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RET Gene

protein-coding   GIFtS: 77
GCID: GC10P043572

Ret Proto-Oncogene

(Previous names: multiple endocrine neoplasia and medullary thyroid carcinoma...)
(Previous symbols: HSCR1, MEN2A, MTC1, MEN2B)
  See RET-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ret Proto-Oncogene1 2     RET512 3
HSCR11 2 5     EC 2.7.10.13 8
MEN2A1 2 5     Hirschsprung Disease 11
MEN2B1 2     Multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 11
MTC11 2     RET-ELE12
Cadherin-Related Family Member 161 2     Hydroxyaryl-Protein Kinase2
Cadherin Family Member 122 3     Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret2
Proto-Oncogene C-Ret2 3     Receptor Tyrosine Kinase2
CDHF122 3     Ret Proto-Oncogene (Multiple Endocrine Neoplasia And Medullary Thyroid
Carcinoma 1, Hirschsprung Disease)2
CDHR162 3     RET Transforming Sequence2
PTC2 3     EC 2.7.108

External Ids:    HGNC: 99671   Entrez Gene: 59792   Ensembl: ENSG000001657317   OMIM: 1647615   UniProtKB: P079493   

Export aliases for RET gene to outside databases

Previous GC identifers: GC10P042861 GC10P043040 GC10P043347 GC10P042856 GC10P042892 GC10P040098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RET Gene:
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are
cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role
in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic
rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA,
multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript
variants encoding different isoforms have been found for this gene. Additional transcript variants have been
described but their biological validity has not been confirmed. (provided by RefSeq, Jul 2008)

GeneCards Summary for RET Gene:
RET (ret proto-oncogene) is a protein-coding gene. Diseases associated with RET include multiple endocrine neoplasia, and multiple endocrine neoplasia type 2a. GO annotations related to this gene include protein tyrosine kinase activity and calcium ion binding. An important paralog of this gene is FLT4.

UniProtKB/Swiss-Prot: RET_HUMAN, P07949
Function: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation,
neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic
factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional
information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the
development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation
of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell
adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g.
ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of
ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a
dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and
down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor
survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several
diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell
migration

Gene Wiki entry for RET (RET proto-oncogene) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RET gene promoter:
         NF-1   NF-1/L   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRET promoter sequence
   Search Chromatin IP Primers for RET

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RET


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q11.2   Ensembl cytogenetic band:  10q11.21   HGNC cytogenetic band: 10q11.2

RET Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RET gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P043572:  view genomic region     (about GC identifiers)

Start:
43,572,475 bp from pter      End:
43,625,799 bp from pter
Size:
53,325 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RET_HUMAN, P07949 (See protein sequence)
Recommended Name: Proto-oncogene tyrosine-protein kinase receptor Ret precursor  
Size: 1114 amino acids; 124319 Da
Subunit: Phosphorylated form interacts with the PBT domain of DOK2, DOK4 and DOK5. The phosphorylated form
interacts with PLCG1 and GRB7. Interacts (not phosphorylated) with CC PTK2/FAK1 (via FERM domain). Extracellular
cell-membrane anchored RET cadherin fragments form complex in neurons with reduced trophic status, preferentially
at the contact sites between somas. Interacts with AIP in the pituitary gland; this interaction prevents the
formation of the AIP-survivin complex. Binds to ARTN. Interacts (inactive) with CBLC and CD2AP; dissociates upon
activation by GDNF which increases CBLC:CD2AP interaction
Miscellaneous: Treatment with withaferin A (WA) leads tumor regression in medullary thyroid carcinomas (MTC)
Sequence caution: Sequence=AAA36524.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAA36786.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA33787.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAC14882.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for RET (see all 9):
1XPD (3D)        2IVS (3D)        2IVT (3D)        2IVU (3D)        2IVV (3D)        2X2K (3D)    
Secondary accessions: A8K6Z2 Q15250 Q9BTB0 Q9H4A2
Alternative splicing: 2 isoforms:  P07949-1   P07949-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RET: NX_P07949

Explore proteomics data for RET at MOPED

Post-translational modifications: 

  • Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation. Dephosphorylated by PTPRJ on Tyr-905,
    Tyr-1015 and Tyr-10621
  • Proteolytically cleaved by caspase-3. The soluble RET kinase fragment is able to induce cell death. The
    extracellular cell-membrane anchored RET cadherin fragment accelerates cell adhesion in sympathetic neurons1
  • Glycosylation2 at Asn98, Asn151, Asn199, Asn336, Asn343, Asn361, Asn367, Asn377, Asn394, Asn448,
                                 Asn468, Asn554
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for RET (P07949)
     RDLAARN  VAVKMLK  WMAIESL 


    See RET Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_065681.1  NP_066124.1  

    ENSEMBL proteins: 
     ENSP00000347942   ENSP00000419080   ENSP00000344798  

    RET Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant RET Protein
    R&D Systems Recombinant & Natural Proteins for RET
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RET
    OriGene Protein Over-expression Lysate for RET
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RET
    GenScript Custom Purified and Recombinant Proteins Services for RET
    Novus Biologicals RET Proteins
    Novus Biologicals RET Lysates
    Sino Biological Recombinant Protein for RET
    Sino Biological Cell Lysate for RET
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RET

     
    Search eBioscience for Proteins for RET 

    RET Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RET
    R&D Systems Antibodies for RET
    Cell Signaling Technology (CST) Antibodies for RET 
    OriGene Antibodies for RET
    OriGene Custom Antibody Services for RET
    Novus Biologicals RET Antibodies
    Abcam antibodies for RET
    Cloud-Clone Corp. Antibodies for RET
    ThermoFisher Antibody for RET
    LSBio Antibodies in human, mouse, rat for RET

    RET Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RET
    R&D Systems ELISAs for RET         (see all)
    GenScript RET-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for RET
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RET
    Cloud-Clone Corp. CLIAs for RET
    Search eBioscience for ELISAs for RET 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDHR: Cadherins / Cadherin-related

    IUPHAR Guide to PHARMACOLOGY protein family classification: ret proto-oncogene
    Ret family

    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR015919 Cadherin-like
     IPR000719 Prot_kinase_dom
     IPR016249 Tyr_kinase_Ret_rcpt

    Graphical View of Domain Structure for InterPro Entry P07949

    ProtoNet protein and cluster: P07949

    2 Blocks protein domains:
    IPB002126 Cadherin
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: RET_HUMAN, P07949
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family
    Similarity: Contains 1 cadherin domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with RET           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RET_HUMAN, P07949
    Function: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation,
    neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic
    factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional
    information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the
    development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation
    of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell
    adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g.
    ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of
    ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a
    dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and
    down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor
    survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several
    diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell
    migration
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Repressed by 4-(3-hydroxyanilino)-quinolines derivatives, indolin-2-one-derivatives,
    2-(alkylsulfanyl)-4-(3-thienyl) nicotinonitrile analogs, 3- and 4-substituted beta-carbolin-1-ones, vandetanib,
    motesanib, sorafenib (BAY 43-9006), cabozantinib (XL184), sunitinib, and withaferin A (WA). Inactivation by
    sorafenib both reduces kinase activity and promotes lysosomal degradation
    Induction: Positively regulated by NKX2-1, PHOX2B, SOX10 and PAX3

         Genatlas biochemistry entry for RET:
    glial cell line derived neurotrophic factor (GDNF) receptor component,homodimerizing and binding the GDNF-GFRA
    complex,expressed in the developing kidney,the presumptive enteric neuroblats,cranial ganglia (VII,VIII,IX and X)
    and in the presumptive motor neurons of the spinal cord,interacting with SHC1 transduction adaptor
    protein,potentially involved in peripheral nerve repair

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS7824936
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0004872receptor activity TAS7824936
    GO:0005509calcium ion binding IDA11445581
         
    Find genes that share ontologies with RET           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RET:
     Increased colony dispersion (i  Increased mitotic index 

         Selected MGI mutant phenotypes (inferred from 43 alleles(MGI details for Ret) (see all 20):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  muscle  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with RET           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RET: Rettm1.1Ddg Rettm1Cos Rettm1.1Kln Rettm1.2Pern Rettm6.2Vpa Rettm13.1Jmi

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RET
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RET

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RET
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RET

    miRNA
    Products:
        
    miRTarBase miRNAs that target RET:
    hsa-mir-192-5p (MIRT026714), hsa-mir-215-5p (MIRT024374), hsa-mir-29a-3p (MIRT005908), hsa-mir-31-5p (MIRT004969)

