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Aliases for KDR Gene

Aliases for KDR Gene

  • Kinase Insert Domain Receptor 2 3 4 5
  • Fetal Liver Kinase 1 2 3 4
  • Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase) 2 3
  • Protein-Tyrosine Kinase Receptor Flk-1 3 4
  • EC 2.7.10.1 4 63
  • VEGFR2 3 4
  • FLK1 3 4
  • Vascular Endothelial Growth Factor Receptor 2 2
  • Tyrosine Kinase Growth Factor Receptor 3
  • Fetal Liver Kinase-1 3
  • Soluble VEGFR2 3
  • CD309 Antigen 4
  • EC 2.7.10 63
  • VEGFR-2 4
  • CD309 3
  • VEGFR 3
  • FLK-1 4

External Ids for KDR Gene

Previous GeneCards Identifiers for KDR Gene

  • GC04M055748
  • GC04M055906
  • GC04M055860
  • GC04M055785
  • GC04M055639
  • GC04M055944
  • GC04M051893

Summaries for KDR Gene

Entrez Gene Summary for KDR Gene

  • Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

GeneCards Summary for KDR Gene

KDR (Kinase Insert Domain Receptor) is a Protein Coding gene. Diseases associated with KDR include hemangioma, capillary infantile and hemangioma. Among its related pathways are Degradation of the extracellular matrix and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGFR1.

UniProtKB/Swiss-Prot for KDR Gene

  • Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.

Gene Wiki entry for KDR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KDR Gene

Genomics for KDR Gene

Regulatory Elements for KDR Gene

Promoters for KDR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KDR on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the KDR gene promoter:

Genomic Location for KDR Gene

Chromosome:
4
Start:
55,078,259 bp from pter
End:
55,125,595 bp from pter
Size:
47,337 bases
Orientation:
Minus strand

Genomic View for KDR Gene

Genes around KDR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KDR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KDR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KDR Gene

Proteins for KDR Gene

  • Protein details for KDR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35968-VGFR2_HUMAN
    Recommended name:
    Vascular endothelial growth factor receptor 2
    Protein Accession:
    P35968
    Secondary Accessions:
    • A2RRS0
    • B5A925
    • C5IFA0
    • O60723
    • Q14178

    Protein attributes for KDR Gene

    Size:
    1356 amino acids
    Molecular mass:
    151527 Da
    Quaternary structure:
    • Homodimer in the presence of bound dimeric VEGFA, VEGFC or VEGFD ligands; monomeric in the absence of bound ligands. Can also form heterodimers with FLT1/VEGFR1 and FLT4/VEGFR2. Interacts (tyrosine phosphorylated) with LFYN, NCK1, PLCG1. Interacts (tyrosine-phosphorylated active form preferentially) with DAB2IP (via C2 domain and active form preferentially); the interaction occurs at the late phase of VEGFA response and inhibits KDR/VEGFR2 activity. Interacts with SHBSH2D2A/TSAD, GRB2, MYOF, CBL and PDCD6. Interacts with HIV-1 Tat (PubMed:10102632, PubMed:10590123, PubMed:12649282, PubMed:12881528, PubMed:1417831, PubMed:15026417, PubMed:15215251, PubMed:15837294, PubMed:15962004, PubMed:16966330, PubMed:17253678, PubMed:18529047, PubMed:18593464, PubMed:19033661, PubMed:19668192, PubMed:20080685, PubMed:20145116, PubMed:20224550, PubMed:20705758, PubMed:21827946, PubMed:21893193, PubMed:9160888). Interacts (via C-terminus domain) with ERN1 (via kinase domain); the interaction is facilitated in a XBP1 isoform 1- and vascular endothelial growth factor (VEGF)-dependent manner in endothelial cells (PubMed:23529610).

    Three dimensional structures from OCA and Proteopedia for KDR Gene

    Alternative splice isoforms for KDR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KDR Gene

Proteomics data for KDR Gene at MOPED

Post-translational modifications for KDR Gene

  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-951 is important for interaction with SH2D2A/TSAD and VEGFA-mediated reorganization of the actin cytoskeleton. Phosphorylation at Tyr-1175 is important for interaction with PLCG1 and SHB. Phosphorylation at Tyr-1214 is important for interaction with NCK1 and FYN. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-1054, Tyr-1059, Tyr-1175 and Tyr-1214.
  • N-glycosylated.
  • The inhibitory disulfide bond between Cys-1024 and Cys-1045 may serve as a specific molecular switch for H(2)S-induced modification that regulates VEGFR2 function.
  • Ubiquitinated. Tyrosine phosphorylation of the receptor promotes its poly-ubiquitination, leading to its degradation via the proteasome or lysosomal proteases.
  • Glycosylation at Asn 46, Asn 66, Asn 96, Asn 143, Asn 158, Asn 245, Asn 318, Asn 374, Asn 395, Asn 511, Asn 523, Asn 580, Asn 613, Asn 619, Asn 631, Asn 675, Asn 704, and Asn 721
  • Modification sites at PhosphoSitePlus

