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Aliases for ERG Gene

Aliases for ERG Gene

  • ERG, ETS Transcription Factor 2 3 5
  • Transcriptional Regulator ERG (Transforming Protein ERG) 2 3
  • V-Ets Avian Erythroblastosis Virus E26 Oncogene Related 2 3
  • V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2 3
  • V-Ets Erythroblastosis Virus E26 Oncogene Like 2 3
  • Erythroblast Transformation-Specific Transcription Factor ERG Variant 10 3
  • V-Ets Erythroblastosis Virus E26 Oncogene Homolog 3
  • TMPRSS2-ERG Prostate Cancer Specific 2
  • Transcriptional Regulator ERG 3
  • Transforming Protein ERG 4
  • TMPRSS2/ERG Fusion 3
  • Ets-Related 3
  • Erg-3 3
  • P55 3

External Ids for ERG Gene

Previous GeneCards Identifiers for ERG Gene

  • GC21M036332
  • GC21M038672
  • GC21M038675
  • GC21M039751
  • GC21M025221

Summaries for ERG Gene

Entrez Gene Summary for ERG Gene

  • This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

CIViC summary for ERG Gene

GeneCards Summary for ERG Gene

ERG (ERG, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with ERG include Extraskeletal Ewing Sarcoma and Ewing Sarcoma. Among its related pathways are Transcriptional misregulation in cancer and Chromatin Regulation / Acetylation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and signal transducer activity. An important paralog of this gene is FLI1.

UniProtKB/Swiss-Prot for ERG Gene

  • Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Gene Wiki entry for ERG Gene

Additional gene information for ERG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERG Gene

Genomics for ERG Gene

Regulatory Elements for ERG Gene

Enhancers for ERG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H038493 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20.1 +164.7 164693 7 BCOR POLR2A JUN ZNF512 ZMYM3 ZBTB40 ERG PSMG1 SNRPGP13 GC21P038433
GH21H038830 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -169.9 -169868 1 PKNOX1 FOXA2 MLX ARNT ARID4B YBX1 YY1 ZNF766 FOS DEK ETS2 ENSG00000229986 RPSAP64 HMGN1 ERG
GH21H038800 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -145.9 -145941 15 MLX FEZF1 YY1 SLC30A9 ZNF143 ZNF548 SP3 MEF2D ZNF610 GLIS1 HMGN1 ETS2 ERG ENSG00000229986
GH21H038485 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.1 +172.5 172548 7 HDAC1 TAL1 JUN CEBPB ZIC2 NR2F2 FOXA1 FOSL1 CTBP1 JUND ERG HMGN1 SNRPGP13 GC21P038433
GH21H038954 1.5 Ensembl ENCODE dbSUPER 11.1 -295.6 -295599 6 FOXA2 PKNOX1 YY1 TCF12 ZNF766 GATA2 ELK1 FOS ATF7 REST RPSAP64 HMGN1 ERG LOC400867 LINC01700
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERG on UCSC Golden Path with GeneCards custom track

Genomic Location for ERG Gene

Chromosome:
21
Start:
38,367,261 bp from pter
End:
38,661,833 bp from pter
Size:
294,573 bases
Orientation:
Minus strand

Genomic View for ERG Gene

Genes around ERG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERG Gene

Proteins for ERG Gene

  • Protein details for ERG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11308-ERG_HUMAN
    Recommended name:
    Transcriptional regulator ERG
    Protein Accession:
    P11308
    Secondary Accessions:
    • B4DTW5
    • B4E0T4
    • Q16113
    • Q6XXX4
    • Q6XXX5
    • Q8IXK9

    Protein attributes for ERG Gene

    Size:
    486 amino acids
    Molecular mass:
    54608 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.

    Three dimensional structures from OCA and Proteopedia for ERG Gene

    Alternative splice isoforms for ERG Gene

neXtProt entry for ERG Gene

Post-translational modifications for ERG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ERG (ERG)

No data available for DME Specific Peptides for ERG Gene

Domains & Families for ERG Gene

Gene Families for ERG Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

P11308

UniProtKB/Swiss-Prot:

ERG_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ERG: view

Function for ERG Gene

Molecular function for ERG Gene

GENATLAS Biochemistry:
avian erythroblastosis virus E26 (v-ets) oncogene related protein,rearranged in myeloid leukemia with translocation t(16;21)(p11;q11) (see FUS) and in Ewing sarcoma with t(21;22) translocation
UniProtKB/Swiss-Prot Function:
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.

