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EGFR Gene

protein-coding   GIFtS: 79
GCID: GC07P055054

Epidermal Growth Factor Receptor

(Previous name: epidermal growth factor receptor (avian erythroblastic leukemia...)
(Previous symbol: ERBB)
  See EGFR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Epidermal Growth Factor Receptor1 2     Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian)1
ERBB1 2 3     PIG612
Proto-Oncogene C-ErbB-12 3     Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog2
Receptor Tyrosine-Protein Kinase ErbB-12 3     Cell Growth Inhibiting Protein 402
ERBB12 3     Cell Proliferation-Inducing Protein 612
HER12 3     mENA2
EC 2.7.10.13 8     EC 2.7.108
Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral
(V-Erb-B) Oncogene Homolog)1
     

External Ids:    HGNC: 32361   Entrez Gene: 19562   Ensembl: ENSG000001466487   OMIM: 1315505   UniProtKB: P005333   

Export aliases for EGFR gene to outside databases

Previous GC identifers: GC07P054550 GC07P054794 GC07P054828 GC07P054860


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EGFR Gene:
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase
superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface
protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization
and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung
cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found
for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for EGFR Gene:
EGFR (epidermal growth factor receptor) is a protein-coding gene. Diseases associated with EGFR include paronychia, and brain ependymoma. GO annotations related to this gene include chromatin binding and identical protein binding. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
Function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to
convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha,
amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding
triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The
phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling
cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT,
PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates
other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the
G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and
CTNNB1/beta-catenin
Function: Isoform 2 may act as an antagonist of EGF action

summary for EGFR Gene:
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members
of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates
receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in
receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling
cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal
rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for EGFR (Epidermal growth factor receptor) Gene

PharmGKB "VIP" summary for EGFR


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the EGFR gene promoter:
         Max1   p53   STAT3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): EGFR promoter sequence
   Search Chromatin IP Primers for EGFR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EGFR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p12

EGFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EGFR gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P055054:  view genomic region     (about GC identifiers)

Start:
55,086,714 bp from pter      End:
55,324,313 bp from pter
Size:
237,600 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 55,092,507-55,280,831     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533 (See protein sequence)
Recommended Name: Epidermal growth factor receptor precursor  
Size: 1210 amino acids; 134277 Da
Subunit: Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its
autophosphorylation. Heterodimer with ERBB2. Interacts with ERRFI1; inhibits dimerization of the kinase domain
and autophosphorylation. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. Interacts with GRB2; an
adapter protein coupling the receptor to downstream signaling pathways. Interacts with GAB2; involved in
signaling downstream of EGFR. Interacts with STAT3; mediates EGFR downstream signaling in cell proliferation.
Interacts with RIPK1; involved in NF-kappa-B activation. Interacts (autophosphorylated) with CBL, CBLB and CBLC;
involved in EGFR ubiquitination and regulation. Interacts with SOCS5; regulates EGFR degradation through TCEB1-
and TCEB2-mediated ubiquitination and proteasomal degradation. Interacts with PRMT5; methylates EGFR and enhances
interaction with PTPN6. Interacts (phosphorylated) with PTPN6; inhibits EGFR-dependent activation of MAPK/ERK.
Interacts with COPG1; essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde
trafficking from the Golgi to the ER. Interacts with TNK2; this interaction is dependent on EGF stimulation and
kinase activity of EGFR. Interacts with PCNA; positively regulates PCNA. Interacts with PELP1. Interacts with
MUC1. Interacts with AP2M1. Interacts with FER. May interact with EPS8; mediates EPS8 phosphorylation. Interacts
(via SH2 domains) with GRB2, NCK1 and NCK2. Interacts with ATX2. Interacts with GAREM. Interacts (ubiquitinated)
with ANKRD13A/B/D; the interaction is direct and may regulate EGFR internalization after EGF stimulation.
Interacts with GPER1; the interaction occurs in an estrogen-dependent manner
Selected PDB 3D structures from and Proteopedia for EGFR (see all 93):
1DNQ (3D)        1DNR (3D)        1IVO (3D)        1M14 (3D)        1M17 (3D)        1MOX (3D)    
Secondary accessions: O00688 O00732 P06268 Q14225 Q68GS5 Q92795 Q9BZS2 Q9GZX1 Q9H2C9 Q9H3C9
Q9UMD7 Q9UMD8 Q9UMG5
Alternative splicing: 4 isoforms:  P00533-1   P00533-2   P00533-3   P00533-4   