Other Protein References for KDR Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

Assay Products

  • Cloud-Clone Corp Assay Kits for KDR

Domains & Families for KDR Gene

Graphical View of Domain Structure for InterPro Entry

P35968

UniProtKB/Swiss-Prot:

VGFR2_HUMAN :
  • The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Domain:
  • The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding.
  • Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with KDR: view

Function for KDR Gene

Molecular function for KDR Gene

GENATLAS Biochemistry:
vascular endothelial growth factor receptor,expressed on the surface of endothelial cells,activated by VEGF in cooperation with integrin alpha V (ITGAV) beta 3 (ITGB3),involved in angiogenesis,also regulating the migration of early mesodermally derived precursors into a microenvironnement that is permissive for hematopoiesis (marker defining hematopoietic stem cells)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by the small molecule PTK inhibitor SU5614 ((3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one). May be regulated by hydrogen sulfide (H(2)S) levels via a H(2)S-sensitive intracellular disulfide bond.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.

Enzyme Numbers (IUBMB) for KDR Gene

Gene Ontology (GO) - Molecular Function for KDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,IDA 10037737
GO:0004716 receptor signaling protein tyrosine kinase activity TAS 10022831
GO:0038085 vascular endothelial growth factor binding IPI 20660291
genes like me logo Genes that share ontologies with KDR: view
genes like me logo Genes that share phenotypes with KDR: view

Human Phenotype Ontology for KDR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KDR Gene

MGI Knock Outs for KDR:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KDR

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for KDR Gene

Localization for KDR Gene

Subcellular locations from UniProtKB/Swiss-Prot for KDR Gene

Cell junction. Endoplasmic reticulum. Note=Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). {ECO:0000250, ECO:0000269 PubMed:23529610}.
Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.
Isoform 2: Secreted.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KDR Gene COMPARTMENTS Subcellular localization image for KDR gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
nucleus 5
plasma membrane 5
cytoskeleton 2
cytosol 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for KDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005768 endosome IDA 23262137
GO:0030054 cell junction ISS --
genes like me logo Genes that share ontologies with KDR: view

Pathways & Interactions for KDR Gene

genes like me logo Genes that share pathways with KDR: view

SIGNOR curated interactions for KDR Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KDR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 10022831
GO:0001570 vasculogenesis ISS --
GO:0002042 cell migration involved in sprouting angiogenesis ISS --
GO:0003158 endothelium development ISS --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with KDR: view

Drugs & Compounds for KDR Gene

(171) Drugs for KDR Gene - From: Novoseek, DGIdb, IUPHAR, HMDB, ApexBio, ClinicalTrials, DrugBank, PharmGKB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sunitinib Approved, Investigational Pharma inhibitor, Target, multitarget VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors, Potent VEGFR, PDGFRbeta and KIT inhibitor 486
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor, Target, antagonist Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 671
Pazopanib Approved Pharma inhibitor, Target VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
regorafenib Approved Pharma inhibitor, Target Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Axitinib Approved, Investigational Pharma Inhibition, inhibitor, Target Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 100

(35) Additional Compounds for KDR Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with KDR: view

Transcripts for KDR Gene

mRNA/cDNA for KDR Gene

Unigene Clusters for KDR Gene

Kinase insert domain receptor (a type III receptor tyrosine kinase):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KDR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KDR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2:
SP3:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b
SP1:
SP2:
SP3:

Relevant External Links for KDR Gene

GeneLoc Exon Structure for
KDR
ECgene alternative splicing isoforms for
KDR

Expression for KDR Gene

mRNA expression in normal human tissues for KDR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KDR Gene

This gene is overexpressed in Uterus (x4.4) and Adipose - Visceral (Omentum) (x4.1).

Protein differential expression in normal tissues from HIPED for KDR Gene

This gene is overexpressed in Heart (25.4), Placenta (14.9), Lymph node (13.5), and Brain (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KDR Gene



SOURCE GeneReport for Unigene cluster for KDR Gene Hs.479756

mRNA Expression by UniProt/SwissProt for KDR Gene

P35968-VGFR2_HUMAN
Tissue specificity: Detected in cornea (at protein level). Widely expressed.
genes like me logo Genes that share expression patterns with KDR: view

Protein tissue co-expression partners for KDR Gene

Primer Products

In Situ Assay Products

Orthologs for KDR Gene

This gene was present in the common ancestor of animals.