Phenotypes From GWAS Catalog for ERG Gene

Gene Ontology (GO) - Molecular Function for ERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 23093599
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IC --
GO:0003677 DNA binding TAS 8502479
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with ERG: view
genes like me logo Genes that share phenotypes with ERG: view

Animal Models for ERG Gene

MGI Knock Outs for ERG:

Animal Model Products

CRISPR Products

miRNA for ERG Gene

Targeted motifs for ERG Gene
HOMER Transcription Factor Regulatory Elements motif ERG
  • Consensus sequence: ACAGGAAGTG Submotif: canonical Cell Type: VCaP GEO ID: GSE14097

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for ERG Gene

Localization for ERG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERG Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERG gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005737 cytoplasm IEA --
GO:0030529 intracellular ribonucleoprotein complex IDA 17289661
genes like me logo Genes that share ontologies with ERG: view

Pathways & Interactions for ERG Gene

genes like me logo Genes that share pathways with ERG: view

Pathways by source for ERG Gene

1 Cell Signaling Technology pathway for ERG Gene
1 BioSystems pathway for ERG Gene
1 KEGG pathway for ERG Gene

Gene Ontology (GO) - Biological Process for ERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003197 endocardial cushion development IEA --
GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ERG: view

No data available for SIGNOR curated interactions for ERG Gene

Drugs & Compounds for ERG Gene

(23) Drugs for ERG Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 2052
Hydroxocobalamin Approved Pharma 267
Cyanocobalamin Approved Nutra 268
Folic Acid Approved, Vet_approved Nutra 4513
Vitamin A Approved, Vet_approved Nutra 511
genes like me logo Genes that share compounds with ERG: view

Transcripts for ERG Gene

Unigene Clusters for ERG Gene

V-ets erythroblastosis virus E26 oncogene homolog (avian):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERG Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7:
SP8:

Relevant External Links for ERG Gene

GeneLoc Exon Structure for
ERG
ECgene alternative splicing isoforms for
ERG

Expression for ERG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERG Gene

This gene is overexpressed in Artery - Aorta (x5.5).

Protein differential expression in normal tissues from HIPED for ERG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (50.2) and Adipocyte (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ERG Gene



Protein tissue co-expression partners for ERG Gene

NURSA nuclear receptor signaling pathways regulating expression of ERG Gene:

ERG

SOURCE GeneReport for Unigene cluster for ERG Gene:

Hs.473819

Phenotype-based relationships between genes and organs from Gene ORGANizer for ERG Gene

Germ Layers:
  • mesoderm
Systems:
  • skeleton
Organs:
Head and neck:
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with ERG: view

No data available for mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for ERG Gene

Orthologs for ERG Gene

This gene was present in the common ancestor of animals.

Orthologs for ERG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERG 34 33
  • 99.73 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERG 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERG 33 34
  • 91.61 (n)
oppossum
(Monodelphis domestica)
Mammalia ERG 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERG 33 34
  • 90.9 (n)
mouse
(Mus musculus)
Mammalia Erg 33 16 34
  • 89.85 (n)
rat
(Rattus norvegicus)
Mammalia Erg 33
  • 88.69 (n)
chicken
(Gallus gallus)
Aves ERG 33 34
  • 84.84 (n)
lizard
(Anolis carolinensis)
Reptilia ERG 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia erg 33
  • 79.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia erg-A 33
zebrafish
(Danio rerio)
Actinopterygii erg 33 34
  • 71.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ets65A 35
  • 62 (a)
Ets21C 35 34
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea C42D8.4 35
  • 78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1256 33
Species where no ortholog for ERG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERG Gene

ENSEMBL:
Gene Tree for ERG (if available)
TreeFam:
Gene Tree for ERG (if available)