Explore the universe of human proteins at neXtProt for EGFR: NX_P00533

Explore proteomics data for EGFR at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-695 is partial and occurs only if Thr-693 is phosphorylated. Phosphorylation at Thr-678 and
    Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Dephosphorylation by PTPRJ prevents endocytosis and
    stabilizes the receptor at the plasma membrane. Autophosphorylation at Tyr-1197 is stimulated by methylation at
    Arg-1199 and enhances interaction with PTPN6. Autophosphorylation at Tyr-1092 and/or Tyr-1110 recruits STAT3.
    Dephosphorylated by PTPN1 and PTPN21
  • Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or
    signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63',
    but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occurs. Deubiquitination by OTUD7B prevents degradation1
  • Methylated. Methylation at Arg-1199 by PRMT5 stimulates phosphorylation at Tyr-11971
  • Ubiquitination2 at Lys716, Lys737, Lys754, Lys860, Lys867, Lys929, Lys970
  • Glycosylation2 at Asn56, Asn73, Asn128, Asn175, Asn196, Asn352, Asn361, Asn413, Asn444, Asn528,
                                 Asn568, Asn603, Asn623
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EGFR (P00533) (see all 27)
     KPYDGIP  YGVTVWE  RDLAARN  RYLVIQG 


    See EGFR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_005219.2  NP_958439.1  NP_958440.1  NP_958441.1  

    ENSEMBL proteins: 
     ENSP00000415559   ENSP00000342376   ENSP00000345973   ENSP00000413843   ENSP00000275493  
     ENSP00000413354   ENSP00000410031   ENSP00000395243  
    Reactome Protein details: P00533

    EGFR Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant EGFR Protein
    R&D Systems Recombinant & Natural Proteins for EGFR (EGF R/ErbB1)
    Enzo Life Sciences proteins for EGFR
    OriGene Purified Proteins for EGFR
    OriGene Protein Over-expression Lysate for EGFR
    OriGene MassSpec for EGFR
    OriGene Custom Protein Services for EGFR
    GenScript Custom Purified and Recombinant Proteins Services for EGFR
    Novus Biologicals EGFR Proteins
    Novus Biologicals EGFR Lysates
    Sino Biological Recombinant Protein for EGFR
    Sino Biological Cell Lysate for EGFR
    ProSpec Recombinant Protein for EGFR
    Cloud-Clone Corp. Proteins for EGFR

     
    Search eBioscience for Proteins for EGFR 

     
    antibodies-online proteins for EGFR (38 products) 

     
    antibodies-online peptides for EGFR

    EGFR Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EGFR
    R&D Systems Antibodies for EGFR (EGF R/ErbB1)
    Cell Signaling Technology (CST) Antibodies for EGFR 
    OriGene Antibodies for EGFR
    OriGene Custom Antibody Services for EGFR
    Novus Biologicals EGFR Antibodies
    Abcam antibodies for EGFR
    Cloud-Clone Corp. Antibodies for EGFR
    ThermoFisher Antibody for EGFR
    antibodies-online antibodies for EGFR (1374 products) 

    EGFR Assay Products:

    EMD Millipore Kits and Assays for the Analysis of EGFR
    OriGene Custom Assay Services for EGFR
    R&D Systems ELISAs for EGFR (EGF R/ErbB1)         (see all)
    GenScript EGFR-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for EGFR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EGFR
    Cloud-Clone Corp. CLIAs for EGFR
    Search eBioscience for ELISAs for EGFR 
    antibodies-online kits for EGFR (96 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: epidermal growth factor receptor
    ErbB (epidermal growth factor) receptor family

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR000494 EGF_rcpt_L
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR009030 Growth_fac_rcpt_N_dom

