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Aliases for FMO5 Gene

Aliases for FMO5 Gene

  • Flavin Containing Monooxygenase 5 2 3
  • EC 1.14.13.8 4 64
  • Hepatic Flavin-Containing Monooxygenase 5 4
  • Dimethylaniline Oxidase 5 4
  • FMO 5 4

External Ids for FMO5 Gene

Summaries for FMO5 Gene

Entrez Gene Summary for FMO5 Gene

  • Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for FMO5 Gene

FMO5 (Flavin Containing Monooxygenase 5) is a Protein Coding gene. Diseases associated with FMO5 include trimethylaminuria. Among its related pathways are Busulfan Pathway, Pharmacodynamics and Biological oxidations. GO annotations related to this gene include flavin adenine dinucleotide binding and N,N-dimethylaniline monooxygenase activity. An important paralog of this gene is FMO4.

UniProtKB/Swiss-Prot for FMO5 Gene

  • In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme

Gene Wiki entry for FMO5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO5 Gene

Genomics for FMO5 Gene

Genomic Location for FMO5 Gene

Start:
147,175,351 bp from pter
End:
147,243,050 bp from pter
Size:
67,700 bases
Orientation:
Minus strand

Genomic View for FMO5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FMO5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO5 Gene

Regulatory Elements for FMO5 Gene

Proteins for FMO5 Gene

  • Protein details for FMO5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49326-FMO5_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 5
    Protein Accession:
    P49326
    Secondary Accessions:
    • B2RBG1
    • C9JJD1
    • Q8IV22

    Protein attributes for FMO5 Gene

    Size:
    533 amino acids
    Molecular mass:
    60221 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FMO5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMO5 Gene

Proteomics data for FMO5 Gene at MOPED

Post-translational modifications for FMO5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for FMO5 Gene

UniProtKB/Swiss-Prot:

FMO5_HUMAN
Family:
  • Belongs to the FMO family.:
    • P49326
genes like me logo Genes that share domains with FMO5: view

No data available for Gene Families for FMO5 Gene

Function for FMO5 Gene

Molecular function for FMO5 Gene

GENATLAS Biochemistry: flavin containing monooxygenase 5,microsomal
UniProtKB/Swiss-Prot CatalyticActivity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O
UniProtKB/Swiss-Prot Function: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme

Enzyme Numbers (IUBMB) for FMO5 Gene

Gene Ontology (GO) - Molecular Function for FMO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004499 N,N-dimethylaniline monooxygenase activity IEA --
GO:0016491 oxidoreductase activity --
GO:0050660 flavin adenine dinucleotide binding IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with FMO5: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FMO5 Gene

Localization for FMO5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO5 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMO5 Gene COMPARTMENTS Subcellular localization image for FMO5 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
peroxisome 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FMO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FMO5: view

Pathways for FMO5 Gene

genes like me logo Genes that share pathways with FMO5: view

Pathways by source for FMO5 Gene

1 KEGG pathway for FMO5 Gene

Interacting Proteins for FMO5 Gene

Gene Ontology (GO) - Biological Process for FMO5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FMO5: view

Compounds for FMO5 Gene

(7) HMDB Compounds for FMO5 Gene

Compound Synonyms Cas Number PubMed IDs
Dimethylaniline-N-oxide
  • Dimethylaniline N-oxide
874-52-2
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
N,N-Dimethylaniline
  • Dimethylaminobenzene
121-69-7
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6

(4) Novoseek inferred chemical compound relationships for FMO5 Gene

Compound -log(P) Hits PubMed IDs
n-octylamine 82.2 1
benzydamine 80 3
methimazole 77 1
pyrophosphate 60 2
genes like me logo Genes that share compounds with FMO5: view

Transcripts for FMO5 Gene

Unigene Clusters for FMO5 Gene

Flavin containing monooxygenase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMO5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3:

Relevant External Links for FMO5 Gene

GeneLoc Exon Structure for
FMO5
ECgene alternative splicing isoforms for
FMO5

Expression for FMO5 Gene

mRNA expression in normal human tissues for FMO5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO5 Gene

This gene is overexpressed in Liver (12.5) and Stomach (11.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FMO5 Gene

SOURCE GeneReport for Unigene cluster for FMO5 Gene Hs.642706

mRNA Expression by UniProt/SwissProt for FMO5 Gene

P49326-FMO5_HUMAN
Tissue specificity: Expressed in fetal and adult liver
genes like me logo Genes that share expressions with FMO5: view

Orthologs for FMO5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FMO5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMO5 36
  • 99.62 (n)
  • 99.44 (a)
FMO5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FMO5 36
  • 87.55 (n)
  • 85.18 (a)
FMO5 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO5 36
  • 89.49 (n)
  • 88.74 (a)
FMO5 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo5 36
  • 84.24 (n)
  • 84.05 (a)
Fmo5 16
Fmo5 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FMO5 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FMO5 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fmo5 36
  • 83.99 (n)
  • 84.24 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 62 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
LOC100857724 36
  • 65.91 (n)
  • 67.68 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 64 (a)
OneToMany
-- 37
  • 69 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fmo5 36
fmo5 36
  • 63.65 (n)
  • 63.19 (a)
fmo5 37
  • 58 (a)
ManyToMany
si:dkey-239i20.2 37
  • 56 (a)
ManyToMany
si:dkey-239i20.4 37
  • 50 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fmo-2 37
  • 31 (a)
ManyToMany
Fmo-2 38
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea fmo-1 37
  • 41 (a)
ManyToMany
fmo-2 37
  • 42 (a)
ManyToMany
fmo-3 37
  • 44 (a)
ManyToMany
fmo-4 37
  • 37 (a)
ManyToMany
fmo-5 36
  • 51.68 (n)
  • 44.75 (a)
fmo-5 37
  • 43 (a)
ManyToMany
fmo-12 38
  • 43 (a)
fmo-15 38
  • 44 (a)
fmo-13 38
  • 44 (a)
C01H6.4 38
  • 32 (a)
fmo-11 38
  • 43 (a)
fmo-14 38
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMO1 37
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
Species with no ortholog for FMO5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FMO5 Gene

ENSEMBL:
Gene Tree for FMO5 (if available)
TreeFam:
Gene Tree for FMO5 (if available)

Paralogs for FMO5 Gene

Paralogs for FMO5 Gene

Selected SIMAP similar genes for FMO5 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for FMO5 Gene

genes like me logo Genes that share paralogs with FMO5: view

Variants for FMO5 Gene

Sequence variations from dbSNP and Humsavar for FMO5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_015370 -
VAR_022308 -
VAR_022309 -

Structural Variations from Database of Genomic Variants (DGV) for FMO5 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
esv529 CNV CNV 17122850
dgv114e1 CNV Complex 17122850
nsv872251 CNV Gain 21882294
nsv872255 CNV Gain 21882294
nsv872257 CNV Gain 21882294
nsv437047 CNV Loss 16327808
esv270836 CNV Insertion 20981092
esv273693 CNV Insertion 20981092
nsv159869 CNV Insertion 16902084
dgv67e199 CNV Deletion 23128226
nsv872258 CNV Loss 21882294
esv2717518 CNV Deletion 23290073
nsv872259 CNV Loss 21882294

Relevant External Links for FMO5 Gene

HapMap Linkage Disequilibrium report
FMO5
Human Gene Mutation Database (HGMD)
FMO5

Disorders for FMO5 Gene

(1) MalaCards Diseases for FMO5 Gene

Search for FMO5 Gene in MalaCards »

Relevant External Links for FMO5

Genetic Association Database (GAD)
FMO5
Human Genome Epidemiology (HuGE) Navigator
FMO5
genes like me logo Genes that share disorders with FMO5: view

No data available for UniProtKB/Swiss-Prot for FMO5 Gene

Publications for FMO5 Gene

  1. Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q. (PMID: 8786146) McCombie R.R. … Shephard E.A. (Genomics 1996) 2 3 23
  2. Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor a genes on 1q21. (PMID: 9119381) Gelb B.D. … Desnick R.J. (Genomics 1997) 2 3 23
  3. Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. (PMID: 7872795) Overby L.H. … Philpot R.M. (Arch. Biochem. Biophys. 1995) 3 4 23
  4. A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. (PMID: 8311461) Lawton M.P. … Phillips I.R. (Arch. Biochem. Biophys. 1994) 3 23
  5. Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450. (PMID: 11128045) Chung W.G. … Cha Y.N. (Jpn. J. Pharmacol. 2000) 3 23

Products for FMO5 Gene

Sources for FMO5 Gene

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