Aliases for CCR5 Gene
External Ids for CCR5 Gene
Previous HGNC Symbols for CCR5 Gene
Previous GeneCards Identifiers for CCR5 Gene
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
GeneCards Summary for CCR5 Gene
CCR5 (Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with CCR5 include susceptibility/resistance to hiv infection and west nile virus. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include G-protein coupled receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is CCR7.
UniProtKB/Swiss-Prot for CCR5 Gene
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
(Microbial infection) Acts as a receptor for human immunodeficiency virus-1/HIV-1.
Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorized into four groups; CC, CXC, CX3C and C (XCL1 and XCL2).