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TH Gene

protein-coding GIFtS: 69

GC11M002141

tyrosine hydroxylase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 1.14.16.2 ^³
OTTHUMP00000011225 ^²
OTTHUMP00000011226 ^²
TYH ^², ³, ⁵

Descriptions
Tyrosine 3-hydroxylase ^³
tyrosine 3-monooxygenase ^²
tyrosine hydroxylase ^²

External Ids
HGNC: 11782¹
Entrez Gene: 7054²
UniProtKB: P07101³
Ensembl: ENSG00000180176⁷

Search outside databases for aliases for TH gene

Previous GC identifers: GC11U990132 GC11M002273 GC11M002144 GC11M002149

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TH:

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the

rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology

of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa

syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted

for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Function: Plays an important role in the physiology of adrenergic neurons

Gene Wiki entry for TH (Tyrosine_hydroxylase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TH gene

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

TH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M002141: (about GC identifiers)

Start:	2,131,627 bp from pter
End:	2,149,611 bp from pter
Size:	17,985 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101 (See protein sequence)

Recommended Name: Tyrosine 3-monooxygenase

Size: 528 amino acids; 58600 Da

Cofactor: Fe(2+) ion

Secondary accessions: Q15585 Q15588 Q15589

Alternative splicing: 4 isoforms: P07101-1 P07101-2 P07101-3 P07101-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000351.2 NP_954986.2 NP_954987.2

ENSEMBL proteins:

ENSP00000370560 ENSP00000325831 ENSP00000370567 ENSP00000325951 ENSP00000370571 ENSP00000328814

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant TH Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TYR + TRP + PHE Hydroxylase, Tyrosine Hydroxylase)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	IDA	10907721
GO:0005790	smooth endoplasmic reticulum	IDA	12457228
GO:0009898	internal side of plasma membrane	IDA	12457228
GO:0031410	cytoplasmic vesicle	IDA	12457228

About this table

Antibodies for TH:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of TH
	Sigma-Aldrich Antibody Arrays and Antibodies for TH
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for TH (Tyrosine hydroxylase)
	Antibodies from Abcam (TYR + TRP + PHE Hydroxylase, Tyrosine Hydroxylase), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for TH

Assays for TH:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of TH
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07101

ProtoNet protein and cluster: P07101

1 Blocks protein family: IPB001273 Aromatic amino acid hydroxylase

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TH)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_199292

Applied Biosystems Silencer® siRNAs for TH

Sigma-Aldrich siRNA and siRNA Panels for TH

Sigma-Aldrich shRNA for TH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000360
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000360
untagged cDNA clones in CMV expression vector (see all 3): NM_000360

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_199292

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Function: Plays an important role in the physiology of adrenergic neurons

Catalytic activity: L-tyrosine + tetrahydrobiopterin + O(2) = 3,4-dihydroxy-L-phenylalanine +

4a-hydroxytetrahydrobiopterin

Enzyme regulation: Phosphorylation leads to an increase in the catalytic activity

Enzyme Number (IUBMB): EC 1.14.16.2

Genatlas biochemistry entry for TH:

tyrosine 3-hydroxylase,58.5kDa,mainly expressed in brain and adrenal glands,rate limiting enzyme in

the biosynthesis of catecholamines,potentially associated with longevity in the male,unlikely to

be associated with bipolar effective disorder (MAFD)

11 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Th):

	behavior/neurological	growth/size	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system	normal	respiratory system
touch/vibrissae

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	IEA	--
GO:0004511	tyrosine 3-monooxygenase activity	IDA	16338639
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	11943812
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for TH (Your Favorite Gene powered by Ingenuity)

Dopamine Receptor Signaling
Tyrosine Metabolism

GeneDecks TH for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Pathway: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2

Gene Network Central^TM Interacting Genes and Proteins Network for TH

5/126 Interacting proteins for TH (ENSP00000370571³) via UniProtKB, MINT, and/or STRING (see all 126 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDC	ENSP00000339928³	STRING (score=.991)
SNCA	ENSP00000338345³	STRING (score=.988)
TYR	ENSP00000263321³	STRING (score=.983)
NR4A2	ENSP00000344479³	STRING (score=.973)
NPY	ENSP00000242152³	STRING (score=.966)

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5/19 Gene Ontology (GO) biological process terms (links to tree view) (see all 19 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	17520326
GO:0001963	synaptic transmission, dopaminergic	ISS	--
GO:0003007	heart morphogenesis	NAS	12113410
GO:0006585	dopamine biosynthetic process from tyrosine	NAS	10907721
GO:0007268	synaptic transmission	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for TH

Sigma-Aldrich Small Molecules for TH:

Inhibitor

Browse Tocris compounds for TH
10/27 Novoseek chemical compound relationships for TH gene (see all 27 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	95.74	4713	1967817 (11), 1350320 (9), 15569247 (8), 11223911 (8) (see all 99)
catecholamine	87.02	415	8103492 (4), 17698732 (4), 11677263 (3), 19120120 (3) (see all 99)
tyrh(.+)	84.44	6	15468323 (1), 14692751 (1), 15287903 (1), 16475826 (1) (see all 6)
tcat	80.85	13	11475015 (1), 12428766 (1), 7551967 (1), 18096443 (1) (see all 7)
tetrahydropterin	80.63	4	1675871 (1), 19281164 (1), 8917440 (1), 16618490 (1)
l-amino acid	79.84	82	9924972 (3), 9148252 (2), 10366680 (2), 11263376 (2) (see all 45)
1 methyl 4 phenylpyridinium	62.64	32	11036157 (5), 10651107 (3), 7911964 (3), 1975089 (2) (see all 9)
dihydrobiopterin	61.95	3	8921004 (1), 9843368 (1)
tetrahydropteridine	61.47	2	9413846 (1)
gtp	59.29	82	10938545 (5), 9692753 (3), 12891655 (3), 17135716 (2) (see all 41)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TH)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_199292

Sigma-Aldrich siRNA and siRNA Panels for TH

Sigma-Aldrich shRNA for TH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000360 NM_199292 NM_199293

REFSEQ mRNAs for TH gene (3 alternative transcripts):

NM_000360.3 NM_199292.2 NM_199293.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000360 NM_199292 NM_199293

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000360
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000360
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000360

Additional cDNA sequence:

AY144494.1 AY144495.1 BC104967.1 BC143611.1 BC143614.1 DQ677336.1 DQ677337.1 M17589.1

M20912.1 M24790.1 X05290.1 Y00414.1

8 DOTS entries:

DT.108479 DT.100751588 DT.100022747 DT.91740988 DT.120712419 DT.95159269 DT.102843985 DT.95237873

6 AceView cDNA sequences:

M24790 BQ718391 T27948 NM_199293 NM_000360 NM_199292

highest scoring ESTs for TH:

M17589 M24790 BQ718391 CA949421 M20912 NM_000360 NM_199292 NM_199293 T27948 X05290

Unigene Cluster for TH:

Tyrosine hydroxylase

Hs.435609 [show with all ESTs]

Unigene Representative Sequence: M17589

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TH (see all 7 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14
SP1:			-								-
SP2:											-
SP3:			-		-						-
SP4:			-		-		-				-
SP5:																					-

About this scheme

ECgene alternative splicing isoforms for TH

6 Ensembl transcripts including schematic representations:

ENST00000381168 ENST00000324155 ENST00000381175 ENST00000352909 ENST00000381178 ENST00000333684

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TH

¹ / ² / ³

3 probe-sets matching TH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32300_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M17589	0.80	1.00	0.91	1
208291_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000360	0.60	1.00	0.82	1
208291_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCTCCCTGC

SOURCE GeneReport for Unigene cluster: Hs.435609
Expression variation in blood from EXPOLDB for TH
UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101
Tissue specificity: Mainly expressed in the brain and adrenal glands

