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Aliases for PECR Gene

Aliases for PECR Gene

  • Peroxisomal Trans-2-Enoyl-CoA Reductase 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 29C Member 1 3 4
  • 2,4-Dienoyl-CoA Reductase-Related Protein 3 4
  • EC 1.3.1.38 4 61
  • HPDHASE 3 4
  • SDR29C1 3 4
  • PVI-ARL 3 4
  • DCR-RP 3 4
  • TERP 3 4
  • Short Chain Dehydrogenase/Reductase Family 29C, Member 1 2
  • Putative Short Chain Alcohol Dehydrogenase 3
  • HSA250303 3
  • PVIARL 3
  • DCRRP 3

External Ids for PECR Gene

Previous GeneCards Identifiers for PECR Gene

  • GC02M215065
  • GC02M215627
  • GC02M216867
  • GC02M217105
  • GC02M216728
  • GC02M216611
  • GC02M208760

Summaries for PECR Gene

GeneCards Summary for PECR Gene

PECR (Peroxisomal Trans-2-Enoyl-CoA Reductase) is a Protein Coding gene. Among its related pathways are Peroxisome and Fatty acid metabolism. GO annotations related to this gene include receptor binding and coenzyme binding. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for PECR Gene

  • Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.

Gene Wiki entry for PECR Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PECR Gene

Genomics for PECR Gene

Regulatory Elements for PECR Gene

Enhancers for PECR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G216000 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13 +80.7 80713 2.7 HDGF SUZ12 WRNIP1 YBX1 EBF1 ZIC2 RELA ZKSCAN1 ARID3A POLR2A PECR TMEM169 XRCC5 MREG GC02M216014 ENSG00000226276
GH02G216031 1.1 ENCODE dbSUPER 16.8 +50.7 50729 1.2 TBP PKNOX1 TBL1XR1 BACH1 RELA ARID3A ZNF366 FOS RELB ETV6 PECR XRCC5 TMEM169 MREG GC02M216014
GH02G216186 1.2 Ensembl ENCODE 10.2 -105.5 -105515 3.0 FOXA2 YY1 TCF12 ZNF766 GATA2 FOS NCOA1 ZNF592 MEF2D SMARCA4 XRCC5 ENSG00000231092 TMEM169 PECR ENSG00000241520 LOC100421349 ENSG00000279348
GH02G216144 0.8 dbSUPER 15.3 -63.3 -63306 4.5 ELF3 FOXA2 RAD21 YY1 CEBPB MAFF ATF4 CEBPA ZBTB33 HNF4A LINC01963 PECR XRCC5 TMEM169 ENSG00000231092 POLHP1 PIR31186
GH02G216015 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.6 +66.4 66377 2.6 HDGF PKNOX1 SIN3A YY1 TCF12 FOS NCOA1 JUNB REST ZNF592 XRCC5 LINC01963 PECR GC02M216014 ENSG00000226276
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PECR on UCSC Golden Path with GeneCards custom track

Promoters for PECR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000130001 116 1401 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF48

Genomic Location for PECR Gene

Chromosome:
2
Start:
215,996,329 bp from pter
End:
216,082,955 bp from pter
Size:
86,627 bases
Orientation:
Minus strand

Genomic View for PECR Gene

Genes around PECR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PECR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PECR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PECR Gene

Proteins for PECR Gene

  • Protein details for PECR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY49-PECR_HUMAN
    Recommended name:
    Peroxisomal trans-2-enoyl-CoA reductase
    Protein Accession:
    Q9BY49
    Secondary Accessions:
    • B2RE42
    • Q53TC4
    • Q6IAK9
    • Q9NRD4
    • Q9NY60
    • Q9P1A4

    Protein attributes for PECR Gene

    Size:
    303 amino acids
    Molecular mass:
    32544 Da
    Quaternary structure:
    • Interacts with PEX5, probably required to target it into peroxisomes.
    SequenceCaution:
    • Sequence=AAF69798.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PECR Gene

    Alternative splice isoforms for PECR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PECR Gene

Selected DME Specific Peptides for PECR Gene

Q9BY49:
  • FLVNNGGGQF
  • PDHDNWP

Post-translational modifications for PECR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PECR Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PECR Gene

Gene Families for PECR Gene

Suggested Antigen Peptide Sequences for PECR Gene

Graphical View of Domain Structure for InterPro Entry

Q9BY49

UniProtKB/Swiss-Prot:

PECR_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with PECR: view

Function for PECR Gene

Molecular function for PECR Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function:
Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.
UniProtKB/Swiss-Prot Induction:
Not induced by IR.

