21882294
esv271796 CNV Insertion 20981092
esv274249 CNV Insertion 20981092
esv2643906 CNV Deletion 19546169
esv1968574 CNV Deletion 18987734
esv3206 CNV Deletion 18987735
esv988675 CNV Deletion 20482838
nsv396362 CNV Loss 16902084
esv2737391 CNV Deletion 23290073
esv1230300 CNV Deletion 17803354
esv9123 CNV Loss 19470904
nsv510164 CNV Loss 20534489
esv2571877 CNV Deletion 19546169
esv2318733 CNV Deletion 18987734
esv2737392 CNV Deletion 23290073
esv2660166 CNV Deletion 23128226
nsv891260 CNV Gain 21882294
nsv6339 CNV Insertion 18451855
esv2676076 CNV Deletion 23128226
esv2667745 CNV Deletion 23128226
esv2737393 CNV Deletion 23290073
esv26932 CNV Loss 19812545
esv2737394 CNV Deletion 23290073
esv2357213 CNV Deletion 18987734

Relevant External Links for ZFPM2 Gene

HapMap Linkage Disequilibrium report
ZFPM2
Human Gene Mutation Database (HGMD)
ZFPM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZFPM2 Gene

Disorders for ZFPM2 Gene

(2) OMIM Diseases for ZFPM2 Gene (603693)

UniProtKB/Swiss-Prot

FOG2_HUMAN
  • Tetralogy of Fallot (TOF) [MIM:187500]: A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. {ECO:0000269 PubMed:14517948, ECO:0000269 PubMed:20807224}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
  • Diaphragmatic hernia 3 (DIH3) [MIM:610187]: Form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension. {ECO:0000269 PubMed:16103912}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 46,XY sex reversal 9 (SRXY9) [MIM:616067]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females or have ambiguous external genitalia. {ECO:0000269 PubMed:24549039}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Conotruncal heart malformations (CTHM) [MIM:217095]: A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. {ECO:0000269 PubMed:20807224}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) Novoseek inferred disease relationships for ZFPM2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for ZFPM2

Genetic Association Database (GAD)
ZFPM2
Human Genome Epidemiology (HuGE) Navigator
ZFPM2
genes like me logo Genes that share disorders with ZFPM2: view

Publications for ZFPM2 Gene

  1. hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. (PMID: 10438528) Holmes M. … Chong B. (J. Biol. Chem. 1999) 2 3 4
  2. Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers. (PMID: 10329627) Fox A.H. … Crossley M. (EMBO J. 1999) 3 23
  3. The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression. (PMID: 20206639) Mwinyi J. … Ingelman-Sundberg M. (Life Sci. 2010) 3 23
  4. Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. (PMID: 9927675) Svensson E.C. … Leiden J.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3
  5. Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot. (PMID: 14517948) Pizzuti A. … Dallapiccola B. (Hum. Mutat. 2003) 3 4

Products for ZFPM2 Gene

Sources for ZFPM2 Gene

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