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Aliases for ERCC4 Gene

Aliases for ERCC4 Gene

  • ERCC Excision Repair 4, Endonuclease Catalytic Subunit 2 3 5
  • Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4 2 3
  • Xeroderma Pigmentosum Group F-Complementing Protein 3 4
  • Xeroderma Pigmentosum, Complementation Group F 2 3
  • Excision Repair Cross-Complementation Group 4 2 3
  • DNA Repair Protein Complementing XP-F Cells 3 4
  • DNA Excision Repair Protein ERCC-4 3 4
  • ERCC11 3 4
  • XPF 3 4
  • Excision-Repair, Complementing Defective, In Chinese Hamster 3
  • DNA Repair Endonuclease XPF 3
  • EC 3.1.-.- 4
  • FANCQ 3
  • XFEPS 3
  • RAD1 3

External Ids for ERCC4 Gene

Previous HGNC Symbols for ERCC4 Gene

  • XPF

Previous GeneCards Identifiers for ERCC4 Gene

  • GC16P013959
  • GC16P014166
  • GC16P013980
  • GC16P013922

Summaries for ERCC4 Gene

Entrez Gene Summary for ERCC4 Gene

  • The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]

GeneCards Summary for ERCC4 Gene

ERCC4 (ERCC Excision Repair 4, Endonuclease Catalytic Subunit) is a Protein Coding gene. Diseases associated with ERCC4 include Xfe Progeroid Syndrome and Xeroderma Pigmentosum, Group F. Among its related pathways are DNA Double-Strand Break Repair and Nucleotide excision repair. GO annotations related to this gene include nucleic acid binding and protein N-terminus binding.

UniProtKB/Swiss-Prot for ERCC4 Gene

  • Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.

Gene Wiki entry for ERCC4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERCC4 Gene

Genomics for ERCC4 Gene

Regulatory Elements for ERCC4 Gene

Enhancers for ERCC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G013955 1.7 FANTOM5 Ensembl ENCODE 23 +37.2 37243 3.8 PKNOX1 FOXA2 ARNT SIN3A FEZF1 YBX1 ZNF2 SLC30A9 ZNF207 FOS ENSG00000183458 NPIPA3 NPIPA2 ERCC4 RPS26P52 PLA2G10 MKL2 ENSG00000263234 LINC02185
GH16G014500 1.6 Ensembl ENCODE dbSUPER 9.9 +582.2 582173 3.9 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 FOS ZNF263 BFAR MIR193B RPS26P52 ERCC4 LOC100505915 LOC105371094 RN7SL274P
GH16G013940 0.7 ENCODE 21.3 +20.5 20489 0.8 RFX1 FOXA3 MAFG MAX MNT RAD21 ZNF592 FOXA1 ZNF316 MAFF ERCC4 ENSG00000262732 ENSG00000263234
GH16G014497 1.4 Ensembl ENCODE dbSUPER 9.9 +578.2 578200 2.2 PKNOX1 FOXA2 MLX ZNF48 SLC30A9 FOS MXD4 KAT8 SSRP1 PBX2 MIR193B ERCC4 RPS26P52 LOC105371094 RN7SL274P
GH16G013919 1.1 ENCODE 12.4 +0.4 391 2.4 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ERCC4 GC16M013923
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERCC4 on UCSC Golden Path with GeneCards custom track

Promoters for ERCC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083614 55 1201 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 FEZF1

Genomic Location for ERCC4 Gene

Chromosome:
16
Start:
13,920,145 bp from pter
End:
13,952,348 bp from pter
Size:
32,204 bases
Orientation:
Plus strand

Genomic View for ERCC4 Gene

Genes around ERCC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERCC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERCC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERCC4 Gene

Proteins for ERCC4 Gene

  • Protein details for ERCC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92889-XPF_HUMAN
    Recommended name:
    DNA repair endonuclease XPF
    Protein Accession:
    Q92889
    Secondary Accessions:
    • A5PKV6
    • A8K111
    • O00140
    • Q8TD83

    Protein attributes for ERCC4 Gene

    Size:
    916 amino acids
    Molecular mass:
    104486 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Heterodimer composed of ERCC1 and XPF/ERCC4. Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-XPF/ERCC1 complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair.
    SequenceCaution:
    • Sequence=AAB07689.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ERCC4 Gene

    Alternative splice isoforms for ERCC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERCC4 Gene

Post-translational modifications for ERCC4 Gene

  • Ubiquitination at Lys753
  • Modification sites at PhosphoSitePlus

Other Protein References for ERCC4 Gene

No data available for DME Specific Peptides for ERCC4 Gene

Domains & Families for ERCC4 Gene

Suggested Antigen Peptide Sequences for ERCC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q92889

UniProtKB/Swiss-Prot:

XPF_HUMAN :
  • Belongs to the XPF family.
Family:
  • Belongs to the XPF family.
genes like me logo Genes that share domains with ERCC4: view

Function for ERCC4 Gene

Molecular function for ERCC4 Gene

GENATLAS Biochemistry:
excision repair 103 kDa,single strand DNA endonuclease,cross-complementing rodent repair defect in CHO cells,complementation group 4 and group 11,yeast RAD1 homolog,same as ERCC11,homologous with eukaryotic DNA repair and recombination proteins MEI-9 from Drosophila,RAD16 S pombe,RAD1 S cerevisiae
UniProtKB/Swiss-Prot Function:
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.

