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Aliases for CTRC Gene

Aliases for CTRC Gene

  • Chymotrypsin C 2 3 5
  • Caldecrin 2 3 4
  • Chymotrypsin C (Caldecrin) 2 3
  • Elastase 4 2 3
  • CLCR 3 4
  • Serum Calcium Decreasing Factor 3
  • Elastase IV 3
  • EC 4
  • EC 3.4.21 63
  • ELA4 3

External Ids for CTRC Gene

Previous GeneCards Identifiers for CTRC Gene

  • GC01P015162
  • GC01P014943
  • GC01P015033
  • GC01P015127
  • GC01P015510
  • GC01P015637
  • GC01P015764
  • GC01P014284

Summaries for CTRC Gene

Entrez Gene Summary for CTRC Gene

  • This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTRC Gene

CTRC (Chymotrypsin C) is a Protein Coding gene. Diseases associated with CTRC include pancreatitis, hereditary and ctrc-related hereditary pancreatitis. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is CELA2B.

UniProtKB/Swiss-Prot for CTRC Gene

  • Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.

Gene Wiki entry for CTRC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRC Gene

Genomics for CTRC Gene

Regulatory Elements for CTRC Gene

Genomic Location for CTRC Gene

15,438,439 bp from pter
15,449,247 bp from pter
10,809 bases
Plus strand

Genomic View for CTRC Gene

Genes around CTRC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTRC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTRC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRC Gene

Proteins for CTRC Gene

  • Protein details for CTRC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K082
    • O00765
    • Q9NUH5

    Protein attributes for CTRC Gene

    268 amino acids
    Molecular mass:
    29484 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTRC Gene

neXtProt entry for CTRC Gene

Proteomics data for CTRC Gene at MOPED

Selected DME Specific Peptides for CTRC Gene

Post-translational modifications for CTRC Gene

  • Glycosylation at Asn 25, Asn 52, and Asn 226

Other Protein References for CTRC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CTRC (Chymotrypsin C/CTRC)

Domains & Families for CTRC Gene

Suggested Antigen Peptide Sequences for CTRC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Elastase subfamily.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CTRC: view

No data available for Gene Families for CTRC Gene

Function for CTRC Gene

Molecular function for CTRC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Leu- -Xaa, Tyr- -Xaa, Phe- -Xaa, Met- -Xaa, Trp- -Xaa, Gln- -Xaa, Asn- -Xaa.
UniProtKB/Swiss-Prot Function:
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.

Enzyme Numbers (IUBMB) for CTRC Gene

genes like me logo Genes that share phenotypes with CTRC: view

Human Phenotype Ontology for CTRC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CTRC Gene

Localization for CTRC Gene

Subcellular locations from

Jensen Localization Image for CTRC Gene COMPARTMENTS Subcellular localization image for CTRC gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CTRC Gene

Pathways & Interactions for CTRC Gene

genes like me logo Genes that share pathways with CTRC: view

Gene Ontology (GO) - Biological Process for CTRC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
genes like me logo Genes that share ontologies with CTRC: view

No data available for SIGNOR curated interactions for CTRC Gene

Drugs & Compounds for CTRC Gene

(9) Drugs for CTRC Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pancrelipase Approved Pharma 880
Secretin Approved, Investigational Pharma Full agonist, Agonist 29
Gastrointestinal Agents Pharma 6401
Hormone Antagonists Pharma 10002
Hormones Pharma 11748

(1) Additional Compounds for CTRC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTRC: view

Transcripts for CTRC Gene

Unigene Clusters for CTRC Gene

Chymotrypsin C (caldecrin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTRC Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1: -
SP2: - - -
SP3: - -

Relevant External Links for CTRC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTRC Gene

mRNA expression in normal human tissues for CTRC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTRC Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for CTRC Gene

This gene is overexpressed in Pancreatic juice (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTRC Gene

SOURCE GeneReport for Unigene cluster for CTRC Gene Hs.631869

mRNA Expression by UniProt/SwissProt for CTRC Gene

Tissue specificity: Pancreas.
genes like me logo Genes that share expression patterns with CTRC: view

Protein tissue co-expression partners for CTRC Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CTRC Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTRC 35
  • 83.46 (n)
  • 80.97 (a)
  • 81 (a)
(Canis familiaris)
Mammalia CTRC 35
  • 84.52 (n)
  • 81.65 (a)
  • 81 (a)
(Mus musculus)
Mammalia Ctrc 35
  • 79.1 (n)
  • 78.73 (a)
Ctrc 16
Ctrc 36
  • 78 (a)
(Pan troglodytes)
Mammalia CTRC 35
  • 98.38 (n)
  • 98.51 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ctrc 35
  • 78.11 (n)
  • 77.99 (a)
(Monodelphis domestica)
Mammalia CTRC 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia CTRC 36
  • 75 (a)
(Gallus gallus)
Aves CTRC 35
  • 71.21 (n)
  • 67.8 (a)
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctrc 35
  • 66.41 (n)
  • 61.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23779 35
(Danio rerio)
Actinopterygii -- 35
ela2l 36
  • 58 (a)
ela2 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10472 37
  • 37 (a)
CG7542 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for CTRC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRC Gene

Gene Tree for CTRC (if available)
Gene Tree for CTRC (if available)

Paralogs for CTRC Gene

Paralogs for CTRC Gene

genes like me logo Genes that share paralogs with CTRC: view

Variants for CTRC Gene

Sequence variations from dbSNP and Humsavar for CTRC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_010928 -
VAR_043516 -
rs184977421 - 15,440,362(+) GAGAG(A/G)ATGCC reference, missense
rs145868278 - 15,440,369(+) TGCCC(A/G)GCCCC reference, missense
rs536812916 - 15,440,503(+) CCTCC(A/G)GTACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CTRC Gene

Variant ID Type Subtype PubMed ID
nsv833536 CNV Loss 17160897
esv2117572 CNV Deletion 18987734

Variation tolerance for CTRC Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTRC Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRC Gene

Disorders for CTRC Gene

MalaCards: The human disease database

(9) MalaCards diseases for CTRC Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • pancreatitis, chronic
ctrc-related hereditary pancreatitis
  • ctrc-related calcific pancreatitis
tropical pancreatitis
  • tropical calcific pancreatitis
prss1-related hereditary pancreatitis
- elite association - COSMIC cancer census association via MalaCards
Search CTRC in MalaCards View complete list of genes associated with diseases


  • Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269 PubMed:18059268, ECO:0000269 PubMed:18172691, ECO:0000269 PubMed:22580415, ECO:0000269 PubMed:22942235}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235). {ECO:0000269 PubMed:18059268, ECO:0000269 PubMed:22942235}.

Relevant External Links for CTRC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CTRC: view

No data available for Genatlas for CTRC Gene

Publications for CTRC Gene

  1. Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis. (PMID: 18172691) Masson E. … FAcrec C. (Hum. Genet. 2008) 3 4 23 48 67
  2. Molecular cloning and expression of human caldecrin. (PMID: 8635596) Tomomura A. … Saheki T. (FEBS Lett. 1996) 2 3 23
  3. Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan. (PMID: 19407484) Chang M.C. … Wong J.M. (Pancreatology 2009) 3 23
  4. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. (PMID: 18059268) Rosendahl J. … Sahin-Toth M. (Nat. Genet. 2008) 3 23
  5. Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y. (PMID: 17592142) Szmola R. … Sahin-TA^th M. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23

Products for CTRC Gene

Sources for CTRC Gene

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