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NRAS Gene

protein-coding   GIFtS: 71
GCID: GC01M115247

Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog1 2     NRAS12
Transforming Protein N-Ras2 3     GTPase NRas2
ALPS42 5     N-Ras Protein Part 42
NS62 5     V-Ras Neuroblastoma RAS Viral Oncogene Homolog2
N-ras2     HRAS13

External Ids:    HGNC: 79891   Entrez Gene: 48932   Ensembl: ENSG000002132817   OMIM: 1647905   UniProtKB: P011113   

Export aliases for NRAS gene to outside databases

Previous GC identifers: GC01M115662 GC01M114131 GC01M114349 GC01M114548 GC01M114961 GC01M115048 GC01M113105


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NRAS Gene:
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma
membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex.
The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor
and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal
cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile
myelomonocytic leukemia. (provided by RefSeq, Jun 2011)

GeneCards Summary for NRAS Gene:
NRAS (neuroblastoma RAS viral (v-ras) oncogene homolog) is a protein-coding gene. Diseases associated with NRAS include large congenital melanocytic nevus, and noonan syndrome 6. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is REM1.

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity

Gene Wiki entry for NRAS (Neuroblastoma RAS viral oncogene homolog) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRAS gene promoter:
         c-Fos   AP-1   ATF-2   STAT3   MyoD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRAS promoter sequence
   Search Chromatin IP Primers for NRAS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRAS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

NRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRAS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M115247:  view genomic region     (about GC identifiers)

Start:
115,247,085 bp from pter      End:
115,259,515 bp from pter
Size:
12,431 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RASN_HUMAN, P01111 (See protein sequence)
Recommended Name: GTPase NRas precursor  
Size: 189 amino acids; 21229 Da
Subunit: Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound
form) with RASSF7
Miscellaneous: Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells
and are implicated in a variety of human tumors
1 PDB 3D structure from and Proteopedia for NRAS:
3CON (3D)    
Secondary accessions: Q14971 Q15104 Q15282

Explore the universe of human proteins at neXtProt for NRAS: NX_P01111

Explore proteomics data for NRAS at MOPED

Post-translational modifications: 

  • Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid
    exchange between plasma membrane and Golgi1
  • Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs) (By similarity)1
  • Ubiquitination2 at Lys128
  • Modification sites at PhosphoSitePlus

  • See NRAS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002515.1  
    ENSEMBL proteins: 
     ENSP00000358548  
    Reactome Protein details: P01111

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    NRAS Antibody Products:

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    Abcam antibodies for NRAS (P01116, P01112, P01111)
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    LSBio Antibodies in human, mouse, rat for NRAS

    NRAS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NRAS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NRAS
    Cloud-Clone Corp. CLIAs for NRAS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P01111

    ProtoNet protein and cluster: P01111

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RASN_HUMAN, P01111
    Similarity: Belongs to the small GTPase superfamily. Ras family


    NRAS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RASN_HUMAN, P01111
    Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
    Enzyme regulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by
    a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)

         Genatlas biochemistry entry for NRAS:
    neuroblastoma Ras viral (v-ras) oncogene homolog

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
    GO:0032403protein complex binding IDA--
         
    NRAS for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NRAS:
     Decreased Wnt reporter activit  Decreased focal adhesion (FA)  

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Nras) (see all 16):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  no phenotypic analysis  normal  tumorigenesis 

    NRAS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NRAS: Nrastm1Rak Nrastm1Mok

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRAS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NRAS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NRAS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NRAS

    miRNA
    Products:
        
    miRTarBase miRNAs that target NRAS:
    hsa-mir-98-5p (MIRT027862), hsa-mir-124-3p (MIRT023141), hsa-mir-148b-3p (MIRT007317), hsa-mir-145-5p (MIRT007107), hsa-let-7a-5p (MIRT001854), hsa-mir-877-3p (MIRT037130), hsa-mir-20a-5p (MIRT003903), hsa-let-7c-5p (MIRT004531), hsa-let-7b-5p (MIRT003836)

    Block miRNA regulation of human, mouse, rat NRAS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRAS (see all 81):
    hsa-miR-146a hsa-miR-218-1* hsa-miR-1304 hsa-miR-3150b-3p hsa-miR-510 hsa-miR-3148 hsa-miR-27a hsa-let-7i
    SwitchGear 3'UTR luciferase reporter plasmidNRAS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NRAS
    Predesigned siRNA for gene silencing in human, mouse, rat NRAS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NRAS