    Graphical View of Domain Structure for InterPro Entry P00533

    ProtoNet protein and cluster: P00533

    4 Blocks protein domains:
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with EGFR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EGFR_HUMAN, P00533
    Function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to
    convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha,
    amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding
    triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The
    phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling
    cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT,
    PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates
    other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the
    G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and
    CTNNB1/beta-catenin
    Function: Isoform 2 may act as an antagonist of EGF action
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Endocytosis and inhibition of the activated EGFR by phosphatases like PTPRJ and PTPRK
    constitute immediate regulatory mechanisms. Upon EGF-binding phosphorylates EPS15 that regulates EGFR endocytosis
    and activity. Moreover, inducible feedback inhibitors including LRIG1, SOCS4, SOCS5 and ERRFI1 constitute
    alternative regulatory mechanisms for the EGFR signaling

         Genatlas biochemistry entry for EGFR:
    epidermal growth factor receptor,also binding transforming growth factor alpha (TGFA),involved in early
    craniofacial development and palate closure,phosphorylating GJB1,amplified in prostate carcinoma and in
    astrocytomas,deleted in glioblastomas and mutated in malignant oral keratinocytes

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IEA--
    GO:0003682chromatin binding IDA--
    GO:0003690double-stranded DNA binding NAS6325948
    GO:0004672protein kinase activity ----
    GO:0004709MAP kinase kinase kinase activity NAS15542601
         
    Find genes that share ontologies with EGFR           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for EGFR:
     Decreased focal adhesion (FA)   Decreased p24 protein expressi  Decreased substrate adherent c  Decreased viability with pacli 
     Increased S DNA content  Increased cell death HMECs cel 

         Selected MGI mutant phenotypes (inferred from 15 alleles(MGI details for Egfr) (see all 27):
     adipose tissue  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    Find genes that share phenotypes with EGFR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for EGFR: Egfrtm1Arge Egfrtm1Rdk Egfrtm1.1Dwt Egfrtm1Mag

       genOway: Develop your customized and physiologically relevant rodent model for EGFR

    miRNA
    Products:
        
    miRTarBase miRNAs that target EGFR:
    hsa-mir-133a-3p (MIRT007032), hsa-mir-146a-5p (MIRT004730), hsa-mir-7-5p (MIRT002289), hsa-mir-542-5p (MIRT006330), hsa-let-7a-5p (MIRT035541), hsa-mir-1 (MIRT001370), hsa-mir-335-5p (MIRT018378), hsa-mir-30a-5p (MIRT028600), hsa-mir-133b (MIRT007069), hsa-mir-16-5p (MIRT001470), hsa-mir-155-5p (MIRT020911), hsa-mir-128-3p (MIRT004353), hsa-mir-21-5p (MIRT005807), hsa-mir-128b (MIRT006585), hsa-mir-301b (MIRT036702), hsa-mir-27a-3p (MIRT007360)

    Block miRNA regulation of human, mouse, rat EGFR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EGFR (see all 17):
    hsa-miR-579 hsa-miR-607 hsa-miR-186* hsa-miR-586 hsa-miR-875-5p hsa-miR-27a hsa-miR-548o hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmidEGFR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EGFR
    Predesigned siRNA for gene silencing in human, mouse, rat EGFR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EGFR

    Clone
    Products:
         
    OriGene clones in human, mouse for EGFR (see all 26)
    OriGene ORF clones in mouse, rat for EGFR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): EGFR (NM_201282)
    Sino Biological Human cDNA Clone for EGFR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGFR
    Addgene plasmids for EGFR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EGFR
    Browse ESI BIO Cell Lines and PureStem Progenitors for EGFR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFR

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11736 VA4-11747) for EGFR 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EGFR_HUMAN, P00533: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus
    membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. Note=In response to EGF,
    translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand.
    Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF)
    EGFR_HUMAN, P00533: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    extracellular5
    golgi apparatus5
    nucleus5
    plasma membrane5
    cytosol4
    cytoskeleton3
    lysosome2
    mitochondrion2
    vacuole2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005615extracellular space NAS9103388
    GO:0005622intracellular ----
    GO:0005634nucleus IDA12828935
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with EGFR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EGFR About   (see all 109)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    ErbB receptor signaling network0.00
    2Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    3Development Dopamine D2 receptor transactivation of EGFR
    Development Dopamine D2 receptor transactivation of EGFR0.66
    Apoptosis and survival BAD phosphorylation0.41
    Development Alpha 2 adrenergic receptor activation of ERK0.66
    BAD Phosphorylation0.41
    4Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    EGF Pathway0.39
    Development ERBB family signaling0.57
    5Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA transactivation of EGFR0.41
    Estrogen signaling pathway0.34
    GnRH signaling pathway0.38


