Aliases for HSP90AB1 Gene
External Ids for HSP90AB1 Gene
Previous HGNC Symbols for HSP90AB1 Gene
Previous GeneCards Identifiers for HSP90AB1 Gene
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
GeneCards Summary for HSP90AB1 Gene
HSP90AB1 (Heat Shock Protein 90kDa Alpha Family Class B Member 1) is a Protein Coding gene. Diseases associated with HSP90AB1 include gliosarcoma. Among its related pathways are Immune System and Cellular response to heat stress. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding. An important paralog of this gene is TRAP1.
UniProtKB/Swiss-Prot for HSP90AB1 Gene
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).