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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NRAS Gene

protein-coding GIFtS: 70
GCID: GC01M115247

neuroblastoma RAS viral (v-ras) oncogene homolog

Explore 80 diseases affiliated with
NRAS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog¹ ²		NRAS1²
N-Ras¹		GTPase NRas²
Transforming Protein N-Ras² ³		N-Ras Protein Part 4²
ALPS4² ⁵		V-Ras Neuroblastoma RAS Viral Oncogene Homolog²
NS6² ⁵		HRAS1³

External Ids:	HGNC: 7989¹	Entrez Gene: 4893²	Ensembl: ENSG00000213281⁷	OMIM: 164790⁵	UniProtKB: P01111³

Export aliases for NRAS gene to outside databases

Previous GC identifers: GC01M115662 GC01M114131 GC01M114349 GC01M114548 GC01M114961 GC01M115048 GC01M113105

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NRAS:

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma

membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The

encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and

inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer,

follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic

leukemia. (provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111

Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity

Gene Wiki entry for NRAS (Neuroblastoma RAS viral oncogene homolog)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NRAS gene promoter:
c-Fos AP-1 ATF-2 STAT3 MyoD c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NRAS promoter sequence

Search SABiosciences Chromatin IP Primers for NRAS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRAS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.2

NRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRAS gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M115247: view genomic region (about GC identifiers)

Start:	115,247,078 bp from pter	End:	115,259,515 bp from pter
Size:	12,438 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111 (See protein sequence)

Recommended Name: GTPase NRas precursor

Size: 189 amino acids; 21229 Da

Subunit: Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound form)

with RASSF7

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor.

Note=Shuttles between the plasma membrane and the Golgi apparatus

Miscellaneous: Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are

implicated in a variety of human tumors

1 PDB 3D structure from and Proteopedia for NRAS:

3CON (3D)

Secondary accessions: Q14971 Q15104 Q15282

Explore the universe of human proteins at neXtProt for NRAS: NX_P01111

Post-translational modifications:

Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange

between plasma membrane and Golgi¹

Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs) (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01111

NRAS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002515.1

ENSEMBL proteins:

ENSP00000358548

Reactome Protein details: P01111
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NRAS OriGene Protein Over-expression Lysate: NRAS OriGene Custom Protein Services for NRAS
	GenScript Custom Purified and Recombinant Proteins Services for NRAS
	Novus Biologicals NRAS Proteins Novus Biologicals NRAS Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for NRAS
	Uscn Proteins for NRAS

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--

NRAS for ontologies About GeneDecksing

NRAS Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NRAS
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 5): NRAS OriGene Custom Antibody Services for NRAS
	GenScript Custom Superior Antibodies Services for NRAS
	Novus Biologicals NRAS Antibodies
	Abcam antibodies for NRAS
	Uscn Antibodies for NRAS
	ThermoFisher Antibody for NRAS

Assay Products for NRAS:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NRAS
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NRAS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NRAS for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry P01111

ProtoNet protein and cluster: P01111

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111

Similarity: Belongs to the small GTPase superfamily. Ras family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111

Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity

Enzyme regulation: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a

guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)

Genatlas biochemistry entry for NRAS:

neuroblastoma Ras viral (v-ras) oncogene homolog

miRNA Products:		miRTarBase miRNAs that target NRAS: hsa-let-7a (MIRT001854), hsa-mir-20a (MIRT003903), hsa-let-7c (MIRT004531), hsa-let-7b (MIRT003836)

		OriGene 3'-UTR Clone: NRAS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NRAS
		8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate NRAS (see all 81):
		hsa-miR-146a hsa-miR-218-1* hsa-miR-1304 hsa-miR-3150b-3p hsa-miR-510 hsa-miR-3148 hsa-miR-27a hsa-let-7i

		SwitchGear 3'UTR luciferase reporter plasmid: NRAS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRAS (see all 7) OriGene shRNA RFP: NRAS OriGene siRNA: NRAS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRAS

