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Aliases for WNT1 Gene

Aliases for WNT1 Gene

  • Wnt Family Member 1 2 3
  • Wingless-Type MMTV Integration Site Family Member 1 3 5
  • Proto-Oncogene Int-1 Homolog 3 4
  • INT1 3 4
  • Wingless-Type MMTV Integration Site Family, Member 1 (Oncogene INT1) 3
  • Wingless-Type MMTV Integration Site Family, Member 1 2
  • BMND16 3
  • OI15 3

External Ids for WNT1 Gene

Previous HGNC Symbols for WNT1 Gene

  • INT1

Previous GeneCards Identifiers for WNT1 Gene

  • GC12M049438
  • GC12P049088
  • GC12P047658
  • GC12P049372
  • GC12P046403
  • GC12P048981
  • GC12P048985

Summaries for WNT1 Gene

Entrez Gene Summary for WNT1 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT1 Gene

WNT1 (Wnt Family Member 1) is a Protein Coding gene. Diseases associated with WNT1 include osteogenesis imperfecta, type xv and osteoporosis, early-onset autosomal dominant. Among its related pathways are Signaling by GPCR and Developmental Biology. GO annotations related to this gene include receptor binding and transcription regulatory region DNA binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot for WNT1 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.

Gene Wiki entry for WNT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT1 Gene

Genomics for WNT1 Gene

Regulatory Elements for WNT1 Gene

Promoters for WNT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WNT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WNT1 Gene

Chromosome:
12
Start:
48,978,453 bp from pter
End:
48,982,613 bp from pter
Size:
4,161 bases
Orientation:
Plus strand

Genomic View for WNT1 Gene

Genes around WNT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT1 Gene

Proteins for WNT1 Gene

  • Protein details for WNT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04628-WNT1_HUMAN
    Recommended name:
    Proto-oncogene Wnt-1
    Protein Accession:
    P04628
    Secondary Accessions:
    • Q5U0N2

    Protein attributes for WNT1 Gene

    Size:
    370 amino acids
    Molecular mass:
    40982 Da
    Quaternary structure:
    • Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 (By similarity). Interacts with WLS (By similarity).

neXtProt entry for WNT1 Gene

Proteomics data for WNT1 Gene at MOPED

Post-translational modifications for WNT1 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Palmitoleylation is necessary for proper trafficking to cell surface (Probable). Depalmitoleylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).
  • Glycosylation at Asn 29, Asn 316, Asn 346, and Asn 359
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WNT1 Gene

Domains & Families for WNT1 Gene

Gene Families for WNT1 Gene

Protein Domains for WNT1 Gene

Suggested Antigen Peptide Sequences for WNT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04628

UniProtKB/Swiss-Prot:

WNT1_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT1: view

Function for WNT1 Gene

Molecular function for WNT1 Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 1,Drosophila wingless (wg),segment polarity gene homolog,modulating cell fate and cell behavior during vertebrate development e
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.

LifeMap Function Summary for WNT1 Gene

During embryonic development, WNT1 as signaling molecule is secreted from the following cells
It affects the following cells:
WNT1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for WNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0048018 receptor agonist activity IC,NAS 23461676
genes like me logo Genes that share ontologies with WNT1: view
genes like me logo Genes that share phenotypes with WNT1: view

Human Phenotype Ontology for WNT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT1 Gene

MGI Knock Outs for WNT1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT1 Gene

Localization for WNT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT1 Gene COMPARTMENTS Subcellular localization image for WNT1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
endoplasmic reticulum 4
cytoskeleton 2
nucleus 2
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for WNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with WNT1: view

Pathways & Interactions for WNT1 Gene

genes like me logo Genes that share pathways with WNT1: view

SIGNOR curated interactions for WNT1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for WNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling IEA,ISS --
GO:0007520 myoblast fusion IEA --
GO:0008284 positive regulation of cell proliferation IEA,IMP 19778454
GO:0009611 response to wounding IEP 17982423
GO:0010592 positive regulation of lamellipodium assembly IMP 19756656
genes like me logo Genes that share ontologies with WNT1: view

Drugs & Compounds for WNT1 Gene

(4) Drugs for WNT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for WNT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WNT1: view

Transcripts for WNT1 Gene

mRNA/cDNA for WNT1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT1 Gene

Wingless-type MMTV integration site family, member 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT1 Gene

No ASD Table

Relevant External Links for WNT1 Gene

GeneLoc Exon Structure for
WNT1
ECgene alternative splicing isoforms for
WNT1

Expression for WNT1 Gene

mRNA expression in normal human tissues for WNT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x11.5), Brain - Putamen (basal ganglia) (x5.7), Brain - Cortex (x4.8), and Brain - Caudate (basal ganglia) (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT1 Gene