    Clone
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    OriGene clones in human, mouse for NRAS (see all 6)
    OriGene ORF clones in mouse, rat for NRAS
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    GenScript: all cDNA clones in your preferred vector: NRAS (NM_002524)
    Sino Biological Human cDNA Clone for NRAS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRAS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRAS

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NRAS 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRAS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RASN_HUMAN, P01111: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor.
    Note=Shuttles between the plasma membrane and the Golgi apparatus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane5
    cytosol3
    nucleus3
    cytoskeleton2
    extracellular2
    endosome1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0070062extracellular vesicular exosome IDA--

    NRAS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NRAS About   (see all 103)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    2Sorafenib Pharmacodynamics
    Sorafenib Pharmacodynamics0.37
    VEGF Pathway0.36
    Vemurafenib Pathway, Pharmacodynamics0.37
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    4ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    5MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NRAS (see all 109)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling
    CDK5 Pathway

    5 Tocris Bioscience Pathways for NRAS
        Insulin Pathway
    Apoptosis Pathway
    TGF-beta Pathway
    NF-kappaB Pathway
    VEGF Pathway

    4 GeneGo (Thomson Reuters) Pathways for NRAS
        Development EPO-induced MAPK pathway
    G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Development EGFR signaling via small GTPases
    G-protein signaling N-RAS regulation pathway

    Selected BioSystems Pathways for NRAS (see all 7)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    G Protein Signaling Pathways
    Signaling Pathways in Glioblastoma
    MAPK Cascade

    2 Sino Biological Pathways for NRAS
        VEGF Signaling
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for NRAS (see all 24)
        FCERI mediated MAPK activation
    RAF activation
    RAF phosphorylates MEK
    FRS2-mediated cascade
    EGFR Transactivation by Gastrin

    5 PharmGKB Pathways for NRAS
        Bisphosphonate Pathway, Pharmacodynamics
    EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics
    VEGF Signaling Pathway
    Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for NRAS) (see all 46):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway


    NRAS for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NRAS (see all 8): 
              mTOR Signaling in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              VEGF Signaling in human mouse rat
              Liver Cancer in human mouse rat
              Cancer Drug Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NRAS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NRAS (P011112, 3 ENSP000003585484) via UniProtKB, MINT, STRING, and/or I2D (see all 448)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCE1Q9P2122, 3, ENSP000002607664MINT-65550 I2D: score=5 STRING: ENSP00000260766
    ENSG00000237825O152113, ENSP000003900984I2D: score=2 STRING: ENSP00000390098
    ENSG00000206282O152113I2D: score=2 
    ENSG00000224841O152113I2D: score=2 
    ENSG00000228736O152113I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0006184GTP catabolic process IEA--
    GO:0007165signal transduction ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    NRAS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRAS (RASN)

    1 HMDB Compound for NRAS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for NRAS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 16.1 5 18450602 (2), 16467864 (1), 16281072 (1)
    oligonucleotide 0 1 8255093 (1)
    agar 0 1 16462768 (1)



    NRAS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NRAS gene: 
    NM_002524.4  

    Unigene Cluster for NRAS:

    Neuroblastoma RAS viral (v-ras) oncogene homolog
    Hs.486502  [show with all ESTs]
    Unigene Representative Sequence: NM_002524
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369535(uc009wgu.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat NRAS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRAS (see all 81):
    hsa-miR-146a hsa-miR-218-1* hsa-miR-1304 hsa-miR-3150b-3p hsa-miR-510 hsa-miR-3148 hsa-miR-27a hsa-let-7i
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NRAS
      QuantiFast Probe-based Assays in human, mouse, rat NRAS

    Additional mRNA sequence: 

    AF493919.1 AY941100.1 AY941101.1 BC005219.1 BC013214.1 BT019734.1 BT019735.1 X02751.1 

    11 DOTS entries:

    DT.40115049  DT.100693486  DT.100811463  DT.121460043  DT.92360379  DT.100693463  DT.121460084  DT.121460006 
    DT.121459944  DT.91838834  DT.92474389 

    Selected AceView cDNA sequences (see all 1776):

    BG778279 BM663111 CF140475 BC017662 AA665567 AA192113 AI207185 BQ941042 
    BP349129 BX397406 CA435429 AI905766 BF221818 AW674304 CD358795 CB052420 
    AI567075 AW675792 AU103652 AA151169 CR593292 BQ639704 BG178853 BM453613 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRAS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NRAS Expression
    About this image


