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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT1 Gene

protein-coding   GIFtS: 68
GCID: GC12P049372

wingless-type MMTV integration site family, member 1


(Previous symbol: INT1)
 Explore 58 diseases affiliated with
WNT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WNT1    

Aliases
for WNT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 11 2
INT11 2 3 5
Proto-Oncogene Int-1 Homolog2 3
Proto-Oncogene Wnt-12
Wingless-Type MMTV Integration Site Family, Member 1 (Oncogene INT1)2

External Ids:    HGNC: 127741   Entrez Gene: 74712   Ensembl: ENSG000001250847   OMIM: 1648205   UniProtKB: P046283   

Export aliases for WNT1 gene to outside databases

Previous GC identifers: GC12M049438 GC12P049088 GC12P047658 GC12P046403


Summaries
for WNT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT1:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins
have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and
the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The
studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This
gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with
cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have
a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome
12q13 region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT1_HUMAN, P04628
Function: Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes,
is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a
signaling molecule important in CNS development. Is likely to signal over only few cell diameters

Gene Wiki entry for WNT1


Genomic Views
for WNT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT1 gene promoter:
         SREBP-1c   E2F-2   HNF-4alpha2   HNF-4alpha1   SREBP-1b   PPAR-gamma1   E2F-1   SREBP-1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

WNT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P049372:  view genomic region     (about GC identifiers)

Start:
 49,372,236 bp from pter      End:
 49,376,396 bp from pter
Size:
 4,161 bases      Orientation:
 plus strand

Proteins
for WNT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WNT1_HUMAN, P04628 (See protein sequence)
Recommended Name: Proto-oncogene Wnt-1 precursor  
Size: 370 amino acids; 40982 Da
Subunit: Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 (By similarity). Interacts with WLS (By
similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q5U0N2

Explore the universe of human proteins at neXtProt for WNT1: NX_P04628

Post-translational modifications:

  • Palmitoylation at Ser-224 is required for efficient binding to frizzled receptors. It is also required for subsequent
    • palmitoylation at Cys-93. Palmitoylation is necessary for proper trafficking to cell surface1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04628

    • WNT1 Protein expression data from MOPED and PaxDb:    About this image 
    WNT1 Protein Expression
    REFSEQ proteins: NP_005421.1  
    ENSEMBL proteins: 
     ENSP00000293549  
    Reactome Protein details: P04628
    Human Recombinant Protein Products for WNT1: 
    EMD Millipore Purified and/or Recombinant WNT1 Protein
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    Novus Biologicals WNT1 Proteins
    Novus Biologicals WNT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WNT1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005737cytoplasm IDA19756656
    GO:0005769early endosome IBA--
    GO:0005770late endosome IBA--

    WNT1 for ontologies           About GeneDecksing



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    Assay Products for WNT1: 
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    Uscn ELISAs and CLIAs for WNT1

    Protein Domains /
    Families
    for WNT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WNT1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009139 Wnt1
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P04628

    ProtoNet protein and cluster: P04628

    1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT1_HUMAN, P04628
    Similarity: Belongs to the Wnt family


    Function
    for WNT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT1_HUMAN, P04628
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes,
    is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a
    signaling molecule important in CNS development. Is likely to signal over only few cell diameters

         Genatlas biochemistry entry for WNT1:
    wingless-type MMTV integration site 1,Drosophila wingless (wg),segment polarity gene homolog,modulating cell fate and
    cell behavior during vertebrate development e

         Summary:  
    During embryonic development, WNT1 as signaling molecule is secreted from the following cells: Isthmus Cells in Neural Plate It affects the following cells: Dopaminergic Progenitor Cells in Substantia Nigra pars Compacta, Dopaminergic Progenitor Cells in Ventral Tegmental Area (see all 4).

    WNT1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Retinoic acid-induced cells (see all 4).

