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Aliases for DICER1 Gene

Aliases for DICER1 Gene

  • Dicer 1, Ribonuclease III 2 3
  • Dicer 1, Ribonuclease Type III 2 3 5
  • Helicase MOI 3 4
  • EC 3.1.26.3 4 63
  • Dicer 3 4
  • HERNA 3 4
  • Dicer 1, Double-Stranded RNA-Specific Endoribonuclease 3
  • Double-Stranded RNA-Specific Endoribonuclease 2
  • Dicer1, Dcr-1 Homolog (Drosophila) 2
  • Helicase With RNAse Motif 3
  • Helicase With RNase Motif 4
  • Dicer 1 Ribonuclease III 3
  • Multinodular Goitre 1 2
  • Dicer1, Dcr-1 Homolog 3
  • K12H4.8-LIKE 3
  • EC 3.1.26 63
  • KIAA0928 4
  • Dicer 1 2
  • Dicer1e 3
  • RMSE2 3
  • DCR1 3
  • MNG1 3

External Ids for DICER1 Gene

Previous HGNC Symbols for DICER1 Gene

  • MNG1

Previous GeneCards Identifiers for DICER1 Gene

  • GC14M093065
  • GC14M089372
  • GC14M093542
  • GC14M094622
  • GC14M095552
  • GC14M075736

Summaries for DICER1 Gene

Entrez Gene Summary for DICER1 Gene

  • This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for DICER1 Gene

DICER1 (Dicer 1, Ribonuclease III) is a Protein Coding gene. Diseases associated with DICER1 include pleuropulmonary blastoma and goiter, multinodular 1, with or without sertoli-leydig cell tumors. Among its related pathways are Gene Expression and Mitotic Prophase. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX58.

UniProtKB/Swiss-Prot for DICER1 Gene

  • Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3 overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

Gene Wiki entry for DICER1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DICER1 Gene

Genomics for DICER1 Gene

Regulatory Elements for DICER1 Gene

Promoters for DICER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DICER1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DICER1 gene promoter:

Genomic Location for DICER1 Gene

Chromosome:
14
Start:
95,086,228 bp from pter
End:
95,158,010 bp from pter
Size:
71,783 bases
Orientation:
Minus strand

Genomic View for DICER1 Gene

Genes around DICER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DICER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DICER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DICER1 Gene

Proteins for DICER1 Gene

  • Protein details for DICER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPY3-DICER_HUMAN
    Recommended name:
    Endoribonuclease Dicer
    Protein Accession:
    Q9UPY3
    Secondary Accessions:
    • A7E2D3
    • B3KRG4
    • E0AD28
    • O95943
    • Q9UQ02

    Protein attributes for DICER1 Gene

    Size:
    1922 amino acids
    Molecular mass:
    218682 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, AGO1, PIWIL1 and PRKRA. Associates with the 60S ribosome. Interacts with BCDIN3D.
    SequenceCaution:
    • Sequence=CAB38857.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DICER1 Gene

    Alternative splice isoforms for DICER1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DICER1 Gene

Proteomics data for DICER1 Gene at MOPED

Post-translational modifications for DICER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DICER1 (DICER1)

Domains & Families for DICER1 Gene

Gene Families for DICER1 Gene

Suggested Antigen Peptide Sequences for DICER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPY3

UniProtKB/Swiss-Prot:

DICER_HUMAN :
  • Contains 1 Dicer dsRNA-binding fold domain.
  • Belongs to the helicase family. Dicer subfamily.
Domain:
  • Contains 1 Dicer dsRNA-binding fold domain.
  • Contains 1 DRBM (double-stranded RNA-binding) domain.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 PAZ domain.
  • Contains 2 RNase III domains.
Family:
  • Belongs to the helicase family. Dicer subfamily.
genes like me logo Genes that share domains with DICER1: view

Function for DICER1 Gene

Molecular function for DICER1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage to 5-phosphomonoester.
UniProtKB/Swiss-Prot Function:
Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3 overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

