Aliases for GDF7 Gene
External Ids for GDF7 Gene
Previous GeneCards Identifiers for GDF7 Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]
GeneCards Summary for GDF7 Gene
GDF7 (Growth Differentiation Factor 7) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway and TGF-beta signaling pathway (KEGG). GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is GDF6.
UniProtKB/Swiss-Prot for GDF7 Gene
May play an active role in the motor area of the primate neocortex.