Show Advanced Search
""
""

Advanced Search (alpha)

""
 
Search By
Section
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS
Search by expression pattern


TP53 Gene

protein-coding   GIFtS: 81

GC17M007565
tumor protein p53
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ""Services    
 "" "" "" "" "" "" "" "" "" "" "" "" ""

Aliases &
Descriptions
for TP53 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
tumor protein p531 2     transformation-related protein 532
LFS11 2 5     FLJ929432
p531 2     p53 tumor suppressor2
Phosphoprotein p532 3     p53 transformation suppressor2
P533 5     Tumor suppressor p533
p53 antigen2     Antigen NY-CO-133
TRP532     

External Ids:    HGNC: 119981   Entrez Gene: 71572   Ensembl: ENSG000001415107   UniProtKB: P046373   

Search outside databases for aliases for TP53 gene

Previous GC identifers: GC17P008026 GC17M008311 GC17M007514 GC17M007772 GC17M007512

Summaries
for TP53 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for TP53:
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce
cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level
in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to
transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and
oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes
that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in
a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor
suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as
germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative
promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can
regulate p53 transcriptional activity. (provided by RefSeq)

UniProtKB/Swiss-Prot: P53_HUMAN, P04637
Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes
is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and
FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over

"" summary for TP53:
p53 (aka TP53) is a transcription factor whose protein levels and post-translational modification state alter
in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins
through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitn
ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent
MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further
modifications such as methylation and acetylation lead to an increase in p53 binding to gene specific
response elements. p53 regulates a large number of genes (>100 genes) that control a number of key tumor
suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation
of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression.

Gene Wiki entry for TP53 (P53)

Genomic Views
for TP53 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the TP53 gene upstream (promoter) region "":
C/EBPbeta   AhR   p53   MIF-1   Sp1   RFX1   E2F-5   E2F-4   E2F-2   E2F-1   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for TP53:  ""
MePH21488-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

TP53 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007565:  view genomic region     (about GC identifiers)

Start:
 7,565,257 bp from pter
End:
 7,590,863 bp from pter
Size:
 25,607 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  

Proteins
for TP53 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: P53_HUMAN, P04637 (See protein sequence)
Recommended Name: Cellular tumor antigen p53  
Size: 393 amino acids; 43653 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with AXIN1. Probably part of a complex consisting of TP53, HIPK2 and AXIN1 (By similarity). Binds
DNA as a homotetramer. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and
recruits them to promoters. In vitro, the interaction of TP53 with cancer-associated/HPV (E6) viral proteins leads to
ubiquitination and degradation of TP53 giving a possible model for cell growth regulation. This complex formation
requires an additional factor, E6-AP, which stably associates with TP53 in the presence of E6. Interacts (via
C-terminus) with TAF1; when TAF1 is part of the TFIID complex. Interacts with ING4; this interaction may be indirect.
Found in a complex with CABLES1 and TP73. Interacts with HIPK1, HIPK2, and P53DINP1. Interacts with WWOX. May interact
with HCV core protein. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with CHD8; leading to recruit
histone H1 and prevent transactivation activity (By similarity). Interacts with ARMC10, BANP, CDKN2AIP and E4F1.
Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58'
inhibits this interaction. Interacts (via DNA-binding domain) with MAML1 (via N-terminus). Interacts with MKRN1.
Directly interacts with FBXO42; leading to ubiquination and degradation of TP53. Interacts (phosphorylated at Ser-15
by ATM) with the phosphatase PP2A-PPP2R5C holoenzyme; regulates stress-induced TP53-dependent inhibition of cell
proliferation. Interacts with PPP2R2A
Subcellular location: Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Interaction with BANP promotes nuclear
localization
PDB structures from "" and Proteopedia "" :
1A1U (3D) ""    1AIE (3D) ""    1C26 (3D) ""    1DT7 (3D) ""    1GZH (3D) ""    1H26 (3D) ""    1HS5 (3D) ""    1JSP (3D) ""    
1KZY (3D) ""    1MA3 (3D) ""    1OLG (3D) ""    1OLH (3D) ""    1PES (3D) ""    1PET (3D) ""    1SAE (3D) ""    1SAF (3D) ""    
1SAH (3D) ""    1SAJ (3D) ""    1SAK (3D) ""    1SAL (3D) ""    1TSR (3D) ""    1TUP (3D) ""    1UOL (3D) ""    1XQH (3D) ""    
1YC5 (3D) ""    1YCQ (3D) ""    1YCR (3D) ""    1YCS (3D) ""    2AC0 (3D) ""    2ADY (3D) ""    2AHI (3D) ""    2ATA (3D) ""    
2B3G (3D) ""    2BIM (3D) ""    2BIN (3D) ""    2BIO (3D) ""    2BIP (3D) ""    2BIQ (3D) ""    2F1X (3D) ""    2FEJ (3D) ""    2FOJ (3D) ""    2FOO (3D) ""    2GS0 (3D) ""    2H1L (3D) ""    2H2D (3D) ""    2H2F (3D) ""    2H4F (3D) ""    2H4H (3D) ""    
2H4J (3D) ""    2H59 (3D) ""    2J0Z (3D) ""    2J10 (3D) ""    2J11 (3D) ""    2J1W (3D) ""    2J1X (3D) ""    2J1Y (3D) ""    
2J1Z (3D) ""    2J20 (3D) ""    2J21 (3D) ""    2K8F (3D) ""    2OCJ (3D) ""    2PCX (3D) ""    2QVQ (3D) ""    2QXA (3D) ""    
2QXB (3D) ""    2QXC (3D) ""    2VUK (3D) ""    2WGX (3D) ""    2X0U (3D) ""    2X0V (3D) ""    2X0W (3D) ""    2Z5S (3D) ""    
2Z5T (3D) ""    3D05 (3D) ""    3D06 (3D) ""    3D07 (3D) ""    3D08 (3D) ""    3D09 (3D) ""    3D0A (3D) ""    3DAB (3D) ""    
3DAC (3D) ""    3KMD (3D) ""    3SAK (3D) ""    
Secondary accessions: Q15086 Q15087 Q15088 Q16535 Q16807 Q16808 Q16809 Q16810 Q16811 Q16848 Q86UG1
Q8J016 Q99659 Q9BTM4 Q9HAQ8 Q9NP68 Q9NPJ2 Q9NZD0 Q9UBI2 Q9UQ61
Alternative splicing: 2 isoforms:  P04637-1   P04637-2   

