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Aliases for HSP90AB1 Gene

Aliases for HSP90AB1 Gene

  • Heat Shock Protein 90kDa Alpha Family Class B Member 1 2 3 5
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 1 2 3
  • Heat Shock 90kD Protein 1, Beta 2 3
  • Heat Shock 84 KDa 3 4
  • HSP90B 3 4
  • HSPC2 3 4
  • HSPCB 3 4
  • HSP84 3 4
  • Heat Shock 90kDa Protein 1, Beta 2
  • Heat Shock Protein 90 KDa 3
  • HSP90-Beta 3
  • D6S182 3
  • HSP 84 4
  • HSP 90 4

External Ids for HSP90AB1 Gene

Previous HGNC Symbols for HSP90AB1 Gene

  • HSPC2
  • HSPCB

Previous GeneCards Identifiers for HSP90AB1 Gene

  • GC06P044323
  • GC06P044324
  • GC06P044214
  • GC06P043936

Summaries for HSP90AB1 Gene

Entrez Gene Summary for HSP90AB1 Gene

  • This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

GeneCards Summary for HSP90AB1 Gene

HSP90AB1 (Heat Shock Protein 90kDa Alpha Family Class B Member 1) is a Protein Coding gene. Diseases associated with HSP90AB1 include bronchitis and gliosarcoma. Among its related pathways are Immune System and Cellular response to heat stress. GO annotations related to this gene include poly(A) RNA binding and protein kinase binding. An important paralog of this gene is TRAP1.

UniProtKB/Swiss-Prot for HSP90AB1 Gene

  • Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Tocris Summary for HSP90AB1 Gene

  • Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).

Gene Wiki entry for HSP90AB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AB1 Gene

Genomics for HSP90AB1 Gene

Regulatory Elements for HSP90AB1 Gene

Promoters for HSP90AB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSP90AB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSP90AB1 Gene

Chromosome:
6
Start:
44,246,166 bp from pter
End:
44,253,888 bp from pter
Size:
7,723 bases
Orientation:
Plus strand

Genomic View for HSP90AB1 Gene

Genes around HSP90AB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSP90AB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSP90AB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90AB1 Gene

Proteins for HSP90AB1 Gene

  • Protein details for HSP90AB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08238-HS90B_HUMAN
    Recommended name:
    Heat shock protein HSP 90-beta
    Protein Accession:
    P08238
    Secondary Accessions:
    • B2R5P0
    • Q5T9W7
    • Q9NQW0
    • Q9NTK6

    Protein attributes for HSP90AB1 Gene

    Size:
    724 amino acids
    Molecular mass:
    83264 Da
    Quaternary structure:
    • Homodimer. Interacts with p53/TP53 (By similarity). Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7 (By similarity). Interacts with FKBP4. May interact with NWD1 (PubMed:24681825).
    SequenceCaution:
    • Sequence=AAD14062.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66478.1; Type=Frameshift; Positions=709; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HSP90AB1 Gene

neXtProt entry for HSP90AB1 Gene

Proteomics data for HSP90AB1 Gene at MOPED

Post-translational modifications for HSP90AB1 Gene

Other Protein References for HSP90AB1 Gene

Antibody Products

  • R&D Systems Antibodies for HSP90AB1 (HSP90 beta)
  • Cell Signaling Technology (CST) Antibodies for HSP90AB1 (HSP90B)

No data available for DME Specific Peptides for HSP90AB1 Gene

Domains & Families for HSP90AB1 Gene

Gene Families for HSP90AB1 Gene

Graphical View of Domain Structure for InterPro Entry

P08238

UniProtKB/Swiss-Prot:

HS90B_HUMAN :
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
  • Belongs to the heat shock protein 90 family.
Domain:
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AB1: view

Function for HSP90AB1 Gene

Molecular function for HSP90AB1 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Gene Ontology (GO) - Molecular Function for HSP90AB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0005525 GTP binding IEA --
GO:0019887 protein kinase regulator activity IEA --
GO:0019900 kinase binding IPI 21855797
GO:0023026 MHC class II protein complex binding IDA 20458337
genes like me logo Genes that share ontologies with HSP90AB1: view
genes like me logo Genes that share phenotypes with HSP90AB1: view

Animal Model Products

CRISPR Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSP90AB1 Gene

Localization for HSP90AB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AB1 Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSP90AB1 Gene COMPARTMENTS Subcellular localization image for HSP90AB1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 3
endoplasmic reticulum 2
cytoskeleton 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSP90AB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031526 brush border membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HSP90AB1: view

Pathways & Interactions for HSP90AB1 Gene

genes like me logo Genes that share pathways with HSP90AB1: view

SIGNOR curated interactions for HSP90AB1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HSP90AB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006986 response to unfolded protein NAS 2768249
GO:0007411 axon guidance TAS --
GO:0009651 response to salt stress IEA --
GO:0031396 regulation of protein ubiquitination IDA 16809764
genes like me logo Genes that share ontologies with HSP90AB1: view

Drugs & Compounds for HSP90AB1 Gene

(46) Drugs for HSP90AB1 Gene - From: Novoseek, DGIdb, ApexBio, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Geldanamycin Experimental Pharma Target Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor 0
Radicicol Experimental Pharma Target Hsp90 inhibitor. Antifungal antibiotic 0
(5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE Experimental Pharma Target 0
(5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE Experimental Pharma Target 0
(5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE Experimental Pharma Target 0

(8) Additional Compounds for HSP90AB1 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
17-AAG
75747-14-7
CCT 018159
171009-07-7
genes like me logo Genes that share compounds with HSP90AB1: view