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TH gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TH¹	--	tyrosine hydroxylase	87.34(n) 89.9(a)	403444 XM_850454.1 XP_855547.1
chimpanzee (Pan troglodytes)	TH¹	--	tyrosine hydroxylase	98.6(n) 98.8(a)	450955 XM_508221.2 XP_508221.2
cow (Bos taurus)	TH¹	--	tyrosine hydroxylase	84.83(n) 84.29(a)	280707 NM_173884.2 NP_776309.1
rat (Rattus norvegicus)	Th¹	--	tyrosine hydroxylase	84.07(n) 89.31(a)	25085 NM_012740.2 NP_036872.1
mouse (Mus musculus)	Th^{1, 5}	7 (69.20 cM)⁵	tyrosine hydroxylase^{1, 5}	83(n)¹ 88.31(a)¹	21823¹ NM_009377.1¹ NP_033403.1¹ AF415235⁵ AK139568⁵ (see all 9)

About this table Species with no ortholog for TH

ENSEMBL Gene Tree for TH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TH gene

TPH1² TPH2² PAH²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/74 NCBI SNPs in TH are shown (see all 74 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 76)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10770140^1,2	A,C,F,H	2150173(+)	`CGCCCT/CGTGGG`	3	--	ng3¹		4		EU EA WA	364
	rs10743149^1,2	A,C,F,H	2150751(+)	`GAGCCC/TGCCTT`	3	--	ng3¹		8		EU EA WA	830
	rs7115640^1,2	A,C,F,H	2151490(+)	`TCCACG/AGTGTT`	3	--	ng3¹		3		EA WA	296
--	rs10840490^1,2	A,C,F,H	2150393(+)	`TCCCTC/GGGGGT`	3	--	ng3¹		8		EU EA WA	792
	rs10770141^1,2	A,C,F,H	2150416(+)	`TCTTTG/AAAGAG`	3	--	ng3¹		8		EU EA WA	834
	rs7119275^1,2	A,C,F,H	2151386(+)	`GCTCCC/TCTGGA`	3	--	ng3¹		8		EU EA WA	830
	rs10840491^1,2	C,F,H	2150966(+)	`TTCTCG/AAAGGC`	3	--	ng3¹		8		EU EA WA	838
--	rs3842727^1,2	A,C,F	2141424(-)	`CCTGGC/AAGGGA`	3	--	ng5¹		6		EU CA EA WA CSA NS	756
	rs6356^1,2	C,F,H	2147527(-)	`AGGCCG/ATGCTA`	3	M/V	mis¹ ese³		11		MN EU EA WA NA	1162
--	rs11042962^1,2	A,C	2150086(+)	`TGTCTC/TGTAGA`	3	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for TH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 191290 disorders: 605407

UniProtKB/Swiss-Prot: TY3H_HUMAN, P07101

Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD)

[MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of

DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the

presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some

cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia,

it is an eminently treatable condition, due to a favorable response to L-DOPA

10/93 Novoseek disease relationships for TH gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
parkinson disease	86.66	113	7893377 (4), 10518586 (3), 8822146 (2), 1349211 (2) (see all 71)
dystonia, dopa-responsive, autosomal recessive	76.50	1	15476168 (1)
gtp cyclohydrolase i deficiency	74.53	4	12891655 (3), 10079965 (1)
parkinsonism	70.14	15	11134401 (1), 18419768 (1), 1356749 (1), 10023444 (1) (see all 12)
pheochromocytoma	62.97	72	1678741 (4), 1353277 (4), 12651811 (3), 7602797 (3) (see all 35)
neurodegenerative diseases	55.82	3	9228951 (1), 15933869 (1)
lewy body disease	54.47	8	18386627 (2), 17493034 (1), 15933869 (1), 17985144 (1)
neurodegeneration	52.05	10	16543240 (1), 17442064 (1), 1975089 (1), 15681811 (1) (see all 7)
hyperphenylalaninemia	46.67	4	17432176 (1), 9744478 (1), 16541791 (1)
neuroblastoma metastatic	46.47	3	16384890 (1), 18814238 (1)