Post-translational modifications:

  • Acetylated. Acetylation of Lys-382 by CREBBP enhances transcriptional activity. Deacetylation of Lys-382 by SIRT1
    • impairs its ability to induce proapoptotic program and modulate cell senescence1
  • Phosphorylation on Ser residues mediates transcriptional activation. Phosphorylated by HIPK1 (By similarity).
    • Phosphorylation at Ser-9 by HIPK4 increases repression activity on BIRC5 promoter. Phosphorylated on Thr-18 by VRK1,
    which may prevent the interaction with MDM2. Phosphorylated on Thr-55 by TAF1, which promotes MDM2-mediated
    degradation. Phosphorylated on Ser-46 by HIPK2 upon UV irradiation. Phosphorylation on Ser-46 is required for
    acetylation by CREBBP. Phosphorylated on Ser-392 following UV but not gamma irradiation. Phosphorylated upon DNA
    damage, probably by ATM or ATR. Phosphorylated on Ser-15 upon ultraviolet irradiation; which is enhanced by
    interaction with BANP1
  • Dephosphorylated by PP2A-PPP2R5C holoenzyme at Thr-55. SV40 small T antigen inhibits the dephosphorylation by the AC
    • form of PP2A1
  • May be O-glycosylated in the C-terminal basic region. Studied in EB-1 cell line1
  • Ubiquitinated by SYVN1, which leads to proteasomal degradation. Ubiquitinated by MKRN1 at Lys-291 and Lys-292, which
    • leads to proteasomal degradation. Ubiquitinated by MDM2. Deubiquitinated by USP10, leading to stabilize it1
  • Monomethylated at Lys-372 by SETD7, leading to stabilization and increased transcriptional activation. Monomethylated
    • at Lys-370 by SMYD2, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity.
    Lys-372 monomethylation prevents interaction with SMYD2 and subsequent monomethylation at Lys-3701
  • Sumoylated by SUMO11
  • Demethylation of di-methylated Lys-370 by KDM1A prevents interaction with TP53BP1 and represses TP53-mediated
    • transcriptional activation1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (7 alternative transcripts): 
    NP_000537.3  NP_001119584.1  NP_001119585.1  NP_001119586.1  NP_001119587.1  NP_001119588.1  NP_001119589.1  


    ENSEMBL proteins: 
    ENSP00000394195 ENSP00000352610 ENSP00000391127 ENSP00000402130 ENSP00000398846 ENSP00000379735 
    ENSP00000269305 ENSP00000391478 ENSP00000410739 


    Human Recombinant Proteins 
    ""Millipore Purified and/or Recombinant TP53 Protein
    ""Sigma-Aldrich CompoZr ZFN and Flag-tag genes for TP53
    "" Browse R&D Systems for human recombinant proteins
    ""Enzo Life Sciences proteins for TP53
    ""HuPro® and/or Recombinant Proteins from Abnova for TP53 ""
    "" Origene Purified Recombinant Human Protein: TP53
    ""Novus Biologicals Proteins for TP53  ""
    Novus Biologicals Lysates for TP53
    ""Browse Sino Biological Recombinant Proteins  ""

