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Aliases for CCR5 Gene

Aliases for CCR5 Gene

  • Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene) 2 3
  • CMKBR5 3 4 6
  • HIV-1 Fusion Coreceptor 3 4
  • CC-CKR-5 3 4
  • ChemR13 3 4
  • CCCKR5 3 6
  • IDDM22 3 6
  • CCR-5 3 4
  • C-C Motif Chemokine Receptor 5 A159A 3
  • Chemokine (C-C Motif) Receptor 5 2
  • C-C Chemokine Receptor Type 5 3
  • Chemokine Receptor CCR5 3
  • CD195 Antigen 4
  • C-C CKR-5 4
  • CD195 3
  • CKR-5 3
  • CKR5 3

External Ids for CCR5 Gene

Previous HGNC Symbols for CCR5 Gene

  • CMKBR5

Previous GeneCards Identifiers for CCR5 Gene

  • GC03P045652
  • GC03P046230
  • GC03P046372
  • GC03P046386

Summaries for CCR5 Gene

Entrez Gene Summary for CCR5 Gene

  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCR5 Gene

CCR5 (Chemokine (C-C Motif) Receptor 5 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with CCR5 include west nile virus and diabetes mellitus, insulin-dependent, 22. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include actin binding and coreceptor activity. An important paralog of this gene is CCR7.

UniProtKB/Swiss-Prot for CCR5 Gene

  • Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

Tocris Summary for CCR5 Gene

  • Chemokines (chemotactic cytokines) belong to a family of chemoattractant molecules involved in the directed migration of immune cells. Over fifty human chemokines have been identified that can be categorised into four groups; CC, CXC, CX3C and C (XCL1 and XCL2); depending on the spacing of their first two cysteine residues. Chemokines exert their effects by binding to G-protein-coupled chemokine receptors on the surface of cells, predominantly leukocytes. Eighteen human chemokine receptors have been identified that are classified according to the class of chemokines that they bind. The major function of chemokines is to regulate leukocyte trafficking in hematopoiesis and in innate and adaptive immunity. Other functions include angiogenic activity, apoptosis, T-cell differentiation and phagocyte activation. Inadvertent activation of chemokine receptors leads to autoimmunity by inappropriately targeting self antigens for destruction by cytotoxic T-cells and macrophages.

Gene Wiki entry for CCR5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCR5 Gene

Genomics for CCR5 Gene

Regulatory Elements for CCR5 Gene

Genomic Location for CCR5 Gene

46,370,142 bp from pter
46,376,206 bp from pter
6,065 bases
Plus strand

Genomic View for CCR5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCR5 Gene

Proteins for CCR5 Gene

  • Protein details for CCR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C-C chemokine receptor type 5
    Protein Accession:
    Secondary Accessions:
    • O14692
    • O14693
    • O14695
    • O14696
    • O14697
    • O14698
    • O14699
    • O14700
    • O14701
    • O14702
    • O14703
    • O14704
    • O14705
    • O14706
    • O14707
    • O14708
    • O15538
    • Q9UPA4

    Protein attributes for CCR5 Gene

    352 amino acids
    Molecular mass:
    40524 Da
    Quaternary structure:
    • Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Interacts with human cytomegalovirus/HHV-5 protein UL78. Interacts with CNIH4 (PubMed:24405750). ARRB2. Interacts with human cytomegalovirus/HHV-5 protein UL78.

    Three dimensional structures from OCA and Proteopedia for CCR5 Gene

neXtProt entry for CCR5 Gene

Proteomics data for CCR5 Gene at MOPED

Post-translational modifications for CCR5 Gene

  • O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen.
  • Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry.
  • Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
  • Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4.
  • Glycosylation at Ser6, Ser7, Thr16, and Ser17
  • Modification sites at PhosphoSitePlus

Other Protein References for CCR5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCR5 Gene

Domains for CCR5 Gene

Gene Families for CCR5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCR5: view