    Block miRNA regulation of human, mouse, rat RET using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RET (see all 37):
    hsa-miR-136 hsa-miR-128 hsa-miR-449a hsa-miR-218 hsa-miR-570 hsa-miR-23a hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidRET 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RET
    Predesigned siRNA for gene silencing in human, mouse, rat RET

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RET

    Clone
    Products:
         
    OriGene clones in human, mouse for RET (see all 13)
    OriGene ORF clones in mouse, rat for RET
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RET (NM_020975)
    Sino Biological Human cDNA Clone for RET
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RET
    Addgene plasmids for RET 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RET
    Browse ESI BIO Cell Lines and PureStem Progenitors for RET 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RET


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RET_HUMAN, P07949: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytoskeleton2
    extracellular2
    nucleus2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IDA19823924
    GO:0010008endosome membrane IDA19823924
    GO:0016020membrane ----
    GO:0043235receptor complex IDA--
    GO:0045121membrane raft IEA--

    Find genes that share ontologies with RET           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RET About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Development EGFR signaling pathway
    Development GDNF family signaling0.45
    2Sorafenib Pharmacodynamics
    Sorafenib Pharmacodynamics0.37
    3Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors
    4Thyroid cancer
    Thyroid cancer
    5Signaling events regulated by Ret tyrosine kinase
    Signaling events regulated by Ret tyrosine kinase


    Find genes that share SuperPaths with RET           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for RET
        Neuroscience
    Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for RET
        G-protein signaling H-RAS regulation pathway
    Development GDNF family signaling

    2 BioSystems Pathways for RET
        SIDS Susceptibility Pathways
    Signaling events regulated by Ret tyrosine kinase


    1 PharmGKB Pathway for RET
        Sorafenib Pharmacodynamics

    3 Kegg Pathways  (Kegg details for RET):
        Endocytosis
    Pathways in cancer
    Thyroid cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including RET: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RET

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RET (P079491, 2, 3 ENSP000003479424) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHC1P293532, 3, ENSP000004013034MINT-60981 I2D: score=5 STRING: ENSP00000401303
    PLCG1P191742, 3, ENSP000002440074MINT-8034153 I2D: score=4 STRING: ENSP00000244007
    CBLP226812, 3, ENSP000002640334MINT-50071 MINT-60976 MINT-60969 MINT-50072 MINT-60970 MINT-60968 I2D: score=3 STRING: ENSP00000264033
    STAT3P407632, 3, ENSP000002646574MINT-8033149 MINT-8037607 I2D: score=3 STRING: ENSP00000264657
    FAUP355442, 3, ENSP000002792594MINT-60966 MINT-60965 I2D: score=2 STRING: ENSP00000279259
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEA--
    GO:0001657ureteric bud development IEA--
    GO:0001755neural crest cell migration IEA--
    GO:0001838embryonic epithelial tube formation IEA--
    GO:0006468protein phosphorylation TAS7824936

    Find genes that share ontologies with RET           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for RET
    4 ApexBio Compounds for RET     About this table
    CompoundAction CAS #
    Amuvatinib (MP-470, HPK 56)Multi-kinase inhibitor, inhibits PDGFR, c-Kit, and Flt3[850879-09-3]
    Danusertib (PHA-739358)Pan-aurora kinase inhibitor[827318-97-8]
    Regorafenibmultikinase inhibitor of c-KIT, VEGFR2, B-Raf[755037-03-7]
    TG101209JAK2 and 3 inhibitor, also inhibits Flt3 and RET[936091-14-4]

    Browse Tocris compounds for RET

    2 HMDB Compounds for RET    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 DrugBank Compounds for RET    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sorafenib-- 284461-73-0targetinhibitor16507829 17016424 15466206
    1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine-- --target--10592235
    4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE-- --target--10592235
    Cabozantinibcabozantinib s-malate (see all 2)849217-68-1targetantagonist21606412
    Ponatinib -- 943319-70-8targetinhibitor23526464
    Regorafenib-- 755037-03-7targetinhibitor--

