Aliases for NRAS Gene
External Ids for NRAS Gene
Previous GeneCards Identifiers for NRAS Gene
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
GeneCards Summary for NRAS Gene
NRAS (Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog) is a Protein Coding gene. Diseases associated with NRAS include noonan syndrome 6 and thyroid carcinoma, follicular. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is HRAS.
UniProtKB/Swiss-Prot for NRAS Gene
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity