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Aliases for GDF7 Gene

Aliases for GDF7 Gene

  • Growth Differentiation Factor 7 2 3 5
  • GDF-7 3 4
  • Growth/Differentiation Factor 7 3
  • BMP12 3

External Ids for GDF7 Gene

Previous GeneCards Identifiers for GDF7 Gene

  • GC02U990098
  • GC02P020834
  • GC02P020851
  • GC02P020850
  • GC02P020788

Summaries for GDF7 Gene

Entrez Gene Summary for GDF7 Gene

  • This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]

GeneCards Summary for GDF7 Gene

GDF7 (Growth Differentiation Factor 7) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway and TGF-beta signaling pathway. GO annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is GDF6.

UniProtKB/Swiss-Prot for GDF7 Gene

  • May play an active role in the motor area of the primate neocortex.

Gene Wiki entry for GDF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GDF7 Gene

Genomics for GDF7 Gene

Regulatory Elements for GDF7 Gene

Enhancers for GDF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F020566 1.9 VISTA FANTOM5 Ensembl ENCODE 13.2 -92.6 -92557 14.5 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 FOS RHOB TTC32 GDF7 ENSG00000228950 RNU6-961P HS1BP3-IT1 HS1BP3 ENSG00000269976 GC02P020545
GH02F020589 1.4 FANTOM5 Ensembl ENCODE 12.9 -71.7 -71661 11.6 HDGF PKNOX1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 CBX5 ZNF207 RHOB GDF7 ENSG00000228950 APOB ENSG00000269976 HS1BP3 HS1BP3-IT1 RPS25P3
GH02F020641 0.8 ENCODE 11.9 -24.3 -24345 2.4 ARID4B ZNF48 ZNF2 RAD21 ZNF143 THAP11 ZNF654 MXD4 REST PPARG GDF7 ENSG00000228950 RHOB HS1BP3 GC02M020612
GH02F020698 0.6 Ensembl 11.5 +32.9 32937 1.6 CEBPB GDF7 LDAH ENSG00000270100
GH02F020935 0.2 ENCODE 11.4 +268.9 268912 0.2 PKNOX1 FEZF1 ZXDB GDF7 LDAH GC02P020946 LOC101928271
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around GDF7 on UCSC Golden Path with GeneCards custom track

Promoters for GDF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000586348 536 1201 CTCF KLF1 ZNF792 SAP130 SUZ12 DMAP1 ZNF48 ZIC2 YY1 ZFHX2

Genomic Location for GDF7 Gene

20,666,664 bp from pter
20,679,245 bp from pter
12,582 bases
Plus strand

Genomic View for GDF7 Gene

Genes around GDF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GDF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GDF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GDF7 Gene

Proteins for GDF7 Gene

  • Protein details for GDF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Growth/differentiation factor 7
    Protein Accession:

    Protein attributes for GDF7 Gene

    450 amino acids
    Molecular mass:
    46950 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for GDF7 Gene

Post-translational modifications for GDF7 Gene

  • Glycosylation at Asn 83
  • Modification sites at PhosphoSitePlus

Other Protein References for GDF7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GDF7

No data available for DME Specific Peptides for GDF7 Gene

Domains & Families for GDF7 Gene

Suggested Antigen Peptide Sequences for GDF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TGF-beta family.
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with GDF7: view

No data available for Gene Families for GDF7 Gene

Function for GDF7 Gene

Molecular function for GDF7 Gene

UniProtKB/Swiss-Prot Function:
May play an active role in the motor area of the primate neocortex.