    Selected Novoseek inferred chemical compound relationships for RET gene (see all 46)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 83.5 488 7678053 (4), 8363602 (4), 11564708 (4), 8114938 (3) (see all 99)
    zd6474 77.5 25 19029224 (4), 18245671 (3), 20225331 (2), 15867345 (2) (see all 13)
    cysteine 58.5 100 16732321 (3), 20119574 (3), 9097963 (3), 12734540 (2) (see all 67)
    succinate 50.8 22 12419172 (1), 17264467 (1), 18334619 (1), 15988378 (1) (see all 17)
    sunitinib 48.7 9 19887470 (2), 19453268 (1), 17505827 (1), 19188185 (1) (see all 8)
    phosphotyrosine 41.1 7 16847065 (2), 8812115 (1), 10728700 (1), 18756447 (1) (see all 5)
    sodium iodide 32.1 1 17391636 (1)
    threonine 30.6 10 9075701 (4), 7559902 (1), 11356339 (1), 11351254 (1) (see all 7)
    methionine 29.6 6 7559902 (1), 11356339 (1), 11351254 (1), 8884827 (1) (see all 6)
    cipa 29.4 4 8957089 (1), 12652644 (1)

    1 PharmGKB related drug/compound annotation for RET gene    About this table
    Drug/compound PharmGKB Annotation
    vandetanib



    Find genes that share compounds with RET           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RET gene (4 alternative transcripts): 
    NM_020630.4  NM_020975.4  NM_000323.2  NM_020629.2  

    Unigene Cluster for RET:

    Ret proto-oncogene
    Hs.350321  [show with all ESTs]
    Unigene Representative Sequence: NM_020975
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355710(uc001jal.3) ENST00000498820 ENST00000340058(uc001jak.1 uc010qez.1)
    ENST00000479913
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RET using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RET (see all 37):
    hsa-miR-136 hsa-miR-128 hsa-miR-449a hsa-miR-218 hsa-miR-570 hsa-miR-23a hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidRET 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RET
    Predesigned siRNA for gene silencing in human, mouse, rat RET
    Clone
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    OriGene clones in human, mouse for RET (see all 13)
    OriGene ORF clones in mouse, rat for RET
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RET (NM_020975)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RET
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RET
    Addgene plasmids for RET 
    Primer
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    OriGene qPCR primer pairs and template standards for RET
    OriGene qSTAR qPCR primer pairs in human, mouse for RET
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RET
      QuantiTect SYBR Green Assays in human, mouse, rat RET
      QuantiFast Probe-based Assays in human, mouse, rat RET

    Additional mRNA sequence: 

    AB698668.1 AB698669.1 AJ844649.1 AK291807.1 AK294827.1 BC003072.2 BC004257.1 X15262.1 
    Y12528.1 

    9 DOTS entries:

    DT.40222723  DT.121287046  DT.121287035  DT.95362735  DT.97823574  DT.95362738  DT.100783057  DT.100783060 
    DT.100807107 

    Selected AceView cDNA sequences (see all 93):

    H24996 AI204150 NM_020630 AI167534 AL514642 NM_020975 AA716772 BM664772 
    AI263439 BG519723 BF311917 CD630504 CD630494 X15262 AW297789 BQ720918 
    BX353743 BU858188 CD630502 BC004257 CD630498 BX283511 BX387509 AL523813 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RET    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
    SP1:                                                                                                                                            -         
    SP2:                                                                                                                                                      
    SP3:                                                  -     -     -     -     -     -     -     -     -                                                   
    SP4:        -     -     -     -     -     -     -     -                                                                                                   


    ECgene alternative splicing isoforms for RET

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RET expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RET Expression
    About this image


    RET expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Kidney (Urinary System)    fully expand to see all 9 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
             mK3
             Intermediate mesoderm derivatives
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
             Dopaminergic neuron-like cells
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Dopaminergic Neurons (Nervous System)
             Dopaminergic neuron-like cells
    RET Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RET Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.350321
        Pathway & Disease-focused RT2 Profiler PCR Array including RET: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RET
    OriGene qSTAR qPCR primer pairs in human, mouse for RET
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RET
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    QuantiFast Probe-based Assays in human, mouse, rat RET
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RET

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RET gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ret1 , 5 ret proto-oncogene1, 5 82.78(n)1
    83.47(a)1
      6 (55.86 cM)5
    197131  NM_009050.21  NP_033076.21 
     1181517485 
    chicken
    (Gallus gallus)
    Aves RET1 ret proto-oncogene 66.44(n)
    67.5(a)
      396107  NM_205190.1  NP_990521.1 
    lizard
    (Anolis carolinensis)
    Reptilia RET6
    ret proto-oncogene
    60(a)
    1 ↔ 1
    GL343233.1(583056-678251)
    African clawed frog
    (Xenopus laevis)
    Amphibia ret-A2 ret proto-oncogene 75.55(n)    AF286643.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ret12 receptor tyrosine kinase 77.47(n)   30512  AF007949.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tor3 eggshell pattern formation
    transmembrane receptor more
    49(a)
    (best of 2)
      43E12   --


