HSP90AB1 Gene
protein-coding GIFtS: 63
GCID: GC06P044214
|
|
heat shock protein 90kDa alpha (cytosolic), class B member...(Previous names: heat shock 90kD protein 1, beta, heat shock 90kDa protein...)
(Previous symbols: HSPC2, HSPCB)
| |
Aliases
for HSP90AB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 11 2 | | Heat Shock 90kDa Protein 1, Beta1 | | HSPC21 2 3 5 | | D6S1822 | | HSPCB1 2 3 5 | | HSP90-Beta1 | | HSP90B2 3 5 | | Heat Shock Protein HSP 90-Beta2 | | Heat Shock 90kD Protein 1, Beta1 2 | | HSP 843 | | Heat Shock 84 KDa2 3 | | HSP 903 | | HSP842 3 | | |
Export aliases for HSP90AB1 gene to outside databasesPrevious GC identifers: GC06P044323 GC06P044324 GC06P043936 |
Summaries
for HSP90AB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HSP90AB1:
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction,protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicingresults in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. (provided byRefSeq, Dec 2012)
UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specifictarget proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle thatis linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, therebycausing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition,ATPase cycle and chaperone function
 summary
for HSP90AB1: Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins.
Gene Wiki entry for HSP90AB1
|
Genomic Views
for HSP90AB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HSP90AB1 gene promoter:
NF-1 Elk-1 Sp1 p300 Lmo2 YY1 Egr-4 MZF-1 CP2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSP90AB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p12 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p12HSP90AB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P044214: view genomic region
(about GC identifiers)
Start:
|
44,214,824 bp from pter |
End:
|
44,221,620 bp from pter |
Size:
|
6,797 bases |
Orientation:
|
plus strand |
|
Proteins
for HSP90AB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238 (See
protein sequence)Recommended Name: Heat shock protein HSP 90-beta Size: 724 amino acids; 83264 Da
Subunit: Homodimer. Interacts with p53/TP53 (By similarity). Forms a complex with CDK6 and Hsp90/HSP90AB1. Interactswith UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7 (Bysimilarity). Interacts with FKBP4
Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage Ito stage IV
Sequence caution: Sequence=AAD14062.3; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAB66478.1; Type=Frameshift; Positions=709;
4 PDB 3D structures from  and Proteopedia  for HSP90AB1:1QZ2 (3D)
1UYM (3D)
3NMQ (3D)
3PRY (3D)
Secondary accessions: B2R5P0 Q5T9W7 Q9NQW0 Q9NTK6Explore the universe of human proteins at neXtProt for HSP90AB1: NX_P08238
Post-translational modifications:
Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro)1
ISGylated1
S-nitrosylated; negatively regulates the ATPase activity (Probable)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P08238
HSP90AB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001258898.1 NP_001258899.1 NP_001258900.1 NP_001258901.1 NP_031381.2
ENSEMBL proteins: ENSP00000399096 ENSP00000360709 ENSP00000325875 ENSP00000360609 ENSP00000397409 ENSP00000400457 ENSP00000405093 Reactome Protein details: P08238
Human Recombinant Protein Products:
Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table
HSP90AB1 for ontologies About GeneDecksing
HSP90AB1 Antibody Products:
Assay Products for HSP90AB1: |
Protein
Domains /
Families
for HSP90AB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSP90AB1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P08238ProtoNet protein and cluster: P08238 2 Blocks protein families: IPB001404 Heat shock protein Hsp90 IPB003594 ATP-binding region
UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins (By similarity)Similarity: Belongs to the heat shock protein 90 family |
Function
for HSP90AB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specifictarget proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle thatis linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, therebycausing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition,ATPase cycle and chaperone function
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HSP90AB1 (NM_007355) | |  | Sino Biological Human cDNA Clone for HSP90AB1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSP90AB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AB1 |
Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table
HSP90AB1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HSP90AB1:
Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Hsp90ab1):
HSP90AB1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HSP90AB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) | | | 2 | NLRP3 oligomerizes via NACHT domains | | | 3 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | | | 4 | Inflammasomes | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for HSP90AB1