    Find genes that share SuperPaths with EGFR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for EGFR
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EGFR (see all 78)
        Telomerase Components in Cell Signaling
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for EGFR
        Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for EGFR
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for EGFR (see all 24)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Development EGFR signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways
    Development ERBB-family signaling
    Cell adhesion PLAU signaling

    Selected BioSystems Pathways for EGFR (see all 31)
        MAPK signaling pathway
    Focal Adhesion
    EGFR1 Signaling Pathway
    ErbB signaling pathway
    Integrated Breast Cancer Pathway

    1 Sino Biological Pathway for EGFR
        EGFR Signaling Pathway

    Selected Reactome Pathways for EGFR (see all 17)
        EGFR Transactivation by Gastrin
    EGFR downregulation
    Signaling by ERBB2
    Signal transduction by L1
    GAB1 signalosome

    3 PharmGKB Pathways for EGFR
        EGFR Inhibitor Pathway, Pharmacodynamics
    Erlotinib Pathway, Pharmacokinetics
    Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for EGFR) (see all 30):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Calcium signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EGFR (see all 24): 
              Lung Cancer in human mouse rat
              Wound Healing in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EGFR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EGFR (P005331, 2, 3 ENSP000002754934) via UniProtKB, MINT, STRING, and/or I2D (see all 853)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHC1P293531, 2, 3, ENSP000004013034EBI-297353,EBI-78835 MINT-74727 MINT-74729 MINT-8038549 MINT-74731 MINT-1782377 MINT-61491 MINT-8038504 MINT-1782352 MINT-74732 MINT-61499 MINT-8401401 MINT-8038534 MINT-61501 MINT-74730 MINT-17353 MINT-8401377 MINT-61495 MINT-61482 MINT-74728 MINT-61503 MINT-61489 MINT-8038489 MINT-8038564 I2D: score=10 STRING: ENSP00000401303
    ENSG00000215328P081071, 3, ENSP000003829154EBI-297353,EBI-629985 I2D: score=3 STRING: ENSP00000382915
    ENSG00000237724P081071, 3, ENSP000004063594EBI-297353,EBI-629985 I2D: score=3 STRING: ENSP00000406359
    HSPA1AP081071, 3, ENSP000003648024EBI-297353,EBI-629985 I2D: score=3 STRING: ENSP00000364802
    ENSG00000212866P081071, 3EBI-297353,EBI-629985 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 87):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade NAS15542601
    GO:0000186activation of MAPKK activity ----
    GO:0000902cell morphogenesis ----
    GO:0001503ossification NAS12925580
    GO:0001889liver development IEA--

    Find genes that share ontologies with EGFR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for EGFR
    Selected ApexBio Compounds for EGFR (see all 31)     About this table
    CompoundAction CAS #
    AC480 (BMS-599626)orally bioavailable inhibitor of the HER1, HER2 and HER4[714971-09-2]
    AEE788 (NVP-AEE788)novel multitargeted HER 1/2 and VEGFR 1/2[497839-62-0]
    Afatinib (BIBW2992)Irreversible EGFR and HER2 inhibitor[439081-18-2]
    AG-18Inhibits EGFR,PDGFR[118409-57-7]
    AG-490inhibitor of EGFR[133550-30-8]
    AP26113Dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR)[1197958-12-5]
    ARRY-380orally bioavailable inhibitor of the human EGFR tyrosine kinase ErbB-2[937265-83-3]
    AZD8931 (Sapitinib)ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3[848942-61-0]
    BMS-690514potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4[859853-30-8]
    Buteina reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-kinase beta[487-52-5]

    Compounds for EGFR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Iressa Orally active, selective EGFR inhibitor [184475-35-2]
    AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
    JNJ 28871063 hydrochloridePotent ErbB receptor family inhibitor[944341-54-2]
    AG 1478 hydrochlorideHighly potent EGFR-kinase inhibitor[153436-53-4]
    GenisteinEGFR kinase inhibitor. Also estrogen and PPARgamma ligand[446-72-0]

    4 HMDB Compounds for EGFR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-117681751
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Tyrosine(-)-a-Amino-p-hydroxyhydrocinnamate (see all 28)60-18-4--