    ENSEMBL Gene Tree for RET (if available)
    TreeFam Gene Tree for RET (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RET gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  KIT2  FGFR32  PDGFRA2  KDR2  
    FGFR12  FGFR22  FLT32  FLT12  
    Selected SIMAP similar genes for RET using alignment to 14 protein entries:     RET_HUMAN (see all proteins) (see all similar genes):
    CUX1    R11    RET proto-oncogene    ret    urf-ret    RET/PTC2
    CCDC6-RETa    CCDC6-RETc    R12    FLT1    FLT3    FLT4
    NTRK1    ROR1    IGF1R    INSR    NTRK3    ABL1

    Find genes that share paralogs with RET           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    RET_HUMAN, P07949: The Cys-982 polymorphism may be associated with an increased risk for developing Hirschsprung
    disease


    Selected SNPs for RET (see all 1494)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs767646891,2,,4
    CHirschsprung disease 1 (HSCR1)4 other143712918(+) CTTCTC/TGAGGG 4 S L mis10--------
    rs775964241,2,,4
    CHirschsprung disease 1 (HSCR1)4 other143713014(+) GGTGCC/TCAGCT 4 P L mis10--------
    rs1924890111,2,,4
    CCongenital central hypoventilation syndrome (CCHS)4 --43713023(+) CTTCCA/GCCTGG 4 H R mis10--------
    rs767361111,2,,4
    CRenal adysplasia (RADYS)4 pathogenic143715033(+) TGTGCA/CCCAAC 4 T P mis10--------
    rs796615161,2,,4
    CHirschsprung disease 1 (HSCR1)4 other143717453(+) GGACCA/GCGAGC 4 H R mis10--------
    rs777028911,2,,4
    CHirschsprung disease 1 (HSCR1)4 other143718882(+) GAGGCA/GGTACA 4 Q R mis10--------
    rs802365711,2,,4
    CHirschsprung disease 1 (HSCR1)4 other143718933(+) CTTCCA/GGGTGG 4 Q R mis10--------
    rs780984821,2,,4
    CHirschsprung disease 1 (HSCR1)4 other143721582(+) CACTTA/CAACGT 4 L F mis10--------
    rs1837291151,2,,4
    CHirschsprung disease 1 (HSCR1)4 --43721592(+) TGTCGA/GTGCTG 4 M V mis10--------
    rs775582921,2,,4
    CMultiple neoplasia 2A (MEN2A)4 pathogenic143726056(+) GCACCA/C/G/
            
    GCAAC
    8 S R G C mis10--------

    HapMap Linkage Disequilibrium report for RET (43572475 - 43625799 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RET:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522566CNV Loss19592680
    nsv522592CNV Loss19592680
    dgv644n71CNV Loss21882294
    nsv825350CNV Gain20364138
    esv275022CNV Gain+Loss21479260

    Human Gene Mutation Database (HGMD): RET
    Locus Specific Mutation Databases (LSDB): RET

    Selected Site Specific Mutation Identification with PCR Assays for RET (see all 10):
    Cosmic IdAA Change
    966p.C634R
    964p.C630R
    1048p.E632_T636>SS
    21338p.E768D
    977p.A883F
    Selected Site Specific Cancer Mutation PCR Panels containing RET (see all 6):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    Lung and Colon Cancers (Expanded Panel) 384HT
    Thyroid Cancer
    Cancer Comprehensive Panel 384HT
    SeqTarget long-range PCR primers for resequencing RET
    DNA2.0 Custom Variant and Variant Library Synthesis for RET

