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DICER1 Gene

protein-coding   GIFtS: 68
GCID: GC14M095552

Dicer 1, Ribonuclease Type III

(Previous names: Dicer1, Dcr-1 homolog (Drosophila), multinodular goitre...)
(Previous symbol: MNG1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dicer 1, Ribonuclease Type III1 2     Double-Stranded RNA-Specific Endoribonuclease1
MNG11 2 5     DCR12
HERNA2 3 5     Dicer2
Multinodular Goitre 11 2     K12H4.8-LIKE2
Helicase MOI2 3     Dicer 1, Double-Stranded RNA-Specific Endoribonuclease2
Helicase With RNase Motif2 3     Dicer1, Dcr-1 Homolog2
EC 3.1.26.33 8     Endoribonuclease Dicer2
RMSE22 5     helicase-moi2
KIAA09283 5     DICER3
Dicer 11     EC 3.1.268
Dicer1, Dcr-1 Homolog (Drosophila)1     

External Ids:    HGNC: 170981   Entrez Gene: 234052   Ensembl: ENSG000001006977   OMIM: 6062415   UniProtKB: Q9UPY33   

Export aliases for DICER1 gene to outside databases

Previous GC identifers: GC14M093065 GC14M089372 GC14M093542 GC14M094622 GC14M075736


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DICER1 Gene:
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an
RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA
interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses
gene expression. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2010)

GeneCards Summary for DICER1 Gene:
DICER1 (dicer 1, ribonuclease type III) is a protein-coding gene. Diseases associated with DICER1 include pleuropulmonary blastoma, and malignant sertoli-leydig cell tumor. GO annotations related to this gene include miRNA binding and ATP-dependent helicase activity. An important paralog of this gene is IFIH1.

UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3
Function: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated
post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs
(miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing
respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the
RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene
silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile
and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance.
The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes

Gene Wiki entry for DICER1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DICER1 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDICER1 promoter sequence
   Search Chromatin IP Primers for DICER1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DICER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.13   Ensembl cytogenetic band:  14q32.13   HGNC cytogenetic band: 14q32.13

DICER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DICER1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M095552:  view genomic region     (about GC identifiers)

Start:
95,552,565 bp from pter      End:
95,624,347 bp from pter
Size:
71,783 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3 (See protein sequence)
Recommended Name: Endoribonuclease Dicer  
Size: 1922 amino acids; 218682 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (Probable)
Subunit: Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is
composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to
mature miRNAs and then load them onto AGO2. Note that the trimeric RLC/miRLC is also referred to as RISC.
Interacts with DHX9, AGO1, PIWIL1 and PRKRA. Associates with the 60S ribosome. Interacts with BCDIN3D
Caution: It is uncertain whether Met-1 or Met-11 is the initiator
Sequence caution: Sequence=CAB38857.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for DICER1:
2EB1 (3D)    
Secondary accessions: A7E2D3 E0AD28 O95943 Q9UQ02
Alternative splicing: 2 isoforms:  Q9UPY3-1   Q9UPY3-2   

Explore the universe of human proteins at neXtProt for DICER1: NX_Q9UPY3

Explore proteomics data for DICER1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DICER1 (Q9UPY3) (see all 52)
     LTDLRSA  INYRFKN  ECTLLSN  FEKKINY 


    See DICER1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001182502.1  NP_085124.2  NP_803187.1  NP_001258211.1  

    ENSEMBL proteins: 
     ENSP00000343745   ENSP00000437256   ENSP00000435681   ENSP00000451041   ENSP00000452556  
     ENSP00000433060   ENSP00000433926   ENSP00000376783   ENSP00000444719  
    Reactome Protein details: Q9UPY3

    DICER1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DICER1
    OriGene Protein Over-expression Lysate for DICER1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DICER1
    GenScript Custom Purified and Recombinant Proteins Services for DICER1
    Novus Biologicals DICER1 Protein
    Novus Biologicals DICER1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DICER1

    DICER1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DICER1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DICER1 
    OriGene Antibodies for DICER1
    OriGene Custom Antibody Services for DICER1
    Novus Biologicals DICER1 Antibodies
    Abcam antibodies for DICER1
    Cloud-Clone Corp. Antibodies for DICER1
    ThermoFisher Antibodies for DICER1
    LSBio Antibodies in human, mouse, rat for DICER1

    DICER1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DICER1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DICER1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DICER1
    Cloud-Clone Corp. CLIAs for DICER1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR003100 PAZ_dom
     IPR014720 dsRNA-bd_dom
     IPR027417 P-loop_NTPase
     IPR000999 RNase_III_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPY3

    ProtoNet protein and cluster: Q9UPY3

    4 Blocks protein domains:
    IPB000999 Ribonuclease III family
    IPB001159 Double-stranded RNA binding (DsRBD) domain
    IPB003100 Argonaute and Dicer protein
    IPB005034 Protein of unknown function DUF283


    UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3
    Similarity: Belongs to the helicase family. Dicer subfamily
    Similarity: Contains 1 Dicer dsRNA-binding fold domain
    Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 PAZ domain
    Similarity: Contains 2 RNase III domains


    DICER1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DICER_HUMAN, Q9UPY3
    Function: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated
    post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs
    (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing
    respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the
    RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene
    silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile
    and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance.
    The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes
    Catalytic activity: Endonucleolytic cleavage to 5'-phosphomonoester

         Enzyme Numbers (IUBMB): EC 3.1.26.31 2 EC 3.1.262

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IDA12411504
    GO:0004386helicase activity ----
         
    DICER1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DICER1:
     Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 16 alleles(MGI details for Dicer1) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  liver/biliary system  mortality/aging  nervous system 

    DICER1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DICER1: Dicer1tm1Ghan Dicer1tm1.1Mmk Dicer1tm1.2Mnn Dicer1tm1Gz Dicer1tm1.1Snj Dicer1tm1.1Bdh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DICER1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DICER1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DICER1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DICER1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DICER1:
    hsa-mir-130a-3p (MIRT006258), hsa-mir-154-5p (MIRT005679), hsa-mir-29c-3p (MIRT020398), hsa-mir-374a-5p (MIRT005572), hsa-let-7a-5p (MIRT004346), hsa-let-7c-5p (MIRT004348), hsa-mir-425-5p (MIRT016677), ebv-mir-bart6-5p (MIRT004758), hsa-let-7b-5p (MIRT005322), hsa-mir-221-3p (MIRT006376), hsa-mir-103a-3p (MIRT005347), hsa-let-7d-5p (MIRT004347), hsa-mir-16-5p (MIRT051245), hsa-mir-107 (MIRT005348), hsa-mir-192-5p (MIRT026884), hsa-mir-519a-3p (MIRT005571), hsa-mir-98-5p (MIRT027858), hsa-mir-29a-3p (MIRT006379), hsa-mir-130b-3p (MIRT007384), hsa-mir-222-3p (MIRT006377), hsa-mir-296-3p (MIRT038408), hsa-mir-18a-5p (MIRT007178), hsa-mir-215-5p (MIRT024517)

    Block miRNA regulation of human, mouse, rat DICER1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DICER1 (see all 153):
    hsa-miR-411* hsa-miR-640 hsa-miR-519a hsa-miR-298 hsa-miR-642b hsa-miR-130b hsa-miR-519e hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): DICER1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DICER1
    Predesigned siRNA for gene silencing in human, mouse, rat DICER1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DICER1

    Clone
    Products:
         
    OriGene clones in human, mouse for DICER1 (see all 11)
    OriGene ORF clones in mouse, rat for DICER1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DICER1 (NM_177438)
    Sino Biological Human cDNA Clone for DICER1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DICER1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DICER1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DICER1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DICER1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DICER1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DICER_HUMAN, Q9UPY3: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IEA--
    GO:0005829cytosol TAS--
    GO:0016442RISC complex IDA15973356
    GO:0030424axon IEA--
    GO:0030425dendrite IEA--

    DICER1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DICER1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Regulatory RNA pathways
    Regulatory RNA pathways0.88
    Small Interfering RNA (siRNA) Biogenesis0.00
    MicroRNA (miRNA) Biogenesis0.88
    2mRNA Splicing - Major Pathway
    mRNA processing0.44
    3Gene Expression
    Gene Expression0.40
    4Translational Control
    Translational Control
    5RNAi Pathway
    RNAi Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DICER1
        RNAi Pathway

    1 Cell Signaling Technology (CST) Pathway for DICER1
        Translational Control

    1 BioSystems Pathway for DICER1
        mRNA processing


    2 Reactome Pathways for DICER1
        MicroRNA (miRNA) biogenesis
    Small interfering RNA (siRNA) biogenesis


    1 Kegg Pathway  (Kegg details for DICER1):
        MicroRNAs in cancer


    DICER1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DICER1
    Interactions:

        GeneGlobe Interaction Network for DICER1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DICER1 (Q9UPY31, 2, 3 ENSP000003437454) via UniProtKB, MINT, STRING, and/or I2D (see all 337)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TARBP2Q156331, 2, 3, ENSP000002669874EBI-395506,EBI-978581 MINT-1957896 MINT-6489217 MINT-6488488 MINT-1957702 I2D: score=7 STRING: ENSP00000266987
    AGO2Q9UKV81, 2, 3, ENSP000002205924EBI-395506,EBI-528269 MINT-6489217 MINT-6489539 I2D: score=6 STRING: ENSP00000220592
    PRKRAO755691, 2, 3, ENSP000003181764EBI-395506,EBI-713955 MINT-1957760 MINT-1957581 I2D: score=2 STRING: ENSP00000318176
    FXR1P511142, 3, ENSP000003501704MINT-6489539 I2D: score=2 STRING: ENSP00000350170
    PIWIL1Q96J941, 3, ENSP000002452554EBI-395506,EBI-527417 I2D: score=2 STRING: ENSP00000245255
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 54):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001525angiogenesis IEA--
    GO:0001942hair follicle development ----
    GO:0006396RNA processing ----
    GO:0006915apoptotic process ----