    Selected DrugBank Compounds for EGFR (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LapatinibFMM (see all 5)388082-78-8targetantagonist15163842 14751502 16894399 20110044 12214266 18803986 14967461 14737100 11752352 20658522 15374980 14633707
    Panitumumab-- 339177-26-3targetsuppressor12620146 11894013 20481659 18343240 16012181 14967460 18503402 16857825 17355997 11752352 20623992 11255078
    CetuximabAnti EGFR (see all 2)205923-56-4targetantagonist10480573 11408594 11752352 11431346 10628369 10601294
    ErlotinibCP358774 (see all 2)183321-74-6targetantagonist12517254 12814826 12820772 11752352 12840797 12498017
    Gefitinib-- 184475-35-2targetantagonist11585753 11566608 11752352 11522647 10815932 11673690
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352
    LidocaineDilocaine (see all 2)137-58-6targetantagonist16551906
    N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE-- --target--10592235
    S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE-- --target--10592235
    TrastuzumabAnti HER2 (see all 2)180288-69-1target--11752352

    7 IUPHAR Ligands for EGFR (epidermal growth factor receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    EGF
    NoneNone--
    betacellulin
    NoneNone--
    epiregulin
    NoneNone--
    HB-EGF
    NoneNone--
    amphiregulin
    NoneNone--
    TGFalpha
    NoneNone--
    epigen
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for EGFR gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gefitinib 97.2 2922 17361439 (8), 16106023 (7), 16818686 (7), 16956694 (7) (see all 99)
    erlotinib 96.4 1156 16818686 (7), 17453292 (7), 16928826 (6), 19130057 (6) (see all 99)
    cetuximab 95.9 1196 12850474 (7), 16106023 (7), 20010090 (6), 17531336 (6) (see all 99)
    tyrosine 93.9 4999 16263724 (9), 16287490 (8), 12589790 (7), 10068444 (6) (see all 99)
    ag 1478 93.3 467 14676326 (5), 19947936 (5), 17092939 (4), 19816982 (4) (see all 99)
    panitumumab 92 186 17671148 (2), 18086972 (2), 20044619 (2), 18343240 (2) (see all 99)
    lapatinib 88.2 334 17635524 (6), 18644997 (5), 18199554 (5), 19529774 (4) (see all 99)
    pd153035 88 105 16211241 (2), 17934341 (2), 10473113 (2), 15562758 (2) (see all 60)
    zd6474 85.6 171 15604279 (8), 12684431 (5), 17145834 (4), 16688779 (3) (see all 67)
    trastuzumab 85.3 164 19188134 (5), 16161043 (4), 17622245 (4), 16163699 (2) (see all 95)

    Selected PharmGKB related drug/compound annotations for EGFR gene (see all 14)    About this table
    Drug/compound PharmGKB Annotation
    Alkylating AgentsCA  
    afatinib
    carboplatinCA  
    cetuximab  CA  
    docetaxelCA  
    egfr inhibitorsCA  
    erlotinib  CA  
    gefitinib  CA  
    geldanamycinCA  
    gemcitabineCA  



    Find genes that share compounds with EGFR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for EGFR gene (4 alternative transcripts): 
    NM_005228.3  NM_201282.1  NM_201283.1  NM_201284.1  

    Unigene Cluster for EGFR:

    Epidermal growth factor receptor
    Hs.488293  [show with all ESTs]
    Unigene Representative Sequence: NM_005228
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455089(uc022adm.1 uc010kzg.2 uc022ado.1) ENST00000342916(uc003tqi.3)
    ENST00000344576(uc003tqj.3) ENST00000420316(uc003tqh.3) ENST00000275493(uc003tqk.3 uc022adn.1 uc011kco.2)
    ENST00000459688 ENST00000463948 ENST00000450046 ENST00000485503 ENST00000442591(uc011kcq.1 uc011kcp.1)
    ENST00000454757
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EGFR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EGFR (see all 17):
    hsa-miR-579 hsa-miR-607 hsa-miR-186* hsa-miR-586 hsa-miR-875-5p hsa-miR-27a hsa-miR-548o hsa-miR-545
    SwitchGear 3'UTR luciferase reporter plasmidEGFR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EGFR
    Predesigned siRNA for gene silencing in human, mouse, rat EGFR
    Clone
    Products:
         