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IC19756656
    GO:0005110frizzled-2 binding IBA--
    GO:0005125cytokine activity ISS--
    GO:0005515protein binding IPI10347172
         
    WNT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT1:
     Decreased p24 protein expressi 

         12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Wnt1):
     behavior/neurological  cellular  craniofacial  embryogenesis  hearing/vestibular/ear 
     hematopoietic system  immune system  mortality/aging  muscle  nervous system 
     respiratory system  skeleton 

    WNT1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for WNT1: Wnt1tm1Amc Wnt1tm1Mrc Wnt1tm1Brd
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for WNT1 

    miRNA
    Products:            		miRTarBase miRNAs that target WNT1:
    hsa-let-7e (MIRT005718), hsa-mir-34a (MIRT001231)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT1
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT1 (see all 58):
    hsa-miR-3678-3p hsa-miR-140-5p hsa-miR-1321 hsa-miR-429 hsa-let-7d hsa-miR-139-5p hsa-miR-486-3p hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmid: WNT1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT1 (see all 7)
    OriGene shRNA RFP: WNT1
    OriGene siRNA: WNT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT1
    Sirion Biotech Custom design and validation of potent shRNA sequences against WNT1 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of WNT1 
    Sirion Biotech Customized adenovirus for potent knockdown of WNT1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT1 (see all 3)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WNT1 (NM_005430)
    Sino Biological Human cDNA Clone for WNT1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT1 

    Cell Line
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    Search LifeMap BioReagents cell lines for WNT1
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT1


    Pathways & Interactions
    for WNT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt Signaling Pathway0.33
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt signaling pathway0.30
    		DNA damage response (only ATM dependent)0.35
    		Wnt Signaling Pathway NetPath0.22
    2Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Wnt Pathway0.37
    		Hedgehog signaling pathway0.41
    		Melanogenesis0.32
    3Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		GSK3 Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for WNT1
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT1
        Wnt Signaling Pathway

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT1 (see all 10)
        Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    Reelin Pathway (Cajal-Retzius cells)
    GSK3 Signaling

    1 Tocris Bioscience Pathway for WNT1
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT1
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/10 BioSystems Pathways for WNT1 (see all 10) 
        Adipogenesis
    Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency
    Neural Crest Differentiation

    4        Reactome Pathways for WNT1
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    5         Kegg Pathways  (Kegg details for WNT1):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    WNT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/77 Interacting proteins for WNT1 (P046283 ENSP000002935494) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYKP349253, ENSP000002960844I2D: score=3 STRING: ENSP00000296084
    FZD1Q9UP383, ENSP000002879344I2D: score=1 STRING: ENSP00000287934
    WIF1Q9Y5W53, ENSP000002865744I2D: score=1 STRING: ENSP00000286574
    LRP6O755813, ENSP000002613494I2D: score=3 STRING: ENSP00000261349
    FZD8Q9H4613, ENSP000003638264I2D: score=4 STRING: ENSP00000363826
    About this table

    Gene Ontology (GO): 5/56 biological process terms (GO ID links to tree view) (see all 56):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000578embryonic axis specification ISS--
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0007165signal transduction ----
    GO:0007223Wnt receptor signaling pathway, calcium modulating pathway IBA--

    WNT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WNT1 for compounds           About GeneDecksing

    EMD Millipore small molecules for WNT1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT1
    10 Novoseek chemical compound relationships for WNT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 47.8 6 9601641 (1), 12213737 (1), 17691973 (1), 10861796 (1) (see all 6)
    lithium 34.2 2 10861796 (1), 15592505 (1)
    retinoic acid 24.2 13 11358845 (5), 7958454 (4)
    oligonucleotide 0 1 18461473 (1)
    progesterone 0 2 12213737 (1), 17074804 (1)
    tyrosine 0 2 17897439 (1), 8288227 (1)
    phosphatidylinositol 0 1 12154096 (1)
    agar 0 1 11980918 (1)
    estrogen 0 4 12469206 (2), 17897439 (1), 15824740 (1)
    glutamate 0 1 8226929 (1)

    Search CenterWatch for drugs/clinical trials and news about WNT1 

    Transcripts
    for WNT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNT1 gene: 
    NM_005430.3  

    Unigene Cluster for WNT1:

    Wingless-type MMTV integration site family, member 1
    Hs.248164  [show with all ESTs]
    Unigene Representative Sequence: NM_005430
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000293549(uc001rsu.3)

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    hsa-miR-3678-3p hsa-miR-140-5p hsa-miR-1321 hsa-miR-429 hsa-let-7d hsa-miR-139-5p hsa-miR-486-3p hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmid: WNT1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT1