    5/14 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 14 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005626 insoluble fraction IDA12915590
    GO:0005634 nucleus IDA7720704 14744935 16507995 18756595
    GO:0005654 nucleoplasm IDA11080164 12915590
    GO:0005657 replication fork IEA--
    GO:0005669colocalizes with transcription factor TFIID complex IDA15053879
    About this table

    "" TP53 for ontologies           About GeneDecksing



    Antibodies for TP53: 
    ""Millipore Mono- and Polyclonal Antibodies for the study of TP53
    ""Sigma-Aldrich Antibody Arrays and Antibodies for TP53
    ""R&D Systems Antibodies for TP53 (p53)
    ""Cell Signaling Technology (CST) Antibodies for TP53  (p53)
    ""Monoclonal and Polyclonal Antibodies from Abnova (TP53)
    "" Origene Antibodies (see all 15): TP53 ""
    ""Novus Biologicals Antibodies for TP53
    ""Epitomics antibodies for TP53

    Assays for TP53: 
    ""Millipore Kits and Assays for the Analysis of TP53
    ""Sigma-Aldrich ELISAs for TP53
    ""R&D Systems ELISAs for TP53 (p53)
    ""Cell Signaling Technology (CST) Sandwich ELISA Kits for TP53 (p53)
    ""Enzo Life Sciences assays for TP53

    Protein Domains/
    Families
    for TP53 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" TP53 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7 ):
     IPR011615 p53_DNA_bd
     IPR010991 p53_tetrameristn
     IPR012346 p53/RUNT-type_TF_DNA_bd
     IPR002117 p53_tumour_Ag
     IPR008967 p53-like_TF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry P04637

    ProtoNet protein and cluster: P04637

    1 Blocks protein family: IPB010991 p53

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
    Domain: The nuclear export signal acts as a transcriptional repression domain
    Similarity: Belongs to the p53 family

    Gene Function
    for TP53 gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Millipore RNAi Products for the Analysis of TP53 Gene knock-down
    ""Abnova Chimera RNAi Products for Gene knock-down (TP53)
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 7): TP53
    Origene shRNA RFP (see all 7): TP53
    Origene basic RS shRNA (see all 7): TP53

    ""Applied Biosystems Silencer® siRNAs for TP53
    ""Sigma-Aldrich siRNA for TP53
    Sigma-Aldrich shRNA Panels and shRNA for TP53
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 7): TP53
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): TP53
    Origene untagged cDNA clones in CMV expression vector (see all 7): TP53
    ""Sino Biological Human cDNA Clone for TP53  ""

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637
    Function: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the
    physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to
    negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes
    is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and
    FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over

    Genatlas biochemistry entry for TP53:
    tumor suppressor protein p53 required for G1 growth arrest by WAF1 (CDKN1A),following DNA damage or induction of
    apoptosis,also regulating a G2 checkpoint through cyclin B1,transcriptional activator through acetylation of
    transactivation site by CREBBP binding MDM2 resulting in transcriptional silencing and ubiquitin/proteasome dependent
    degradation of p53,activated by conjugation to UBL1 (SUMO1),putative up-regulated c-MYC target gene,putative
    teratologic suppressor gene and modulator of TFIIH (GTF2H),associated in nucleotide excision repair,activated by ATM
    in association with 14.3.3 proteins (YWHA*),tumor suppressor gene (see TSG17A),mutated in cancers such as pancreas and
    endometrial carcinomas,in Barrett's adenocarcinoma (and esophageal squamous cell carcinoma),in hepatocellular
    carcinoma with poor prognosis

    5/17 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 17 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000739 DNA strand annealing activity IDA8183576
    GO:0003677 DNA binding IMP2144364
    GO:0003682 chromatin binding IDA17599062
    GO:0003700 transcription factor activity IDA7587074
    GO:0005507 copper ion binding IDA7824276
    About this table

    "" TP53 for ontologies           About GeneDecksing

    Animal Models: 15/30 MGI mutant phenotypes (inferred from 46 alleles"") (MGI details for Trp53) (see all 30 ):

    adipose tissuebehavior/neurologicalcardiovascular systemcellularcraniofacial
    digestive/alimentaryembryogenesisendocrine/exocrine glandgrowth/sizehearing/vestibular/ear
    hematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatallethality-prenatal/perinatal

    "" TP53 for phenotypes           About GeneDecksing

    Pathways & Interactions
    for TP53 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" TP53 for pathways           About GeneDecksing

    5/16 "" Millipore Pathways for TP53 (see all 16 )
      ""  DNA damage ATM/ATR regulation of G1/S checkpoint
    Proteolysis Putative SUMO-1 pathway
    Immune response MIF in innate immunity response
    DNA damage DNA-damage-induced responses
    DNA damage Role of SUMO in p53 regulation