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 164761   
    OMIM disorders: 171400  155240  162300  209880  171300  191830  142623  
    UniProtKB/Swiss-Prot: RET_HUMAN, P07949
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The disease
    may be caused by mutations affecting the gene represented in this entry
  • Hirschsprung disease 1 (HSCR1) [MIM:142623]: A disorder of neural crest development characterized by
    absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital
    intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting,
    abdominal distention and failure to pass stool, to chronic constipation in the older child. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Medullary thyroid carcinoma (MTC) [MIM:155240]: Rare tumor derived from the C cells of the thyroid. Three
    hereditary forms are known, that are transmitted in an autosomal dominant fashion: (a) multiple neoplasia type 2A
    (MEN2A), (b) multiple neoplasia type IIB (MEN2B) and (c) familial MTC (FMTC), which occurs in 25-30% of MTC cases
    and where MTC is the only clinical manifestation. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Multiple neoplasia 2B (MEN2B) [MIM:162300]: Uncommon inherited cancer syndrome characterized by
    predisposition to MTC and phaeochromocytoma which is associated with marfanoid habitus, mucosal neuromas,
    skeletal and ophthalmic abnormalities, and ganglioneuromas of the intestine tract. Then the disease progresses
    rapidly with the development of metastatic MTC and a pheochromocytome in 50% of cases. Note=The disease is caused
    by mutations affecting the gene represented in this entry
  • Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal
    medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and
    norepinephrine, is hypertension, which may be persistent or intermittent. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry
  • Multiple neoplasia 2A (MEN2A) [MIM:171400]: The most frequent form of medullary thyroid cancer (MTC). It
    is an inherited cancer syndrome characterized by MTC, phaeochromocytoma and/or hyperparathyroidism. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in
    disease pathogenesis. Chromosomal aberrations involving RET have been found in thyroid papillary carcinomas.
    Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene; inversion inv(10)(q11.2;q11.2) generates
    the RET/NCOA4 (PTC3) oncogene; translocation t(10;14)(q11;q32) with GOLGA5 generates the RET/GOLGA5 (PTC5)
    oncogene; translocation t(8;10)(p21.3;q11.2) with PCM1 generates the PCM1/RET fusion; translocation
    t(6;10)(p21.3;q11.2) with RFP generates the Delta RFP/RET oncogene; translocation t(1;10)(p13;q11) with TRIM33
    generates the TRIM33/RET (PTC7) oncogene; translocation t(7;10)(q32;q11) with TRIM24/TIF1 generates the
    TRIM24/RET (PTC6) oncogene. The PTC5 oncogene has been found in 2 cases of PACT in children exposed to
    radioactive fallout after Chernobyl. A chromosomal aberration involving TRIM27/RFP is found in thyroid papillary
    carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta
    TRIM27/RET oncogenes
  • Renal adysplasia (RADYS) [MIM:191830]: Renal agenesis refers to the absence of one (unilateral) or both
    (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases,
    including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe
    obstructive uropathy. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Congenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal
    control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A
    deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal
    responses to hypercapnia and hypoxemia. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • Selected diseases for RET (see all 48):    
    About MalaCards
    multiple endocrine neoplasia    multiple endocrine neoplasia type 2a    familial papillary thyroid carcinoma    hirschsprung's disease
    ret-related pheochromocytoma    ret-related renal adysplasia    renal agenesis    lichen amyloidosis
    ret-related hirschsprung disease    thyroid medullary carcinoma    sipple syndrome    wagenmann-froboese syndrome
    familial medullary thyroid carcinoma    renal hypoplasia, isolated    congenital central hypoventilation syndrome    central hypoventilation syndrome, congenital, with or without hirschsprung disease
    retinitis pigmentosa 33    unilateral renal agenesis    pheochromocytoma, modifier of    renal hypodysplasia/aplasia 1

    12 diseases from the University of Copenhagen DISEASES database for RET:
    Thyroid cancer     Hirschsprung's disease     Autosomal dominant disease     Hyperparathyroidism
    Paraganglioma     Phaeochromocytoma     Hemangioma     Carcinoma
    Renal agenesis     Intestinal obstruction     Adenoma     Parathyroid adenoma

