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DICER1 Gene

protein-coding GIFtS: 62

GC14M094622

dicer 1, ribonuclease type III
(Previous names: Dicer1, Dcr-1 homolog (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DCR1 ^²
DICER ^³
Dicer ^¹, ²
EC 3.1.26.- ^³
HERNA ^¹, ², ³, ⁵
K12H4.8-LIKE ^¹, ²
KIAA0928 ^¹, ², ³, ⁵
dicer1 ^²
helicase-moi ^²

Descriptions
Dicer1, Dcr-1 homolog ^²
Dicer1, Dcr-1 homolog (Drosophila) ^¹
Helicase MOI ^³
Helicase with RNase motif ^², ³
dicer 1, double-stranded RNA-specific endoribonuclease ^²
dicer 1, ribonuclease type III ^²

External Ids
HGNC: 17098¹
Entrez Gene: 23405²
UniProtKB: Q9UPY3³
Ensembl: ENSG00000100697⁷

Search outside databases for aliases for DICER1 gene

Previous GC identifers: GC14M093065 GC14M089372 GC14M093542

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DICER1:

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino

terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease

and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the

active small RNA component that represses gene expression. Two transcript variants encoding the

same protein have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3

Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC

loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is

composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required

to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2.

EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate

from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs

(siRNAs) which target the selective destruction of complementary RNAs

Gene Wiki entry for DICER1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DICER1 gene

Entrez Gene cytogenetic band: 14q32.13 Ensembl cytogenetic band: 14q32.13 HGNC cytogenetic band: 14q32.2

DICER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M094622: (about GC identifiers)

Start:	94,622,319 bp from pter
End:	94,693,512 bp from pter
Size:	71,194 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3 (See protein sequence)

Recommended Name: Endoribonuclease Dicer

Size: 1912 amino acids; 217628 Da

Cofactor: Binds 2 magnesium or manganese ions per subunit (Probable)

Subunit: Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC),

which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also

referred to as RISC. Interacts with DHX9, EIF2C1, PIWIL1 and PRKRA. Associates with the 60S

ribosome

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

2EB1 (3D)

Secondary accessions: O95943 Q9UQ02

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_085124.2 NP_803187.1

ENSEMBL proteins:

ENSP00000376783 ENSP00000343745

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Dicer)
	Human Recombinant Proteins from Abnova (DICER1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	NAS	12560494
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005794	Golgi apparatus	IDA	18029348

About this table

Antibodies for DICER1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DICER1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for DICER1 (Dicer)
	Antibodies from Abcam (Dicer), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DICER1)
	Novus Biologicals Antibodies for DICER1

Assays for DICER1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UPY3

ProtoNet protein and cluster: Q9UPY3

4 Blocks protein families:

IPB000999 Ribonuclease III family

IPB001159 Double-stranded RNA binding (DsRBD) domain

IPB003100 Argonaute and Dicer protein

IPB005034 Protein of unknown function DUF283

UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3

Similarity: Belongs to the helicase family. Dicer subfamily

Similarity: Contains 1 Dicer dsRNA-binding fold domain

Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

Similarity: Contains 1 PAZ domain

Similarity: Contains 2 RNase III domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DICER1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DICER1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_177438

Applied Biosystems Silencer® siRNAs for DICER1

Sigma-Aldrich siRNA for DICER1

Sigma-Aldrich shRNA Panels and shRNA for DICER1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_030621
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_030621
untagged cDNA clones in CMV expression vector (see all 2): NM_030621

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_177438

UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3

Function: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC

loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is

composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required

to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2.

EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate

from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs

(siRNAs) which target the selective destruction of complementary RNAs

Enzyme Number (IUBMB): EC 3.1.26.-

15/19 MGI mutant phenotypes (inferred from 13 alleles) (MGI details for Dicer1) (see all 19 ):

	behavior/neurological	cellular	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	limbs/digits/tail	liver/biliary system	no phenotypic analysis	normal

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003725	double-stranded RNA binding	IDA	12411504
GO:0004386	helicase activity	IEA	--
GO:0004519	endonuclease activity	IEA	--
GO:0004525	ribonuclease III activity	IDA	12560494

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for DICER1

5/342 Interacting proteins for DICER1 (Q9UPY3^{1, 2} ENSP00000343745³) via UniProtKB, MINT, and/or STRING (see all 342 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKRA	O75569², ENSP00000318176³	MINT-1957760 MINT-1957581 STRING (score=.823)
TNRC6B	Q9UPQ9², ENSP00000338371³	MINT-6489217 STRING (score=.875)
MOV10	Q9HCE1², ENSP00000358659³	MINT-6488791 STRING (score=.81)
FMR1	Q06787², ENSP00000359506³	MINT-6488791 STRING (score=.804)
PIWIL1	Q96J94¹, ENSP00000245255³	EBI-395506, EBI-527417 STRING (score=.792)