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GeneTests: TH

Tyrosine Hydroxylase Deficiency

Human Gene Mutation Database: TH
Genetic Association Database: TH
Human Genome Epidemiology Navigator: TH (495 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1214 PubMed articles for TH gene (see all 1214 ):

Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease. (PubMed id 9613851)^{1, 3, 4, 6} Kunugi H.... Nanko S. (1998)
Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism. (PubMed id 9754624)^{1, 3, 4} Ishiguro H.... Shibuya H. (1998)
Polymorphism of the insulin gene is associated with increased prostate cancer risk. (PubMed id 12610512)^{1, 3, 6} Ho G.Y....Chua S.C. (2003)
VNTR polymorphism of tyrosine hydroxylase gene and schizophrenia in the Korean population. (PubMed id 12759555)^{1, 3, 6} Pae C.U....Paik I.H. (2003)
Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene. (PubMed id 8817341)^{1, 3, 4} Luedecke B.... Flatmark T. (1996)
Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes. (PubMed id 16251897)^{3, 6} Rodriguez S....Day I.N. (2006)
Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes. (PubMed id 16360899)^{3, 6} Tochigi M....Sasaki T. (2006)
A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys. (PubMed id 16344718)^{3, 6} Rodriguez S....Day I.N. (2006)
DNA polymorphisms in the tyrosine hydroxylase and GNB3 genes: association with unexpected death from acute myocardial infarction and increased heart weight. (PubMed id 16139102)^{3, 6} Klintschar M....Kleiber M. (2005)
TH01, a tetrameric short tandem repeat locus in the tyrosine hydroxylase gene: association with myocardial hypertrophy and death from myocardial infarction? (PubMed id 15735319)^{3, 6} Klintschar M....Kleiber M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7054	HGNC: 11782	AceView: TH	Ensembl:ENSG00000180176	euGenes: HUgn7054
ECgene: TH	H-InvDB: TH

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=TH
Wikipedia	http://en.wikipedia.org/wiki/Tyrosine_hydroxylase

Licensable Technologies for TH
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TH		Antibodies for TH
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TH		Small molecules for TH
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (TH)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TH (Tyrosine hydroxylase)

	Recombinant Proteins (TYR + TRP + PHE Hydroxylase, Tyrosine Hydroxylase)
	Antibodies (TYR + TRP + PHE Hydroxylase, Tyrosine Hydroxylase)

Search OriGene for TH

Search Tocris compounds for TH

	Drugs for TH
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TH

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TH Gene at Home site.
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TH Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for TH

Summaries
for TH

Genomic Location
for TH

Proteins
for TH

Protein Domains/
Families
for TH

Gene Function
for TH

Pathways & Interactions
for TH

Drugs & Compounds
for TH

Transcripts
for TH

Expression
for TH

Orthologs
for TH

Paralogs
for TH

SNPs/Variants
for TH

Disorders & Mutations
for TH

Medical News
for TH

Publications
for TH

Search for TH

Genome Databases showing TH

Other Databases showing TH

Specialized Databases showing TH

Licensable Technologies
for TH

Services
for TH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TH Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor TH

Summariesfor TH

Genomic Locationfor TH

Proteinsfor TH

Protein Domains/Familiesfor TH

Gene Functionfor TH

Pathways & Interactionsfor TH

Drugs & Compoundsfor TH

Transcriptsfor TH

Expression for TH

Orthologsfor TH

Paralogsfor TH

SNPs/Variantsfor TH

Disorders & Mutationsfor TH

Medical Newsfor TH

Publicationsfor TH

Search for TH

Genome Databases showing TH

Other Databases showing TH

Specialized Databases showing TH

Licensable Technologiesfor TH

Servicesfor TH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TH

Summaries
for TH

Genomic Location
for TH

Proteins
for TH

Protein Domains/
Families
for TH

Gene Function
for TH

Pathways & Interactions
for TH

Drugs & Compounds
for TH

Transcripts
for TH

Expression
for TH

Orthologs
for TH

Paralogs
for TH

SNPs/Variants
for TH

Disorders & Mutations
for TH

Medical News
for TH

Publications
for TH

Licensable Technologies
for TH

Services
for TH