Enzyme Numbers (IUBMB) for DICER1 Gene

Gene Ontology (GO) - Molecular Function for DICER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0004525 ribonuclease III activity IEA,IDA 21753850
GO:0016891 endoribonuclease activity, producing 5-phosphomonoesters IEA --
genes like me logo Genes that share ontologies with DICER1: view
genes like me logo Genes that share phenotypes with DICER1: view

Human Phenotype Ontology for DICER1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DICER1 Gene

MGI Knock Outs for DICER1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DICER1

CRISPR Products

miRNA for DICER1 Gene

miRTarBase miRNAs that target DICER1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DICER1 Gene

Localization for DICER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DICER1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DICER1 Gene COMPARTMENTS Subcellular localization image for DICER1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DICER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IEA --
GO:0030426 growth cone IEA --
GO:0070578 RISC-loading complex IDA 15973356
genes like me logo Genes that share ontologies with DICER1: view

Pathways & Interactions for DICER1 Gene

genes like me logo Genes that share pathways with DICER1: view

Pathways by source for DICER1 Gene

1 BioSystems pathway for DICER1 Gene
1 KEGG pathway for DICER1 Gene
1 Qiagen pathway for DICER1 Gene

SIGNOR curated interactions for DICER1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DICER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0010467 gene expression TAS --
GO:0021675 nerve development ISS --
GO:0030422 production of siRNA involved in RNA interference IDA 15973356
GO:0031047 gene silencing by RNA TAS --
genes like me logo Genes that share ontologies with DICER1: view

Drugs & Compounds for DICER1 Gene

No Compound Related Data Available

Transcripts for DICER1 Gene

Unigene Clusters for DICER1 Gene

Dicer 1, ribonuclease type III:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DICER1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: -
SP2: - - - - - -
SP3: - -
SP4:
SP5:
SP6: - - - -
SP7: - - -
SP8: - - -
SP9: - - - -
SP10: -
SP11:
SP12:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DICER1 Gene

GeneLoc Exon Structure for
DICER1
ECgene alternative splicing isoforms for
DICER1

Expression for DICER1 Gene

mRNA expression in normal human tissues for DICER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DICER1 Gene

This gene is overexpressed in Placenta (10.0), Pancreatic juice (9.5), Fetal Brain (6.8), and Lung (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DICER1 Gene



SOURCE GeneReport for Unigene cluster for DICER1 Gene Hs.87889

genes like me logo Genes that share expression patterns with DICER1: view

Protein tissue co-expression partners for DICER1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DICER1 Gene

Orthologs for DICER1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DICER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DICER1 36
  • 100 (a)
OneToOne
DICER1 35
  • 99.79 (n)
  • 99.9 (a)
cow
(Bos Taurus)
Mammalia DICER1 35
  • 91.9 (n)
  • 95.99 (a)
DICER1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DICER1 36
  • 97 (a)
OneToOne
DICER1 35
  • 93.89 (n)
  • 96.93 (a)
mouse
(Mus musculus)
Mammalia Dicer1 36
  • 93 (a)
OneToOne
Dicer1 16
Dicer1 35
  • 89.05 (n)
  • 93.12 (a)
oppossum
(Monodelphis domestica)
Mammalia DICER1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DICER1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dicer1 35
  • 89.18 (n)
  • 93.11 (a)
chicken
(Gallus gallus)
Aves DICER1 35
  • 86.42 (n)
  • 92.14 (a)
DICER1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DICER1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dicer1 35
  • 78.05 (n)
  • 84.41 (a)
zebrafish
(Danio rerio)
Actinopterygii dicer1 35
  • 72.57 (n)
  • 82.33 (a)
wufc39d11 35
dicer1 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002836 35
  • 49.6 (n)
  • 45.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dcr-1 35
  • 49.62 (n)
  • 45.96 (a)
Dcr-1 37
  • 45 (a)
Dcr-2 37
  • 25 (a)
Dcr-1 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dcr-1 36
  • 34 (a)
OneToOne
dcr-1 37
  • 34 (a)
dcr-1 35
  • 50.05 (n)
  • 43.83 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08270 35
  • 42.71 (n)
  • 31.41 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dcr1 35
  • 47.21 (n)
  • 34.62 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14057 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for DICER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DICER1 Gene