SOURCE GeneReport for Unigene cluster for WNT1 Gene Hs.248164

genes like me logo Genes that share expression patterns with WNT1: view

Protein tissue co-expression partners for WNT1 Gene

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WNT1 Gene

Orthologs for WNT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT1 36
  • 100 (a)
OneToOne
WNT1 35
  • 99.73 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia WNT1 35
  • 92.97 (n)
  • 98.65 (a)
WNT1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT1 36
  • 99 (a)
OneToOne
WNT1 35
  • 93.33 (n)
  • 98.92 (a)
mouse
(Mus musculus)
Mammalia Wnt1 16
Wnt1 36
  • 99 (a)
OneToOne
Wnt1 35
  • 91.53 (n)
  • 98.92 (a)
oppossum
(Monodelphis domestica)
Mammalia WNT1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt1 35
  • 91.17 (n)
  • 98.65 (a)
chicken
(Gallus gallus)
Aves WNT11B 36
  • 33 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia WNT1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491444 35
  • 68.42 (n)
  • 74.56 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt1 36
  • 75 (a)
OneToOne
wnt1 35
  • 71.64 (n)
  • 79.53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009734 35
  • 64.04 (n)
  • 61.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta wg 35
  • 62.08 (n)
  • 60.78 (a)
wg 36
  • 44 (a)
OneToOne
wg 37
  • 58 (a)
Wnt5 37
  • 47 (a)
Wnt6 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-1 36
  • 36 (a)
OneToMany
lin-44 37
  • 29 (a)
mom-2 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
Species with no ortholog for WNT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT1 Gene

ENSEMBL:
Gene Tree for WNT1 (if available)
TreeFam:
Gene Tree for WNT1 (if available)

Paralogs for WNT1 Gene

(18) SIMAP similar genes for WNT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WNT1: view

Variants for WNT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for WNT1 Gene

P04628-WNT1_HUMAN
Genetic variations in WNT1 define the bone mineral density quantitative trait locus 16 (BMND16) [MIM:615221]. Variance in bone mineral density influences bone mass, contributes to size determination in the general population, and is a susceptibility factor for osteoporotic fractures.

Sequence variations from dbSNP and Humsavar for WNT1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_069627 Osteogenesis imperfecta 15 (OI15)
VAR_069628 Osteogenesis imperfecta 15 (OI15)
VAR_069629 Osteoporosis (OSTEOP)
VAR_069630 Osteoporosis (OSTEOP)
VAR_069631 Osteogenesis imperfecta 15 (OI15)

Structural Variations from Database of Genomic Variants (DGV) for WNT1 Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV Gain 17160897

Variation tolerance for WNT1 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT1 Gene

HapMap Linkage Disequilibrium report
WNT1
Human Gene Mutation Database (HGMD)
WNT1

Disorders for WNT1 Gene

MalaCards: The human disease database

(15) MalaCards diseases for WNT1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteogenesis imperfecta, type xv
  • osteogenesis imperfecta type xv
osteoporosis, early-onset autosomal dominant
  • osteoporosis, early-onset, susceptibility to, autosomal dominant
wnt1-related osteogenesis imperfecta
  • osteogenesis imperfecta, type xv
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
osteogenesis imperfecta
  • brittle bone disease
- elite association - COSMIC cancer census association via MalaCards
Search WNT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WNT1_HUMAN
  • Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. {ECO:0000269 PubMed:23499309, ECO:0000269 PubMed:23656646}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Osteogenesis imperfecta 15 (OI15) [MIM:615220]: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI15 is characterized by early-onset recurrent fractures, bone deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae. Tooth development and hearing are normal. Learning and developmental delays and brain anomalies have been observed in some patients. {ECO:0000269 PubMed:23434763, ECO:0000269 PubMed:23499309, ECO:0000269 PubMed:23499310, ECO:0000269 PubMed:23656646}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for WNT1

Genetic Association Database (GAD)
WNT1
Human Genome Epidemiology (HuGE) Navigator
WNT1
Tumor Gene Database (TGDB):
WNT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT1
genes like me logo Genes that share disorders with WNT1: view

No data available for Genatlas for WNT1 Gene

Publications for WNT1 Gene

  1. The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences. (PMID: 2998762) van Ooyen A. … Nusse R. (EMBO J. 1985) 2 3 4 67
  2. Canonical and noncanonical Wnt pathway: a comparison among normal ovary, benign ovarian tumor and ovarian cancer. (PMID: 19148501) Badiglian Filho L. … GonAsalves W.J. (Oncol. Rep. 2009) 3 23
  3. MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation. (PMID: 19398721) Hashimi S.T. … Lee B. (Blood 2009) 3 23
  4. Expression and clinical significance of Wnt-1 and beta-catenin in nasopharyngeal carcinoma. (PMID: 19448422) Wang F.L. … Hong M.H. (Ai Zheng 2009) 3 23
  5. Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. (PMID: 19628668) Dai C. … Liu Y. (J. Am. Soc. Nephrol. 2009) 3 23

Products for WNT1 Gene

Sources for WNT1 Gene

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