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GATA4 Gene

protein-coding GIFtS: 66

GC08P011599

GATA binding protein 4
(Previous name: GATA-binding protein 4 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC126629 ^²
OTTHUMP00000116010 ^²

Descriptions
GATA binding protein 4 ^²
GATA-binding factor 4 ^³
GATA-binding protein 4 ^¹, ²

External Ids
HGNC: 4173¹
Entrez Gene: 2626²
UniProtKB: P43694³
Ensembl: ENSG00000136574⁷

Search outside databases for aliases for GATA4 gene

Previous GC identifers: GC08P011628 GC08P011554 GC08P011405

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for GATA4:

This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this

family recognize the GATA motif which is present in the promoters of many genes. This protein is

thought to regulate genes involved in embryogenesis and in myocardial differentiation and

function. Mutations in this gene have been associated with cardiac septal defects. [provided by

RefSeq]

UniProtKB/Swiss-Prot: GATA4_HUMAN, P43694

Function: Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a

transcriptional activator of ANF in cooperation with NKX2-5 (By similarity)

Gene Wiki entry for GATA4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the GATA4 gene

Entrez Gene cytogenetic band: 8p23.1-p22 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1-p22

GATA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P011599: (about GC identifiers)

Start:	11,599,162 bp from pter
End:	11,654,918 bp from pter
Size:	55,757 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_077531.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: GATA4_HUMAN, P43694 (See protein sequence)

Recommended Name: Transcription factor GATA-4

Size: 442 amino acids; 44565 Da

Subunit: Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5

through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to

activate transcription of ANF. Interacts with NFATC4 (By similarity)

Subcellular location: Nucleus

Secondary accessions: Q3MJ45

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002043.2

ENSEMBL proteins:

ENSP00000334458 ENSP00000371772 ENSP00000259090

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GATA4)
	Human Recombinant Proteins from Abnova (GATA4)

OriGene Purified Recombinant Human Protein: GATA4

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	12845333

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Antibodies for GATA4:

	Invitrogen Antibodies for GATA4
	Millipore Mono- and Polyclonal Antibodies for the study of GATA4
	Sigma-Aldrich Antibodies for GATA4
	R&D Systems Antibodies for GATA4 (GATA-4)
	Antibodies from Abcam (GATA4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (GATA4)
	Search Novus for antibodies for GATA4

Assays for GATA4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P43694

ProtoNet protein and cluster: P43694

2 Blocks protein families:

IPB000679 Zn-finger

IPB008013 GATA-type transcription activator

UniProtKB/Swiss-Prot: GATA4_HUMAN, P43694

Similarity: Contains 2 GATA-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GATA4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GATA4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002052

Applied Biosystems Silencer® siRNAs for GATA4

Sigma-Aldrich siRNA for GATA4

Sigma-Aldrich shRNA for GATA4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002052
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002052
untagged cDNA clone in CMV expression vector: NM_002052

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002052

UniProtKB/Swiss-Prot: GATA4_HUMAN, P43694

Function: Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a

transcriptional activator of ANF in cooperation with NKX2-5 (By similarity)

Genatlas biochemistry entry for GATA4:

transcription factor,GATA sequence binding protein,involved in lineage determination,expressed in

heart,gut,primitive endoderm,gonads,maybe involvedd in heart defects in patients with a deletion

del8 (p213)

15/16 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Gata4) (see all 16 ):

	digestive/alimentary	embryogenesis	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system
muscle	nervous system	no phenotypic analysis	reproductive system	respiratory system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0003704	specific RNA polymerase II transcription factor activity	ISS	--
GO:0008134	transcription factor binding	IPI	9858576
GO:0008270	zinc ion binding	IEA	--
GO:0016563	transcription activator activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for GATA4 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Role of NFAT in Regulation of the Immune Response
Thrombin Signaling
Cardiomyocyte Differentiation via BMP Receptors
Cardiac Hypertrophy Signaling
Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency

