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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NRAS Gene

protein-coding   GIFtS: 71
GCID: GC01M115247

Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog1 2     NRAS12
Transforming Protein N-Ras2 3     GTPase NRas2
ALPS42 5     N-Ras Protein Part 42
NS62 5     V-Ras Neuroblastoma RAS Viral Oncogene Homolog2
N-ras2     HRAS13

External Ids:    HGNC: 79891   Entrez Gene: 48932   Ensembl: ENSG000002132817   OMIM: 1647905   UniProtKB: P011113   

Export aliases for NRAS gene to outside databases

Previous GC identifers: GC01M115662 GC01M114131 GC01M114349 GC01M114548 GC01M114961 GC01M115048 GC01M113105


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NRAS Gene:
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma
membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex.
The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor
and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal
cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile
myelomonocytic leukemia. (provided by RefSeq, Jun 2011)

GeneCards Summary for NRAS Gene: 
NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog) is a protein-coding gene. Diseases associated with NRAS include noonan syndrome 6, and bone marrow cancer, and among its related super-pathways are Glioma and Development Neurotrophin family signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity

Gene Wiki entry for NRAS (Neuroblastoma RAS viral oncogene homolog) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NRAS gene promoter:
         c-Fos   AP-1   ATF-2   STAT3   MyoD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRAS promoter sequence
   Search SABiosciences Chromatin IP Primers for NRAS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRAS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

NRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRAS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M115247:  view genomic region     (about GC identifiers)

Start:
115,247,085 bp from pter      End:
115,259,515 bp from pter
Size:
12,431 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111 (See protein sequence)
Recommended Name: GTPase NRas precursor  
Size: 189 amino acids; 21229 Da
Subunit: Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound
form) with RASSF7
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor.
Note=Shuttles between the plasma membrane and the Golgi apparatus
Miscellaneous: Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells
and are implicated in a variety of human tumors
1 PDB 3D structure from and Proteopedia for NRAS:
3CON (3D)    
Secondary accessions: Q14971 Q15104 Q15282

Explore the universe of human proteins at neXtProt for NRAS: NX_P01111

Explore proteomics data for NRAS at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid
    exchange between plasma membrane and Golgi
  • UniProtKB: Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs) (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01111

  • NRAS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NRAS Protein Expression
    REFSEQ proteins: NP_002515.1  
    ENSEMBL proteins: 
     ENSP00000358548  
    Reactome Protein details: P01111
    Human Recombinant Protein Products for NRAS: 
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    Novus Biologicals NRAS Proteins
    Novus Biologicals NRAS Lysate
    Sino Biological Recombinant Protein for NRAS
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NRAS
    Cloud-Clone Corp. Proteins for NRAS 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    NRAS for ontologies           About GeneDecksing



    NRAS Antibody Products: 
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    ThermoFisher Antibody for NRAS
    LSBio Antibodies in human, mouse, rat for NRAS 

    Assay Products for NRAS: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NRAS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NRAS 
    Cloud-Clone Corp. CLIAs for NRAS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P01111

    ProtoNet protein and cluster: P01111

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RASN_HUMAN, P01111
    Similarity: Belongs to the small GTPase superfamily. Ras family


    NRAS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASN_HUMAN, P01111
    Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
    Enzyme regulation: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a
    guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)

         Genatlas biochemistry entry for NRAS:
    neuroblastoma Ras viral (v-ras) oncogene homolog

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
         
    NRAS for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NRAS:
     Decreased Wnt reporter activit  Decreased focal adhesion (FA)  

         15/16 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Nras) (see all 16):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  no phenotypic analysis  normal  tumorigenesis 

    NRAS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NRAS: Nrastm1Rak Nrastm1Mok

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NRAS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NRAS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NRAS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NRAS 

    miRNA
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    miRTarBase miRNAs that target NRAS:
    hsa-let-7a (MIRT001854), hsa-mir-20a (MIRT003903), hsa-let-7c (MIRT004531), hsa-let-7b (MIRT003836)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NRAS
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate NRAS (see all 81):
    hsa-miR-146a hsa-miR-218-1* hsa-miR-1304 hsa-miR-3150b-3p hsa-miR-510 hsa-miR-3148 hsa-miR-27a hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmidNRAS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    Sino Biological Human cDNA Clone for NRAS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRAS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRAS
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                         Customized lentivirus expression plasmids for stable overexpression of NRAS 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NRAS
    Search LifeMap BioReagents cell lines for NRAS
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRAS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NRAS About   (see all 101)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    2Development HGF signaling pathway
    Development EGFR signaling via small GTPases0.44
    Renal cell carcinoma0.30
    Neurotrophin signaling pathway0.36
    3Sorafenib Pharmacodynamics
    Sorafenib Pharmacodynamics0.37
    VEGF Pathway0.36
    Vemurafenib Pathway, Pharmacodynamics0.37
    4Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    5ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for NRAS
        Development EGFR signaling via small GTPases
    G-protein signaling N-RAS regulation pathway
    Development EPO-induced MAPK pathway
    G-protein signaling Ras family GTPases in kinase cascades (scheme)