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0006396	RNA processing	IEA	--
GO:0019827	stem cell maintenance	IEA	--
GO:0030324	lung development	IEA	--
GO:0030422	RNA interference, production of siRNA	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DICER1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DICER1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DICER1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_177438

Sigma-Aldrich siRNA for DICER1

Sigma-Aldrich shRNA Panels and shRNA for DICER1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_030621 NM_177438

REFSEQ mRNAs for DICER1 gene (2 alternative transcripts):

NM_030621.3 NM_177438.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_030621 NM_177438

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_030621
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_030621
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_030621

Additional cDNA sequence:

AB023145.2 AB028449.1 AF007142.1 AJ132261.2 AK001041.1 AK001827.1 AK002007.1 AK091094.1

AK091513.1 AL122105.1 AL832389.1 AY845867.1 AY845868.1 AY929254.1 AY929255.1 AY929256.1

BC046934.1 BC068591.1 BC150287.1

14 DOTS entries:

DT.317718 DT.95252847 DT.100816980 DT.97763171 DT.91823640 DT.95295120 DT.95266523 DT.95182023

DT.97823900 DT.100816977 DT.120779731 DT.120779673 DT.40293064 DT.99951130

24/320 AceView cDNA sequences (see all 320 ):

CA310117 AI249382 BQ188480 AW339969 BI712506 AA843975 BQ216141 AU119024

AA296802 AL122105 BC046934 BM671458 AI268132 AA976871 AI969443 BU507638

BU147169 AA987461 BQ433107 BM692875 AA639968 AW193662 AL832389 BQ723760

highest scoring ESTs for DICER1:

AB023145 AB028449 BC046934 BQ216141 AA044960 AA057340 AA069444 AA069472 AA091027 AA093761

Unigene Cluster for DICER1:

Dicer 1, ribonuclease type III

Hs.87889 [show with all ESTs]

Unigene Representative Sequence: NM_177438

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DICER1 (see all 12 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17a	·	17b	^	18	^	19a	·
SP1:															-
SP2:					-		-		-		-		-		-
SP3:													-		-
SP4:
SP5:

ExUns:	19b	^	20	^	21	^	22	^	23a	·	23b	^	24	^	25	^	26a	·	26b	·	26c	^	27	^	28a	·	28b	^	29	^	30a	·	30b	^	31a	·	31b	^	32
SP1:	-																										-				-						-
SP2:	-																										-				-						-
SP3:	-																										-				-						-
SP4:																	-										-				-						-
SP5:

About this scheme

ECgene alternative splicing isoforms for DICER1

2 Ensembl transcripts including schematic representations:

ENST00000393063 ENST00000343455

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DICER1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DICER1

¹ / ² / ³

10 probe-sets matching DICER1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38764_at²^{, 3}	U95-A	1	1.00	1.00	0.64	1.50	AF007142	0.60	1.00	0.82	1
38765_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.52	AB028449	0.80	1.00	0.91	1
216260_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK001827	0.60	1.00	0.82	1
212888_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG109746	0.40	1.00	0.76	1
206061_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_030621	0.60	1.00	0.82	1
213229_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF590131	0.60	1.00	0.82	1
216260_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212888_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206061_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213229_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGCAGAAAT

SOURCE GeneReport for Unigene cluster: Hs.87889
Expression variation in blood from EXPOLDB for DICER1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DICER1 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DICER1¹	--	dicer 1, ribonuclease type III	94.02(n) 97.14(a)	480426 XM_537547.2 XP_537547.2
chimpanzee (Pan troglodytes)	DICER1¹	--	dicer 1, ribonuclease type III	99.79(n) 99.9(a)	453137 XM_001154199.1 XP_001154199.1
cow (Bos taurus)	DICER1¹	--	dicer 1, ribonuclease type III	91.9(n) 95.99(a)	337871 NM_203359.1 NP_976235.1
rat (Rattus norvegicus)	Dicer1¹	--	dicer 1, ribonuclease type III	89.67(n) 93.74(a)	299284 XM_001068155.1 XP_001068155.1
mouse (Mus musculus)	Dicer1^{1, 5}	12 (51.00 cM)⁵	Dicer1, Dcr-1 homolog (Drosophila)^{1, 5}	89.22(n)¹ 93.28(a)¹	192119¹ NM_148948.2¹ NP_683750.2¹ AB081470⁵ AF430845⁵ (see all 23)

About this table Species with no ortholog for DICER1

ENSEMBL Gene Tree for DICER1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DICER1 gene