    5/39 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  TP53  (Your Favorite Gene powered by Ingenuity) (see all 39 )
      ""  Role of PKR in Interferon Induction and Antiviral Response
    p53 Signaling
    Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency
    Induction of Apoptosis by HIV1
    HER-2 Signaling in Breast Cancer

    5/48 "" GeneAssist Pathways for TP53 (see all 48 )
      ""  Pathogenesis of Gliomas
    Apoptosis through Death Receptors
    Pathogenesis of ALS
    G1-S Phase Transition
    UVC-Induced MAPK Signaling

    5 "" Cell Signaling Technology (CST) Pathways for TP53: 
      ""  Cell Cycle Control: G2/M DNA Damage Checkpoint
    Mitochondrial Control of Apoptosis
    Akt/PKB Signaling
    SAPK/JNK Signaling Cascades
    Cell Cycle Control: G1/S Checkpoint

    5/21 "" Kegg Pathways  (Kegg details for TP53) (see all 21 ):
      ""  hsa04010 MAPK signaling pathway
    hsa04110 Cell cycle
    hsa04115 p53 signaling pathway
    hsa04210 Apoptosis
    hsa04310 Wnt signaling pathway

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP53

    5/252 Interacting proteins for TP53 (ENSP000002693053 P046371, 2) via UniProtKB, MINT, and/or STRING (see all 252 ) ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2STRING: ENSP00000258149 EBI-366083,EBI-389668 MINT-6540920 MINT-6665330 MINT-4793511 MINT-4793467 MINT-6823775 MINT-7013943 MINT-4049616 MINT-4054304 MINT-6540905 MINT-6540889 MINT-68742 MINT-7013780 MINT-56681 MINT-58468 MINT-7013791 MINT-68743 MINT-7013956 MINT-6540807 MINT-4545014 MINT-4049631 MINT-6540776 MINT-6801380 MINT-58465 MINT-7013688 MINT-7013802 MINT-6540796 MINT-4303990 EBI-366083,EBI-389668 MINT-6540920 MINT-6665330 MINT-4793511 MINT-4793467 MINT-6823775 MINT-7013943 MINT-4049616 MINT-4054304 MINT-6540905 MINT-6540889 MINT-68742 MINT-7013780 MINT-56681 MINT-58468 MINT-7013791 MINT-68743 MINT-7013956 MINT-6540807 MINT-4545014 MINT-4049631 MINT-6540776 MINT-6801380 MINT-58465 MINT-7013688 MINT-7013802 MINT-6540796 MINT-4303990
    UBCP629881, 2STRING: ENSP00000344818 EBI-366083,EBI-413034 MINT-7220023 MINT-4051326 MINT-4304004 MINT-4054804 MINT-4304143 MINT-6801380 MINT-6615153 MINT-6541035 MINT-7299234 MINT-7298704 MINT-6799774 MINT-7013815 MINT-4052207 MINT-7219995 MINT-5114741
    MDM4O151511, 2STRING: ENSP00000356151 EBI-366083,EBI-398437 MINT-7291988 MINT-7292025 MINT-7291962 MINT-2517887 MINT-7291975 EBI-366083,EBI-398437 MINT-7291988 MINT-7292025 MINT-7291962 MINT-2517887 MINT-7291975
    USP7Q930091, 2STRING: ENSP00000371310 EBI-366083,EBI-302474 MINT-4304022 MINT-14904 MINT-15878 MINT-15877 MINT-15876 EBI-366083,EBI-302474 MINT-4304022 MINT-14904 MINT-15878 MINT-15877 MINT-15876
    EP300Q094721, 2STRING: ENSP00000263253 EBI-366083,EBI-447295 MINT-69507 MINT-2830826 MINT-7263630 MINT-6628507 EBI-366083,EBI-447295 MINT-69507 MINT-2830826 MINT-7263630 MINT-6628507
    About this table

    5/61 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 61 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060 protein import into nucleus, translocation IEA--
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001701 in utero embryonic development IEA--
    GO:0001756 somitogenesis ----
    GO:0001836 release of cytochrome c from mitochondria IEA--
    About this table

    "" TP53 for ontologies           About GeneDecksing


    Drugs & Compounds
    for TP53 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" TP53 for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for TP53
    ""Browse Small Molecules at Sigma-Aldrich

    "" Compounds for TP53 available from Tocris Bioscience
    CompoundAction CAS number
    CP 31398 dihydrochloridep53-stabilizing agent[259199-65-0]
    Pifithrin-alpha hydrobromidep53 inhibitor. Also aryl hydrocarbon receptor agonist[63208-82-2]
    MIRA-1Restores mutant p53 activity; proapoptotic[72835-26-8]
    RITAp53-MDM2 interaction inhibitor; antitumor[213261-59-7]
    RETRA hydrochlorideAntitumor agent; suppresses mutant p53-bearing cancer cells[1036069-26-7]
    About this table