    5/109 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NRAS (see all 109)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    CDK5 Pathway

    5 Tocris Bioscience Pathways for NRAS
        Insulin Pathway
    Apoptosis Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    VEGF Pathway

    4 GeneGo (Thomson Reuters) Pathways for NRAS
        Development EPO-induced MAPK pathway
    G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Development EGFR signaling via small GTPases
    G-protein signaling N-RAS regulation pathway

    5/7 BioSystems Pathways for NRAS (see all 7)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    G Protein Signaling Pathways
    Signaling Pathways in Glioblastoma
    Regulation of Actin Cytoskeleton

    2 Sino Biological Pathways for NRAS 
        VEGF Signaling
    TGF-beta Signaling Pathway

    5/67        Reactome Pathways for NRAS (see all 67)
        SHC-related events
    EGFR Transactivation by Gastrin
    p38MAPK events
    SHC-mediated signalling
    IRS-mediated signalling

    5 PharmGKB Pathways for NRAS
        Bisphosphonate Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics
    VEGF Signaling Pathway
    Vemurafenib Pathway, Pharmacodynamics

    5/41         Kegg Pathways  (Kegg details for NRAS) (see all 41):
        MAPK signaling pathway
    ErbB signaling pathway
    Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Axon guidance


    NRAS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NRAS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/168 Interacting proteins for NRAS (P011112, 3 ENSP000003585484) via UniProtKB, MINT, STRING, and/or I2D (see all 168)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCE1Q9P2122, 3, ENSP000002607664MINT-65550 I2D: score=5 STRING: ENSP00000260766
    ENSG00000237825O152113, ENSP000003900984I2D: score=2 STRING: ENSP00000390098
    ENSG00000206282O152113I2D: score=2 
    ENSG00000224841O152113I2D: score=2 
    ENSG00000228736O152113I2D: score=2 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    NRAS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NRAS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NRAS (RASN)

    1 HMDB Compound for NRAS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for NRAS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 16.1 5 18450602 (2), 16467864 (1), 16281072 (1)
    oligonucleotide 0 1 8255093 (1)
    agar 0 1 16462768 (1)

    Search CenterWatch for drugs/clinical trials and news about NRAS / RASN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NRAS gene: 
    NM_002524.4  

    Unigene Cluster for NRAS:

    Neuroblastoma RAS viral (v-ras) oncogene homolog
    Hs.486502  [show with all ESTs]
    Unigene Representative Sequence: NM_002524
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369535(uc009wgu.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NRAS
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate NRAS (see all 81):
    hsa-miR-146a hsa-miR-218-1* hsa-miR-1304 hsa-miR-3150b-3p hsa-miR-510 hsa-miR-3148 hsa-miR-27a hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmidNRAS 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NRAS (NM_002524)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRAS
    Sirion Biotech Customized lentivirus for stable overexpression of NRAS 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRAS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRAS

    Additional mRNA sequence: 

    AF493919.1 AY941100.1 AY941101.1 BC005219.1 BC013214.1 BT019734.1 BT019735.1 X02751.1 

    11 DOTS entries:

    DT.40115049  DT.100693486  DT.100811463  DT.121460043  DT.92360379  DT.100693463  DT.121460084  DT.121460006 
    DT.121459944  DT.91838834  DT.92474389 

    24/1776 AceView cDNA sequences (see all 1776):

    BG284809 AW339347 AW167771 AA665567 BG777513 BM990357 BU687948 AI753417 
    CA395659 BP354478 BP336322 AI092959 BM995247 BQ951518 BU507905 CR598435 
    AI150097 AI754393 BM550780 BU181683 AU123547 BP349129 CB529986 BP343792 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NRAS expression in normal human tissues (normalized intensities)      NRAS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NRAS Expression
    About this image


    NRAS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             brain/midbrain   