Enzyme Numbers (IUBMB) for ERCC4 Gene

Gene Ontology (GO) - Molecular Function for ERCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000014 single-stranded DNA endodeoxyribonuclease activity IBA --
GO:0001094 TFIID-class transcription factor binding IEA --
GO:0003677 contributes_to DNA binding IEA,IDA 14734547
GO:0003684 damaged DNA binding IMP 11790111
GO:0003697 single-stranded DNA binding IDA 10413517
genes like me logo Genes that share ontologies with ERCC4: view
genes like me logo Genes that share phenotypes with ERCC4: view

Human Phenotype Ontology for ERCC4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ERCC4 Gene

Localization for ERCC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERCC4 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERCC4 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ERCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000109 nucleotide-excision repair complex IDA 10644440
GO:0000110 nucleotide-excision repair factor 1 complex IDA 10413517
GO:0000781 chromosome, telomeric region IDA 14690602
GO:0000784 nuclear chromosome, telomeric region IDA 14690602
GO:0005634 nucleus IDA,IEA 12571280
genes like me logo Genes that share ontologies with ERCC4: view

Pathways & Interactions for ERCC4 Gene

genes like me logo Genes that share pathways with ERCC4: view

Pathways by source for ERCC4 Gene

SIGNOR curated interactions for ERCC4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ERCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 resolution of meiotic recombination intermediates IBA --
GO:0000723 telomere maintenance IMP 14690602
GO:0000724 double-strand break repair via homologous recombination IMP 14728600
GO:0006259 DNA metabolic process IEA --
GO:0006281 DNA repair IGI,IMP 19596235
genes like me logo Genes that share ontologies with ERCC4: view

Drugs & Compounds for ERCC4 Gene

(7) Drugs for ERCC4 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Platinum compounds Pharma 0
Magnesium Nutra 0

(3) Additional Compounds for ERCC4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ERCC4: view

Transcripts for ERCC4 Gene

Unigene Clusters for ERCC4 Gene

Excision repair cross-complementing rodent repair deficiency, complementation group 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERCC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - -
SP2: -
SP3:
SP4: - -
SP5:
SP6:

Relevant External Links for ERCC4 Gene

GeneLoc Exon Structure for
ERCC4
ECgene alternative splicing isoforms for
ERCC4

Expression for ERCC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERCC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ERCC4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.7) and Heart (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ERCC4 Gene



Protein tissue co-expression partners for ERCC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ERCC4 Gene:

ERCC4

SOURCE GeneReport for Unigene cluster for ERCC4 Gene:

Hs.567265

Evidence on tissue expression from TISSUES for ERCC4 Gene

  • Nervous system(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ERCC4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lacrimal apparatus
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • pituitary gland
  • skull
  • tongue
  • tooth
  • vocal cord
Thorax:
  • breast
  • chest wall
  • clavicle
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • thymus
Abdomen:
  • abdominal wall
  • intestine
  • kidney
  • large intestine
  • liver
  • spleen
  • stomach
Pelvis:
  • anus
  • ovary
  • pelvis
  • penis
  • prostate
  • rectum
  • testicle
  • ureter
  • urinary bladder
  • uterus
  • vagina
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with ERCC4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ERCC4 Gene

Orthologs for ERCC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERCC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERCC4 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia ERCC4 34 35
  • 86.1 (n)
oppossum
(Monodelphis domestica)
Mammalia ERCC4 35
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERCC4 34 35
  • 85.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ERCC4 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ercc4 34 16 35
  • 80.49 (n)
rat
(Rattus norvegicus)
Mammalia Ercc4l1 34
  • 79.77 (n)
chicken
(Gallus gallus)
Aves ERCC4 34 35
  • 74.52 (n)
lizard
(Anolis carolinensis)
Reptilia ERCC4 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ercc4 34
  • 70.42 (n)
Str.15254 34
zebrafish
(Danio rerio)
Actinopterygii ercc4 34 35
  • 63.24 (n)
wufi03a05 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002805 34
  • 51.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta mei-9 36 34 35
  • 50.94 (n)
worm
(Caenorhabditis elegans)
Secernentea C47D12.8 35
  • 29 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR456C 34
  • 49.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD1 34 35 37
  • 46.55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12210g 34
  • 46.16 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons UVH1 34
  • 49.73 (n)
rice
(Oryza sativa)
Liliopsida Os03g0100400 34
  • 48.83 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07440 34
  • 50.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rad16 34
  • 46.96 (n)
Species where no ortholog for ERCC4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERCC4 Gene