    10/1766 ""Novoseek chemical compound relationships for TP53 gene (see all 1766 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    bcl2 100.00 415 9651943 (7), 18470731 (6), 11712682 (6), 8693593 (5) (see all 100)
    bpde 31.56 118 16244358 (10), 7586197 (7), 17630511 (7), 10786695 (6) (see all 47)
    leptomycin b 31.25 63 18784437 (7), 12539224 (6), 14662026 (5), 9819415 (4) (see all 33)
    roscovitine 19.70 70 18846503 (6), 17384267 (5), 11577989 (5), 11423970 (5) (see all 27)
    273h 16.87 23 11917017 (6), 19351493 (3), 8649776 (2), 17636407 (2) (see all 12)
    9-hydroxyellipticine 15.59 21 11724337 (5), 10652599 (5), 9883907 (4), 10737712 (4) (see all 5)
    cd437 15.07 35 11103825 (6), 10383141 (5), 11956107 (4), 10327056 (4) (see all 13)
    cisplatin 13.79 1112 9811465 (9), 15113856 (9), 12492119 (9), 17291459 (8) (see all 100)
    camptothecin 11.57 150 10536167 (6), 9815856 (5), 19445707 (5), 9673414 (4) (see all 95)
    advexin 11.45 9 19086841 (3), 16856803 (2), 12749760 (2), 20021420 (1) (see all 5)
    About this table

    2 PharmGKB drug compound relationships for TP53 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    mercaptopurineCO  PD  PK  FA  GN  12704389 10406363
    methotrexatePD  FA  GN  12704389
    About this table


    Transcripts
    for TP53 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Millipore RNAi Products for the Analysis of TP53 Gene knock-down
    ""Abnova Chimera RNAi Products for Gene knock-down (TP53)
    ""Applied Biosystems Silencer® siRNAs:  NM_000546  NM_001126112  NM_001126113  NM_001126114  NM_001126115  NM_001126116  NM_001126117  
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 7): TP53
    Origene shRNA RFP (see all 7): TP53
    Origene basic RS shRNA (see all 7): TP53

    ""Sigma-Aldrich siRNA for TP53
    Sigma-Aldrich shRNA Panels and shRNA for TP53
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""Search SABiosciences for microRNAs that regulate TP53: ""
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_000546  NM_001126112  NM_001126113  NM_001126114  NM_001126115  NM_001126116  NM_001126117  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 7): TP53
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): TP53
    Origene untagged cDNA clones in CMV expression vector (see all 7): TP53
    Primers:"" Origene genome-wide validated SYBR primer pairs: TP53
    ""SABiosciences RT2 qPCR Primer Assay for TP53: PPH00213A ""

    REFSEQ mRNAs for TP53 gene (7 alternative transcripts): 

    NM_000546.4  NM_001126112.1  NM_001126113.1  NM_001126114.1  NM_001126115.1  NM_001126116.1  NM_001126117.1  

    Additional cDNA sequence: 

    AB082923.1 AF052180.1 AF307851.1 AK223026.1 AK225838.1 AK297462.1 AK297927.1 AK303277.1 
    AK312568.1 AM076970.1 AM076971.1 AM076972.1 AY429684.1 AY627884.1 BC003596.1 BT019622.1 
    CR608294.1 CR624912.1 DQ186648.1 DQ186649.1 DQ186650.1 DQ186651.1 DQ186652.1 DQ191317.1 
    DQ263704.1 DQ286964.1 DQ401704.1 DQ485152.1 DQ648883.1 DQ648884.1 DQ648885.1 DQ648886.1 
    DQ648887.1 EF101867.1 EF101868.1 EF101869.1 FJ207420.1 M14694.1 M14695.1 S66666.1 
    X01405.1 X02469.1 X60010.1 X60011.1 X60012.1 X60013.1 X60014.1 X60015.1 
    X60016.1 X60017.1 X60018.1 X60019.1 X60020.1 

    18 DOTS entries:

    DT.92469229  DT.100788714  DT.120961435  DT.100788713  DT.75152217  DT.40283865  DT.95274968  DT.100712946 
    DT.120961349  DT.100788719  DT.40120491  DT.120961395  DT.100788715  DT.92010563  DT.120961350  DT.120961391 
    DT.120961408  DT.99987012 

    24/112 AceView cDNA sequences (see all 112 ):

    CR608294 AY627884 AW865736 BX952582 X60012 CA432254 AA662570 CR624912 
    AI539544 BE886147 BQ057682 X60018 BQ066009 S66666 AA358870 X60016 
    BU673953 AA291539 AA379547 BU174921 CK904490 X02469 AL530477 AF307851 

    1 RNAdb entry of non coding RNAs:

    LIT1750   

    "" highest scoring ESTs for TP53:

    X02469 AA171861 AA296373 AB082923 AF307851 AU076984 AU120569 AU121050 AU129655 AU131952 

    Unigene Cluster for TP53:

    Tumor protein p53
    Hs.654481  [show with all ESTs]
    Unigene Representative Sequence: NM_001126114


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TP53 (see all 9 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                                -                             -           -     -                           
    SP2:                                                              -                                             
    SP3:                                                              -           -                                 
    SP4:                                                              -           -     -                           
    SP5:                                                                          -     -                           

    About this scheme

    ECgene alternative splicing isoforms for TP53

    9 Ensembl transcripts including schematic representations:
    ENST00000414315  ENST00000359597  ENST00000420246  ENST00000419024  ENST00000455263  ENST00000396473  
    ENST00000269305  ENST00000445888  ENST00000413465  

    Expression
    for TP53 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    TP53 expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for TP53

    1""  / 2""  / 3""

    7 probe-sets matching TP53 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1974_s_at2, 3 U95-A 1 1.00 1.00 0.82 0.88 X02469 1.00 1.00 1.00 1
    1939_at2, 3 U95-A 1 0.94 1.00 0.74 1.29 M22898 0.20 1.00 0.72 1
    31618_at2, 3 U95-A 1 0.75 1.00 0.54 0.84 S66666 0.60 1.00 0.82 1
    211300_s_at2, 3 U133-A 1 1.00 1.00 -- -- K03199 0.80 1.00 0.91 1
    201746_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000546 0.60 1.00 0.82 1
    211300_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    201746_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    "" TP53 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTTTGTAGAG

    SOURCE GeneReport for Unigene cluster: Hs.654481

    Expression variation in blood from EXPOLDB for TP53

    Primers:"" Origene genome-wide validated SYBR primer pairs: TP53 ""
    ""SABiosciences RT2 qPCR Primer Assay for TP53: PPH00213A ""

    Orthologs
    for TP53 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

      User Feedback
    Orthologs for TP53 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 TP531   -- tumor protein p53 84.3(n)
    83.42(a)    		 403869  NM_001003210.1  NP_001003210.1 
    chimpanzee
    (Pan troglodytes)    		 TP531   -- tumor protein p53 99.75(n)
    100(a)    		 455214  XM_001172091.1  XP_001172091.1 
    cow
    (Bos taurus)    		 TP531   -- tumor protein p53 83.9(n)
    82.08(a)    		 281542  NM_174201.2  NP_776626.1 
    rat
    (Rattus norvegicus)    		 Tp531   -- tumor protein p53 81.44(n)
    78.35(a)    		 24842  NM_030989.1  NP_112251.1 
    mouse
    (Mus musculus)    		 Trp531, 5 11 (39.00 cM)5
    		 transformation related protein 531, 5 80.45(n)1
    78.29(a)1    		 220591  NM_011640.11  NP_035770.11 
     AB0178155  AB0178165  (see all 51)
    About this table        Species with no ortholog for TP53

    ENSEMBL Gene Tree for TP53

    Paralogs
    for TP53 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      User Feedback
    Paralogs for TP53 gene
    TP732  TP632  

    "" TP53 for paralogs           About GeneDecksing


    Genomic Variants
    for TP53 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

      User Feedback
    10/94 NCBI SNPs in TP53 are shown (see all 94 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 114)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs16427851,2
    		C,F,A,H7473234(-) ACCCCG/CACCCC 7 -- int1 ng51""10Minor allele frequency- C:0.35MN NS NA 754""
    ""
    rs22874991,2
    		C,F,A,H7485583(-) CTCCCG/CTAGCT 4 -- ng51""27Minor allele frequency- C:0.33EA NA NS MN WA 3558""
    ""
    rs10425221,2
    		C,F,A,H7472921(-) TCCCCG/CCGTGG 3 -- ng51""32Minor allele frequency- C:0.44MN NS EA NA WA 3230""
    ""
    rs18003711,2
    		C,F,O7472997(-) TGTCCC/TCGGAC 3 -- ng51 ese3""13Minor allele frequency- T:0.01MN NA NS EA 1326""
    ""
    rs16149841,2
    		C,F,A7464901(-) TAGGAC/TTGGGC 7 -- ng31""10Minor allele frequency- T:0.39NS MN NA EA 746""
    --
    rs17942871,2
    		C,F,A7472286(-) ccactC/Taggag 7 -- int1 ng51""4Minor allele frequency- T:0.06NS NA 170""
    ""
    rs22874981,2
    		C,F7485975(-) TGGGAG/AAAGCT 4 -- ng51""33Minor allele frequency- A:0.23EA NA NS MN WA 4270""
    --
    rs49681871,2
    		C,F7572442(+) TAGACC/TCCATG 7 -- ut31""16Minor allele frequency- T:0.05NS EA MN 1660""
    ""
    rs25435481,2
    		H7473408(-) GGAAGT/CGTCTC 7 -- int1 ng51""4Minor allele frequency- C:0.00NS EA 420""
    ""
    rs17942861,2
    		C7472660(-) CCCTTT/AGGCTT 7 -- int1 ng51""1Minor allele frequency- A:0.00MN 184""
    About this table