    See NRAS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NRAS

    SOURCE GeneReport for Unigene cluster: Hs.486502
        SABiosciences Expression via Pathway-Focused PCR Arrays including NRAS (see all 8): 
              mTOR Signaling in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              VEGF Signaling in human mouse rat
              Liver Cancer in human mouse rat
              Cancer Drug Targets in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRAS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NRAS gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nras1 , 5 neuroblastoma ras oncogene1, 5 91.71(n)1
    99.47(a)1
      3 (45.25 cM)5
    181761  NM_010937.21  NP_035067.21 
     1030583395 
    chicken
    (Gallus gallus)
    Aves NRAS1 neuroblastoma RAS viral (v-ras) oncogene homolog 81.13(n)
    96.83(a)
      419885  NM_001012549.1  NP_001012567.1 
    lizard
    (Anolis carolinensis)
    Reptilia NRAS6
    Uncharacterized protein
    94(a)
    1 ↔ 1
    4(130382670-130387388)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8952 African clawed frog N-ras mRNA, complete cds 79.19(n)    M97960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_131145.12   -- 79.79(n)   30380  NM_131145.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ras85D3 eggshell pattern formation RAS small
    monomeric more
    85(a)   3 85D21   --
    worm
    (Caenorhabditis elegans)
    Secernentea C08F8.73 RAS-related protein 45(a)   IV(11177461-11178071)   --


    ENSEMBL Gene Tree for NRAS (if available)
    TreeFam Gene Tree for NRAS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NRAS gene
    RAP2C2  DIRAS12  RAP1B2  RALA2  RIT22  RAP2A2  RIT12  RALB2  
    RAP1A2  RAP2B2  DIRAS22  KRAS2  HRAS2  DIRAS32  
    18/95 SIMAP similar genes for NRAS using alignment to 2 protein entries:     RASN_HUMAN (see all proteins) (see all similar genes):
    N-ras    c-bas/has    HRAS    KRAS    RALA    RAP1B
    RAP2A    RIT2    RALB    RAP1A    RIT1    RRAS2
    RAB1C    RAP2C    RAB1B    DKFZp547A0616    RAP2B    RRAS

    NRAS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/306 SNPs in NRAS are shown (see all 306)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0211944
    Leukemia4--see VAR_0211942 G C mis40--------
    VAR_0630844
    Autoimmune lymphoproliferative syndrome 4 (ALPS4)4--see VAR_0630842 G D mis40--------
    VAR_0630864
    Noonan syndrome 6 (NS6)4--see VAR_0630862 G E mis40--------
    VAR_0630854
    Noonan syndrome 6 (NS6)4--see VAR_0630852 T I mis40--------
    VAR_0068454
    Colorectal cancer4--see VAR_0068452 G R mis40--------
    rs115542901,2,4
    C,F,HLung carcinoma cell4 pathogenic1115325486(-) TGGACA/C/G/
            
    AGAAG
    4 Q P R L mis16NS EA NA 408
    rs1214345961,2
    Cpathogenic1115327701(-) AGGTGA/C/G/
            
    TGTTG
    4 D A G V mis10--------
    rs1219132371,2
    Cpathogenic1115327704(-) AGCAGA/C/G/
            
    TGGTG
    4 D A G V mis10--------
    rs1219132541,2
    Cuntested1115325487(-) CTGGAA/C/GAAGAA 3 K Q E mis10--------
    rs1219132481,2
    Cuntested1115327687(-) AAAGCA/C/GCACTG 2 T A mis10--------

    HapMap Linkage Disequilibrium report for NRAS (115247085 - 115259515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NRAS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv28734CNV Loss19812545