IFIH1² DHX58² DDX58²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/300 NCBI SNPs in DICER1 are shown (see all 300 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 118)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs12323635^1,2	A,C,F,H	94695464(+)	`CTTAAT/CTTATC`	1	--	ng3¹ tfbs³		3	EU EA	300
	rs1057035^1,2	C,F,H,O	94623895(+)	`ACACGC/TGCTCA`	2	--	ut3¹ ese³		13	MN EU EA WA NA	1236
	rs1953536^1,2	A,C,F,H	94678203(+)	`CTTTTC/TGtttt`	2	--	int¹ ng3¹ trp³		4	EU EA WA	412
	rs17091788^1,2	C,F,H	94621875(+)	`GATTCA/GTATTA`	2	--	ng5¹		11	NA EU EA WA	980
--	rs3742331^1,2	C,F,H	94695007(+)	`TCGATT/CTCTGA`	1	--	ng3¹		4	EU EA WA	414
	rs13078^1,2	C,F,H	94626500(+)	`CACTAT/ACAACT`	2	--	ut3¹		4	EU EA WA	420
	rs1187652^1,2	C,F,H	94624958(+)	`TTCCAT/CGAAGC`	2	--	ut3¹ ese³		4	EU EA WA	414
	rs3742330^1,2	C,F,H	94623115(+)	`ATTAGA/GCACCC`	2	--	ut3¹		8	EA EU WA NA	2038
	rs8006947^1,2	F,H	94622099(+)	`AATTTC/ACAAAA`	2	--	ng5¹		4	EU EA WA	420
	rs10149088^1,2	F,H	94694029(+)	`CCCACT/ACGCCT`	1	--	ng3¹		4	EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for DICER1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606241

Human Genome Epidemiology Navigator: DICER1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/108 PubMed articles for DICER1 gene (see all 108 ):

Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase. (PubMed id 10786632)^{2, 3, 4} Matsuda S....Hamaguchi M. (2000)
Interaction of 5-lipoxygenase with cellular proteins. (PubMed id 10051563)^{2, 3, 4} Provost P.... Radmark O. (1999)
Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. (PubMed id 14749716)^{1, 3, 4} Tahbaz N....Hobman T.C. (2004)
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. (PubMed id 19219043)^{3, 4} Melo S.A.... Esteller M. (2009)
In vitro reconstitution of the human RISC-loading complex. (PubMed id 18178619)^{3, 4} MacRae I.J....Doudna J.A. (2008)
Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. (PubMed id 17452327)^{3, 4} Kok K.H....Jin D.Y. (2007)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. (PubMed id 16142218)^{3, 4} Haase A.D....Filipowicz W. (2005)
Single processing center models for human Dicer and bacterial RNase III. (PubMed id 15242644)^{3, 4} Zhang H....Filipowicz W. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{3, 4} Nakajima D.... Nagase T. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23405	HGNC: 17098	AceView: DICER1	Ensembl:ENSG00000100697	euGenes: HUgn23405
ECgene: DICER1	H-InvDB: DICER1

(According to HUGE)
About This Section

HUGE: KIAA0928

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt087.shtml

Licensable Technologies for DICER1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DICER1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DICER1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DICER1		Antibodies for DICER1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DICER1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (DICER1)
	Antibodies (DICER1)
	Chimera RNAi (DICER1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for DICER1 (Dicer)

	Recombinant Proteins (Dicer)
	Antibodies (Dicer)

Search OriGene for DICER1

Search Tocris compounds for DICER1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for DICER1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
DICER1 Gene at Home site.
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DICER1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for DICER1

Summaries
for DICER1

Genomic Location
for DICER1

Proteins
for DICER1

Protein Domains/
Families
for DICER1

Gene Function
for DICER1

Pathways & Interactions
for DICER1

Drugs & Compounds
for DICER1

Transcripts
for DICER1

Expression
for DICER1

Orthologs
for DICER1

Paralogs
for DICER1

SNPs/Variants
for DICER1

Disorders & Mutations
for DICER1

Medical News
for DICER1

Publications
for DICER1

Search for DICER1

Genome Databases showing DICER1

Other Databases showing DICER1

Specialized Databases showing DICER1

Licensable Technologies
for DICER1

Services
for DICER1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DICER1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor DICER1

Summariesfor DICER1

Genomic Locationfor DICER1

Proteinsfor DICER1

Protein Domains/Familiesfor DICER1

Gene Functionfor DICER1

Pathways & Interactionsfor DICER1

Drugs & Compoundsfor DICER1

Transcriptsfor DICER1

Expression for DICER1

Orthologsfor DICER1

Paralogsfor DICER1

SNPs/Variantsfor DICER1

Disorders & Mutationsfor DICER1

Medical Newsfor DICER1

Publicationsfor DICER1

Search for DICER1

Genome Databases showing DICER1

Other Databases showing DICER1

Specialized Databases showing DICER1

Licensable Technologiesfor DICER1

Servicesfor DICER1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DICER1

Summaries
for DICER1

Genomic Location
for DICER1

Proteins
for DICER1

Protein Domains/
Families
for DICER1

Gene Function
for DICER1

Pathways & Interactions
for DICER1

Drugs & Compounds
for DICER1

Transcripts
for DICER1

Expression
for DICER1

Orthologs
for DICER1

Paralogs
for DICER1

SNPs/Variants
for DICER1

Disorders & Mutations
for DICER1

Medical News
for DICER1

Publications
for DICER1

Licensable Technologies
for DICER1

Services
for DICER1