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NRAS

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRAS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRAS OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NRAS (NM_002524)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRAS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRAS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NRAS
		Search LifeMap BioReagents cell lines for NRAS

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRAS

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	--	--
GO:0005525	GTP binding	IEA	--

NRAS for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for NRAS:

Decreased Wnt reporter activit

Decreased focal adhesion (FA)

Animal Models:
Mouse knock-outs for NRAS: Nras^tm1Rak Nras^tm1Mok
15 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Nras):

cardiovascular system	cellular	digestive/alimentary	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail
liver/biliary system	mortality/aging	normal	tumorigenesis	vision/eye

NRAS for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/92 super-pathways (see all 92) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SHC-mediated signalling

8/13 pathways (see all 13)
SHC-mediated signalling	1.00	MEK activation	0.47
SHC-related events	0.88	RAF phosphorylates MEK	0.47
SHC-related events triggered by IGF1R	0.83	RAF activation	0.33
SHC1 events in EGFR signaling	0.76	EGFR Transactivation by Gastrin	0.26

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

ErbB4 Pathway

8/12 pathways (see all 12)
ErbB4 Pathway	1.00	Thrombopoietin Pathway	0.43
ErbB Family Pathway	0.59	LPS Stimulated MAPK Signaling	0.36
Prolactin Signaling	0.54	VEGF Signaling Pathway	0.35
ErbB2-ErbB3 Heterodimers	0.47	TREM1 Pathway	0.32

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	Signaling by Insulin receptor	0.74
IRS-related events triggered by IGF1R	0.93

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Paxillin Interactions	0.53
Breast Cancer Regulation by Stathmin1	0.58	P2Y Receptor Signaling	0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for NRAS

	Development EGFR signaling via small GTPases
	G-protein signaling N-RAS regulation pathway
	Development EPO-induced MAPK pathway
	G-protein signaling Ras family GTPases in kinase cascades (scheme)

5/109 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NRAS (see all 109)

	Fc-GammaR Pathway
	Molecular Mechanisms of Cancer
	eIF2 Pathway
	Intracellular Calcium Signaling
	CDK5 Pathway

5 Tocris Bioscience Pathways for NRAS

	Insulin Pathway
	Apoptosis Pathway
	TGF-beta Pathway
	NF-kappaB Pathway
	VEGF Pathway

4 GeneGo (Thomson Reuters) Pathways for NRAS

	Development EPO-induced MAPK pathway
	G-protein signaling Ras family GTPases in kinase cascades (scheme)
	Development EGFR signaling via small GTPases
	G-protein signaling N-RAS regulation pathway

5/7 BioSystems Pathways for NRAS (see all 7)

	G Protein Signaling Pathways
	MAPK signaling pathway
	Signaling Pathways in Glioblastoma
	EGFR1 Signaling Pathway
	Regulation of Actin Cytoskeleton

5/65 Reactome Pathways for NRAS (see all 65)

	SHC-related events
	EGFR Transactivation by Gastrin
	p38MAPK events
	SHC-mediated signalling
	IRS-mediated signalling

5 PharmGKB Pathways for NRAS

	Bisphosphonate Pathway, Pharmacodynamics
	EGFR Inhibitor Pathway, Pharmacodynamics
	Sorafenib Pharmacodynamics
	VEGF Signaling Pathway
	Vemurafenib Pathway, Pharmacodynamics

5/31 Kegg Pathways (Kegg details for NRAS) (see all 31):

	MAPK signaling pathway
	ErbB signaling pathway
	Chemokine signaling pathway
	Axon guidance
	VEGF signaling pathway

NRAS for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NRAS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/165 Interacting proteins for NRAS (P01111^{2, 3} ENSP00000358548⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 165)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLCE1	Q9P212²^,³, ENSP00000260766⁴	MINT-65550 I2D: score=5 STRING: ENSP00000260766
BCL2	P10415³, ENSP00000329623⁴	I2D: score=2 STRING: ENSP00000329623
DNAJB1	P25685³, ENSP00000254322⁴	I2D: score=2 STRING: ENSP00000254322
PIK3CA	P42336³, ENSP00000263967⁴	I2D: score=2 STRING: ENSP00000263967
RASSF5	Q8WWW0³, ENSP00000347443⁴	I2D: score=2 STRING: ENSP00000347443