Function for CCR5 Gene

Molecular function for CCR5 Gene

GENATLAS Biochemistry:
chemokine CC,beta,receptor 5,expressed in lymphoid organs and cells,with multiple transcripts with 5 end heterogeneity and dual promoter usage,mediating macrophage-tropic strains of HIV-1 entry in CD4+ cells with a reduced risk of AIDS lymphoma in patients with the CCR5-delta 32 mutation,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

Gene Ontology (GO) - Molecular Function for CCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 12421915
GO:0004435 phosphatidylinositol phospholipase C activity TAS 8663314
GO:0004930 G-protein coupled receptor activity --
GO:0004950 chemokine receptor activity TAS 10201901
GO:0005515 protein binding IPI 12421915
genes like me logo Genes that share ontologies with CCR5: view
genes like me logo Genes that share phenotypes with CCR5: view

Animal Models for CCR5 Gene

MGI Knock Outs for CCR5:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CCR5 Gene

Localization for CCR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCR5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CCR5 Gene COMPARTMENTS Subcellular localization image for CCR5 gene
Compartment Confidence
endosome 5
plasma membrane 5
nucleus 3
extracellular 2
cytoskeleton 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10415069
GO:0005768 endosome IDA 10679098
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10393923
GO:0009897 external side of plasma membrane IDA 10679098
genes like me logo Genes that share ontologies with CCR5: view

Pathways for CCR5 Gene

genes like me logo Genes that share pathways with CCR5: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEP 12032188
GO:0002407 dendritic cell chemotaxis TAS 16621978
GO:0006816 calcium ion transport IDA 8699119
GO:0006935 chemotaxis TAS 10741397
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with CCR5: view

Drugs for CCR5 Gene

(3) Drugbank Compounds for CCR5 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
376348-65-1 3002977 Target antagonist approved, investigational
Target investigational
Target investigational

(5) Tocris Compounds for CCR5 Gene

Compound Action Cas Number
AMD 3100 octahydrochloride Highly selective CXCR4 antagonist [155148-31-5]
AMD 3465 hexahydrobromide Potent, selective CXCR4 antagonist [185991-07-5]
RS 504393 Highly selective CCR2 chemokine receptor antagonist [300816-15-3]
SB 225002 Potent and selective CXCR2 antagonist [182498-32-4]
SB 328437 Potent and selective CCR3 antagonist [247580-43-4]

(2) HMDB Compounds for CCR5 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(29) IUPHAR Ligand for CCR5 Gene

Ligand Type Action Affinity Pubmed IDs
CCL3 Agonist Full agonist 10.2
CCL11 Antagonist Antagonist 10
[125I]CCL4 (human) Agonist Full agonist 9.6
[3H]maraviroc Antagonist Antagonist 9.1
vicriviroc Antagonist Antagonist 9.1
[3H]ancriviroc Antagonist Antagonist 8.9
[125I]CCL3 (human) Agonist Full agonist 8.8
BP-CCL3 Agonist Full agonist 8.8
E913 Antagonist Antagonist 8.7
ancriviroc Antagonist Antagonist 8.7
TAK-652 Antagonist Antagonist 8.6
aplaviroc Antagonist Antagonist 8.5
TAK-220 Antagonist Antagonist 8.5
[125I]CCL8 (human) Agonist Full agonist 8.3
[125I]CCL5 (human) Agonist Full agonist 8.2
CCL5 Agonist Full agonist 8.2
CCL16 Agonist Full agonist 8.1
CCL7 Agonist Full agonist 8.1
vMIP-II Antagonist Antagonist 8.1
maraviroc Antagonist Antagonist 8.1
CCL4 Antagonist Antagonist 7.8
CCL2 Agonist Full agonist 7.8
TAK-779 Antagonist Antagonist 7.5
CCL14 Agonist Full agonist 7.4
Flu-CCL3 Agonist Full agonist 7.1
CCL8 Agonist Agonist
CCL13 Agonist Agonist
R5-HIV-1 gp120 Agonist Full agonist
MRK-1 Antagonist Antagonist