GeneDecks GATA4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for GATA4

5/136 Interacting proteins for GATA4 (P43694² ENSP00000334458³) via UniProtKB, MINT, and/or STRING (see all 136 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KLF13	Q9Y2Y9², ENSP00000302456³	MINT-3379492 MINT-3379533 MINT-3379514 STRING (score=.821)
NKX2-5	ENSP00000327758³	STRING (score=.999)
ZFPM2	ENSP00000346051³	STRING (score=.998)
TBX5	ENSP00000309913³	STRING (score=.995)
EDN1	ENSP00000368683³	STRING (score=.994)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001947	heart looping	ISS	--
GO:0006366	transcription from RNA polymerase II promoter	ISS	12845333
GO:0007267	cell-cell signaling	ISS	--
GO:0010575	positive regulation vascular endothelial growth factor production	ISS	--
GO:0035054	embryonic heart tube anterior/posterior pattern formation	ISS	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for GATA4
10/12 Novoseek chemical compound relationships for GATA4 gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	54.47	35	11842118 (4), 17290010 (2), 9312027 (1), 12439631 (1) (see all 23)
azathioprine	46.83	2	19253817 (1)
glycogen	18.02	1	11382772 (1)
epoxide	5.77	1	14984931 (1)
steroid	0.83	2	15919738 (1), 16537928 (1)
forskolin	0.00	3	12554796 (1), 16109788 (1)
oligonucleotide	0.00	2	12532156 (1)
matrigel	0.00	1	12021244 (1)
nitric oxide	0.00	5	15572049 (3)
calcium	0.00	4	17640476 (1), 15913645 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (GATA4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (GATA4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002052

Sigma-Aldrich siRNA for GATA4

Sigma-Aldrich shRNA for GATA4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002052

REFSEQ mRNAs for GATA4 gene:

NM_002052.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002052

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002052
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002052
                                 untagged cDNA clone in CMV expression vector: NM_002052

Additional cDNA sequence:

AF180736.1 AF318320.1 AK097060.1 AY740706.1 BC033672.1 BC068079.1 BC101580.1 BC105108.1

BC143434.1 BC143479.1 CR609988.1 D78260.1 L34357.1

4 DOTS entries:

DT.97840387 DT.452800 DT.306804 DT.95371365

24/105 AceView cDNA sequences (see all 105 ):

AW087784 BE502232 BQ685606 BF513628 BF058124 BC033672 AI187315 CA776901

CR609988 NM_002052 AI809988 BE672057 AI218830 BM931880 AI218020 BV185661

AL572860 R01769 BF115597 BF194806 BF196317 BC068079 BI826615 BM768320

highest scoring ESTs for GATA4:

L34357 AA398865 AA416792 AA431347 AA431631 AA435865 AA527367 AA812789 AF180736 AI024047

Unigene Cluster for GATA4:

GATA binding protein 4

Hs.243987 [show with all ESTs]

Unigene Representative Sequence: NM_002052

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000335135 ENST00000382335 ENST00000259090

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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GATA4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for GATA4

¹ / ² / ³

5 probe-sets matching GATA4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34241_at²^{, 3}	U95-A	1	0.94	1.00	1.00	1.00	L34357	1.00	1.00	1.00	1
205517_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AV700724	0.80	1.00	0.91	1
205517_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1570276_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1553131_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks GATA4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: GAGACTCCTT

SOURCE GeneReport for Unigene cluster: Hs.243987
Expression variation in blood from EXPOLDB for GATA4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for GATA4 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	GATA4¹	--	GATA binding protein 4	92.01(n) 95.02(a)	486079 XM_543205.2 XP_543205.2
chimpanzee (Pan troglodytes)	GATA4¹	--	GATA binding protein 4	98.58(n) 98.99(a)	472698 XM_528070.2 XP_528070.2
cow (Bos taurus)	GATA4¹	--	GATA binding protein 4	90.95(n) 95.02(a)	327716 XM_616466.3 XP_616466.2
rat (Rattus norvegicus)	Gata4¹	--	GATA binding protein 4	89.5(n) 94.52(a)	54254 NM_144730.1 NP_653331.1
mouse (Mus musculus)	Gata4^{1, 5}	14 (28.00 cM)⁵	GATA binding protein 4^{1, 5}	88.58(n)¹ 94.06(a)¹	14463¹ NM_008092.3¹ NP_032118.2¹ AB075549⁵ AF179424⁵ (see all 17)