    OriGene clones in human, mouse for EGFR (see all 26)
    OriGene ORF clones in mouse, rat for EGFR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): EGFR (NM_201282)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EGFR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EGFR
    Addgene plasmids for EGFR 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EGFR
    OriGene qSTAR qPCR primer pairs in human, mouse for EGFR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGFR
      QuantiTect SYBR Green Assays in human, mouse, rat EGFR
      Search QuantiFast Probe-based Assays in human, mouse, rat EGFR
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11736 VA4-11747) for EGFR 

    Additional mRNA sequence: 

    AB209442.1 AF125253.1 AF277897.1 AK225422.1 AK290352.1 AK294750.1 AY550966.1 AY698023.1 
    AY698024.1 BC070081.1 BC094761.1 BC118665.1 BC128419.1 BC134346.1 DQ088980.1 EF210210.1 
    EF210211.1 GU255993.1 HM437234.1 HM437235.1 HQ730875.1 HQ912715.1 HQ999997.1 K03193.1 
    U48722.1 U95089.1 X00588.1 X00663.1 

    21 DOTS entries:

    DT.97784849  DT.453606  DT.121058602  DT.86855651  DT.95165593  DT.101978019  DT.92446350  DT.100752430 
    DT.121058582  DT.91654361  DT.121058480  DT.121058532  DT.121058546  DT.121058650  DT.418647  DT.95254161 
    DT.97822681  DT.91963338  DT.95095929  DT.95165591  DT.95229256 

    Selected AceView cDNA sequences (see all 484):

    AL041799 T82902 BM747582 BX108964 BG619090 BC057802 AA768080 BQ575631 
    AW275823 CD671692 AI744605 CB269761 NM_201284 AI074153 BC070081 CA436447 
    H80439 AI301624 BM742695 CB268886 AU105293 BM743093 BX378635 H80438 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    EGFR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGCATTAG
    EGFR Expression
    About this image


    EGFR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Semilunar Valve Cells Semilunar Valves
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             Rib
             Bone marrow-derived mesenchymal stem cells
     
     Placenta (Extraembryonic Tissues)
             Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
     
     Epithelial Cells
             Primary Hair Placode Cells Hair Follicle
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
    EGFR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EGFR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.488293

    UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
    Tissue specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EGFR (see all 24): 
              Lung Cancer in human mouse rat
              Wound Healing in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Prostate Cancer in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EGFR
    OriGene qSTAR qPCR primer pairs in human, mouse for EGFR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EGFR
    QuantiTect SYBR Green Assays in human, mouse, rat EGFR
    Search QuantiFast Probe-based Assays in human, mouse, rat EGFR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EGFR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for EGFR gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Egfr1 , 5 epidermal growth factor receptor1, 5 85.13(n)1
    90.65(a)1
      11 (9.41 cM)5
    136491  NM_207655.21  NP_997538.11 
     167522035 
    chicken
    (Gallus gallus)
    Aves EGFR1 epidermal growth factor receptor 73.92(n)
    78.48(a)
      396494  NM_205497.2  NP_990828.2 
    lizard
    (Anolis carolinensis)
    Reptilia EGFR6
    epidermal growth factor receptor
    73(a)
    1 ↔ 1
    6(51109057-51161436)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia egfr1 epidermal growth factor receptor 65.85(n)
    68.05(a)
      100492965  XM_002939914.2  XP_002939960.2 
    zebrafish
    (Danio rerio)
    Actinopterygii egfr2 epidermal growth factor receptor 75.84(n)   378478  AY154658.1 


    ENSEMBL Gene Tree for EGFR (if available)
    TreeFam Gene Tree for EGFR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for EGFR gene
    SYK2  TNK12  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  
    ERBB32  PTK22  ERBB22  ZAP702  PTK2B2  
    Selected SIMAP similar genes for EGFR using alignment to 29 protein entries:     EGFR_HUMAN (see all proteins) (see all similar genes):
    EPHA4    ERBB2    ERBB4    FLT4    MATK    ERBB3
    TXK    FGFR1    ABL1    RET/PTC2    DKFZp686M05208    c-erbB-3
    MAPK3    RPS6KA2    TNK2    HER-2    TYK2    JAK2