    NRAS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
    NRAS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRAS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.486502
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NRAS (see all 8): 
              mTOR Signaling in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              VEGF Signaling in human mouse rat
              Liver Cancer in human mouse rat
              Cancer Drug Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NRAS
    OriGene qSTAR qPCR primer pairs in human, mouse for NRAS
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    QuantiFast Probe-based Assays in human, mouse, rat NRAS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRAS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NRAS gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nras1 , 5 neuroblastoma ras oncogene1, 5 91.71(n)1
    99.47(a)1
      3 (45.25 cM)5
    181761  NM_010937.21  NP_035067.21 
     1030583395 
    chicken
    (Gallus gallus)
    Aves NRAS1 neuroblastoma RAS viral (v-ras) oncogene homolog 81.13(n)
    96.83(a)
      419885  NM_001012549.1  NP_001012567.1 
    lizard
    (Anolis carolinensis)
    Reptilia NRAS6
    neuroblastoma RAS viral (v-ras) oncogene homolog
    94(a)
    1 ↔ 1
    4(130382670-130387388)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8952 African clawed frog N-ras mRNA, complete cds 79.19(n)    M97960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_131145.12   -- 79.79(n)   30380  NM_131145.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ras85D3 eggshell pattern formation RAS small
    monomeric more
    85(a)   3 85D21   --
    worm
    (Caenorhabditis elegans)
    Secernentea C08F8.73 RAS-related protein 45(a)   IV(11177461-11178071)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAS16
    RAS26
    GTPase involved in G-protein signaling in the aden...
    GTP-binding protein that regulates the nitrogen st...
    36(a)
    35(a)
    many ↔ many
    many ↔ many
    XV(515244-516173) YOR101W
    XIV(439602-440570) YNL098C


    ENSEMBL Gene Tree for NRAS (if available)
    TreeFam Gene Tree for NRAS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRAS gene
    REM12  RALA2  RRAS2  RALB2  ERAS2  RRAD2  REM22  KRAS2  
    GEM2  RRAS22  HRAS2  MRAS2  
    Selected SIMAP similar genes for NRAS using alignment to 2 protein entries:     RASN_HUMAN (see all proteins) (see all similar genes):
    N-ras    c-bas/has    HRAS    KRAS    RALA    RAP1B
    RAP2A    RIT2    RALB    RAP1A    RIT1    RRAS2
    RAB1C    RAP2C    RAB1B    DKFZp547A0616    RAP2B    RRAS

    NRAS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRAS (see all 306)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115542901,2,,4
    C,F,HLung carcinoma cell4 pathogenic1115325486(-) TGGACA/C/G/
            
    AGAAG
    4 Q P R L mis16NS EA NA 408
    VAR_0211944
    Leukemia4--see VAR_0211942 G C mis40--------
    VAR_0630844
    Autoimmune lymphoproliferative syndrome 4 (ALPS4)4--see VAR_0630842 G D mis40--------
    VAR_0630864
    Noonan syndrome 6 (NS6)4--see VAR_0630862 G E mis40--------
    VAR_0630854
    Noonan syndrome 6 (NS6)4--see VAR_0630852 T I mis40--------
    VAR_0068454
    Colorectal cancer4--see VAR_0068452 G R mis40--------
    rs1214345961,2
    Cpathogenic1115327701(-) AGGTGA/C/G/
            
    TGTTG
    4 D A G V mis10--------
    rs1219132371,2
    Cpathogenic1115327704(-) AGCAGA/C/G/
            
    TGGTG
    4 D A G V mis10--------
    rs1219132541,2
    Cuntested1115325487(-) CTGGAA/C/GAAGAA 3 K Q E mis10--------
    rs1219132481,2
    Cuntested1115327687(-) AAAGCA/C/GCACTG 2 T A mis10--------

    HapMap Linkage Disequilibrium report for NRAS (115247085 - 115259515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NRAS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv28734CNV Loss19812545

