Aliases for HSP90AB1 Gene
External Ids for HSP90AB1 Gene
Previous HGNC Symbols for HSP90AB1 Gene
Previous GeneCards Identifiers for HSP90AB1 Gene
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
GeneCards Summary for HSP90AB1 Gene
HSP90AB1 (Heat Shock Protein 90kDa Alpha Family Class B Member 1) is a Protein Coding gene. Diseases associated with HSP90AB1 include bronchitis and gliosarcoma. Among its related pathways are Allograft rejection and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding. An important paralog of this gene is TRAP1.
UniProtKB/Swiss-Prot for HSP90AB1 Gene
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).