1  R&D Systems Pathway for HSP90AB1
1 
Cell Signaling Technology (CST) Pathway for HSP90AB1
1 Tocris Bioscience Pathway for HSP90AB1
5/6  GeneGo (Thomson Reuters) Pathways for HSP90AB1 (see all 6)
3  BioSystems Pathways for HSP90AB1
5/15 
Reactome Pathways for HSP90AB1 (see all 15)
5/6 
Kegg Pathways (Kegg details for HSP90AB1) (see all 6):
HSP90AB1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSP90AB1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/1194 Interacting proteins for HSP90AB1 (P082381, 2, 3 ENSP000003258754) via UniProtKB, MINT, STRING, and/or I2D (see all 1194)About this table
Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table
HSP90AB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HSP90AB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HSP90AB1 for compounds About GeneDecksing
Compounds for HSP90AB1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| CCT 018159 | Hsp90 inhibitor | [171009-07-7] | | 17-AAG | Selective Hsp90 inhibitor | [75747-14-7] | | Macbecin I | Hsp90 inhibitor | [73341-72-7] | | Gedunin | Hsp90 inhibitor; anticancer and antimalarial activity | [2753-30-2] | | Radicicol | Hsp90 inhibitor. Antifungal antibiotic | [12772-57-5] |
10/13 DrugBank Compounds for HSP90AB1 (see all 13) About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine | -- | -- | target | -- | 17139284 17016423 10592235 | | Adenosine-5'-Diphosphate | -- | 20398-34-9 | target | -- | 17139284 17016423 10592235 | | Geldanamycin | -- | 30562-34-6 | target | -- | 17139284 17016423 10592235 | | (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE | -- | -- | target | -- | 10592235 | | (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE | -- | -- | target | -- | 10592235 | | (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE | -- | -- | target | -- | 10592235 | | (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE | -- | -- | target | -- | 10592235 | | 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE | -- | -- | target | -- | 10592235 | | 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL | -- | -- | target | -- | 10592235 | | 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL | -- | -- | target | -- | 10592235 |
10/13 Novoseek chemical compound relationships for HSP90AB1 gene (see all 13) About this table
Search CenterWatch for drugs/clinical trials and news about HSP90AB1 / HS90B
|
Transcripts
for HSP90AB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HSP90AB1 gene (5 alternative transcripts): NM_001271969.1 NM_001271970.1 NM_001271971.1 NM_001271972.1 NM_007355.3 Unigene Cluster for HSP90AB1: Heat shock protein 90kDa alpha (cytosolic), class B member 1 Hs.509736 [show with all ESTs]Unigene Representative Sequence: NM_0012719697 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000441736 ENST00000371646(uc003oxa.1 uc011dvr.1 uc011dvs.1 uc003oxc.1)
ENST00000353801(uc003oxb.1) ENST00000371554 ENST00000435812 ENST00000415133
ENST00000428822
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HSP90AB1 (NM_007355) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSP90AB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AB1 |
Additional cDNA sequence: AF275719.1 AK025370.1 AK130494.1 AK290734.1 AK294643.1 AK297367.1 AK312255.1 AL136543.1 AY359878.1 BC004928.1 BC007327.2 BC009206.2 BC012807.2 BC014485.1 BC016753.2 BC068474.1 BX649079.1 D28342.1 M16660.1 24/178 DOTS entries (see all 178): DT.95313805 DT.92408441 DT.92470997 DT.121336150 DT.100725038 DT.92326561 DT.100725015 DT.91902593 DT.92411584 DT.121336080 DT.95139876 DT.121336390 DT.121336180 DT.100652561 DT.100725069 DT.121336358 DT.100804704 DT.121336274 DT.97869713 DT.91657672 DT.100725071 DT.100725012 DT.100724999 DT.121336112 24/219 AceView cDNA sequences (see all 219): AA487401 AW963867 T51115 T59827 H50320 AA075645 CA398011 T51023 AA101959 T59996 BI494859 T59691 AA487283 AA075646 BM014574 AW439011 AW675427 AA284704 AA211753 AI874069 AA287134 AI094312 BM875458 AA101958
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AB1 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | |
| ExUns: | 16b |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for HSP90AB1
|
Expression
for HSP90AB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSP90AB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTCCCACT
About this image
See HSP90AB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSP90AB1
SOURCE GeneReport for Unigene cluster: Hs.509736
SABiosciences Expression via Pathway-Focused PCR Arrays including HSP90AB1 (see all 146): | Antiviral Response in human mouse rat | | Multiple Sclerosis in human mouse rat | | Wound Healing in human mouse rat | | Prostate Cancer in human mouse rat | | Drug Metabolism: Phase I Enzymes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSP90AB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSP90AB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AB1 |
Orthologs
