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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEC Gene

protein-coding   GIFtS: 68
GCID: GC04M048137

tec protein tyrosine kinase
 Explore 19 diseases affiliated with
TEC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TEC    

Aliases
for TEC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tec Protein Tyrosine Kinase1 2
PSCTK41 2 3
EC 2.7.10.23 8
Tyrosine-Protein Kinase Tec2
EC 2.7.108

External Ids:    HGNC: 117191   Entrez Gene: 70062   Ensembl: ENSG000001356057   OMIM: 6005835   UniProtKB: P426803   

Export aliases for TEC gene to outside databases

Previous GC identifers: GC04M048214 GC04M048447 GC04M047987 GC04M048053 GC04M047978 GC04M047832 GC04M047457


Summaries
for TEC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TEC:
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a
pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine
receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are
also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling
and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TEC_HUMAN, P42680
Function: Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal
transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to
ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of
conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates
DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA
expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and
activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient
cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the
granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and
functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation.
Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription.
GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G
protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte
proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2
unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological
conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast
differentiation

Gene Wiki entry for TEC


Genomic Views
for TEC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006238.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEC gene promoter:
         FOXD3   HNF-3beta   Arnt   E47   PPAR-alpha   SRY   POU2F1   POU2F1a   SEF-1 (1)   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TEC promoter sequence
   Search SABiosciences Chromatin IP Primers for TEC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p12   Ensembl cytogenetic band:  4p11   HGNC cytogenetic band: 4p12

TEC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M048137:  view genomic region     (about GC identifiers)

Start:
 48,137,800 bp from pter      End:
 48,271,881 bp from pter
Size:
 134,082 bases      Orientation:
 minus strand

Proteins
for TEC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TEC_HUMAN, P42680 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Tec  
Size: 631 amino acids; 73581 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with CD28, FASLG, FGF2, GRB10, LYN and KIT. Interacts
with VAV1 and JAK2 (By similarity)
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following
B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin
and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac
myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures
upon various stimuli, including ATP (By similarity)
Caution: It is uncertain whether Met-1 is the initiator
1 PDB 3D structure from and Proteopedia for TEC:
2LUL (3D)    
Secondary accessions: B7ZKZ6 Q3MIS5

Explore the universe of human proteins at neXtProt for TEC: NX_P42680

Post-translational modifications:

  • Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at
    • Tyr-519. Undergoes also tyrosine phosphorylation during platelet activation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P42680

    • 4/7 DME Specific Peptides for TEC (P42680) (see all 7)
     PIYIVTE  RDLAARN  YYLAEKH  KSDVWSFG 

    TEC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003206.2  
    ENSEMBL proteins: 
     ENSP00000370912   ENSP00000420836   ENSP00000424567   ENSP00000424365  
    Reactome Protein details: P42680
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant TEC Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate: TEC
    OriGene Custom Protein Services for TEC 
    GenScript Custom Purified and Recombinant Proteins Services for TEC
    Novus Biologicals TEC Protein
    Novus Biologicals TEC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TEC

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IDA9652744
    GO:0005886plasma membrane IEA--


    TEC for ontologies           About GeneDecksing



    TEC Antibody Products: 
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    ThermoFisher Antibodies for TEC

    Assay Products for TEC: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TEC

    Protein Domains /
    Families
    for TEC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TEC for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR001849 Pleckstrin_homology
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P42680

    ProtoNet protein and cluster: P42680

    5 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: TEC_HUMAN, P42680
    Domain: The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its targeting to
    the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec homology) domain,
    which consists of about 80 residues preceding the SH3 domain
    Domain: The SH3 domain is essential for its targeting to activated CD28 costimulatory molecule (By similarity)
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Function
    for TEC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TEC_HUMAN, P42680
    Function: Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal
    transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to
    ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of
    conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates
    DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA
    expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and
    activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient
    cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the
    granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and
    functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation.
    Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription.
    GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G
    protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte
    proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2
    unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological
    conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast
    differentiation
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by tyrosine phosphorylation by a wide range of cytokine stimulations. When T-cells or
    B-cells receptors are activated, a series of phosphorylation leads to the recruitment of TEC to the cell membrane,
    where it is phosphorylated at Tyr-519. Also activated in response to SCF. Integrin engagement induces tyrosine
    phosphorylation of TEC in platelets. STAP1 participates in a positive feedback loop by increasing the activity of TEC.
    SOCS1 is an inhibitor of TEC kinase activity

