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Aliases for ZNF365 Gene

Aliases for ZNF365 Gene

  • Zinc Finger Protein 365 2 3
  • Protein Su48 3 4
  • Talanin 2 3
  • KIAA0844 4
  • ZNF365D 3
  • Su48 3
  • UAN 3

External Ids for ZNF365 Gene

Previous GeneCards Identifiers for ZNF365 Gene

  • GC10P064026
  • GC10P063478
  • GC10P063803
  • GC10P064133
  • GC10P058125

Summaries for ZNF365 Gene

Entrez Gene Summary for ZNF365 Gene

  • This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010]

GeneCards Summary for ZNF365 Gene

ZNF365 (Zinc Finger Protein 365) is a Protein Coding gene. Diseases associated with ZNF365 include nephrolithiasis, uric acid and nephrolithiasis. An important paralog of this gene is FBXO41.

UniProtKB/Swiss-Prot for ZNF365 Gene

  • May play a role in uric acid excretion

Gene Wiki entry for ZNF365 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF365 Gene

Genomics for ZNF365 Gene

Regulatory Elements for ZNF365 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF365 Gene

62,374,157 bp from pter
62,672,011 bp from pter
297,855 bases
Plus strand

Genomic View for ZNF365 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF365 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF365 Gene

Proteins for ZNF365 Gene

  • Protein details for ZNF365 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for ZNF365 Gene

    216 amino acids
    Molecular mass:
    24036 Da
    Quaternary structure:
    No Data Available
    • Isoform 4 (talanin) of ZNF365 does not exist in rodents. In primates, a canonical intron-exon structure exist, with several stop codons preventing talanin production in old world and new world monkeys. It seems therefore that isoform 4 transcript emerged during primate evolution from a noncoding genomic sequence

    Alternative splice isoforms for ZNF365 Gene

  • Protein details for ZNF365 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ZNF365
    Protein Accession:
    Secondary Accessions:
    • A8K0F0
    • O94930
    • Q05D75
    • Q5HYE6
    • Q68SG8
    • Q6NSK2
    • Q6P9D4
    • Q70YC6
    • Q70YC7

    Protein attributes for ZNF365 Gene

    407 amino acids
    Molecular mass:
    46542 Da
    Quaternary structure:
    • Homodimer. Interacts with NDE1 and NDEL1. Does not interact with TUBG1.
    • Sequence=AAH17841.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA74867.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF365 Gene

neXtProt entry for ZNF365 Gene

Proteomics data for ZNF365 Gene at MOPED

Post-translational modifications for ZNF365 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF365 Gene

Domains & Families for ZNF365 Gene

Gene Families for ZNF365 Gene

Protein Domains for ZNF365 Gene


Suggested Antigen Peptide Sequences for ZNF365 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF365: view

No data available for UniProtKB/Swiss-Prot for ZNF365 Gene

Function for ZNF365 Gene

Molecular function for ZNF365 Gene

UniProtKB/Swiss-Prot Function:
May play a role in uric acid excretion

Gene Ontology (GO) - Molecular Function for ZNF365 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16682949
genes like me logo Genes that share ontologies with ZNF365: view

Phenotypes for ZNF365 Gene

GenomeRNAi human phenotypes for ZNF365:
genes like me logo Genes that share phenotypes with ZNF365: view

miRNA for ZNF365 Gene

miRTarBase miRNAs that target ZNF365

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF365

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF365 Gene

Localization for ZNF365 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF365 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=localizes to the centrosome at all stages of the cell cycle.

Subcellular locations from

Jensen Localization Image for ZNF365 Gene COMPARTMENTS Subcellular localization image for ZNF365 gene
Compartment Confidence
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for ZNF365 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with ZNF365: view

Pathways & Interactions for ZNF365 Gene

SuperPathways for ZNF365 Gene

No Data Available

Interacting Proteins for ZNF365 Gene

Gene Ontology (GO) - Biological Process for ZNF365 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF365 Gene

Drugs & Compounds for ZNF365 Gene

No Compound Related Data Available

Transcripts for ZNF365 Gene

Unigene Clusters for ZNF365 Gene

Zinc finger protein 365:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF365

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF365 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: - - - - - -
SP3: -

Relevant External Links for ZNF365 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF365 Gene

mRNA expression in normal human tissues for ZNF365 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF365 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.8), Brain - Anterior cingulate cortex (BA24) (x6.3), and Brain - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for ZNF365 Gene

This gene is overexpressed in Liver (42.1), Kidney (14.1), and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF365 Gene

