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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PGD Gene

protein-coding GIFtS: 66
GCID: GC01P010458

phosphogluconate dehydrogenase

Explore 35 diseases affiliated with
PGD via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphogluconate Dehydrogenase¹ ²
EC 1.1.1.44³ ⁸
6-Phosphogluconate Dehydrogenase, Decarboxylating²
6PGD²
PGDH³

External Ids:	HGNC: 8891¹	Entrez Gene: 5226²	Ensembl: ENSG00000142657⁷	OMIM: 172200⁵	UniProtKB: P52209³

Export aliases for PGD gene to outside databases

Previous GC identifers: GC01P010420 GC01P010302 GC01P010068 GC01P010168 GC01P010393 GC01P009613

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PGD:

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme

is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined

deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two

enzymopathies. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: 6PGD_HUMAN, P52209

Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with

concomitant reduction of NADP to NADPH (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_021937.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PGD gene promoter:
Bach1 Sox5 NF-1/L NF-1 HOXA5 NF-AT C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PGD promoter sequence

Search SABiosciences Chromatin IP Primers for PGD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22

PGD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGD gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P010458: view genomic region (about GC identifiers)

Start:	10,458,649 bp from pter	End:	10,480,201 bp from pter
Size:	21,553 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 6PGD_HUMAN, P52209 (See protein sequence)

Recommended Name: 6-phosphogluconate dehydrogenase, decarboxylating

Size: 483 amino acids; 53140 Da

Subunit: Homodimer

Subcellular location: Cytoplasm (By similarity)

3 PDB 3D structures from and Proteopedia for PGD:

2JKV (3D)

4GWG (3D)

4GWK (3D)

Secondary accessions: A8K2Y9 Q9BWD8

Explore the universe of human proteins at neXtProt for PGD: NX_P52209

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P52209

4/22 DME Specific Peptides for PGD (P52209) (see all 22)

IIDGGNS

NWTGHGG

SGGEEGA

LQNLLLD

PGD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002622.2

ENSEMBL proteins:

ENSP00000466358 ENSP00000465311 ENSP00000270776 ENSP00000466156 ENSP00000466574

ENSP00000467362 ENSP00000442285 ENSP00000437822

Reactome Protein details: P52209
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	Uscn Proteins for PGD

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

PGD for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PGD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PGD for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR006115 6PGDH_NADP-bd

IPR008927 6-PGluconate_DH_C-like

IPR006113 6PGDH_decarbox

IPR006184 6PGdom_BS

IPR012284 Fibritin/6PGD_C-extension

Graphical View of Domain Structure for InterPro Entry P52209

ProtoNet protein and cluster: P52209

1 Blocks protein family: IPB006115 6-phosphogluconate dehydrogenase

UniProtKB/Swiss-Prot: 6PGD_HUMAN, P52209

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: 6PGD_HUMAN, P52209

Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with

concomitant reduction of NADP to NADPH (By similarity)

Catalytic activity: 6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH

Genatlas biochemistry entry for PGD:

phosphogluconate dehydrogenase,pentose phosphate pathway

Enzyme Number (IUBMB): EC 1.1.1.44¹ ²

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGD
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		hsa-miR-3673 hsa-miR-206 hsa-miR-145 hsa-miR-613 hsa-miR-1 hsa-miR-3616-3p
		SwitchGear 3'UTR luciferase reporter plasmid: PGD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGD

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	ISS	--
GO:0050661	NADP binding	IEA	--

PGD for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for PGD:

Decreased influenza A virus in

Upregulation of Wnt/beta-caten

Wnt reporter downregulated

Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pgd):

behavior/neurological

other

reproductive system

PGD for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Pentose phosphate pathway (hexose monophosphate shunt)

	Pentose phosphate pathway (hexose monophosphate shunt)	1.00			pentose phosphate pathway	0.67
	Pentose Phosphate Pathway	0.88

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Pentose Phosphate Pathway (Erythrocyte)

Pentose Phosphate Pathway (Erythrocyte)

1.00

pentose phosphate pathway (oxidative branch)