Transcripts for HSP90AB1 Gene

Unigene Clusters for HSP90AB1 Gene

Heat shock protein 90kDa alpha (cytosolic), class B member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7: - - - - - - - - - - - - - - - -
SP8:
SP9: - - - -
SP10:
SP11: -
SP12:

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HSP90AB1 Gene

GeneLoc Exon Structure for
HSP90AB1
ECgene alternative splicing isoforms for
HSP90AB1

Expression for HSP90AB1 Gene

mRNA expression in normal human tissues for HSP90AB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSP90AB1 Gene

This gene is overexpressed in Lymph node (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSP90AB1 Gene



SOURCE GeneReport for Unigene cluster for HSP90AB1 Gene Hs.509736

genes like me logo Genes that share expression patterns with HSP90AB1: view

Protein tissue co-expression partners for HSP90AB1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSP90AB1 Gene

Orthologs for HSP90AB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSP90AB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSP90AB1 35
  • 90.84 (n)
  • 99.59 (a)
HSP90AB1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSP90AB1 35
  • 91.39 (n)
  • 99.86 (a)
SLC29A1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsp90ab1 35
  • 89.69 (n)
  • 99.59 (a)
Hsp90ab1 16
Hsp90ab1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSP90AB1 35
  • 99.54 (n)
  • 99.86 (a)
HSP90AB1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsp90ab1 35
  • 89.83 (n)
  • 99.59 (a)
oppossum
(Monodelphis domestica)
Mammalia HSP90AB1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSP90AB1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSP90AB1 35
  • 81.54 (n)
  • 94.2 (a)
HSP90AB1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSP90AB1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsp90ab1 35
  • 80.73 (n)
  • 92.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29353 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
hsp90ab1 35
  • 79.89 (n)
  • 91.7 (a)
hsp90ab1 36
  • 90 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1282 35
African malaria mosquito
(Anopheles gambiae)
Insecta HSP83_ANOGA 35
  • 71.78 (n)
  • 80.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsp83 35
  • 71.78 (n)
  • 78.48 (a)
Hsp83 36
  • 79 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-21 35
  • 70.95 (n)
  • 78.18 (a)
daf-21 36
  • 77 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL148C 35
  • 61.82 (n)
  • 62.82 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12958g 35
  • 60.59 (n)
  • 63.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSP82 35
  • 60.53 (n)
  • 62.48 (a)
HSP82 36
  • 62 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons HSP90.1 35
  • 65.8 (n)
  • 70.95 (a)
rice
(Oryza sativa)
Liliopsida Os08g0500700 35
  • 68.09 (n)
  • 69.66 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.217 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04142 35
  • 67.48 (n)
  • 67.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hsp90 35
  • 62.7 (n)
  • 64.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11103 36
  • 78 (a)
OneToMany
Species with no ortholog for HSP90AB1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HSP90AB1 Gene

ENSEMBL:
Gene Tree for HSP90AB1 (if available)
TreeFam:
Gene Tree for HSP90AB1 (if available)

Paralogs for HSP90AB1 Gene

Paralogs for HSP90AB1 Gene

(14) SIMAP similar genes for HSP90AB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSP90AB1: view

Variants for HSP90AB1 Gene

Sequence variations from dbSNP and Humsavar for HSP90AB1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11538975 - 44,251,135(+) AGAAG(A/G)AAAAG reference, missense
rs13296 -- 44,250,383(-) TTGGG(C/T)TTTTC reference, synonymous-codon
rs324128 -- 44,244,574(-) CGCCT(A/G)TAGTC upstream-variant-2KB
rs324129 -- 44,244,759(-) actcc(A/G)tctca upstream-variant-2KB
rs324130 -- 44,244,951(-) AGTTC(A/G)CAACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSP90AB1 Gene

Variant ID Type Subtype PubMed ID
nsv885851 CNV Loss 21882294
nsv5282 CNV Insertion 18451855
nsv885852 CNV Loss 21882294
nsv462936 CNV Loss 19166990
dgv6843n71 CNV Loss 21882294
nsv524398 CNV Loss 19592680

Variation tolerance for HSP90AB1 Gene

Residual Variation Intolerance Score: 5.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSP90AB1 Gene

HapMap Linkage Disequilibrium report
HSP90AB1
Human Gene Mutation Database (HGMD)
HSP90AB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90AB1 Gene

Disorders for HSP90AB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HSP90AB1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bronchitis
  • acute bronchitis
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HSP90AB1

Genetic Association Database (GAD)
HSP90AB1
Human Genome Epidemiology (HuGE) Navigator
HSP90AB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSP90AB1
genes like me logo Genes that share disorders with HSP90AB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSP90AB1 Gene

Publications for HSP90AB1 Gene

  1. Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. (PMID: 2768249) Rebbe N.F. … Hickman S. (J. Biol. Chem. 1989) 2 3 4 67
  2. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B. … Monteiro A. (Genomics 2005) 2 3 23
  3. Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. (PMID: 20353823) Cheng M.B. … Shen Y.F. (Cell. Signal. 2010) 3 23
  4. A block in the road to fertility: autoantibodies to heat-shock protein 90-beta in human ovarian autoimmunity. (PMID: 19022436) Pires E.S. … Khole V.V. (Fertil. Steril. 2009) 3 23
  5. Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. (PMID: 19380486) Chen H. … Lu Z. (Mol. Cell. Biol. 2009) 3 23

Products for HSP90AB1 Gene

Sources for HSP90AB1 Gene

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