About this table Species with no ortholog for GATA4

ENSEMBL Gene Tree for GATA4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for GATA4 gene

GATA3² GATA2² GATA1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/419 NCBI SNPs in GATA4 are shown (see all 419 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 201)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1062219^1,2	A,C,F,H,O	11653819(+)	`GGATGC/TGACGG`	1	--	ut3¹ ese³		3	EU EA	250
--	rs12825^1,2	A,C,F,H,O	11653956(-)	`CCCCTG/CTAGCT`	1	--	ut3¹ ese³		6	MN EU EA WA	790
	rs867858^1,2	A,C,F,H,O	11653747(-)	`CCGCTT/GGTTCT`	1	--	ut3¹ ese³		12	MN EU EA WA NA	1090
--	rs884662^1,2	A,C,F,H,O	11653910(-)	`CCACAA/GTTTTG`	1	--	ut3¹		5	EU EA WA MN	594
--	rs904018^1,2	A,C,F,H	11653925(-)	`CTTGTG/ATGTCA`	1	--	ut3¹ ese³		5	MN EU EA WA	592
	rs12458^1,2	A,C,F,H	11654649(+)	`GCTCAA/TGGAGA`	1	--	ut3¹ ese³		9	MN EU EA WA NA	2440
	rs11785481^1,2	C,F,H	11654551(+)	`CACGGC/TAGGGG`	1	--	ut3¹ ese³		8	EU EA WA	822
	rs3203358^1,2	C,F,H	11654914(+)	`TATTCC/GTCTTT`	1	--	ut3¹ trp³		5	EA EU WA	1908
	rs10108052^1,2	A,C,F	11655172(+)	`AAACAG/AAGTTC`	1	--	ng3¹		3	NA	126
	rs3729856^1,2	C,F	11651984(+)	`GGCACA/GGCAGC`	1	S/G	mis¹ ese³		5	NA EU EA WA	478

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HapMap Linkage Disequilibrium images for GATA4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600576 disorders: 607941

UniProtKB/Swiss-Prot: GATA4_HUMAN, P43694

Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is

a congenital heart malformation characterized by incomplete closure of the wall between the atria

resulting in blood flow from the left to the right atria. ASD2 patients show other heart

abnormalities including ventricular and atrioventricular septal defects, pulmonary valve

thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the

cardiac conduction system or non-cardiac abnormalities

10/34 Novoseek disease relationships for GATA4 gene (see all 34 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cardiac hypertrophy	60.51	13	15249177 (2), 18005871 (1), 18036354 (1), 14761664 (1) (see all 10)
septal defect	55.41	11	12845333 (4), 18055909 (3), 17352393 (1), 17643447 (1) (see all 5)
heart defects congenital	53.11	9	16604480 (2), 16077733 (1), 18305343 (1), 10096597 (1) (see all 7)
adrenal tumor	52.43	7	15256532 (2), 14666170 (2), 17207921 (1), 10449810 (1) (see all 5)
congenital heart disease	51.93	19	10096597 (6), 17592645 (2), 18672102 (2), 15249177 (1) (see all 11)
atrial septal defects	49.82	11	18305343 (2), 15810002 (2), 14557051 (2), 17053787 (1) (see all 7)
hypertrophy	46.72	8	11739382 (2), 15220332 (1), 15574430 (1), 18830417 (1) (see all 7)
atrioventricular septal defect	46.26	1	17592645 (1)
cardiomyopathy	39.94	3	10677255 (1), 17643447 (1), 12231398 (1)
ventricular septal defects	37.71	2	19302747 (1)