Enzyme Numbers (IUBMB) for PECR Gene

Gene Ontology (GO) - Molecular Function for PECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 11669066
GO:0008670 NOT 2,4-dienoyl-CoA reductase (NADPH) activity IDA 11669066
GO:0016491 oxidoreductase activity IEA --
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity EXP,IDA 16546181
genes like me logo Genes that share ontologies with PECR: view
genes like me logo Genes that share phenotypes with PECR: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PECR

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PECR Gene

Localization for PECR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PECR Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PECR gene
Compartment Confidence
peroxisome 5
mitochondrion 3
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA,IDA 11669066
GO:0005778 peroxisomal membrane TAS --
genes like me logo Genes that share ontologies with PECR: view

Pathways & Interactions for PECR Gene

genes like me logo Genes that share pathways with PECR: view

UniProtKB/Swiss-Prot Q9BY49-PECR_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for PECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001561 fatty acid alpha-oxidation TAS --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0033306 phytol metabolic process IDA 16546181
genes like me logo Genes that share ontologies with PECR: view

No data available for SIGNOR curated interactions for PECR Gene

Drugs & Compounds for PECR Gene

(3) Drugs for PECR Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenine Approved Nutra Target 0
myristoyl-coa Experimental Pharma 0
Propionyl-CoA Experimental Pharma 0

(34) Additional Compounds for PECR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with PECR: view

Transcripts for PECR Gene

Unigene Clusters for PECR Gene

Peroxisomal trans-2-enoyl-CoA reductase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PECR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for PECR Gene

GeneLoc Exon Structure for
PECR
ECgene alternative splicing isoforms for
PECR

Expression for PECR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PECR Gene

mRNA differential expression in normal tissues according to GTEx for PECR Gene

This gene is overexpressed in Liver (x9.8).

Protein differential expression in normal tissues from HIPED for PECR Gene

This gene is overexpressed in Liver (27.2), Fetal Liver (13.4), and Nasopharynx (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PECR Gene



NURSA nuclear receptor signaling pathways regulating expression of PECR Gene:

PECR

SOURCE GeneReport for Unigene cluster for PECR Gene:

Hs.281680

Evidence on tissue expression from TISSUES for PECR Gene

  • Liver(4.5)
  • Intestine(4.4)
  • Gall bladder(2.1)
  • Lung(2.1)
  • Thyroid gland(2.1)
  • Kidney(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with PECR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PECR Gene

Orthologs for PECR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PECR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PECR 34 35
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia PECR 34 35
  • 81.84 (n)
dog
(Canis familiaris)
Mammalia PECR 34 35
  • 81.41 (n)
mouse
(Mus musculus)
Mammalia Pecr 34 16 35
  • 77.34 (n)
rat
(Rattus norvegicus)
Mammalia Pecr 34
  • 77.12 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PECR 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PECR 34 35
  • 65.22 (n)
lizard
(Anolis carolinensis)
Reptilia PECR 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pecr 34
  • 62.17 (n)
zebrafish
(Danio rerio)
Actinopterygii pecr 34 35
  • 60.73 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14009 34
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15521g 34
  • 46.52 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPS19 35
  • 32 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os11g0443700 34
  • 49.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2168 34
Species where no ortholog for PECR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PECR Gene

ENSEMBL:
Gene Tree for PECR (if available)
TreeFam:
Gene Tree for PECR (if available)

Paralogs for PECR Gene

(7) SIMAP similar genes for PECR Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PECR: view

Variants for PECR Gene

Sequence variations from dbSNP and Humsavar for PECR Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000016210 -- 216,037,689(+) CACCT(A/C)ATTAG intron-variant
rs1000047597 -- 216,036,222(+) TTGAA(C/T)AACCA intron-variant
rs1000060809 -- 216,060,430(+) GTCAA(A/G)GTGAG intron-variant
rs1000201554 -- 216,053,809(+) AATCT(C/T)TAGCT intron-variant
rs1000365963 -- 216,047,934(+) GTTTT(G/T)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PECR Gene

Variant ID Type Subtype PubMed ID
esv2658029 CNV deletion 23128226
esv3594289 CNV loss 21293372
nsv1011506 CNV gain 25217958
nsv998837 CNV gain 25217958

Variation tolerance for PECR Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.22; 76.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PECR Gene

Human Gene Mutation Database (HGMD)
PECR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PECR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PECR Gene

Disorders for PECR Gene

Relevant External Links for PECR

Genetic Association Database (GAD)
PECR
Human Genome Epidemiology (HuGE) Navigator
PECR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PECR

No disorders were found for PECR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PECR Gene

Publications for PECR Gene

  1. Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element. (PMID: 11937624) Braastad C.D. … Hendrickson E.A. (Nucleic Acids Res. 2002) 3 4 22 64
  2. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. (PMID: 11669066) Amery L. … Fransen M. (Comb. Chem. High Throughput Screen. 2001) 2 3 4 64
  3. Molecular cloning and expression of mammalian peroxisomal trans-2- enoyl-coenzyme A reductase cDNAs. (PMID: 10811639) Das A.K. … Hajra A.K. (J. Biol. Chem. 2000) 2 3 4 64
  4. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. (PMID: 20463177) Hersh C.P. … Silverman E.K. (Am. J. Respir. Crit. Care Med. 2010) 3 46 64
  5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 64

Products for PECR Gene

Sources for PECR Gene

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