    Find genes that share paralogs with EGFR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for EGFR (see all 4546)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289294951,2,,4
    Cpathogenic155247498(+) TGCTGA/G/TGCTCC 3 S G C mis1 ese30--------
    rs1219134281,2
    Cpathogenic155247499(+) GCTGGA/C/GCTCCG 3 D A G mis10--------
    rs1214345691,2
    Cpathogenic155254862(+) CATCAC/TGCAGC 2 T M mis10--------
    rs1048860121,2
    Cuntested155265277(+) ACACCA/G/TCAGCA 2 P syn11NA 4552
    rs1219134181,2
    Cunknown155248302(+) TCCTCA/G/TATGTG 3 N D Y mis10--------
    rs1214345681,2,,4
    Cother155265306(+) TGGGCG/TGGCCA 2 R L mis10--------
    rs3739346481,2
    C--55088252(+) GTCTT-/ACAC  
            
    ACACA
    4 -- int10--------
    rs455595421,2
    F--55088253(+) GTCTT-/AC/ACAC/ACACAC/ACACACAC/ACACACACAC/ACACACACACAC/ACACACACAC
    ACAC
    /ACACACACACACACAC/ACACACACACACACACAC/ACACACACACACACACACAC
    CGGAT
    16 -- int1 cds11--846
    rs710146761,2
    C--55088286(+) CACAC-/ACACA/
    ACACACAC
    CGGAT
    4 -- int11NA 2
    rs1871425261,2
    --55090691(+) CTAGTA/CATTCT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for EGFR (55086714 - 55324313 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EGFR (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1133e201CNV Deletion23290073
    esv2734425CNV Deletion23290073
    esv2734437CNV Deletion23290073
    esv2734441CNV Deletion23290073
    esv2734440CNV Deletion23290073
    esv2660266CNV Deletion23128226
    esv2590945CNV Insertion19546169
    nsv5753CNV Insertion18451855
    nsv515544CNV Loss19592680
    nsv5752CNV Loss18451855

    Human Gene Mutation Database (HGMD): EGFR
    Selected Site Specific Mutation Identification with PCR Assays for EGFR (see all 56):
    Cosmic IdAA Change
    13427p.E709A
    13551p.E746_T751>I
    6252p.G719S
    21687p.A289V
    21684p.T263P
    Selected Site Specific Cancer Mutation PCR Panels containing EGFR (see all 12):
    Esophageal Cancer
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    Oncogene Panel 384HT
    Receptor Tyrosine Kinase (RTK) (Panel I)
    4 Copy Number PCR Panels containing EGFR:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    Lung Cancer
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing EGFR
    DNA2.0 Custom Variant and Variant Library Synthesis for EGFR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 131550   
    OMIM disorders: 211980  
    UniProtKB/Swiss-Prot: EGFR_HUMAN, P00533
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form
    of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes:
    squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced
    stage and has a poor prognosis. Note=The gene represented in this entry is involved in disease pathogenesis

  • Selected diseases for EGFR (see all 61):    
    About MalaCards
    paronychia    brain ependymoma    adenocarcinoma of lung, response to tyrosine kinase inhibitor in    giant cell glioblastoma
    esophageal basaloid squamous cell carcinoma    nonsmall cell lung cancer, response to tyrosine kinase inhibitor in    lung cancer, egfr-related    non-small cell lung carcinoma
    spinal chordoma    congenital pulmonary airway malformation    troyer syndrome    basaloid squamous cell carcinoma
    ring chromosome 7    orbital lymphangioma    gliosarcoma    superior vena cava syndrome
    sinonasal undifferentiated carcinoma    ethmoid sinus adenocarcinoma    intraocular melanoma    transitional cell carcinoma

    20 diseases from the University of Copenhagen DISEASES database for EGFR:
    Lung cancer     Breast cancer     Carcinoma     Exanthem
    Colorectal cancer     Malignant glioma     Diarrhea     Pancreatic cancer
    Ovarian cancer     Urinary bladder cancer     Prostate cancer     Neutropenia
    Ductal carcinoma in situ     Lung disease     Folliculitis     Esophageal cancer
    Brain cancer     Cervical cancer     Laryngeal carcinoma     Renal cell carcinoma