    Human Gene Mutation Database (HGMD): NRAS
    5/19 SABiosciences Cancer Mutation PCR Assays for NRAS (see all 19):
    Cosmic IdAA Change
    581p.Q61E
    577p.A18T
    570p.G13C
    583p.Q61L
    575p.G13A
    5/32 SABiosciences Cancer Mutation PCR Arrays containing NRAS (see all 32):
    Breast Cancer
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    Liver Cancer
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing NRAS:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing NRAS
    DNA2.0 Custom Variant and Variant Library Synthesis for NRAS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164790   
    OMIM disorders: 114500  188470  613224  
    UniProtKB/Swiss-Prot: RASN_HUMAN, P01111
  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic
    syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell
    compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes,
    rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Noonan syndrome 6 (NS6) [MIM:613224]: A syndrome characterized by facial dysmorphic features such as
    hypertelorism, a downward eyeslant and low-set posteriorly rotated ears. Other features can include short
    stature, a short neck with webbing or redundancy of skin, cardiac anomalies, deafness, motor delay and variable
    intellectual deficits. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Autoimmune lymphoproliferative syndrome 4 (ALPS4) [MIM:614470]: A disorder of apoptosis, characterized by
    chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the
    development of hematologic malignancies. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • 20/73 diseases for NRAS (see all 73):    About MalaCards
    noonan syndrome 6    bone marrow cancer    nras-related noonan syndrome    juvenile myelomonocytic leukemia
    spitz nevus    noonan syndrome    thyroid cancer    chronic myelomonocytic leukemia
    autoimmune lymphoproliferative syndrome    skin melanoma    ocular melanoma    cystic teratoma
    myelodysplastic syndromes    autoimmune pancreatitis    paroxysmal nocturnal hemoglobinuria    plasma cell leukemia
    systemic mastocytosis    hemoglobinuria    papillary thyroid carcinoma    mastocytosis

    17 diseases from the University of Copenhagen DISEASES database for NRAS:
    Colorectal cancer     Carcinoma     Lung cancer     Pancreatic cancer
    Adenoma     Melanoma     Noonan syndrome     Leukemia
    Pancreatitis     Endometrial cancer     Gallbladder cancer     Familial adenomatous polyposis
    Exanthem     Lynch syndrome     Ovarian cancer     Bone marrow cancer
    Cholangiocarcinoma

    NRAS for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for NRAS gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    juvenile myelomonocytic leukemia 84.9 1 20471511 (1)
    melanoma 77.3 114 15917418 (5), 18227705 (5), 18375819 (4), 19509136 (4) (see all 41)
    preleukemia 73 1 7949098 (1)
    somatic mutations 65.4 6 15188009 (1), 10216104 (1), 20096196 (1), 17507627 (1) (see all 6)
    myelodysplastic syndromes 64.7 4 15257941 (2), 15474158 (1), 9379676 (1)
    nevi 61.6 8 16845322 (2), 17518771 (1), 17507627 (1)
    leukemogenesis 59.3 1 9680114 (1)
    nevi melanocytic 55 2 16845322 (1), 15009714 (1)
    uveal melanoma 53.3 1 14522897 (1)
    metastatic melanoma 51.6 2 14695152 (1), 17518771 (1)

    Genetic Association Database (GAD): NRAS
    Human Genome Epidemiology (HuGE) Navigator: NRAS (62 documents)
    Tumor Gene Database (TGDB): NRAS

    Export disorders for NRAS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NRAS gene, integrated from 9 sources (see all 329):
    (articles sorted by number of sources associating them with NRAS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. (PubMed id 16098042)1, 4, 9 Akslen L.A....Kumar R. (2005)
    2. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. (PubMed id 18450602)1, 4, 9 Schlenk R.F....Dohner H. (2008)
    3. Deletion at chromosome arm 9p in relation to BRAF/NRA S mutations and prognostic significance for primary melanoma. (PubMed id 20140953)1, 4, 9 Conway C....Newton-Bishop J.A. (2010)
    4. Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. (PubMed id 18615679)1, 4, 9 Agaram N.P....Antonescu C.R. (2008)
    5. Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma. (PubMed id 17507627)1, 4, 9 Thomas N.E....Conway K. (2007)
    6. Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. (PubMed id 19047918)1, 4, 9 Yoshida N....Kojima S. (2008)
    7. Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, J AK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes a nd acute myeloid leukemias. (PubMed id 20678218)1, 4 Rocquain J....Mozziconacci M.J. (2010)
    8. Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers. (PubMed id 20881644)1, 4 Lee S.Y....Park J.Y. (2010)
    9. Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients. (PubMed id 20150643)1, 4 Jin Y....Toguchida J. (2010)
    10. NRAS mutations are rare in colorectal cancer. (PubMed id 20736745)1, 4 Irahara N....Ogino S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4893 HGNC: 7989 AceView: NRASandUNR Ensembl:ENSG00000213281 euGenes: HUgn4893
    ECgene: NRAS Kegg: 4893 H-InvDB: NRAS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NRAS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NRAS Genetics and Cytogenetics in Oncology and Haematology
    NRASbasehttp://bioinf.uta.fi/NRASbase/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nras/
    Wikipedia http://en.wikipedia.org/wiki/RAS_proteins

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NRAS gene:
    Search GeneIP for patents involving NRAS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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