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Aliases for GDF7 Gene

Aliases for GDF7 Gene

  • Growth Differentiation Factor 7 2 3 5
  • GDF-7 3 4
  • BMP12 3

External Ids for GDF7 Gene

Previous GeneCards Identifiers for GDF7 Gene

  • GC02U990098
  • GC02P020834
  • GC02P020851
  • GC02P020850
  • GC02P020788

Summaries for GDF7 Gene

Entrez Gene Summary for GDF7 Gene

  • This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008]

GeneCards Summary for GDF7 Gene

GDF7 (Growth Differentiation Factor 7) is a Protein Coding gene. Diseases associated with GDF7 include narcolepsy. Among its related pathways are Axon guidance and Hippo signaling pathway. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is BMP2.

UniProtKB/Swiss-Prot for GDF7 Gene

  • May play an active role in the motor area of the primate neocortex.

Gene Wiki entry for GDF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDF7 Gene

Genomics for GDF7 Gene

Regulatory Elements for GDF7 Gene

Promoters for GDF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around GDF7 on UCSC Golden Path with GeneCards custom track

Genomic Location for GDF7 Gene

Chromosome:
2
Start:
20,666,664 bp from pter
End:
20,679,245 bp from pter
Size:
12,582 bases
Orientation:
Plus strand

Genomic View for GDF7 Gene

Genes around GDF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDF7 Gene

Proteins for GDF7 Gene

  • Protein details for GDF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4P5-GDF7_HUMAN
    Recommended name:
    Growth/differentiation factor 7
    Protein Accession:
    Q7Z4P5

    Protein attributes for GDF7 Gene

    Size:
    450 amino acids
    Molecular mass:
    46950 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for GDF7 Gene

Proteomics data for GDF7 Gene at MOPED

Post-translational modifications for GDF7 Gene

  • Glycosylation at Asn 83
  • Modification sites at PhosphoSitePlus

Other Protein References for GDF7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GDF7 Gene

Domains & Families for GDF7 Gene

Protein Domains for GDF7 Gene

Suggested Antigen Peptide Sequences for GDF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z4P5

UniProtKB/Swiss-Prot:

GDF7_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with GDF7: view

No data available for Gene Families for GDF7 Gene

Function for GDF7 Gene

Molecular function for GDF7 Gene

UniProtKB/Swiss-Prot Function:
May play an active role in the motor area of the primate neocortex.
genes like me logo Genes that share phenotypes with GDF7: view

Animal Models for GDF7 Gene

MGI Knock Outs for GDF7:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GDF7 Gene

Localization for GDF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDF7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GDF7 Gene COMPARTMENTS Subcellular localization image for GDF7 gene
Compartment Confidence
extracellular 4
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for GDF7 Gene

Pathways & Interactions for GDF7 Gene

genes like me logo Genes that share pathways with GDF7: view

Pathways by source for GDF7 Gene

Gene Ontology (GO) - Biological Process for GDF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IEA --
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA 16049014
GO:0021915 neural tube development IEA --
GO:0030509 BMP signaling pathway IEA,IDA 16049014
GO:0030855 epithelial cell differentiation IEA --
genes like me logo Genes that share ontologies with GDF7: view

No data available for SIGNOR curated interactions for GDF7 Gene

Drugs & Compounds for GDF7 Gene

No Compound Related Data Available

Transcripts for GDF7 Gene

mRNA/cDNA for GDF7 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDF7 Gene

Growth differentiation factor 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GDF7 Gene

No ASD Table

Relevant External Links for GDF7 Gene

GeneLoc Exon Structure for
GDF7
ECgene alternative splicing isoforms for
GDF7

Expression for GDF7 Gene

mRNA expression in normal human tissues for GDF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDF7 Gene

This gene is overexpressed in Artery - Aorta (x6.7), Cervix - Ectocervix (x5.6), Liver (x5.4), and Vagina (x4.0).

Protein differential expression in normal tissues from HIPED for GDF7 Gene

This gene is overexpressed in Lung (36.7) and Plasma (32.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GDF7 Gene



SOURCE GeneReport for Unigene cluster for GDF7 Gene Hs.447688

genes like me logo Genes that share expression patterns with GDF7: view

Protein tissue co-expression partners for GDF7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for GDF7 Gene

Orthologs for GDF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GDF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GDF7 35
  • 99.3 (n)
  • 98.84 (a)
GDF7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GDF7 36
  • 83 (a)
OneToOne
GDF7 35
  • 85.31 (n)
  • 83.29 (a)
dog
(Canis familiaris)
Mammalia GDF7 36
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gdf7 16
Gdf7 36
  • 81 (a)
OneToOne
Gdf7 35
  • 80.58 (n)
  • 80.58 (a)
oppossum
(Monodelphis domestica)
Mammalia GDF7 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GDF7 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gdf7 35
  • 80.66 (n)
  • 80.82 (a)
chicken
(Gallus gallus)
Aves GDF7 35
  • 64.99 (n)
  • 61.87 (a)
lizard
(Anolis carolinensis)
Reptilia GDF7 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496775 35
  • 56.62 (n)
  • 54.2 (a)
zebrafish
(Danio rerio)
Actinopterygii gdf7 36
  • 47 (a)
OneToOne
gdf7 35
  • 54.67 (n)
  • 53.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta dpp 36
  • 15 (a)
OneToMany
Species with no ortholog for GDF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDF7 Gene

ENSEMBL:
Gene Tree for GDF7 (if available)
TreeFam:
Gene Tree for GDF7 (if available)

Paralogs for GDF7 Gene

Paralogs for GDF7 Gene

(3) SIMAP similar genes for GDF7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GDF7: view

Variants for GDF7 Gene

Sequence variations from dbSNP and Humsavar for GDF7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs4666456 -- 20,666,733(+) CGGTC(C/T)GGAGG utr-variant-5-prime
rs7589372 -- 20,668,419(+) GTGAG(A/G)CTGTG intron-variant
rs10205228 -- 20,666,960(+) TGGCA(C/G)TCGCT utr-variant-5-prime
rs13023783 -- 20,666,816(+) TGTTT(A/C)TCTGC utr-variant-5-prime
rs13023784 -- 20,666,818(+) TTTCT(A/C)TGCGG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GDF7 Gene

Variant ID Type Subtype PubMed ID
nsv508828 CNV Insertion 20534489
nsv527901 CNV Loss 19592680
dgv4069n71 CNV Loss 21882294

Variation tolerance for GDF7 Gene

Gene Damage Index Score: 4.22; 62.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GDF7 Gene

HapMap Linkage Disequilibrium report
GDF7
Human Gene Mutation Database (HGMD)
GDF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDF7 Gene

Disorders for GDF7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GDF7 Gene - From: GeneCards

Disorder Aliases PubMed IDs
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards
Search GDF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GDF7

Genetic Association Database (GAD)
GDF7
Human Genome Epidemiology (HuGE) Navigator
GDF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GDF7
genes like me logo Genes that share disorders with GDF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GDF7 Gene

Publications for GDF7 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48 67
  2. Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily. (PMID: 10022976) Davidson A.J. … Crosier P.S. (Genome Res. 1999) 2 3
  3. Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord. (PMID: 9808626) Lee K.J. … Jessell T.M. (Genes Dev. 1998) 2 3
  4. Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus. (PMID: 25447851) Palles C. … Jankowski J. (Gastroenterology 2015) 3
  5. BMP12 induces tenogenic differentiation of adipose-derived stromal cells. (PMID: 24155967) Shen H. … Thomopoulos S. (PLoS ONE 2013) 3

Products for GDF7 Gene

Sources for GDF7 Gene

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