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	--
GO:0000186	activation of MAPKK activity	TAS	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0007265	Ras protein signal transduction	TAS	--

NRAS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NRAS for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NRAS

1 HMDB Compound for NRAS About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

3 Novoseek chemical compound relationships for NRAS gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	16.1	5	18450602 (2), 16467864 (1), 16281072 (1)
oligonucleotide	0	1	8255093 (1)
agar	0	1	16462768 (1)

Search CenterWatch for drugs/clinical trials and news about NRAS / RASN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NRAS gene:

NM_002524.4

Unigene Cluster for NRAS:

Neuroblastoma RAS viral (v-ras) oncogene homolog

Hs.486502 [show with all ESTs]

Unigene Representative Sequence: NM_002524

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000369535(uc009wgu.3)

miRNA Products:		OriGene 3'-UTR Clone: NRAS Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NRAS
		8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate NRAS (see all 81):
		hsa-miR-146a hsa-miR-218-1* hsa-miR-1304 hsa-miR-3150b-3p hsa-miR-510 hsa-miR-3148 hsa-miR-27a hsa-let-7i

		SwitchGear 3'UTR luciferase reporter plasmid: NRAS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRAS (see all 7) OriGene shRNA RFP: NRAS OriGene siRNA: NRAS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRAS

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRAS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRAS OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NRAS (NM_002524)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRAS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRAS

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRAS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NRAS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRAS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRAS

Additional cDNA sequence:

AF493919.1 AY941100.1 AY941101.1 BC005219.1 BC013214.1 BT019734.1 BT019735.1 X02751.1

11 DOTS entries:

DT.40115049 DT.100693486 DT.100811463 DT.121460043 DT.92360379 DT.100693463 DT.121460084 DT.121459944

DT.121460006 DT.91838834 DT.92474389

24/1776 AceView cDNA sequences (see all 1776):

BE858061 BP365024 AW304909 BU509480 AA780939 AI339397 BF979096 AW028940

BE748331 AA665567 AI475111 BP358982 BM667890 AU123547 CB177844 BQ433939

CA394488 AA034186 BP359705 BX352858 BM696520 BG504488 AA916152 BF969612

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NRAS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

NRAS expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Lung Bud

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NRAS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NRAS

SOURCE GeneReport for Unigene cluster: Hs.486502

SABiosciences Expression via Pathway-Focused PCR Arrays including NRAS (see all 8):

mTOR Signaling in human mouse rat

Oncogenes & Tumor Suppressor Genes in human mouse rat

VEGF Signaling in human mouse rat

Liver Cancer in human mouse rat

Cancer Drug Targets in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRAS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NRAS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRAS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRAS

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRAS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NRAS gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NRAS¹	neuroblastoma RAS viral (v-ras) oncogene homolog	81.13(n) 96.83(a)		419885 NM_001012549.1 NP_001012567.1
lizard (Anolis carolinensis)	Reptilia	NRAS⁶	--	94(a)	1 ↔ 1	4(130382670-130387371)
African clawed frog (Xenopus laevis)	Amphibia	Xl.895²	African clawed frog N-ras mRNA, complete cds	79.19(n)		M97960.1
zebrafish (Danio rerio)	Actinopterygii	NM_131145.1²	--	79.79(n)		30380 NM_131145.1
fruit fly (Drosophila melanogaster)	Insecta	Ras85D³	eggshell pattern formation RAS small monomeric more	85(a)		3 85D21 --
worm (Caenorhabditis elegans)	Secernentea	C08F8.7³	RAS-related protein	45(a)		IV(11177461-11178071) --

ENSEMBL Gene Tree for NRAS (if available)
TreeFam Gene Tree for NRAS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NRAS gene