    HapMap Linkage Disequilibrium images for TP53 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
          Database of Genomic Variants (DGV) variations for TP53: --

    Disorders & Mutations
    for TP53 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      User Feedback
    "" TP53 for disorders           About GeneDecksing

    OMIM: 191170   disorders: 114500  151623  114550  259500  260500  161550  260350  202300  114480  

    UniProtKB/Swiss-Prot: P53_HUMAN, P04637

  • TP53 is found in increased amounts in a wide variety of transformed cells. TP53 is frequently mutated or
    • inactivated in about 60% of cancers
  • Defects in TP53 are involved in esophageal squamous cell carcinoma (ESCC) [MIM:133239]. ESCC is a tumor of the
    • esophagus
  • Defects in TP53 are a cause of Li-Fraumeni syndrome (LFS) [MIM:151623]. LFS is an autosomal dominant familial
    • cancer syndrome that in its classic form is defined by the existence of a proband affected by a sarcoma before 45
    years with a first degree relative affected by any tumor before 45 years and another first degree relative with any
    tumor before 45 years or a sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819
    and PubMed:8718514) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a diverse
    set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in TP53
    germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and
    adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of 15,
    rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and gastric cancers
  • Defects in TP53 may be associated with nasopharyngeal carcinoma [MIM:161550]; also known as nasopharyngeal
    • cancer
  • Defects in TP53 are found in Barrett metaplasia; also known as Barrett esophagus. It is a condition in which
    • the normally stratified squamous epithelium of the lower esophagus is replaced by a metaplastic columnar epithelium.
    The condition develops as a complication in approximately 10% of patients with chronic gastroesophageal reflux disease
    and predisposes to the development of esophageal adenocarcinoma
  • Defects in TP53 are involved in head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as
    • squamous cell carcinoma of the head and neck
  • Defects in TP53 are involved in oral squamous cell carcinoma (OSCC). Cigarette smoke is a prime mutagenic
    • agent in cancer of the aerodigestive tract
  • Defects in TP53 are a cause of lung cancer [MIM:211980]
  • Defects in TP53 are a cause of choroid plexus papilloma [MIM:260500]. Choroid plexus papilloma is a
    • slow-growing benign tumor of the choroid plexus that often invades the leptomeninges. In children it is usually in a
    lateral ventricle but in adults it is more often in the fourth ventricle. Hydrocephalus is common, either from
    obstruction or from tumor secretion of cerebrospinal fluid. If it undergoes malignant transformation it is called a
    choroid plexus carcinoma. Primary choroid plexus tumors are rare and usually occur in early childhood
  • Defects in TP53 are a cause of one form of hereditary adrenocortical carcinoma (ADCC) [MIM:202300]. ADCC is a
    • rare childhood tumor, representing about 0.4% of childhood tumors, with a high incidence of associated tumors. ADCC
    occurs with increased frequency in patients with the Beckwith-Wiedemann syndrome [MIM:130650] and is a component tumor
    in Li-Fraumeni syndrome [MIM:151623]

    10/2562 ""Novoseek disease relationships for TP53 gene (see all 2562 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 100.00 463 19428789 (9), 10063271 (9), 9839169 (8), 8293408 (7) (see all 100)
    bladder cancer 100.00 917 11690548 (7), 7869472 (6), 17982131 (6), 12629332 (6) (see all 100)
    squamous cell carcinoma 100.00 2049 12610510 (10), 9127380 (9), 15390206 (9), 9388973 (7) (see all 100)
    colorectal cancer 100.00 1716 9587516 (8), 16416012 (8), 19954513 (7), 15958644 (7) (see all 100)
    glioblastoma 100.00 545 9839169 (8), 19706164 (7), 9166509 (6), 18462472 (6) (see all 100)
    retinoblastoma 100.00 982 9367711 (8), 9186339 (8), 7850321 (8), 10792093 (8) (see all 100)
    li-fraumeni syndrome 100.00 486 8649766 (9), 19834951 (7), 11245491 (6), 9703430 (5) (see all 100)
    tumor progression 100.00 725 19638963 (4), 18425359 (4), 16247444 (4), 12907609 (4) (see all 100)
    escc 100.00 408 19730383 (8), 17060721 (7), 16271069 (6), 16230424 (6) (see all 100)
    growth arrest 100.00 919 8756351 (6), 8183918 (5), 9314841 (4), 8754845 (4) (see all 100)
    About this table

    5 PharmGKB disease relationships for TP53 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, LymphocyticCO  PK  GN  10406363
    Leukemia, Lymphocytic, Acute, L1PD  FA  GN  12704389
    Neoplasms, Radiation-InducedCO  PK  GN  10406363
    Neoplasms, Second PrimaryCO  PK  GN  10406363
    Ovarian NeoplasmsCO  GN  15221786
    About this table