    Find genes that share disorders with EGFR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EGFR gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nsclc 91.1 3311 18710625 (7), 16106023 (6), 15777970 (6), 18347146 (6) (see all 99)
    tumors 87.7 6585 14967457 (9), 11727256 (8), 8151316 (8), 18450321 (8) (see all 99)
    glioblastoma 85 799 11511795 (7), 15618223 (6), 10728703 (6), 10029453 (5) (see all 99)
    cancer 84.6 2745 11597399 (7), 1717146 (5), 16378905 (5), 17827454 (5) (see all 99)
    cancer lung 84.4 1481 12720099 (7), 19331130 (6), 16226114 (6), 17876048 (5) (see all 99)
    carcinoma squamous cell 83.6 957 9828815 (5), 16550055 (5), 9816015 (5), 7970803 (5) (see all 99)
    adenocarcinoma lung 83.3 453 16357156 (5), 18508816 (5), 19130320 (5), 7599067 (4) (see all 99)
    breast cancer 82.5 1846 15095477 (8), 11859875 (8), 9066618 (6), 8960138 (6) (see all 99)
    glioblastoma multiforme 79.6 193 15746047 (4), 17236582 (4), 11504770 (4), 17679463 (3) (see all 99)
    adenocarcinoma 78.4 750 16449241 (11), 17321325 (5), 15211117 (5), 16052218 (5) (see all 99)

    Genatlas disease: EGFR
    glioblastoma,multiform (amplification of deleted/rearranged EGFR)

    Genetic Association Database (GAD): EGFR
    Human Genome Epidemiology (HuGE) Navigator: EGFR (572 documents)
    Tumor Gene Database (TGDB): EGFR

    Export disorders for EGFR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EGFR gene, integrated from 10 sources (see all 8198):
    (articles sorted by number of sources associating them with EGFR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung. (PubMed id 17904685)1, 4, 9 Kim Y.T....Kim J.H. (Lung Cancer 2008)
    2. Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma. (PubMed id 18271929)1, 4, 9 Toyooka S....Date H. (Cancer Sci. 2008)
    3. Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma. (PubMed id 19726454)1, 4, 9 Hama T....Urashima M. (Oncologist 2009)
    4. Correlation of EGFR mutations with chromosomal alterations and expression of EGFR, ErbB3 and VEGF in tumor samples of lung adenocarcinoma patients. (PubMed id 18450321)1, 4, 9 Reinmuth N....Meister M. (Lung Cancer 2008)
    5. Are there imaging characteristics associated with epidermal growth factor receptor and KRAS mutations in patients with adenocarcinoma of the lung with bronchioloalveolar features? (PubMed id 20087229)1, 4, 9 Glynn C....Ginsberg M.S. (J Thorac Oncol 2010)
    6. Epidermal growth factor receptor mutations and their correlation with gefitinib therapy in patients with non-small cell lung cancer: a meta-analysis based on updated individual patient data from six medical centers in mainland China. (PubMed id 17473659)1, 4, 9 Wu Y.L....Mok T. (J Thorac Oncol 2007)
    7. Epidermal growth factor receptor mutation status and adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung. (PubMed id 17761979)1, 4, 9 Suehisa H....Date H. (J. Clin. Oncol. 2007)
    8. A correlation between EGFR gene mutation status and bronchioloalveolar carcinoma features in Japanese patients with adenocarcinoma. (PubMed id 16449241)1, 4, 9 Haneda H....Fujii Y. (Jpn. J. Clin. Oncol. 2006)
    9. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. (PubMed id 17538160)1, 4, 9 Temam S....Mao L. (J. Clin. Oncol. 2007)
    10. Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib response. (PubMed id 17453292)1, 4, 9 Tzeng C.W....Arnoletti J.P. (Ann. Surg. Oncol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1956 HGNC: 3236 AceView: EGFR Ensembl:ENSG00000146648 euGenes: HUgn1956
    ECgene: EGFR Kegg: 1956 H-InvDB: EGFR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EGFR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EGFR Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=EGFR[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/egfr/
    Wikipedia http://en.wikipedia.org/wiki/Epidermal_growth_factor_receptor

    (Patent information from GeneIP,
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    Patent Information for EGFR gene:
    Search GeneIP for patents involving EGFR

    Licensable Technologies for EGFR gene:
    Weizmann Institute:Combination of Antibodies to EGFR
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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