    Human Gene Mutation Database (HGMD): NRAS
    Selected Site Specific Mutation Identification with PCR Assays for NRAS (see all 19):
    Cosmic IdAA Change
    581p.Q61E
    577p.A18T
    570p.G13C
    583p.Q61L
    575p.G13A
    Selected Site Specific Cancer Mutation PCR Panels containing NRAS (see all 32):
    Breast Cancer
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    Liver Cancer
    2 Copy Number PCR Panels containing NRAS:
    Oncogenes & Tumor Suppressor Genes 384HC
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing NRAS
    DNA2.0 Custom Variant and Variant Library Synthesis for NRAS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164790   
    OMIM disorders: 614470  613224  162900  188470  114500  
    UniProtKB/Swiss-Prot: RASN_HUMAN, P01111
  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic
    syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell
    compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes,
    rashes, and hemorrhages. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Noonan syndrome 6 (NS6) [MIM:613224]: A form of Noonan syndrome, a disease characterized by short
    stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated
    ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can
    include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits,
    multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk
    of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of
    myelomonocytic cells. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Autoimmune lymphoproliferative syndrome 4 (ALPS4) [MIM:614470]: A disorder of apoptosis, characterized by
    chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the
    development of hematologic malignancies. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • Selected diseases for NRAS (see all 90):    
    About MalaCards
    large congenital melanocytic nevus    noonan syndrome 6    autoimmune lymphoproliferative syndrome type iv    bone marrow cancer
    nras-related noonan syndrome    autoimmune lymphoproliferative syndrome, type ib    epidermal nevus, somatic    thyroid cancer
    spitz nevus    thyroid carcinoma, follicular, somatic    autoimmune lymphoproliferative syndrome    juvenile myelomonocytic leukemia
    core binding factor acute myeloid leukemia    noonan syndrome    chronic myelomonocytic leukemia    exanthem
    acral lentiginous melanoma    skin melanoma    noonan syndrome 1    cystic teratoma

    17 diseases from the University of Copenhagen DISEASES database for NRAS:
    Colorectal cancer     Carcinoma     Lung cancer     Pancreatic cancer
    Adenoma     Melanoma     Noonan syndrome     Leukemia
    Pancreatitis     Endometrial cancer     Gallbladder cancer     Familial adenomatous polyposis
    Exanthem     Lynch syndrome     Ovarian cancer     Bone marrow cancer
    Cholangiocarcinoma

    NRAS for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NRAS gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    juvenile myelomonocytic leukemia 84.9 1 20471511 (1)
    melanoma 77.3 114 15917418 (5), 18227705 (5), 18375819 (4), 19509136 (4) (see all 41)
    preleukemia 73 1 7949098 (1)
    somatic mutations 65.4 6 15188009 (1), 10216104 (1), 20096196 (1), 17507627 (1) (see all 6)
    myelodysplastic syndromes 64.7 4 15257941 (2), 15474158 (1), 9379676 (1)
    nevi 61.6 8 16845322 (2), 17518771 (1), 17507627 (1)
    leukemogenesis 59.3 1 9680114 (1)
    nevi melanocytic 55 2 16845322 (1), 15009714 (1)
    uveal melanoma 53.3 1 14522897 (1)
    metastatic melanoma 51.6 2 14695152 (1), 17518771 (1)

    Genetic Association Database (GAD): NRAS
    Human Genome Epidemiology (HuGE) Navigator: NRAS (62 documents)
    Tumor Gene Database (TGDB): NRAS

    Export disorders for NRAS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRAS gene, integrated from 10 sources (see all 353):
    (articles sorted by number of sources associating them with NRAS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. (PubMed id 16098042)1, 4, 9 Akslen L.A....Kumar R. (J. Invest. Dermatol. 2005)
    2. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. (PubMed id 18450602)1, 4, 9 Schlenk R.F....DAPhner H. (N. Engl. J. Med. 2008)
    3. Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma. (PubMed id 20140953)1, 4, 9 Conway C....Newton-Bishop J.A. (amp 2010)
    4. Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. (PubMed id 18615679)1, 4, 9 Agaram N.P....Antonescu C.R. (amp 2008)
    5. Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma. (PubMed id 17507627)1, 4, 9 Thomas N.E....Conway K. (amp 2007)
    6. Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. (PubMed id 19047918)1, 4, 9 Yoshida N....Kojima S. (Pediatr. Res. 2009)
    7. Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. (PubMed id 20678218)1, 4 Rocquain J....Mozziconacci M.J. (BMC Cancer 2010)
    8. Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers. (PubMed id 20881644)1, 4 Lee S.Y....Park J.Y. (J Thorac Oncol 2010)
    9. Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients. (PubMed id 20150643)1, 4 Jin Y....Toguchida J. (Anticancer Res. 2010)
    10. NRAS mutations are rare in colorectal cancer. (PubMed id 20736745)1, 4 Irahara N....Ogino S. (Diagn. Mol. Pathol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4893 HGNC: 7989 AceView: NRASandUNR Ensembl:ENSG00000213281 euGenes: HUgn4893
    ECgene: NRAS Kegg: 4893 H-InvDB: NRAS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NRAS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NRAS Genetics and Cytogenetics in Oncology and Haematology
    NRASbasehttp://bioinf.uta.fi/NRASbase/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nras/
    Wikipedia http://en.wikipedia.org/wiki/RAS_proteins

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRAS gene:
    Search GeneIP for patents involving NRAS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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