         Genatlas biochemistry entry for TEC:
    Tec non receptor protein tyrosine kinase,73.6kDa

    Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEC
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TEC (see all 16):
    hsa-miR-607 hsa-miR-601 hsa-miR-429 hsa-miR-3120-3p hsa-miR-410 hsa-miR-570 hsa-miR-1305 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TEC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEC (see all 7)
    OriGene shRNA RFP: TEC
    OriGene siRNA: TEC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TEC

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEC (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TEC (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TEC (NM_058222)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEC 

    Cell Line
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    Search LifeMap BioReagents cell lines for TEC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEC

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA10518561
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0005543phospholipid binding IEA--


    TEC for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Tectm1Welm for TEC
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tec):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    TEC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TEC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Prolactin receptor signaling
    		Development_Prolactin receptor signaling1.00
    		Prolactin Signaling Pathway0.39
    		Development Prolactin receptor signaling1.00
    2ICos-ICosL Pathway in T-Helper Cell
    		ICos-ICosL Pathway in T-Helper Cell1.00
    		CD28 Signaling in T-Helper Cell0.66
    3Signaling events mediated by Stem cell factor receptor (c-Kit)
    		Signaling events mediated by Stem cell factor receptor (c-Kit)1.00
    		Kit Receptor Signaling Pathway0.37
    4Interleukin receptor SHC signaling
    		Interleukin-3, 5 and GM-CSF signaling0.57
    		Signaling by Interleukins0.25
    5B cell receptor signaling pathway
    		T cell receptor signaling pathway0.40
    		PI3K Signaling in B-Lymphocyte0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TEC
        Development Prolactin receptor signaling

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TEC (see all 6)
        G12-G13 in Cellular Signaling
    ICos-ICosL Pathway in T-Helper Cell
    PI3K Signaling in B-Lymphocyte
    CD28 Signaling in T-Helper Cell
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for TEC
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for TEC
        Development Prolactin receptor signaling

    5/7 BioSystems Pathways for TEC (see all 7) 
        Kit Receptor Signaling Pathway
    Prolactin Signaling Pathway
    IL-6 Signaling Pathway
    B Cell Receptor Signaling Pathway
    IL-3 Signaling Pathway

    5/6        Reactome Pathways for TEC (see all 6)
        Cytokine Signaling in Immune system
    Interleukin-3, 5 and GM-CSF signaling
    Signal Transduction
    Signaling by Interleukins
    Signaling by SCF-KIT


    2         Kegg Pathways  (Kegg details for TEC):
        Osteoclast differentiation
    T cell receptor signaling pathway


    TEC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TEC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for TEC (P426802, 3 ENSP000003709124) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74777 I2D: score=2 STRING: ENSP00000269571
    ASAP1Q9ULH12, 3, ENSP000003502974MINT-7145675 I2D: score=1 STRING: ENSP00000350297
    MED28Q9H2042, 3, ENSP000002373804MINT-7041716 I2D: score=1 STRING: ENSP00000237380
    DOK1Q997043, ENSP000002336684I2D: score=4 STRING: ENSP00000233668
    VAV1P154983, ENSP000003022694I2D: score=3 STRING: ENSP00000302269
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS7934162
    GO:0007229integrin-mediated signaling pathway IDA9652744
    GO:0007243intracellular protein kinase cascade TAS7934162
    GO:0010543regulation of platelet activation IDA9652744
    GO:0035556intracellular signal transduction ----


    TEC for ontologies           About GeneDecksing



    Drugs & Compounds
    for TEC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TEC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEC

    2 HMDB Compounds for TEC    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    10/11 Novoseek chemical compound relationships for TEC gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 81.7 212 15899983 (4), 9446655 (4), 14647425 (3), 11123316 (3) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 64.8 1 15492005 (1)
    phosphatidylinositol 50.3 8 11123316 (3), 10688822 (1), 11382770 (1), 15492005 (1) (see all 5)
    phosphoinositide 37 3 15240663 (2), 11994416 (1)
    inositol 35.1 1 9240435 (1)
    wortmannin 22.3 4 15899983 (1), 11123316 (1)
    proline 18.5 5 12163161 (3), 15214045 (2)
    calcium 4.8 5 15899983 (2), 15184383 (1), 10224128 (1), 11058574 (1)
    adp 2.23 1 12734372 (1)
    fibrinogen 0 1 9652744 (1)

    Search CenterWatch for drugs/clinical trials and news about TEC 

    Transcripts
    for TEC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TEC gene: 
    NM_003215.2  

    Unigene Cluster for TEC:

    Tec protein tyrosine kinase
    Hs.479670  [show with all ESTs]
    Unigene Representative Sequence: D29767
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381501(uc003gxz.3) ENST00000506752 ENST00000505452 ENST00000515146
    ENST00000511150 ENST00000511471

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEC
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TEC (see all 16):
    hsa-miR-607 hsa-miR-601 hsa-miR-429 hsa-miR-3120-3p hsa-miR-410 hsa-miR-570 hsa-miR-1305 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TEC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEC (see all 7)
    OriGene shRNA RFP: TEC
    OriGene siRNA: TEC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEC
    Clone
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    GenScript: all cDNA clones in your preferred vector: TEC (NM_058222)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEC 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TEC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TEC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEC

    Additional cDNA sequence: 

    BC101711.1 BC101713.1 BC143487.1 D29767.1 

    6 DOTS entries:

    DT.309718  DT.91969344  DT.91716446  DT.95152949  DT.95342354  DT.86857648 

    24/27 AceView cDNA sequences (see all 27):

    AI652941 AA779321 BF791619 AW451753 AL602776 AV714704 CD369126 AI640432 
    D29767 BX092226 BE378187 CB985022 AA934653 AW268498 AA262400 AW292943 
    NM_003215 CB046252 CB046251 AV711220 BQ353545 AA534336 BM148012 AA243613 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TEC (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                    -                                                           -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                          -                                 
    SP4:                                                                                                                                                            
    SP5:                                            -                                                                                                               


    ECgene alternative splicing isoforms for TEC

    Expression
    for TEC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGTTCCGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TEC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TEC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEC

    SOURCE GeneReport for Unigene cluster: Hs.479670

    UniProtKB/Swiss-Prot: TEC_HUMAN, P42680
    Tissue specificity: Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell
    lineages

        SABiosciences Expression via Pathway-Focused PCR Array including TEC: 
              Notch Signaling Targets in human mouse rat

    Primer
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    Orthologs
    for TEC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TEC gene from 6/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TEC1 tec protein tyrosine kinase 78.66(n)
    83.76(a)    		   396407  NM_001030372.1  NP_001025543.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TEC6
    		 --
    		 85(a)
    		 1 ↔ 1
    		 GL343293.1(655440-690753)
    zebrafish
    (Danio rerio)    		 Actinopterygii tec1 tec protein tyrosine kinase 66.44(n)
    69.43(a)    		   571588  NM_001114743.1  NP_001108215.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Btk29A1 , 3 male genital morphogenesis (sensu
    Holometabola) more3
    Btk family kinase at 29A1    		 54(a)3
    52.83(n)1
    50.6(a)1    		   29A13
    341321  NM_057397.41  NP_476745.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G576106
    AT3G469206
    (see all 7)    		 octicosapeptide/Phox/Bem1p domain-containing prote...
    octicosapeptide/Phox/Bem1p domain-containing prote...
    (see all 7)    		 9(a)
    9(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 5(23324791-23329347)
    3(17280430-17284857)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 protein kinase domain containing protein, expresse...
    protein kinase domain containing protein, expresse...
    (see all 5)    		 9(a)
    8(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 2(33380337-33387027)
    7(14722116-14730584)