    Find genes that share disorders with RET           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RET gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    men 2a 98.4 707 8849577 (6), 8556060 (6), 9620546 (5), 17573899 (5) (see all 99)
    thyroid carcinoma medullary 98 409 7627269 (5), 7864888 (3), 12694233 (3), 16451770 (3) (see all 99)
    multiple endocrine neoplasia 98 333 8895732 (2), 9067749 (2), 16343738 (2), 11103773 (2) (see all 99)
    thyroid carcinoma, familial medullary 97.6 140 11502806 (3), 14602786 (3), 10323403 (2), 8829625 (2) (see all 99)
    hirschsprung disease 95 341 9824583 (6), 17108762 (4), 11955539 (4), 9384613 (4) (see all 99)
    men 3 94.5 290 11245446 (8), 9620546 (5), 17573899 (5), 1979053 (4) (see all 99)
    thyroid papillary carcinoma 93 251 8626874 (5), 9589668 (4), 17718263 (4), 10337992 (4) (see all 99)
    pheochromocytoma 91.3 299 8912182 (7), 14739491 (7), 10953992 (5), 9761126 (5) (see all 99)
    germ-line mutation 85.7 62 8895732 (2), 19484261 (2), 9179691 (2), 16419493 (2) (see all 53)
    colonic aganglionosis 80.3 9 17640327 (1), 14715928 (1), 7478601 (1), 18081917 (1) (see all 9)

    GeneTests: RET
    GeneReviews: RET
    Genetic Association Database (GAD): RET
    Human Genome Epidemiology (HuGE) Navigator: RET (139 documents)
    Tumor Gene Database (TGDB): RET

    Export disorders for RET gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RET gene, integrated from 10 sources (see all 1626):
    (articles sorted by number of sources associating them with RET)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel case of multiple endocrine neoplasia type 2A associated with two de novo mutations of the RET protooncogene. (PubMed id 10522989)1, 2, 4, 9 Tessitore A.... Colantuoni V. (J. Clin. Endocrinol. Metab. 1999)
    2. Germ-line mutations in nonsyndromic pheochromocytoma. (PubMed id 12000816)1, 2, 4, 9 Neumann H.P.H.... Eng C. (N. Engl. J. Med. 2002)
    3. CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. (PubMed id 18753381)1, 2, 9 Tsui C.C. and Pierchala B.A. (J. Neurosci. 2008)
    4. TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease. (PubMed id 15548547)1, 4, 9 Garcia-Barcelo M....Tam P.K. (Hum. Mol. Genet. 2005)
    5. A complex additive model of inheritance for Hirschsprung disease is supported by both RET mutations and predisposing RET haplotypes. (PubMed id 17108762)1, 4, 9 Ruiz-Ferrer M....Borrego S. (Genet. Med. 2006)
    6. Hirschsprung disease in MEN 2A: increased spectrum of RET exon 10 genotypes and strong genotype-phenotype correlation. (PubMed id 9384613)1, 2, 9 Decker R.A.... Watson P. (Hum. Mol. Genet. 1998)
    7. Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas. (PubMed id 19401695)1, 4, 9 Moura M.M....Leite V. (Br. J. Cancer 2009)
    8. Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study. (PubMed id 18073307)1, 4, 9 Elisei R....Pinchera A. (J. Clin. Endocrinol. Metab. 2008)
    9. RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population. (PubMed id 15240649)1, 4, 9 Elisei R....Pinchera A. (J. Clin. Endocrinol. Metab. 2004)
    10. Identification of RET autophosphorylation sites by mass spectrometry. (PubMed id 14711813)1, 2, 9 Kawamoto Y.... Nakashima I. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5979 HGNC: 9967 AceView: RET Ensembl:ENSG00000165731 euGenes: HUgn5979
    ECgene: RET Kegg: 5979 H-InvDB: RET

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RET Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RET Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=RET[genesymbol]
    MEN2 RET databasehttp://www.arup.utah.edu/database/MEN2/MEN2_welcome.php

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RET gene:
    Search GeneIP for patents involving RET

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     cDNA Clones for RET (Ret)   Proteome Profiler Antibody Arrays for RET (Ret)  
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     OriGene Custom Mass Spec   OriGene clones in human, mouse for RET  
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     OriGene ORF clones in mouse, rat for RET   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
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     Block miRNA regulation of human, mouse, rat RET using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RET
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RET Predesigned siRNA for gene silencing in human, mouse, rat RET
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     PCR Arrays including human, mouse, rat RET Search Chromatin IP Primers for RET
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RET  GeneGlobe Interaction Network for RET
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     GenScript RET-Activity-based Kinase Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for RET
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Antibodies & Assays for RET 

     Search Tocris compounds for RET
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     Search Sino Biological for antibodies, proteins & pathways
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     See all of Abcam's Antibodies, Kits and Proteins for RET
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     SwitchGear 3'UTR luciferase reporter plasmids for RET
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RET
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RET
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      Search eBioscience for proteins for RET
      Search eBioscience for elisas for RET
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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