    Additional cDNA sequence: 

    BC074798.2 BC074799.2 BT019429.1 

    1 DOTS entry:

    DT.91710309 

    3 AceView cDNA sequences:

    BC074798 BC074799 NM_005430 

    GeneLoc Exon Structure


    Expression
    for WNT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    WNT1 Expression
    About this image

    WNT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/22 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 22) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainSubstantia Nigra pars CompactaAdult Dopaminergic NeuronsDopaminergic neurons
    BrainSubstantia Nigra pars CompactaDopaminergic Progenitor CellsDopaminergic neurons
    BrainSubstantia Nigra pars CompactaEmbryonic Dopaminergic NeuronsDopaminergic neurons
    BrainVentral Tegmental AreaAdult Dopaminergic NeuronsDopaminergic neurons
    BrainVentral Tegmental AreaDopaminergic Progenitor CellsDopaminergic neurons
    BrainVentral Tegmental AreaEmbryonic Dopaminergic NeuronsDopaminergic neurons
    Head MesenchymeHead MesenchymeRhombencephalic Neural Crest CellsNeural Crest
    Head MesenchymePrechordal MesenchymeDiencephalic Neural Crest CellsNeural Crest
    Head MesenchymePrechordal MesenchymeMesencephalic Neural Crest CellsNeural Crest
    Neural CrestCardiac Neural CrestCardiac Neural Crest CellsNeural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WNT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT1

    SOURCE GeneReport for Unigene cluster: Hs.248164
        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT1: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              Stem Cells in human mouse rat
              Adipogenesis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT1

    Orthologs
    for WNT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WNT1 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia WNT16
    		 --
    		 88(a)
    		 1 ↔ 1
    		 2(94046832-94064102)
    African clawed frog
    (Xenopus laevis)    		 Amphibia X13138.12   -- 72.82(n)    X13138.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wnt11 wingless-type MMTV integration site family, member more 70.46(n)
    76.94(a)    		   30128  NM_001201398.1  NP_001188327.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta wg1 , 3 frizzled-2 receptor signaling pathway
    frizzled-2 more3
    wingless1    		 58(a)
    (best of 3)3
    61(n)1
    59.82(a)1    		   2 27F13
    340091  NM_078778.31  NP_523502.11 


    ENSEMBL Gene Tree for WNT1 (if available)
    TreeFam Gene Tree for WNT1 (if available) 

    Paralogs
    for WNT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT1 gene
    WNT5B2  WNT162  WNT5A2  WNT62  WNT112  WNT22  WNT2B2  WNT3A2  
    WNT10B2  WNT42  WNT7A2  WNT7B2  WNT10A2  WNT32  
    18 SIMAP similar genes for WNT1 using alignment to 1 protein entry:     WNT1_HUMAN:
    WNT3    WNT4    WNT3A    WNT7A    WNT7B    WNT16
    WNT2    WNT2B    WNT5A    WNT11    WNT8B    WNT5B
    WNT8A    WNT6    WNT9A    WNT10B    WNT9B    WNT10A

    WNT1 for paralogs           About GeneDecksing



    Genomic Variants
    for WNT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/82 NCBI SNPs in WNT1 are shown (see all 82)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1873127641,2
    		--49370347(+) AAAATG/TGGGAG 1 -- us2k10--------
    rs8557231,2
    		C,F,A--49370547(-) GAACCT/CGGGAG 1 -- us2k15Minor allele frequency- C:0.30NA WA 10
    rs1134348591,2
    		--49370803(+) GAGTCC/GCTGGG 1 -- us2k12Minor allele frequency- G:0.04CSA WA 120
    rs47606621,2
    		C,F,A,H--49370857(-) GGATAC/TCCAGA 1 -- us2k119Minor allele frequency- T:0.31NS EA NA CSA WA 2344
    rs1928286611,2
    		--49370869(+) AGTGTG/TGTGGG 1 -- us2k10--------
    rs1851751221,2
    		--49370979(+) GCAACC/GCTTGT 1 -- us2k10--------
    rs1151025601,2
    		--49371025(+) ACATCC/TGCACC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1403092841,2
    		--49371026(+) CATCCA/GCACCA 1 -- us2k10--------
    rs746462561,2
    		--49371183(+) GCCACG/AAGGTA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1503382991,2
    		--49371208(+) ATGACG/TCATAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT1 (49372236 - 49376396 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for WNT1
         1 CNV: 4777