ENSEMBL:
Gene Tree for ERCC4 (if available)
TreeFam:
Gene Tree for ERCC4 (if available)

Paralogs for ERCC4 Gene

No data available for Paralogs for ERCC4 Gene

Variants for ERCC4 Gene

Sequence variations from dbSNP and Humsavar for ERCC4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs121913049 Pathogenic, Xeroderma pigmentosum complementation group F (XP-F) [MIM:278760] 13,947,991(+) GACTA(C/T)GGATT reference, missense
rs121913050 Pathogenic, XFE progeroid syndrome (XFEPS) [MIM:610965] 13,926,630(+) CTTTC(A/C/G)CCAGA reference, missense, utr-variant-5-prime
rs147105770 Pathogenic, Xeroderma pigmentosum type F/Cockayne syndrome (XPF/CS) [MIM:278760] 13,935,697(+) TTGTT(C/T)GGCAG reference, missense
rs149364215 Pathogenic, Fanconi anemia complementation group Q (FANCQ) [MIM:615272] 13,947,661(+) ATATG(A/C/T)GTGAA reference, missense
rs397509402 Pathogenic, Fanconi anemia complementation group Q (FANCQ) [MIM:615272] 13,928,132(+) TATAC(C/T)GGACA reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ERCC4 Gene

Variant ID Type Subtype PubMed ID
nsv984261 CNV duplication 23825009

Variation tolerance for ERCC4 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERCC4 Gene

Human Gene Mutation Database (HGMD)
ERCC4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERCC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERCC4 Gene

Disorders for ERCC4 Gene

MalaCards: The human disease database

(15) MalaCards diseases for ERCC4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
xfe progeroid syndrome
  • xfeps
xeroderma pigmentosum, group f
  • xeroderma pigmentosum, type f/cockayne syndrome
fanconi anemia, complementation group q
  • fanconi anemia complementation group q
cockayne syndrome type i
  • cockayne syndrome classic form
xeroderma pigmentosum-cockayne syndrome complex
  • xp/cs complex
- elite association - COSMIC cancer census association via MalaCards
Search ERCC4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

XPF_HUMAN
  • Fanconi anemia complementation group Q (FANCQ) [MIM:615272]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. {ECO:0000269 PubMed:23623386, ECO:0000269 PubMed:24027083}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Xeroderma pigmentosum complementation group F (XP-F) [MIM:278760]: An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-F patients show a mild phenotype. {ECO:0000269 PubMed:10447254, ECO:0000269 PubMed:8797827, ECO:0000269 PubMed:9579555, ECO:0000269 PubMed:9580660}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Xeroderma pigmentosum type F/Cockayne syndrome (XPF/CS) [MIM:278760]: A variant form of Cockayne syndrome, a disorder characterized by growth retardation, microcephaly, impairment of nervous system development, pigmentary retinopathy, peculiar facies, and progeria together with abnormal skin photosensitivity. Cockayne syndrome dermatological features are milder than those in xeroderma pigmentosum and skin cancers are not found in affected individuals. XPF/CS patients, however, present with severe skin phenotypes, including severe photosensitivity, abnormal skin pigmentation, and skin cancer predisposition. {ECO:0000269 PubMed:23623389}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • XFE progeroid syndrome (XFEPS) [MIM:610965]: A syndrome characterized by aged bird-like facies, lack of subcutaneous fat, dwarfism, cachexia and microcephaly. Additional features include sun-sensitivity from birth, learning disabilities, hearing loss, and visual impairment. {ECO:0000269 PubMed:17183314}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ERCC4

Genetic Association Database (GAD)
ERCC4
Human Genome Epidemiology (HuGE) Navigator
ERCC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERCC4
genes like me logo Genes that share disorders with ERCC4: view

No data available for Genatlas for ERCC4 Gene

Publications for ERCC4 Gene

  1. Homozygous R788W point mutation in the XPF gene of a patient with xeroderma pigmentosum and late-onset neurologic disease. (PMID: 9579555) Sijbers A.M. … Kleijer W.J. (J. Invest. Dermatol. 1998) 2 3 4 22 64
  2. ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs. (PMID: 8887684) Brookman K.W. … Thompson L.H. (Mol. Cell. Biol. 1996) 2 3 4 22 64
  3. Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. (PMID: 19902366) Agalliu I. … Stanford J.L. (Cancer Causes Control 2010) 3 22 46 64
  4. A novel XPF -357A>C polymorphism predicts risk and recurrence of bladder cancer. (PMID: 20062074) Wang M. … Zhang Z. (Oncogene 2010) 3 22 46 64
  5. A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (PMID: 19116388) Vineis P. … Matullo G. (J. Natl. Cancer Inst. 2009) 3 22 46 64

Products for ERCC4 Gene

Sources for ERCC4 Gene

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