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Aliases for F13B Gene

Aliases for F13B Gene

  • Coagulation Factor XIII, B Polypeptide 2 3
  • Protein-Glutamine Gamma-Glutamyltransferase B Chain 3 4
  • Fibrin-Stabilizing Factor B Subunit 3 4
  • Transglutaminase B Chain 3 4
  • Coagulation Factor XIII B Chain 3
  • FXIIIB 3
  • TGASE 3

External Ids for F13B Gene

Previous GeneCards Identifiers for F13B Gene

  • GC01M194735
  • GC01M192466
  • GC01M193474
  • GC01M194296
  • GC01M193739
  • GC01M195274
  • GC01M168165

Summaries for F13B Gene

Entrez Gene Summary for F13B Gene

  • This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

GeneCards Summary for F13B Gene

F13B (Coagulation Factor XIII, B Polypeptide) is a Protein Coding gene. Diseases associated with F13B include factor xiiib deficiency and factor xiii deficiency. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). An important paralog of this gene is CFHR1.

UniProtKB/Swiss-Prot for F13B Gene

  • The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin

Gene Wiki entry for F13B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F13B Gene

Genomics for F13B Gene

Regulatory Elements for F13B Gene

Genomic Location for F13B Gene

197,038,747 bp from pter
197,067,267 bp from pter
28,521 bases
Minus strand

Genomic View for F13B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for F13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F13B Gene

Proteins for F13B Gene

  • Protein details for F13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coagulation factor XIII B chain
    Protein Accession:
    Secondary Accessions:
    • A8K3E5
    • Q5VYL5

    Protein attributes for F13B Gene

    661 amino acids
    Molecular mass:
    75511 Da
    Quaternary structure:
    • Tetramer of two A chains and two B chains

neXtProt entry for F13B Gene

Proteomics data for F13B Gene at MOPED

Post-translational modifications for F13B Gene

  • Glycosylation at Asn162 and Asn545
  • Modification sites at PhosphoSitePlus

Other Protein References for F13B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for F13B Gene

Domains for F13B Gene

Protein Domains for F13B Gene

Suggested Antigen Peptide Sequences for F13B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P05160
  • Contains 10 Sushi (CCP/SCR) domains.
genes like me logo Genes that share domains with F13B: view

No data available for Gene Families for F13B Gene

Function for F13B Gene

Molecular function for F13B Gene

GENATLAS Biochemistry: coagulation factor XIII,B polypeptide,non catalytic (80kDa)
UniProtKB/Swiss-Prot Function: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin
genes like me logo Genes that share phenotypes with F13B: view

miRNA for F13B Gene

miRTarBase miRNAs that target F13B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for F13B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for F13B Gene

Localization for F13B Gene

Subcellular locations from UniProtKB/Swiss-Prot for F13B Gene


Subcellular locations from

Jensen Localization Image for F13B Gene COMPARTMENTS Subcellular localization image for F13B gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for F13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with F13B: view

Pathways for F13B Gene

genes like me logo Genes that share pathways with F13B: view

Gene Ontology (GO) - Biological Process for F13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with F13B: view

Transcripts for F13B Gene

mRNA/cDNA for F13B Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for F13B Gene

Coagulation factor XIII, B polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for F13B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for F13B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for F13B Gene

No ASD Table

Relevant External Links for F13B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for F13B Gene

mRNA expression in normal human tissues for F13B Gene

mRNA differential expression in normal tissues according to GTEx for F13B Gene

This gene is overexpressed in Liver (52.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for F13B Gene

SOURCE GeneReport for Unigene cluster for F13B Gene Hs.435782

genes like me logo Genes that share expressions with F13B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for F13B Gene

Orthologs for F13B Gene

This gene was present in the common ancestor of chordates.

Orthologs for F13B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia F13B 35
  • 99.55 (n)
  • 99.55 (a)
F13B 36
  • 100 (a)
(Bos Taurus)
Mammalia F13B 35
  • 81.59 (n)
  • 75.04 (a)
F13B 36
  • 75 (a)
(Canis familiaris)
Mammalia F13B 35
  • 87.62 (n)
  • 82.66 (a)
F13B 36
  • 82 (a)
(Mus musculus)
Mammalia F13b 35
  • 80.74 (n)
  • 77.31 (a)
F13b 16
F13b 36
  • 76 (a)
(Monodelphis domestica)
Mammalia F13B 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia F13B 36
  • 60 (a)
(Gallus gallus)
Aves F13B 35
  • 61.42 (n)
  • 49.51 (a)
F13B 36
  • 47 (a)
(Anolis carolinensis)
Reptilia F13B 36
  • 49 (a)
(Danio rerio)
Actinopterygii f13b 36
  • 26 (a)
Species with no ortholog for F13B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F13B Gene

Gene Tree for F13B (if available)
Gene Tree for F13B (if available)

Paralogs for F13B Gene

Paralogs for F13B Gene

genes like me logo Genes that share paralogs with F13B: view

Variants for F13B Gene

Sequence variations from dbSNP and Humsavar for F13B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5990 -- 197,039,467(-) TGTAA(G/T)TAACA intron-variant
rs5991 - 197,057,021(-) TCCTG(A/T)GTGTG reference, missense
rs5992 -- 197,061,902(-) ATTCA(A/G)GAGAA reference, synonymous-codon, intron-variant
rs5993 -- 197,061,699(-) TATTA(A/T)TTAAT intron-variant
rs5994 -- 197,060,406(-) CAATG(C/T)TATAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for F13B Gene

Variant ID Type Subtype PubMed ID
nsv528460 CNV Gain 19592680
esv743 CNV CNV 17122850
dgv12e55 CNV Gain 17911159
essv8557 CNV CNV 17122850
essv19099 CNV CNV 17122850
nsv873063 CNV Loss 21882294
nsv873064 CNV Gain 21882294
esv1543078 CNV Insertion 17803354
dgv514n71 CNV Loss 21882294
nsv873066 CNV Loss 21882294
esv7629 CNV Gain 19470904

Relevant External Links for F13B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F13B Gene

Disorders for F13B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for F13B Gene including...

Search for F13B Gene in MalaCards »

(1) OMIM Diseases for F13B Gene (134580)


  • Factor XIII subunit B deficiency (FA13BD) [MIM:613235]: An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. {ECO:0000269 PubMed:11313256, ECO:0000269 PubMed:8324218}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for F13B Gene

Genatlas disease for F13B Gene

bleeding tendency,defective wound healing, habitual abortion,fibrin-stabilizing factor deficiency,type I

Relevant External Links for F13B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with F13B: view

Publications for F13B Gene

  1. A novel polymorphism in the factor XIII B-subunit (His95Arg): relationship to subunit dissociation and venous thrombosis. (PMID: 16241947) Komanasin N. … AriAns R.A. (J. Thromb. Haemost. 2005) 3 23 48
  2. Nucleotide sequence of the gene for the b subunit of human factor XIII. (PMID: 2271707) Bottenus R.E. … Davie E.W. (Biochemistry 1990) 2 3 4
  3. Complete cDNA sequence encoding the B subunit of human factor XIII. (PMID: 2339067) Grundmann U. … Zettlmeissl G. (Nucleic Acids Res. 1990) 2 3 4
  4. Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments. (PMID: 3021194) Ichinose A. … Davie E.W. (Biochemistry 1986) 3 4
  5. Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PMID: 10391209) Cargill M. … Lander E.S. (Nat. Genet. 1999) 3 4

Products for F13B Gene

Sources for F13B Gene

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