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Aliases for CCR5 Gene

Aliases for CCR5 Gene

  • C-C Motif Chemokine Receptor 5 (Gene/Pseudogene) 2 3
  • Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene) 2 5
  • Chemokine (C-C Motif) Receptor 5 2 3
  • HIV-1 Fusion Coreceptor 3 4
  • CC-CKR-5 3 4
  • ChemR13 3 4
  • CMKBR5 3 4
  • CCR-5 3 4
  • C-C Motif Chemokine Receptor 5 A159A 3
  • Chemokine Receptor CCR5 3
  • CD195 Antigen 4
  • C-C CKR-5 4
  • CCCKR5 3
  • IDDM22 3
  • CD195 3
  • CKR-5 3
  • CKR5 3

External Ids for CCR5 Gene

Previous HGNC Symbols for CCR5 Gene

  • CMKBR5

Previous GeneCards Identifiers for CCR5 Gene

  • GC03P045652
  • GC03P046230
  • GC03P046372
  • GC03P046386
  • GC03P046376
  • GC03P046377

Summaries for CCR5 Gene

Entrez Gene Summary for CCR5 Gene

  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]

GeneCards Summary for CCR5 Gene

CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with CCR5 include west nile virus and diabetes mellitus, insulin-dependent, 22. Among its related pathways are Signaling by GPCR and HIV Life Cycle. GO annotations related to this gene include G-protein coupled receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is CCR9.

UniProtKB/Swiss-Prot for CCR5 Gene

  • Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

  • (Microbial infection) Acts as a receptor for human immunodeficiency virus-1/HIV-1.

Tocris Summary for CCR5 Gene

  • Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being adjacent to each other. There are 10 chemokine CC receptors.

Gene Wiki entry for CCR5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR5 Gene

Genomics for CCR5 Gene

Regulatory Elements for CCR5 Gene

Promoters for CCR5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCR5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCR5 Gene

Chromosome:
3
Start:
46,370,142 bp from pter
End:
46,376,206 bp from pter
Size:
6,065 bases
Orientation:
Plus strand

Genomic View for CCR5 Gene

Genes around CCR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR5 Gene

Proteins for CCR5 Gene

  • Protein details for CCR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51681-CCR5_HUMAN
    Recommended name:
    C-C chemokine receptor type 5
    Protein Accession:
    P51681
    Secondary Accessions:
    • O14692
    • O14693
    • O14695
    • O14696
    • O14697
    • O14698
    • O14699
    • O14700
    • O14701
    • O14702
    • O14703
    • O14704
    • O14705
    • O14706
    • O14707
    • O14708
    • O15538
    • Q9UPA4

    Protein attributes for CCR5 Gene

    Size:
    352 amino acids
    Molecular mass:
    40524 Da
    Quaternary structure:
    • Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Interacts with CNIH4 (PubMed:24405750). ARRB2.
    • (Microbial infection) Interacts with HIV-1 surface protein gp120 (PubMed:9632396, PubMed:21763489).
    • (Microbial infection) May interact with human cytomegalovirus/HHV-5 protein UL78.

    Three dimensional structures from OCA and Proteopedia for CCR5 Gene

neXtProt entry for CCR5 Gene

Proteomics data for CCR5 Gene at MOPED

Post-translational modifications for CCR5 Gene

  • O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
  • Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.
  • Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
  • Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
  • Glycosylation at Ser 6, Ser 7, Thr 16, and Ser 17
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCR5 Gene

Domains & Families for CCR5 Gene

Gene Families for CCR5 Gene

Graphical View of Domain Structure for InterPro Entry

P51681

UniProtKB/Swiss-Prot:

CCR5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR5: view

Function for CCR5 Gene

Molecular function for CCR5 Gene

GENATLAS Biochemistry:
chemokine CC,beta,receptor 5,expressed in lymphoid organs and cells,with multiple transcripts with 5 end heterogeneity and dual promoter usage,mediating macrophage-tropic strains of HIV-1 entry in CD4+ cells with a reduced risk of AIDS lymphoma in patients with the CCR5-delta 32 mutation,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human immunodeficiency virus-1/HIV-1.
UniProtKB/Swiss-Prot Induction:
(Microbial infection) May be down-regulated by human cytomegalovirus/HHV-5 protein UL78.

Gene Ontology (GO) - Molecular Function for CCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 12421915
genes like me logo Genes that share ontologies with CCR5: view
genes like me logo Genes that share phenotypes with CCR5: view

Animal Models for CCR5 Gene

MGI Knock Outs for CCR5:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCR5 Gene

Localization for CCR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCR5 Gene COMPARTMENTS Subcellular localization image for CCR5 gene
Compartment Confidence
cytosol 5
endosome 5
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CCR5: view

Pathways & Interactions for CCR5 Gene

genes like me logo Genes that share pathways with CCR5: view

Gene Ontology (GO) - Biological Process for CCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEP 12032188
GO:0006816 calcium ion transport IDA 8699119
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 10201901
GO:0007267 cell-cell signaling IDA 10679098
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA 19523456
genes like me logo Genes that share ontologies with CCR5: view