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    Disorders / Diseases
    for WNT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WNT1 for disorders           About GeneDecksing

    OMIM gene information: 164820    OMIM disorders: --

    20/58 diseases for WNT1 (see all 58):    About MalaCards
    cerebellar hypoplasia    joubert syndrome    familial adenomatous polyposis    adenomatous polyposis coli
    myxoid liposarcoma    squamous cell carcinoma    biliary tract cancer    idiopathic pulmonary fibrosis
    urinary bladder cancer    oral squamous cell carcinoma    arterial calcification    esophageal squamous cell carcinoma
    polyposis    pleomorphic adenoma    pulmonary fibrosis    liposarcoma
    basal cell carcinoma    chronic myeloid leukemia    blastoma    myeloid leukemia

    10/23 Novoseek disease relationships for WNT1 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerebellar hypoplasia 57.8 1 11815869 (1)
    mammary tumor 53.4 3 8738604 (1), 15824740 (1), 17970048 (1)
    familial adenomatous polyposis 39.1 4 16329837 (2), 12213737 (1), 11345525 (1)
    tumors 34.2 51 19423534 (4), 18209144 (4), 18097596 (4), 11358845 (2) (see all 17)
    cancer 29.9 26 15068666 (5), 11358845 (2), 11149923 (2), 12469206 (2) (see all 8)
    breast cancer 28.5 15 18059186 (3), 19580428 (1), 15736421 (1), 17897439 (1) (see all 10)
    pheochromocytoma 24.1 5 12470708 (1), 10837918 (1)
    colon cancer 22.5 1 9843955 (1)
    colorectal tumors 22.4 1 11345525 (1)
    hepatocellular carcinoma 19.5 6 17908501 (3), 19778454 (1), 19423534 (1), 18461473 (1)

    Human Genome Epidemiology (HuGE) Navigator: WNT1 (3 documents)
    Tumor Gene Database (TGDB): WNT1

    Export disorders for WNT1 gene to outside databases

    Publications
    for WNT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT1 gene, integrated from 9 sources (see all 244):
    (articles sorted by number of sources associating them with WNT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences. (PubMed id 2998762)1, 2, 3 van Ooyen A.... Nusse R. (1985)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization. (PubMed id 3281802)1, 3 Arheden K....Mitelman F. (1988)
    4. Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. (PubMed id 17289346)1, 9 Chong Z.Z....Maiese K. (2007)
    5. The effect on cell growth by Wnt1 RNAi in human neuro blastoma SH-SY5Y cell line. (PubMed id 19756656)1, 9 Zhang L....Zheng J. (2009)
    6. Anti-sense morpholino oligonucleotide assay shows critical involvement for NF-kappaB activation in the production of Wnt-1 protein by HepG2 cells: oncology implications. (PubMed id 18461473)1, 9 Sun C.S....Tsai S.L. (2008)
    7. Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients. (PubMed id 18097596)1, 9 Nakashima T....Huang C.L. (2008)
    8. [Roles of Wnt-1, beta-catenin and adenomatous polyposis coli in the differentiation and proliferation of oral squamous cell carcinoma] (PubMed id 16329837)1, 9 Zhang W.M. and Gao Y. (2005)
    9. Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. (PubMed id 15841445)1, 9 Fukutomi T.... Li J. (2005)
    10. Blockade of Wnt-1 signaling leads to anti-tumor effec ts in hepatocellular carcinoma cells. (PubMed id 19778454)1, 9 Wei W....So S.K. (2009)

    External Searches for WNT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing WNT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7471 HGNC: 12774 AceView: WNT1 Ensembl:ENSG00000125084 euGenes: HUgn7471
    ECgene: WNT1 Kegg: 7471 H-InvDB: WNT1

    Other Databases showing WNT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WNT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WNT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNT1 gene:
    Search GeneIP for patents involving WNT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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