0.60

Pentose phosphate pathway

Pentose phosphate pathway

1.00

Glutathione metabolism

Glutathione metabolism

0.70

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for PGD

	Pentose Phosphate Pathway
	pentose phosphate pathway
	pentose phosphate pathway (oxidative branch)

3 Reactome Pathways for PGD

	Metabolism of carbohydrates
	Pentose phosphate pathway (hexose monophosphate shunt)
	Metabolism

1 PharmGKB Pathway for PGD

Pentose Phosphate Pathway (Erythrocyte)

3 Kegg Pathways (Kegg details for PGD):

	Pentose phosphate pathway
	Glutathione metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: 6PGD_HUMAN, P52209

Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate

(oxidative stage): step 3/3

PGD for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PGD

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/188 Interacting proteins for PGD (P52209^{1, 2, 3} ENSP00000270776⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 188)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=2
HIST1H4B	P62805³	I2D: score=2
HIST1H4C	P62805³	I2D: score=2
HIST1H4D	P62805³	I2D: score=2
HIST1H4E	P62805³	I2D: score=2

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006098	pentose-phosphate shunt	TAS	--
GO:0009051	pentose-phosphate shunt, oxidative branch	IDA	3858849
GO:0019322	pentose biosynthetic process	IEA	--
GO:0019521	D-gluconate metabolic process	IEA	--

PGD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PGD for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PGD

8 HMDB Compounds for PGD About this table

Compound	Synonyms	CAS #	PubMed Ids
6-Phosphogluconic acid	6-Phospho-D-gluconate (see all 9)	921-62-0	--
Angiotensin II	Hypertensin (see all 11)	11128-99-7	--
Carbon dioxide	Carbon oxide (see all 5)	124-38-9	--
D-Ribulose 5-phosphate	D-Ribulose 5-phosphate (see all 5)	4151-19-3	--
Manganese	manganese	7439-96-5	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Phenol	acide carbolique (see all 51)	108-95-2	--

10 DrugBank Compounds for PGD About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
6-Phosphogluconic Acid	--	--	target	--	17139284 17016423 10592235
Nicotinamide 8-Bromo-Adenine Dinucleotide Phosphate	--	--	target	--	17139284 17016423 10592235
Pyrophosphate 2-	--	--	target	--	17139284 17016423 10592235
Dacarbazine	Biocarbazine R (see all 9)	4342-03-4	target	inhibitor	20235752 10592235
Furosemide	Dihydroflumethiazide (see all 12)	54-31-9	enzyme	inhibitor	20235752 10592235
Gadopentetate dimeglumine	--	86050-77-3	target	inhibitor	20235752 10592235
Ketotifen	Ketotifen Fumarate (see all 5)	34580-14-8	target	inhibitor	20235752 10592235
Meloxicam	--	71125-38-7	enzyme	inhibitor	20235752 10592235
Methotrexate	Amethopterin (see all 12)	59-05-2	enzyme	inhibitor	20235752 10592235
Ritodrine	Ritodrina [INN-Spanish] (see all 4)	26652-09-5	enzyme	inhibitor	20235752 10592235

10/42 Novoseek chemical compound relationships for PGD gene (see all 42) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
6-phosphogluconate	98.6	214	8790979 (4), 15544466 (3), 9839447 (3), 15374447 (3) (see all 99)
glucose 6-phosphate	87.8	92	8790979 (3), 8955144 (2), 1637668 (2), 2127144 (2) (see all 64)
6-phosphogluconolactone	80	2	8948658 (1)
ribulose 5-phosphate	73.2	7	15553090 (1), 16459157 (1), 8448161 (1)
6-aminonicotinamide	70.5	4	9307279 (1), 8626749 (1), 8687139 (1)
nadph	64.1	11	2109668 (1), 8955144 (1), 17570834 (1), 20127344 (1) (see all 10)
isocitrate	62.4	7	8825442 (1), 1680129 (1), 1471744 (1), 1868063 (1) (see all 6)
malate	60.6	11	9041338 (1), 20127344 (1), 8825442 (1), 18817779 (1) (see all 7)
glyceraldehyde 3-phosphate	56.7	11	9839447 (3), 1471744 (1), 10772695 (1), 1868063 (1) (see all 7)
3alpha-hydroxysteroid	56.3	2	2009030 (1), 7504419 (1)