No data available for SIGNOR curated interactions for CCR5 Gene

Drugs & Compounds for CCR5 Gene

(111) Drugs for CCR5 Gene - From: Novoseek, IUPHAR, DGIdb, ClinicalTrials, Tocris, DrugBank, HMDB, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Maraviroc Approved, Investigational Pharma Antagonist, antagonist, Target Selective CCR5 antagonist,antiretroviral agent 135
Efavirenz Approved, Investigational Pharma Reverse transcriptase inhibitor 398
Etravirine Approved Pharma 73
Ritonavir Approved, Investigational Pharma HIV protease inhibitor 850
Tipranavir Approved, Investigational Pharma 74

(40) Additional Compounds for CCR5 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
DAPTA
106362-34-9
MRK-1
Antagonist
vMIP-II
Antagonist
J 113863
353791-85-2
RS 102895 hydrochloride
1173022-16-6
genes like me logo Genes that share compounds with CCR5: view

Transcripts for CCR5 Gene

mRNA/cDNA for CCR5 Gene

Unigene Clusters for CCR5 Gene

Chemokine (C-C motif) receptor 5 (gene/pseudogene):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR5 Gene

No ASD Table

Relevant External Links for CCR5 Gene

GeneLoc Exon Structure for
CCR5
ECgene alternative splicing isoforms for
CCR5

Expression for CCR5 Gene

mRNA expression in normal human tissues for CCR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR5 Gene

This gene is overexpressed in Whole Blood (x7.9) and Spleen (x6.2).

SOURCE GeneReport for Unigene cluster for CCR5 Gene Hs.450802

mRNA Expression by UniProt/SwissProt for CCR5 Gene

P51681-CCR5_HUMAN
Tissue specificity: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
genes like me logo Genes that share expression patterns with CCR5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCR5 Gene

Orthologs for CCR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCR5 35
  • 86.74 (n)
  • 86.08 (a)
CCR5 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCR5 35
  • 84 (n)
  • 82.67 (a)
CCR5 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccr5 35
  • 84.19 (n)
  • 82.39 (a)
Ccr5 16
chimpanzee
(Pan troglodytes)
Mammalia CCR5 35
  • 99.34 (n)
  • 99.43 (a)
CCR5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccr5 35
  • 84.09 (n)
  • 82.67 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCR2 36
  • 56 (a)
ManyToMany
CCR5 36
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731980 35
  • 60.6 (n)
  • 55.82 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100005081 35
  • 56.54 (n)
  • 44.17 (a)
Species with no ortholog for CCR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR5 Gene

ENSEMBL:
Gene Tree for CCR5 (if available)
TreeFam:
Gene Tree for CCR5 (if available)

Paralogs for CCR5 Gene

genes like me logo Genes that share paralogs with CCR5: view

Variants for CCR5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCR5 Gene

P51681-CCR5_HUMAN
Ser-60 variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors.

Sequence variations from dbSNP and Humsavar for CCR5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_003481 -
VAR_003482 -
VAR_003483 -
VAR_003484 -
VAR_003485 -

Structural Variations from Database of Genomic Variants (DGV) for CCR5 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294
esv271120 CNV Insertion 20981092

Variation tolerance for CCR5 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCR5 Gene

HapMap Linkage Disequilibrium report
CCR5
Human Gene Mutation Database (HGMD)
CCR5

Disorders for CCR5 Gene

MalaCards: The human disease database

(37) MalaCards diseases for CCR5 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
west nile virus
  • west nile virus, susceptibility to
diabetes mellitus, insulin-dependent, 22
  • iddm22
hepatitis c virus
  • hepatitic c virus
susceptibility/resistance to hiv infection
plague
  • yersiniosis
- elite association - COSMIC cancer census association via MalaCards
Search CCR5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CCR5_HUMAN
  • Diabetes mellitus, insulin-dependent, 22 (IDDM22) [MIM:612522]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:19073967}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for CCR5

Genetic Association Database (GAD)
CCR5
Human Genome Epidemiology (HuGE) Navigator
CCR5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCR5
genes like me logo Genes that share disorders with CCR5: view

No data available for Genatlas for CCR5 Gene

Publications for CCR5 Gene

  1. Molecular cloning and functional expression of a new human CC- chemokine receptor gene. (PMID: 8639485) Samson M. … Parmentier M. (Biochemistry 1996) 2 3 4 67
  2. Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4. (PMID: 19692476) Agrawal-Gamse C. … Laakso M.M. (J. Virol. 2009) 3 25 26
  3. Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. (PMID: 16298345) Napier C. … Holbrook M. (Biochem. Pharmacol. 2005) 23 25 26
  4. Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi. (PMID: 20169157) Joubert B.R. … Meshnick S.R. (PLoS ONE 2010) 3 23
  5. Conserved determinants of enhanced CCR5 binding in the human immunodeficiency virus subtype D envelope third variable loop. (PMID: 20377425) Teeravechyan S. … Lee T.H. (AIDS Res. Hum. Retroviruses 2010) 3 23

Products for CCR5 Gene

Sources for CCR5 Gene

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