    GeneTests: TP53
    Li-Fraumeni Syndrome

    Locus Specific Mutation Databases: TP53
    Human Gene Mutation Database: TP53
    Genetic Association Database: TP53
    Human Genome Epidemiology Navigator: TP53 (898 documents)
    Tumor Gene Database: TP53
    Breast Cancer Gene Database: TP53

    Medical News
    for TP53 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      User Feedback

    Publications
    for TP53 gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

      User Feedback    		10/17856 PubMed articles for TP53 gene (see all 17856 ):

    Search for TP53 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

      User Feedback
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TP53 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

      User Feedback
    Entrez Gene: 7157 HGNC: 11998 AceView: TP53 Ensembl:ENSG00000141510 euGenes: HUgn7157
    ECgene: TP53 Kegg: 7157 H-InvDB: TP53

    Other Databases showing TP53 gene

    (According to HUGE)
    About This Section

      User Feedback    		   --

    Specialized Databases showing TP53 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      User Feedback
    NameDescription
    ATLAS Chromosomes in Cancer entry for TP53 Genetics and Cytogenetics in Oncology and Haematology
    IARC TP53 mutation databasehttp://www-p53.iarc.fr/
    p53 web site at the Institut Curiehttp://p53.free.fr/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TP53
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tp53/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=TP53
    Wikipedia http://en.wikipedia.org/wiki/P53

    Intellectual Property
    for TP53 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section

      User Feedback    		Patent Information for TP53 gene: ""
    Search GeneIP for patents involving TP53

    Licensable Technologies for TP53 gene:
     ""Weizmann Institute:Treatment of Systemic Lupus Erythematosus by Down-Regulating the Autoimmune Response to Autoantigens    (see all 2)
     ""Salk Institute: Assays for p53 Function in Cells
    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    Services
    for TP53 gene

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section

      User Feedback    		""
    ""
    Products for TP53:
    "" TaqMan ® Gene Expression Assays
    "" TaqMan ® Genotyping Assays
    		 "" Free SNP selection tool

    ""
    "" Millipore Custom Antibody & Bulk Services
    "" Millipore Preclinical / Clinical Development Services
    "" Millipore Immunoassay Services
    "" Millipore Target Screening & Profiling Services

    ""
    "" Predesigned and custom siRNAs for TP53"" Antibodies for TP53
    "" Explore super-pooled esiRNAs"" Proteins for TP53
    "" Lentivirus-delivered shRNAs for TP53"" Browse small molecules at Sigma-Aldrich
    "" "Your Favorite Gene" Pathways"" ELISAs for TP53
    "" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


     ""  ""
    "" Antibodies  "" Primer Pairs  
    "" Cell Culture Products  "" ELISAs  
    "" Flow Cytometry Kits  "" Protease Activity Assays & Reagents  
    "" Cell Selection/Detection Kits & Reagents  "" ELISA/Assay Development Kits & Reagents  
    "" Multiplex/Array Assay Kits & Reagents  "" ELISpot Kits & Development Modules  
    "" Recombinant & Natural Proteins  

    "" Recombinant Proteins (TP53)
    "" Antibodies (TP53)
    "" Chimera RNAi (TP53)
    "" Custom Service for Mouse Mab
    "" Custom Service for Rabbit Pab from Full-length Protein


    """"""""
    "" Antibodies & Assays for TP53  (p53)

    "" Tagged/untagged cDNA clones
    "" Validated SYBR primer pairs
    "" Purified proteins from HEK293T cells
    "" Western blot validated antibodies
    "" shRNA in GFP-retroviral vector
    "" Custom immunoassay development
    "" Tocris compounds for TP53
    "" Regulatory tfbs in TP53 upstream (promoter) region
    "" Search Chromatin IP Primers for TP53
    "" DNA Methylation qPCR Primer Assays for TP53
    "" RT2 qPCR Primer Assay for TP53
    "" GNC Network for TP53
    "" Search for microRNAs that regulate TP53
    """"""""
    "" Assays/Drugs/Proteins for TP53
    "" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
    "" Novus Tissue Slides
    "" Antibodies for TP53
    "" Proteins for TP53
    "" Lysates for TP53
    "" Antibodies for TP53
    "" Browse Sino Biological Proteins and Antibodies
    "" cDNA Clones for TP53
    "" Antibodies/Proteins Production Services
    "" Rabbit Monoclonal Antibody Platform
    "" Bulk Purchasing
      User Feedback        

    GeneCards Homepage - Last full update: 20 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

    View Random Gene

    Category
    acyl-CoA synthetase family member 3
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2010 , Weizmann Institute of Science. All Rights Reserved.
    tp53 gene at Home site.
    hostname: server4.xennexinc.com db build: 72 index build: 72d solr: 1.4