Search CenterWatch for drugs/clinical trials and news about PGD / 6PGD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PGD gene:

NM_002631.2

Unigene Cluster for PGD:

Phosphogluconate dehydrogenase

Hs.464071 [show with all ESTs]

Unigene Representative Sequence: AK298830

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000491493 ENST00000487775 ENST00000477958 ENST00000270776(uc001arc.3 uc010oak.2)

ENST00000483936 ENST00000465632 ENST00000460189 ENST00000493288 ENST00000498356

ENST00000496718 ENST00000541529 ENST00000538557

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Additional cDNA sequence:

AK290404.1 AK296889.1 AK298830.1 AK300952.1 AK303898.1 AK304423.1 BC000368.2 U30255.1

24/40 DOTS entries (see all 40):

DT.455224 DT.100837729 DT.121327365 DT.100871675 DT.100871676 DT.95073844 DT.97860666 DT.100871664

DT.121327267 DT.100871666 DT.102838651 DT.121327407 DT.99930494 DT.121327373 DT.121327501 DT.100038769

DT.121327357 DT.95073873 DT.121327313 DT.121327406 DT.92459694 DT.95073847 DT.100769693 DT.121327476

24/1030 AceView cDNA sequences (see all 1030):

AA406591 BF733003 AJ713924 BQ278688 AA406610 BU165102 AI423381 BM669751

BE294458 N46014 AW514113 BG034019 BU681453 AI417610 BM741938 AI280543

CR604306 BF939474 BE740446 BM768927 BQ926678 CD653380 AU107207 BQ775688

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PGD (see all 13) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^
SP1:													-								-
SP2:																					-						-		-
SP3:													-
SP4:													-								-				-		-
SP5:																					-				-		-

ExUns:	11a	·	11b	·	11c	^	12	^	13a	·	13b	·	13c	^	14a	·	14b
SP1:	-								-				-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PGD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PGD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGCTGAATT

About this image
See PGD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PGD

SOURCE GeneReport for Unigene cluster: Hs.464071

SABiosciences Custom PCR Arrays for PGD

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for PGD gene from 11/45 species (see all 45) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pgd^{1 , 5}	phosphogluconate dehydrogenase^{1, 5}	87.85(n)¹ 94(a)¹		4 (78.96 cM)⁵ 110208¹ NM_001081274.1¹ NP_001074743.1¹ 149149991⁵
chicken (Gallus gallus)	Aves	PGD¹	phosphogluconate dehydrogenase	80.43(n) 90.04(a)		419450 NM_001006303.1 NP_001006303.1
lizard (Anolis carolinensis)	Reptilia	PGD⁶	--	89(a)	1 ↔ 1	GL343565.1(343338-361981)
African clawed frog (Xenopus laevis)	Amphibia	MGC68486²	hypothetical protein MGC68486	76.18(n)		BC059958.1
zebrafish (Danio rerio)	Actinopterygii	Dr.6619²	Danio rerio similar to phosphogluconate dehydrogenase, more	76.94(n)		AY391449.1
fruit fly (Drosophila melanogaster)	Insecta	Pgd^{1 , 3}	pentose-phosphate shunt phosphogluconate dehydrogenase more³ Phosphogluconate dehydrogenase¹	71(a)³ 67.22(n)¹ 72.38(a)¹		2D4³ 31185¹ NM_057512.3¹ NP_476860.2¹
worm (Caenorhabditis elegans)	Secernentea	T25B9.9¹	Protein T25B9.9	63.62(n) 69.92(a)		177971 NM_069597.4 NP_501998.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GND1(YHR183W)⁴ GND1¹	6-phosphogluconate dehydrogenase (decarboxylating), more⁴ Gnd1p¹	62.28(n)¹ 66.6(a)¹		8(470960-472429)⁴ 856589^{1, 4} NP_012053.3¹ NP_012053.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G02360⁶ AT1G64190⁶ (see all 3)	6-phosphogluconate dehydrogenase (see all 3)	47(a) 47(a) (see all 3)	possible ortholog possible ortholog (see all 3)	3(481898-484147) 1(23825328-23827136)
rice (Oryza sativa)	Liliopsida	AK065920.1²	--	78.06(n)		AK065920.1