for HSP90AB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for HSP90AB1 gene from 9/37 species (see all 37) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HSP90AB11 |
heat shock protein 90kDa alpha (cytosolic), class B more |
81.68(n)
94.89(a) |
|
396188 NM_206959.1 NP_996842.1 |
lizard
(Anolis carolinensis) |
Reptilia |
HSP90AB16 |
-- |
94(a) |
1 ↔ 1 |
1(227919591-227931601) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.293532 |
Xenopus laevis transcribed sequence with moderate similarity more |
82.14(n) |
|
BU914717.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AF042108.12 |
-- |
80.33(n) |
|
30573 AF042108.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Hsp831 |
Heat shock protein 83 |
71.75(n)
78.46(a) |
|
38389 NM_079175.3 NP_523899.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
daf-211 |
Protein DAF-21 |
70.14(n)
77(a) |
|
179971 NM_074225.2 NP_506626.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HSP81-21 |
heat shock protein 81-2 |
68.59(n)
71.47(a) |
|
835701 NM_001203624.1 NP_001190553.1 |
rice
(Oryza sativa) |
Liliopsida |
AB111810.12 |
-- |
74.36(n) |
|
AB111810.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
htpG6 |
protein refolding molecular co-chaperone Hsp90, Hs... |
39(a) |
possible ortholog |
Chromosome(494344-496218) |
ENSEMBL Gene Tree for HSP90AB1 (if available)
TreeFam Gene Tree for HSP90AB1 (if available) |
Paralogs
for HSP90AB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HSP90AB1 gene
- HSP90B12 TRAP12 HSP90AA12
14 SIMAP similar genes for HSP90AB1 using alignment to 6 protein entries: HS90B_HUMAN (see all proteins):HSP90Af HSP90AA1 HSP90Bf HSP90AA2 HSP90AB3P HSP90AB4P
HSP90AA4P HSP90B1 GRP94c HSP90AA5P TRA1 HSP90AB2P
TRAP1 HSP90B2P
HSP90AB1 for paralogs About GeneDecksing
5/13 Pseudogenes.org Pseudogenes for HSP90AB1 (see all 13)
PGOHUM00000238347 PGOHUM00000248469 PGOHUM00000258861 PGOHUM00000234979 PGOHUM00000240431
|
Genomic Variants
for HSP90AB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HSP90AB1 (44214824 - 44221620 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HSP90AB1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSP90AB1 |
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Disorders
/ Diseases
for HSP90AB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSP90AB1 for disorders About GeneDecksing
OMIM gene information: 140572
OMIM disorders: --
20/45  diseases for HSP90AB1 (see all 45): About MalaCardsgastrointestinal stromal tumor myasthenia gravis lupus erythematosus glucocorticoid resistance
mantle cell lymphoma systemic lupus erythematosus laryngitis bronchitis
acute lymphoblastic leukemia laryngeal carcinoma lymphoblastic leukemia myasthenia
laryngeal cancer cystic fibrosis multiple myeloma embryonal carcinoma
dermatomyositis uveitis breast cancer asthma
10/11 Novoseek disease relationships for HSP90AB1 gene (see all 11) About this table
Human Genome Epidemiology (HuGE) Navigator: HSP90AB1 (6 documents)
Export disorders for HSP90AB1 gene to outside databases
|
Publications
for HSP90AB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSP90AB1 gene, integrated from 9 sources (see all 247):
(articles sorted by number of sources associating them with HSP90AB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. (PubMed id 2768249)1, 2, 3 Rebbe N.F.... Hickman S. (1989)
- The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 3, 9 Chen B.... Monteiro A. (2005)
- A cosmid clone at the D6S182 locus on human chromosome 6p12 contains the 90-kDa heat shock protein beta gene (HSP90 beta). (PubMed id 8180474)1, 2, 9 Takahashi I.... Hashimoto K. (1994)
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- A two-dimensional gel database of human colon carcinoma proteins. (PubMed id 9150948)1, 2 Ji H.... Simpson R.J. (1997)
|
External Searches for HSP90AB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HSP90AB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HSP90AB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSP90AB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HSP90AB1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HSP90AB1 gene:
Search GeneIP for patents involving HSP90AB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HSP90AB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for HSP90AB1 | | OriGene shRNA RFP for HSP90AB1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSP90AB1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSP90AB1 | | | OriGene Protein Over-expression Lysate for HSP90AB1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HSP90AB1 | | OriGene 3'-UTR Clone for HSP90AB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HSP90AB1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HSP90AB1 | | OriGene Custom Protein Services for HSP90AB1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSP90AB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSP90AB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AB1 |
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