Paralogs for ERG Gene

genes like me logo Genes that share paralogs with ERG: view

Variants for ERG Gene

Sequence variations from dbSNP and Humsavar for ERG Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000007022 -- 38,374,324(+) AAACA(A/G)TTGTC intron-variant
rs1000008138 -- 38,591,095(+) GGAGG(A/G)GCAGT intron-variant
rs1000012701 -- 38,622,074(+) CAGGA(C/G)ATGCA intron-variant
rs1000012972 -- 38,644,128(+) CACAC(A/G)GGTCT intron-variant
rs1000018318 -- 38,549,071(+) TCGCA(C/T)CACCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERG Gene

Variant ID Type Subtype PubMed ID
dgv2387n106 CNV deletion 24896259
dgv4429n100 CNV gain 25217958
dgv4430n100 CNV gain 25217958
esv1290531 CNV insertion 17803354
esv21857 CNV loss 19812545
esv2264168 CNV deletion 18987734
esv2629526 CNV insertion 19546169
esv2658330 CNV deletion 23128226
esv2667140 CNV deletion 23128226
esv2672087 CNV deletion 23128226
esv2723416 CNV deletion 23290073
esv2723418 CNV deletion 23290073
esv2723419 CNV deletion 23290073
esv2751930 CNV loss 17911159
esv2852 CNV loss 18987735
esv3365274 CNV duplication 20981092
esv3557703 CNV deletion 23714750
esv3647002 CNV loss 21293372
esv3647003 CNV loss 21293372
esv3647005 CNV loss 21293372
nsv1058886 CNV gain 25217958
nsv1064436 CNV gain 25217958
nsv1072605 CNV deletion 25765185
nsv1109435 CNV deletion 24896259
nsv1110759 CNV insertion 24896259
nsv1114291 CNV deletion 24896259
nsv1129679 CNV tandem duplication 24896259
nsv1146789 CNV deletion 26484159
nsv1149979 CNV deletion 26484159
nsv1160712 CNV deletion 26073780
nsv1160713 CNV duplication 26073780
nsv187113 CNV deletion 16902084
nsv187128 CNV deletion 16902084
nsv3515 CNV insertion 18451855
nsv3516 CNV deletion 18451855
nsv472690 CNV novel sequence insertion 20440878
nsv477758 CNV novel sequence insertion 20440878
nsv817930 CNV loss 17921354
nsv834098 CNV gain 17160897
nsv953363 CNV duplication 24416366
nsv956728 CNV deletion 24416366

Variation tolerance for ERG Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERG Gene

Disorders for ERG Gene

MalaCards: The human disease database

(6) MalaCards diseases for ERG Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
extraskeletal ewing sarcoma
  • extraosseous ewing sarcoma
ewing sarcoma
  • neuroepithelioma
myeloid leukemia
  • leukemia myelogenous
sarcoma
  • connective and soft tissue neoplasm
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search ERG in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ERG_HUMAN
  • Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. {ECO:0000269 PubMed:8076344}. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1. {ECO:0000269 PubMed:8076344}.
  • Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS (PubMed:8187069). Translocation t(X;21)(q25-26;q22) with ELF4 (PubMed:16303180). {ECO:0000269 PubMed:16303180, ECO:0000269 PubMed:8187069}.

Relevant External Links for ERG

Genetic Association Database (GAD)
ERG
Human Genome Epidemiology (HuGE) Navigator
ERG
Tumor Gene Database (TGDB):
ERG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERG
genes like me logo Genes that share disorders with ERG: view

No data available for Genatlas for ERG Gene

Publications for ERG Gene

  1. ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22). (PMID: 16303180) Moore SD … Dal Cin P (Leukemia research 2006) 3 4 22 60
  2. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. (PMID: 8187069) Ichikawa H … Ohki M (Cancer research 1994) 3 4 22 60
  3. ERG gene is translocated in an Ewing's sarcoma cell line. (PMID: 8076344) Dunn T … Viola MV (Cancer genetics and cytogenetics 1994) 3 4 22 60
  4. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y … Kamatani N (PLoS genetics 2011) 3 45 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for ERG Gene

  • Addgene plasmids for ERG

Sources for ERG Gene

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