ENSEMBL:
Gene Tree for DICER1 (if available)
TreeFam:
Gene Tree for DICER1 (if available)

Paralogs for DICER1 Gene

Paralogs for DICER1 Gene

(1) SIMAP similar genes for DICER1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DICER1 Gene

genes like me logo Genes that share paralogs with DICER1: view

Variants for DICER1 Gene

Sequence variations from dbSNP and Humsavar for DICER1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_063150 Pleuropulmonary blastoma (PPB)
VAR_065301 Goiter multinodular 1, with or without Sertoli-Leydig cell tumors (MNG1)
VAR_067091 Non-epithelial ovarian tumor
VAR_067092 Non-epithelial ovarian tumor
VAR_067093 Non-epithelial ovarian tumor

Structural Variations from Database of Genomic Variants (DGV) for DICER1 Gene

Variant ID Type Subtype PubMed ID
nsv84515 CNV Loss 16902084

Variation tolerance for DICER1 Gene

Residual Variation Intolerance Score: 1.88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DICER1 Gene

HapMap Linkage Disequilibrium report
DICER1
Human Gene Mutation Database (HGMD)
DICER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DICER1 Gene

Disorders for DICER1 Gene

MalaCards: The human disease database

(33) MalaCards diseases for DICER1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

DICER_HUMAN
  • Pleuropulmonary blastoma (PPB) [MIM:601200]: A rare pediatric intrathoracic neoplasm. The tumor arises from the lung, pleura, or both, and appears to be purely mesenchymal in phenotype. It lacks malignant epithelial elements, a feature that distinguishes it from the classic adult-type pulmonary blastoma. It arises during fetal lung development and is often part of an inherited cancer syndrome. The tumor contain both epithelial and mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are lined with benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cyst walls and form a dense layer beneath the epithelial lining. In a subset of patients, overgrowth of the mesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis. Some patients have multilocular cystic nephroma, a benign kidney tumor. {ECO:0000269 PubMed:19556464}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Goiter multinodular 1, with or without Sertoli-Leydig cell tumors (MNG1) [MIM:138800]: A common disorder characterized by nodular overgrowth of the thyroid gland. Some individuals may also develop Sertoli-Leydig cell tumors, usually of the ovary. {ECO:0000269 PubMed:21205968}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Rhabdomyosarcoma, embryonal, 2 (RMSE2) [MIM:180295]: A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. {ECO:0000269 PubMed:21882293}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=DICER1 mutations have been found in uterine cervix embryonal rhabdomyosarcoma, primitive neuroectodermal tumor, Wilms tumor, pulmonary sequestration and juvenile intestinal polyp (PubMed:21882293). Somatic missense mutations affecting the RNase IIIb domain of DICER1 are common in non-epithelial ovarian tumors. These mutations do not abolish DICER1 function but alter it in specific cell types, a novel mechanism through which perturbation of microRNA processing may be oncogenic (PubMed:22187960). {ECO:0000269 PubMed:21882293, ECO:0000269 PubMed:22187960}.

Relevant External Links for DICER1

Genetic Association Database (GAD)
DICER1
Human Genome Epidemiology (HuGE) Navigator
DICER1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DICER1
genes like me logo Genes that share disorders with DICER1: view

No data available for Genatlas for DICER1 Gene

Publications for DICER1 Gene

  1. DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. (PMID: 21205968) Rio Frio T. … Tischkowitz M. (JAMA 2011) 2 3 4 67
  2. Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells. (PMID: 20232482) Jakymiw A. … Chan E.K. (Genes Chromosomes Cancer 2010) 3 23
  3. Dicer is regulated by cellular stresses and interferons. (PMID: 19118902) Wiesen J.L. … Tomasi T.B. (Mol. Immunol. 2009) 3 23
  4. Characterization of the TRBP domain required for dicer interaction and function in RNA interference. (PMID: 19422693) Daniels S.M. … Gatignol A. (BMC Mol. Biol. 2009) 3 23
  5. DICER1 mutations in familial pleuropulmonary blastoma. (PMID: 19556464) Hill D.A. … Goodfellow P.J. (Science 2009) 3 23

Products for DICER1 Gene

Sources for DICER1 Gene

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