Orthologs for KDR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KDR 36
  • 100 (a)
OneToOne
KDR 35
  • 99.75 (n)
  • 99.78 (a)
cow
(Bos Taurus)
Mammalia KDR 36
  • 91 (a)
OneToOne
KDR 35
  • 89.72 (n)
  • 91.08 (a)
dog
(Canis familiaris)
Mammalia KDR 35
  • 91.39 (n)
  • 93.06 (a)
KDR 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kdr 36
  • 87 (a)
OneToOne
Kdr 16
Kdr 35
  • 85.46 (n)
  • 86.75 (a)
oppossum
(Monodelphis domestica)
Mammalia KDR 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KDR 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kdr 35
  • 85.55 (n)
  • 86.37 (a)
chicken
(Gallus gallus)
Aves KDR 35
  • 72.17 (n)
  • 73.73 (a)
KDR 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KDR 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia kdr-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kdr 35
  • 65.84 (n)
  • 62.66 (a)
zebrafish
(Danio rerio)
Actinopterygii kdr 36
  • 49 (a)
OneToOne
kdr 35
  • 58.06 (n)
  • 53.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta tor 37
  • 45 (a)
Cad96Ca 36
  • 27 (a)
ManyToMany
Pvr 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R09D1.12 37
  • 30 (a)
ver-2 37
  • 27 (a)
ver-3 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for KDR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KDR Gene

ENSEMBL:
Gene Tree for KDR (if available)
TreeFam:
Gene Tree for KDR (if available)

Paralogs for KDR Gene

(4) SIMAP similar genes for KDR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KDR: view

Variants for KDR Gene

Sequence variations from dbSNP and Humsavar for KDR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1350541 -- 55,103,358(-) GTACG(A/C)TGTTG intron-variant
rs1139774 -- 55,098,711(-) TCCTA(C/G/T)GGACC reference, missense
rs1531289 -- 55,089,065(-) TCGTC(A/G)GCTCT intron-variant
rs1870377 - 55,106,807(+) ACAGC(A/T)TGGCT reference, missense
rs1870378 -- 55,100,286(-) CCAGA(A/G)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KDR Gene

Variant ID Type Subtype PubMed ID
nsv526344 CNV Gain 19592680
nsv829939 CNV Gain 17160897

Variation tolerance for KDR Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.74; 86.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KDR Gene

HapMap Linkage Disequilibrium report
KDR
Human Gene Mutation Database (HGMD)
KDR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KDR Gene

Disorders for KDR Gene

MalaCards: The human disease database

(57) MalaCards diseases for KDR Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hemangioma, capillary infantile
  • hemangioma, capillary infantile, somatic
hemangioma
familial capillary hemangioma
ewing sarcoma
  • neuroepithelioma
olecranon bursitis
  • bursitis of elbow
- elite association - COSMIC cancer census association via MalaCards
Search KDR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VGFR2_HUMAN
  • Hemangioma, capillary infantile (HCI) [MIM:602089]: A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring. {ECO:0000269 PubMed:11807987, ECO:0000269 PubMed:18931684}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=Plays a major role in tumor angiogenesis. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.

Relevant External Links for KDR

Genetic Association Database (GAD)
KDR
Human Genome Epidemiology (HuGE) Navigator
KDR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KDR
genes like me logo Genes that share disorders with KDR: view

No data available for Genatlas for KDR Gene

Publications for KDR Gene

  1. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. (PMID: 1417831) Terman B.I. … Boehlen P. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23 67
  2. Sorafenib. (PMID: 16503817) Rini B.I. (Expert Opin Pharmacother 2006) 23 25 26
  3. Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. (PMID: 16757355) Adnane L. … Wilhelm S.M. (Meth. Enzymol. 2006) 23 25 26
  4. Inflammation of actinic keratoses subsequent to therapy with sorafenib, a multitargeted tyrosine-kinase inhibitor. (PMID: 16824050) Lacouture M.E. … Stadler W.M. (Clin. Exp. Dermatol. 2006) 23 25 26
  5. TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells. (PMID: 20084057) Lee S.J. … Stetler-Stevenson W.G. (Lab. Invest. 2010) 3 23

Products for KDR Gene

  • Addgene plasmids for KDR

Sources for KDR Gene

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