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Human Gene Mutation Database: GATA4
Human Genome Epidemiology Navigator: GATA4 (9 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/293 PubMed articles for GATA4 gene (see all 293 ):

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. (PubMed id 12845333)^{1, 3, 4} Garg V.... Srivastava D. (2003)
Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization). (PubMed id 7665171)^{1, 2, 3} White R.A....Wilson D.B. (1995)
Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect. (PubMed id 15810002)^{1, 3, 4} Hirayama-Yamada K....Matsuoka R. (2005)
Identification of a GATA motif in the cardiac alpha-myosin heavy- chain-encoding gene and isolation of a human GATA-4 cDNA. (PubMed id 7721094)^{1, 3, 4} Huang W.Y.... Liew C.C. (1995)
A negative feedback regulatory loop associates the tyrosine kinase receptor ERBB2 and the transcription factor GATA4 in breast cancer cells. (PubMed id 19276186)^{1, 3} Hua G....Imbert J. (2009)
GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors. (PubMed id 18653721)^{1, 3} Kyronlahti A....Anttonen M. (2008)
Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease. (PubMed id 17352393)^{1, 3} Schluterman M.K....Garg V. (2007)
Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types. (PubMed id 17912029)^{1, 3} Fu B....Iacobuzio-Donahue C.A. (2007)
Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD). (PubMed id 17592645)^{1, 3} Reamon-Buettner S.M....Borlak J. (2007)
Spectrum of heart disease associated with murine and human GATA4 mutation. (PubMed id 17643447)^{1, 3} Rajagopal S.K....Pu W.T. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2626	HGNC: 4173	AceView: GATA4	Ensembl:ENSG00000136574	euGenes: HUgn2626
ECgene: GATA4	H-InvDB: GATA4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=GATA4

Licensable Technologies for GATA4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for GATA4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for GATA4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for GATA4		Antibodies for GATA4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for GATA4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (GATA4)
	Antibodies (GATA4)
	Chimera RNAi (GATA4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (GATA4)
	Antibodies (GATA4)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for GATA4

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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GATA4 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for GATA4

Summaries
for GATA4

Genomic Location
for GATA4

Proteins
for GATA4

Protein Domains/
Families
for GATA4

Gene Function
for GATA4

Pathways & Interactions
for GATA4

Drugs & Compounds
for GATA4

Transcripts
for GATA4

Expression
for GATA4

Orthologs
for GATA4

Paralogs
for GATA4

SNPs/Variants
for GATA4

Disorders & Mutations
for GATA4

Medical News
for GATA4

Publications
for GATA4

Search for GATA4

Genome Databases showing GATA4

Other Databases showing GATA4

Specialized Databases showing GATA4

Licensable Technologies
for GATA4

Services
for GATA4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

GATA4 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor GATA4

Summariesfor GATA4

Genomic Locationfor GATA4

Proteinsfor GATA4

Protein Domains/Familiesfor GATA4

Gene Functionfor GATA4

Pathways & Interactionsfor GATA4

Drugs & Compoundsfor GATA4

Transcriptsfor GATA4

Expression for GATA4

Orthologsfor GATA4

Paralogsfor GATA4

SNPs/Variantsfor GATA4

Disorders & Mutationsfor GATA4

Medical Newsfor GATA4

Publicationsfor GATA4

Search for GATA4

Genome Databases showing GATA4

Other Databases showing GATA4

Specialized Databases showing GATA4

Licensable Technologiesfor GATA4

Servicesfor GATA4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for GATA4

Summaries
for GATA4

Genomic Location
for GATA4

Proteins
for GATA4

Protein Domains/
Families
for GATA4

Gene Function
for GATA4

Pathways & Interactions
for GATA4

Drugs & Compounds
for GATA4

Transcripts
for GATA4

Expression
for GATA4

Orthologs
for GATA4

Paralogs
for GATA4

SNPs/Variants
for GATA4

Disorders & Mutations
for GATA4

Medical News
for GATA4

Publications
for GATA4

Licensable Technologies
for GATA4

Services
for GATA4