Gene Ontology (GO) - Molecular Function for GDF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005515 protein binding IPI 16049014
GO:0008083 growth factor activity IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with GDF7: view
genes like me logo Genes that share phenotypes with GDF7: view

Animal Models for GDF7 Gene

MGI Knock Outs for GDF7:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GDF7 Gene

Localization for GDF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GDF7 Gene


Subcellular locations from

Jensen Localization Image for GDF7 Gene COMPARTMENTS Subcellular localization image for GDF7 gene
Compartment Confidence
extracellular 4
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GDF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IBA --
genes like me logo Genes that share ontologies with GDF7: view

Pathways & Interactions for GDF7 Gene

genes like me logo Genes that share pathways with GDF7: view

Pathways by source for GDF7 Gene

Gene Ontology (GO) - Biological Process for GDF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance IEA --
GO:0010628 positive regulation of gene expression IEA --
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA 16049014
GO:0021509 roof plate formation IEA --
GO:0021527 spinal cord association neuron differentiation IEA --
genes like me logo Genes that share ontologies with GDF7: view

No data available for SIGNOR curated interactions for GDF7 Gene

Transcripts for GDF7 Gene

mRNA/cDNA for GDF7 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GDF7 Gene

Growth differentiation factor 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GDF7 Gene

No ASD Table

Relevant External Links for GDF7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GDF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GDF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GDF7 Gene

This gene is overexpressed in Artery - Aorta (x6.7), Cervix - Ectocervix (x5.6), Liver (x5.4), and Vagina (x4.0).

Protein differential expression in normal tissues from HIPED for GDF7 Gene

This gene is overexpressed in Lung (36.7) and Plasma (32.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GDF7 Gene

Protein tissue co-expression partners for GDF7 Gene

NURSA nuclear receptor signaling pathways regulating expression of GDF7 Gene:


SOURCE GeneReport for Unigene cluster for GDF7 Gene:

genes like me logo Genes that share expression patterns with GDF7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for GDF7 Gene

Orthologs for GDF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GDF7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GDF7 34 35
  • 99.3 (n)
(Bos Taurus)
Mammalia GDF7 34 35
  • 85.31 (n)
(Rattus norvegicus)
Mammalia Gdf7 34
  • 80.66 (n)
(Mus musculus)
Mammalia Gdf7 34 16 35
  • 80.58 (n)
(Ornithorhynchus anatinus)
Mammalia GDF7 35
  • 78 (a)
(Monodelphis domestica)
Mammalia GDF7 35
  • 59 (a)
(Canis familiaris)
Mammalia GDF7 35
  • 50 (a)
(Gallus gallus)
Aves GDF7 34
  • 64.99 (n)
(Anolis carolinensis)
Reptilia GDF7 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496775 34
  • 56.62 (n)
(Danio rerio)
Actinopterygii gdf7 34 35
  • 54.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta dpp 35
  • 15 (a)
Species where no ortholog for GDF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GDF7 Gene

Gene Tree for GDF7 (if available)
Gene Tree for GDF7 (if available)

Paralogs for GDF7 Gene

Paralogs for GDF7 Gene

(3) SIMAP similar genes for GDF7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GDF7: view

Variants for GDF7 Gene

Sequence variations from dbSNP and Humsavar for GDF7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10169712 -- 20,675,238(+) AGATC(C/G)CGCAG utr-variant-3-prime
rs10170019 -- 20,675,514(+) AGGCC(A/G)CTCAG utr-variant-3-prime
rs10170028 -- 20,675,560(+) TCTGA(A/G)GCAAG utr-variant-3-prime
rs10194529 -- 20,675,734(+) CAGTC(C/T)CAGAG utr-variant-3-prime
rs10194607 -- 20,675,774(+) CTGTG(C/T)ATGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GDF7 Gene

Variant ID Type Subtype PubMed ID
nsv1071981 CNV deletion 25765185
nsv1118854 CNV deletion 24896259
nsv508828 CNV insertion 20534489
nsv527901 CNV loss 19592680

Variation tolerance for GDF7 Gene

Gene Damage Index Score: 4.22; 62.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GDF7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GDF7 Gene

Disorders for GDF7 Gene

Relevant External Links for GDF7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GDF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GDF7 Gene

Publications for GDF7 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
  3. Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily. (PMID: 10022976) Davidson A.J. … Crosier P.S. (Genome Res. 1999) 2 3 64
  4. Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord. (PMID: 9808626) Lee K.J. … Jessell T.M. (Genes Dev. 1998) 2 3 64
  5. Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study. (PMID: 26445383) Gelberman R.H. … Thomopoulos S. (J. Orthop. Res. 2016) 3 64

Products for GDF7 Gene

Sources for GDF7 Gene

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