REM1² RALA² RIT2² RIT1² RRAS² ERAS² RALB² RRAD²

REM2² KRAS² GEM² RRAS2² HRAS² MRAS²

18/97 SIMAP similar genes for NRAS using alignment to 2 protein entries: RASN_HUMAN (see all proteins) (see all similar genes):

N-ras c-bas/has HRAS KRAS RALA RAP1B

RAP2A RIT2 RALB RAP1A RIT1 RRAS2

RAB1C RAP2C RAB1B DKFZp547A0616 RAP2B RRAS

NRAS for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11554290^1,2	C,H	other	113114988(-)	`TGGACA/C/G/T AGAAG`	4	Q P R L	mis¹		6		NS EA NA	408
rs121913248^1,2	C,	other	113117189(-)	`AAAGCA/C/GCACTG`	3	T P A	mis¹		0	--	--	--	--
rs121434596^1,2	C	other	113117203(-)	`AGGTGA/C/G/T TGTTG`	4	D A G V	mis¹		0	--	--	--	--
rs121434595^1,2	C	other	113117204(-)	`CAGGTA/C/G/T GTGTT`	4	S R G C	mis¹		0	--	--	--	--
rs121913237^1,2	C	other	113117206(-)	`AGCAGA/C/G/T TGGTG`	4	D A G V	mis¹		0	--	--	--	--
rs121913250^1,2	C	other	113117207(-)	`GAGCAA/C/G/T GTGGT`	4	S R G C	mis¹		0	--	--	--	--
rs72994440^1,2	C,	--	113105823(+)	`TCCCTC/ACAGAG`	1	--	ut3¹		2		WA	120
rs11552981^1,2	C	--	113105837(+)	`AGTTCA/GTACAA`	1	--	ut3¹		2		NA	4
rs55813139^1,2	C	--	113105889(+)	`ACGTTC/TTGAAA`	1	--	ut3¹		0	--	--	--	--
rs72994441^1,2	C,	--	113105970(+)	`ATTGTG/CTGGCA`	1	--	ut3¹		2		WA	120

HapMap Linkage Disequilibrium report for NRAS (115247078 - 115259515 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NRAS
3 CNVs: 2322 3306 64651
Human Gene Mutation Database (HGMD): NRAS

5/19 SABiosciences Cancer Mutation PCR Assays for NRAS (see all 19):

Cosmic Id	AA Change
581	p.Q61E
577	p.A18T
570	p.G13C
583	p.Q61L
575	p.G13A

5/32 SABiosciences Cancer Mutation PCR Arrays containing NRAS (see all 32):

Breast Cancer

Cancer Comprehensive Panel 384HT

Lung Cancer

Liver Cancer

2 SABiosciences qBiomarker Copy Number PCR Arrays containing NRAS:

Oncogenes & Tumor Suppressor Genes 384HC

Prostate Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRAS

DNA2.0 Custom Variant and Variant Library Synthesis for NRAS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NRAS for disorders           About GeneDecksing

OMIM gene information: 164790
OMIM disorders: 114500  188470  613224
UniProtKB/Swiss-Prot: RASN_HUMAN, P01111

Defects in NRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric

myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and

2% of leukemia

Defects in NRAS are the cause of Noonan syndrome type 6 (NS6) [MIM:613224]. A syndrome characterized by facial

dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears. Other features

can include short stature, a short neck with webbing or redundancy of skin, cardiac anomalies, deafness, motor delay

and variable intellectual deficits

Defects in NRAS are the cause of autoimmune lymphoproliferative syndrome type 4 (ALPS4) [MIM:614470]. A

disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte

apoptosis, and an increased risk for the development of hematologic malignancies

20/80 diseases for NRAS (see all 80): About MalaCards

juvenile myelomonocytic leukemia autoimmune lymphoproliferative syndrome myelomonocytic leukemia lymphoproliferative syndrome

noonan syndrome malignant peripheral nerve sheath tumor leukemia autoimmune lymphoproliferative syndrome type iv

thyroid cancer paroxysmal nocturnal hemoglobinuria thyroiditis spitz nevus

neuroblastoma noonan syndrome 6 bone marrow cancer familial adenomatous polyposis

soft tissue sarcoma nevus gastrointestinal stromal tumor plasma cell leukemia

15 diseases from the University of Copenhagen DISEASES database for NRAS:

Colorectal cancer Carcinoma Lung cancer Pancreatic cancer

Adenoma Melanoma Noonan syndrome Leukemia

Pancreatitis Endometrial cancer Gallbladder cancer Familial adenomatous polyposis

Lynch syndrome Ovarian cancer Bone marrow cancer

10/21 Novoseek disease relationships for NRAS gene (see all 21) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
juvenile myelomonocytic leukemia	84.9	1	20471511 (1)
melanoma	77.3	114	15917418 (5), 18227705 (5), 18375819 (4), 19509136 (4) (see all 41)
preleukemia	73	1	7949098 (1)
somatic mutations	65.4	6	15188009 (1), 10216104 (1), 20096196 (1), 17507627 (1) (see all 6)
myelodysplastic syndromes	64.7	4	15257941 (2), 15474158 (1), 9379676 (1)
nevi	61.6	8	16845322 (2), 17518771 (1), 17507627 (1)
leukemogenesis	59.3	1	9680114 (1)
nevi melanocytic	55	2	16845322 (1), 15009714 (1)
uveal melanoma	53.3	1	14522897 (1)
metastatic melanoma	51.6	2	14695152 (1), 17518771 (1)

Genetic Association Database (GAD): NRAS
Human Genome Epidemiology (HuGE) Navigator: NRAS (62 documents)
Tumor Gene Database (TGDB): NRAS

Export disorders for NRAS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NRAS gene, integrated from 9 sources (see all 305):
(articles sorted by number of sources associating them with NRAS)

Utopia: connect your pdf to the dynamic
world of online information

BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. (PubMed id 16098042)^{1, 4, 9} Akslen L.A....Kumar R. (2005)
A restricted spectrum of NRAS mutations causes Noonan syndrome. (PubMed id 19966803)^{1, 2} Cirstea I.C.... Zenker M. (2010)
NRAS mutation causes a human autoimmune lymphoproliferative syndrome. (PubMed id 17517660)^{1, 2} Oliveira J.B.... Lenardo M.J. (2007)
DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. (PubMed id 16000296)^{1, 2} Swarthout J.T.... Linder M.E. (2005)
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. (PubMed id 15705808)^{1, 2} Rocks O....Bastiaens P.I.H. (2005)
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. (PubMed id 16076867)^{1, 4} Schnittger S....Falini B. (2005)
Ras gene mutations in patients with acute myeloid leukaemia and exposure to chemical agents. (PubMed id 14688017)^{1, 4} Barletta E....Costantini A.S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay. (PubMed id 1970154)^{1, 2} Yuasa Y.... Tonomura A. (1990)
All ras proteins are polyisoprenylated but only some are palmitoylated. (PubMed id 2661017)^{1, 2} Hancock J.F.... Marshall C.J. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4893	HGNC: 7989	AceView: NRASandUNR	Ensembl:ENSG00000213281	euGenes: HUgn4893
ECgene: NRAS	Kegg: 4893	H-InvDB: NRAS

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NRAS	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NRAS	Genetics and Cytogenetics in Oncology and Haematology
NRASbase	http://bioinf.uta.fi/NRASbase/
NIEHS-SNPs	http://egp.gs.washington.edu/data/nras/
Wikipedia	http://en.wikipedia.org/wiki/RAS_proteins

Intellectual Property for NRAS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NRAS gene:
Search GeneIP for patents involving NRAS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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In Situ Hybridization Assays from
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About This Section

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neuroblastoma RAS viral (v-ras) oncogene homolog

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NRAS Gene

neuroblastoma RAS viral (v-ras) oncogene homolog

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