SOURCE GeneReport for Unigene cluster for ZNF365 Gene Hs.22653

mRNA Expression by UniProt/SwissProt for ZNF365 Gene

Tissue specificity: Isoform 4 is expressed in placenta, lung, kidney and pancreas.
genes like me logo Genes that share expression patterns with ZNF365: view

Protein tissue co-expression partners for ZNF365 Gene

Primer Products

In Situ Assay Products

Orthologs for ZNF365 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF365 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC521207 35
  • 87.33 (n)
  • 88.4 (a)
ZNF365 36
  • 69 (a)
(Canis familiaris)
Mammalia ZNF365 35
  • 85.83 (n)
  • 89.19 (a)
ZNF365 36
  • 70 (a)
(Mus musculus)
Mammalia Zfp365 35
  • 83.46 (n)
  • 85.01 (a)
Zfp365 16
Zfp365 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Zfp365 35
  • 83.7 (n)
  • 86.24 (a)
(Monodelphis domestica)
Mammalia ZNF365 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF365 36
  • 61 (a)
(Pan troglodytes)
Mammalia ZNF365 36
  • 93 (a)
(Gallus gallus)
Aves ZNF365 35
  • 64.33 (n)
  • 61.04 (a)
ZNF365 36
  • 48 (a)
(Anolis carolinensis)
Reptilia ZNF365 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf365 35
  • 60.25 (n)
  • 54.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19768 35
(Danio rerio)
Actinopterygii LOC799320 35
  • 51.73 (n)
  • 44.81 (a)
ZNF365 36
  • 29 (a)
Species with no ortholog for ZNF365:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF365 Gene

Gene Tree for ZNF365 (if available)
Gene Tree for ZNF365 (if available)

Paralogs for ZNF365 Gene

Paralogs for ZNF365 Gene

genes like me logo Genes that share paralogs with ZNF365: view

Variants for ZNF365 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF365 Gene

Thr-62 is associated with increased risk for uric acid nephrolithiasis

Sequence variations from dbSNP and Humsavar for ZNF365 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs729738 -- 62,670,505(+) CCAAT(A/C)AAGTT utr-variant-3-prime
rs729739 -- 62,670,542(+) TCTAA(A/G)CCATC utr-variant-3-prime
rs737314 -- 62,514,418(+) AGCAC(C/T)GTCTT intron-variant
rs753518 -- 62,475,747(-) CATCC(C/T)GCCAT intron-variant
rs868912 -- 62,580,760(+) AGTGA(A/G)GACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF365 Gene

Variant ID Type Subtype PubMed ID
nsv8681 CNV Gain 18304495
esv34099 CNV Loss 18971310
nsv467293 CNV Gain 19166990
nsv825408 CNV Loss 20364138
esv2670021 CNV Deletion 23128226
nsv831891 CNV Gain 17160897
esv271402 CNV Insertion 20981092
esv33660 CNV Loss 17666407
esv2677528 CNV Deletion 23128226
esv29409 CNV Loss 19812545

Variation tolerance for ZNF365 Gene

Residual Variation Intolerance Score: 63.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF365 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ZNF365 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ZNF365 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nephrolithiasis, uric acid
  • uric acid nephrolithiasis
  • stone - kidney/ureter
acute urate nephropathy
  • uric acid nephrolithiasis
  • paroxysmal sleep
crohn's disease
  • enteritis
- elite association


  • Uric acid nephrolithiasis (UAN) [MIM:605990]: A form of nephrolithiasis, a common multifactorial disease characterized by stones formation in the kidney and urinary tract. Nephrolithiasis is due to supersaturation of the urine by stone-forming constituents, including calcium, oxalate and uric acid. Crystals or foreign bodies can act as nidi, upon which ions from the supersaturated urine form microscopic crystalline structures. Uric acid nephrolithiasis occurs when the urine becomes overly concentrated with uric acid and accounts for 20% of all stones. {ECO:0000269 PubMed:12740763}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ZNF365

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ZNF365: view

No data available for Genatlas for ZNF365 Gene

Publications for ZNF365 Gene

  1. Emergence of talanin protein associated with human uric acid nephrolithiasis in the hominidae lineage. (PMID: 15363853) Gianfrancesco F. … Parastu M. (Gene 2004) 23 67
  2. Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate. (PMID: 12740763) Gianfrancesco F. … Pirastu M. (Am. J. Hum. Genet. 2003) 2 67
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 67
  4. A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? (PMID: 25534755) Chaste P. … Devlin B. (Biol. Psychiatry 2015) 67
  5. Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. (PMID: 25489960) Yang S.K. … Song K. (Inflamm. Bowel Dis. 2015) 67

Products for ZNF365 Gene

Sources for ZNF365 Gene

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