ENSEMBL Gene Tree for PGD (if available)
TreeFam Gene Tree for PGD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PGD gene

PGD for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for PGD
PGOHUM00000239859 PGOHUM00000235036

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80345587^1,2	C,F,	--	10457121(+)	`CATTAA/GTGGAA`	1	--	us2k¹		1		NA	120
rs138223641^1,2		--	10457179(+)	`GATGAA/GCCTCA`	1	--	us2k¹		0	--	--	--	--
rs57902453^1,2		--	10457451(+)	`TGACAT/CGTAAA`	1	--	us2k¹		2		CSA WA	120
rs77173593^1,2	F,	--	10457496(+)	`TGTGCT/GGTGAA`	1	--	us2k¹		1		NA	120
rs61166775^1,2	F,	--	10457529(+)	`ATGTCT/GTAGCC`	1	--	us2k¹		1		WA	118
rs12409754^1,2	C,F,A,H,	--	10457540(+)	`GGGCAT/CGGTGT`	1	--	us2k¹		21		NS EA NA WA CSA	2348
rs143603673^1,2		--	10457575(+)	`CAGGAA/GGTTGA`	1	--	us2k¹		0	--	--	--	--
rs183993405^1,2		--	10457673(+)	`GACCTA/GGTCTT`	1	--	us2k¹		0	--	--	--	--
rs12410706^1,2	H	--	10457741(+)	`gggagA/Gctgag`	1	--	us2k¹		0	--	--	--	--
rs12409782^1,2	H	--	10457752(+)	`gtgggA/Tggatc`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PGD (10458649 - 10480201 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PGD
2 CNVs: 30366 3281
Human Gene Mutation Database (HGMD): PGD

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PGD

DNA2.0 Custom Variant and Variant Library Synthesis for PGD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PGD for disorders           About GeneDecksing

OMIM gene information: 172200    OMIM disorders: --

20/35 diseases for PGD (see all 35):    About MalaCards

glucosephosphate dehydrogenase deficiency cervical intraepithelial neoplasia visceral leishmaniasis leishmaniasis

sleeping sickness alcoholic liver cirrhosis liver cirrhosis cutaneous leishmaniasis

rheumatic fever hemolytic anemia hyperlipoproteinemia trypanosomiasis

urethritis bipolar disorder myelodysplastic syndrome anemia

hepatitis b alcoholism hepatocellular carcinoma cervicitis

8 Novoseek disease relationships for PGD gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
enzymopathy	65.5	2	11233775 (1)
leishmaniasis cutaneous	57.6	1	9574789 (1)
g6pd deficiency	43.2	3	11233775 (2)
trypanosomiasis african	38.2	1	17615587 (1)
leishmaniasis visceral	13.2	1	2149740 (1)
tumors	2.26	2	8955144 (1), 18665625 (1)
anemia	0	1	11233775 (1)
carcinoma	0	1	2064345 (1)

Human Genome Epidemiology (HuGE) Navigator: PGD (11 documents)

Export disorders for PGD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PGD gene, integrated from 9 sources (see all 213):
(articles sorted by number of sources associating them with PGD)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a cDNA encoding 6-phosphogluconate dehydrogenase from a human heart cDNA library. (PubMed id 8978909)^{1, 2, 9} Tsui S.K.W.... Lee C.-Y. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species. (PubMed id 9920387)^{1, 9} Rippa M....Hanau S. (1998)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Glycolytic cancer cells lacking 6-phosphogluconate deh ydrogenase metabolize glucose to induce senescence. (PubMed id 22677172)¹ Sukhatme V.P. and Chan B. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)¹ Martins-de-Souza D....Bahn S. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)¹ Neganova I....Lako M. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5226	HGNC: 8891	AceView: PGDandKIF1B	Ensembl:ENSG00000142657	euGenes: HUgn5226
ECgene: PGD	Kegg: 5226	H-InvDB: PGD

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PGD	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PGD gene
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Patent Information for PGD gene:
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GeneCards and IP:
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