(81) Novoseek inferred chemical compound relationships for CCR5 Gene

Compound -log(P) Hits PubMed IDs
rantes 94.3 247
maraviroc 88.4 49
ccl3 86.4 59
aplaviroc 83 17
vicriviroc 80 20

(1) PharmGKB related drug/compound annotations for CCR5 Gene

Drug/compound Annotation
maraviroc DrugLabel
genes like me logo Genes that share compounds with CCR5: view

Transcripts for CCR5 Gene

mRNA/cDNA for CCR5 Gene

Unigene Clusters for CCR5 Gene

Chemokine (C-C motif) receptor 5 (gene/pseudogene):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCR5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCR5 Gene

No ASD Table

Relevant External Links for CCR5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCR5 Gene

mRNA expression in normal human tissues for CCR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCR5 Gene

This gene is overexpressed in Whole Blood (7.9) and Spleen (6.2).

SOURCE GeneReport for Unigene cluster for CCR5 Gene Hs.450802

mRNA Expression by UniProt/SwissProt for CCR5 Gene

Tissue specificity: Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
genes like me logo Genes that share expressions with CCR5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for CCR5 Gene

Orthologs for CCR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCR5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCR5 35
  • 86.74 (n)
  • 86.08 (a)
CCR5 36
  • 86 (a)
(Canis familiaris)
Mammalia CCR5 35
  • 84 (n)
  • 82.67 (a)
CCR5 36
  • 83 (a)
(Mus musculus)
Mammalia Ccr5 35
  • 84.19 (n)
  • 82.39 (a)
Ccr5 16
(Pan troglodytes)
Mammalia CCR5 35
  • 99.34 (n)
  • 99.43 (a)
CCR5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ccr5 35
  • 84.09 (n)
  • 82.67 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
(Gallus gallus)
Aves CCR2 36
  • 56 (a)
CCR5 36
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
-- 36
  • 57 (a)
-- 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731980 35
  • 60.6 (n)
  • 55.82 (a)
(Danio rerio)
Actinopterygii LOC100005081 35
  • 56.54 (n)
  • 44.17 (a)
Species with no ortholog for CCR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCR5 Gene

Gene Tree for CCR5 (if available)
Gene Tree for CCR5 (if available)

Paralogs for CCR5 Gene

genes like me logo Genes that share paralogs with CCR5: view

Variants for CCR5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CCR5 Gene

Ser-60 variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors

Sequence variations from dbSNP and Humsavar for CCR5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_024070 -
VAR_024069 -
VAR_024068 -
VAR_024067 -
VAR_024066 -

Structural Variations from Database of Genomic Variants (DGV) for CCR5 Gene

Variant ID Type Subtype PubMed ID
nsv876734 CNV Gain 21882294
esv271120 CNV Insertion 20981092

Relevant External Links for CCR5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for CCR5 Gene

(3) OMIM Diseases for CCR5 Gene (601373)


  • Diabetes mellitus, insulin-dependent, 22 (IDDM22) [MIM:612522]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:19073967}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(94) Novoseek inferred disease relationships for CCR5 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 87.7 156
hiv infections 80.3 121
aids 71.4 128
virus infection 57.9 53
aids dementia complex 55.1 3

Relevant External Links for CCR5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CCR5: view

No data available for Genatlas for CCR5 Gene

Publications for CCR5 Gene

  1. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha. (PMID: 8663314) Raport C.J. … Charo I.F. (J. Biol. Chem. 1996) 3 4 23
  2. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. (PMID: 8699119) Combadiere C. … Murphy P.M. (J. Leukoc. Biol. 1996) 3 4 23
  3. Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses. (PMID: 9343222) Kuhmann S.E. … Kabat D. (J. Virol. 1997) 3 4 23
  4. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. (PMID: 10089882) Farzan M. … Choe H. (Cell 1999) 3 4 23
  5. Co-receptor usage of HIV-1 primary isolates, viral burden, and CCR5 genotype in mother-to-child HIV-1 transmission. (PMID: 10985308) Ometto L. … De Rossi A. (AIDS 2000) 3 23 48

Products for CCR5 Gene

Sources for CCR5 Gene

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