    ENSEMBL Gene Tree for TEC (if available)
    TreeFam Gene Tree for TEC (if available) 

    Paralogs
    for TEC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TEC gene
    FRK2  LCK2  BLK2  ITK2  LYN2  YES12  TXK2  HCK2  
    ABL12  BMX2  ABL22  SRMS2  FGR2  PTK62  SRC2  FYN2  
    BTK2  
    18/24 SIMAP similar genes for TEC using alignment to 4 protein entries:     TEC_HUMAN (see all proteins) (see all similar genes):
    BTK kinase deficient isoform 4    TXK    BTK kinase deficient isoform 2    DKFZp686M05208    ITK    BMX
    EPHA2    BTK    BLK    FGR    FYN    ABL1
    ABL2    BCR/ABL fusion    FRK    SRC    YES1    LYN

    TEC for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TEC
    PGOHUM00000243697


    Genomic Variants
    for TEC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TEC
         1 CNV: 59206
         2 Indels: 59204 59205
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TEC
    DNA2.0 Custom Variant and Variant Library Synthesis for TEC

    Disorders / Diseases
    for TEC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TEC for disorders           About GeneDecksing

    OMIM gene information: 600583    OMIM disorders: --

    19 diseases for TEC:    About MalaCards
    wiskott-aldrich syndrome    myelodysplastic syndrome    agammaglobulinemia    cervical squamous cell carcinoma
    behcet's disease    squamous cell carcinoma    b cell deficiency    congenital fibrosarcoma
    lymphedema    candidiasis    t cell deficiency    gout
    fibrosarcoma    cervicitis    immunodeficiency    breast cancer
    carcinoma    hepatitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for TEC:
    Agammaglobulinemia

    8 Novoseek disease relationships for TEC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    x-linked agammaglobulinemia 91.4 6 9280283 (1), 9446655 (1), 11104803 (1), 8892607 (1) (see all 5)
    agammaglobulinemia 75.7 2 8090769 (1)
    wiskott-aldrich syndrome 45.3 1 10688822 (1)
    immunodeficiency 39 1 11104803 (1)
    behcet disease 16.7 2 16809408 (1), 15654836 (1)
    tumors 5.46 2 15251464 (1), 18171525 (1)
    necrosis 0 1 15251464 (1)
    cancer 0 2 18171525 (1)

    Human Genome Epidemiology (HuGE) Navigator: TEC (13 documents)

    Export disorders for TEC gene to outside databases

    Publications
    for TEC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEC gene, integrated from 9 sources (see all 185):
    (articles sorted by number of sources associating them with TEC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and analysis of the human Tec protein-tyrosine kinase. (PubMed id 7934162)1, 2, 3, 9 Sato K.... Hirai H. (1994)
    2. SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. (PubMed id 15492005)1, 2, 9 Tomlinson M.G.... Weiss A. (2004)
    3. Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets. (PubMed id 9652744)1, 2, 9 Hamazaki Y....Nagasawa T. (1998)
    4. Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte. (PubMed id 19883687)1, 2, 9 Susaki K....Ishida T. (2010)
    5. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. (PubMed id 10518561)1, 2, 9 Ohya K.... Mano H. (1999)
    6. Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets. (PubMed id 9299487)1, 2, 9 Laffargue M....Chap H. (1997)
    7. Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. (PubMed id 7526158)1, 2, 9 Tang B....Ihle J.N. (1994)
    8. Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. (PubMed id 12573241)1, 2, 9 Nore B.F....Smith C.I. (2003)
    9. Tec-kinase-mediated phosphorylation of fibroblast gro wth factor 2 is essential for unconventional secretion. (PubMed id 20230531)1, 2 Ebert A.D....Nickel W. (2010)
    10. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)

    External Searches for TEC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TEC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7006 HGNC: 11719 AceView: TEC Ensembl:ENSG00000135605 euGenes: HUgn7006
    ECgene: TEC Kegg: 7006 H-InvDB: TEC

    Other Databases showing TEC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TEC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TEC Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TEC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TEC gene:
    Search GeneIP for patents involving TEC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TEC gene

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    About This Section

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