    DICER1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DICER1 (DICER)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DICER1 gene (4 alternative transcripts): 
    NM_001195573.1  NM_030621.3  NM_177438.2  NM_001271282.1  

    Unigene Cluster for DICER1:

    Dicer 1, ribonuclease type III
    Hs.87889  [show with all ESTs]
    Unigene Representative Sequence: NM_177438
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343455(uc010avh.1 uc021sbc.1 uc001ydv.2 uc001ydx.2 uc001yeb.1 uc001ydz.1)
    ENST00000526495(uc001ydw.2 uc001yec.1) ENST00000527416 ENST00000527414
    ENST00000556045(uc001ydy.1) ENST00000527554 ENST00000532939 ENST00000554367
    ENST00000556681 ENST00000532458 ENST00000529206 ENST00000531162(uc001yea.1)
    ENST00000529720 ENST00000393063 ENST00000541352(uc021sbd.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat DICER1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DICER1 (see all 153):
    hsa-miR-411* hsa-miR-640 hsa-miR-519a hsa-miR-298 hsa-miR-642b hsa-miR-130b hsa-miR-519e hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): DICER1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DICER1
    Predesigned siRNA for gene silencing in human, mouse, rat DICER1
    Clone
    Products:
         
    OriGene clones in human, mouse for DICER1 (see all 11)
    OriGene ORF clones in mouse, rat for DICER1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DICER1 (NM_177438)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DICER1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DICER1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DICER1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DICER1
      QuantiTect SYBR Green Assays in human, mouse, rat DICER1
      QuantiFast Probe-based Assays in human, mouse, rat DICER1

    Additional mRNA sequence: 

    AB023145.2 AB028449.1 AF007142.1 AJ132261.2 AK001041.1 AK001827.1 AK002007.1 AK091094.1 
    AK091513.1 AL122105.1 AL832389.1 AY845867.1 AY929254.1 AY929255.1 AY929256.1 BC046934.1 
    BC068591.1 BC150287.1 HM595745.1 

    14 DOTS entries:

    DT.317718  DT.95252847  DT.100816980  DT.97763171  DT.91823640  DT.95295120  DT.95266523  DT.95182023 
    DT.97823900  DT.100816977  DT.120779731  DT.120779673  DT.40293064  DT.99951130 

    Selected AceView cDNA sequences (see all 320):

    AW628967 BM460325 BU507638 AA743316 BC046934 BQ004539 AI249382 AA843975 
    NM_177438 AI287582 W00419 AW297296 CB240700 BQ004558 AA360677 N46077 
    AA262488 AU118706 AA836613 AI969443 AB023145 AA251653 F12643 F10258 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DICER1 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:                                            -                                                                                                               
    SP2:              -     -     -     -     -     -                                                                                                               
    SP3:                                      -     -                                                                                                               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32
    SP1:  -                                                                             -           -                 -         
    SP2:  -                                                                             -           -                 -         
    SP3:  -                                                                             -           -                 -         
    SP4:                                                  -                             -           -                 -         
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for DICER1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DICER1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCAGAAAT
    DICER1 Expression
    About this image


    DICER1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Lung (Respiratory System)
    DICER1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DICER1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.87889
        Custom PCR Arrays for DICER1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DICER1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DICER1
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    QuantiFast Probe-based Assays in human, mouse, rat DICER1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DICER1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for DICER1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dicer11 , 5 Dicer1, Dcr-1 homolog (Drosophila)5
    dicer 1, ribonuclease type III1
    89.05(n)1
    93.12(a)1
      12 (54.83 cM)5
    1921191  NM_148948.21  NP_683750.21 
     1046877425 
    chicken
    (Gallus gallus)
    Aves DICER11 dicer 1, ribonuclease type III 86.42(n)
    92.14(a)
      423437  NM_001040465.1  NP_001035555.1 
    lizard
    (Anolis carolinensis)
    Reptilia DICER16
    dicer 1, ribonuclease type III
    90(a)
    1 ↔ 1
    1(6891096-6936705)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ085417.12   -- 85.32(n)    BJ085417.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc39d112 Danio rerio Dicer1 (dicer1) mRNA, partial cds 78.33(n)    AY386319.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dcr-11 , 3 RNA interference double-stranded RNA
    binding3
    Dicer-11
    45(a)
    (best of 2)3
    49.62(n)1
    45.96(a)1
      94C43
    426931  NM_079729.31  NP_524453.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dcr-11 , 3 dead box helicase3
    dcr-11
    34(a)3
    50.05(n)1
    43.83(a)1
      III(8143853-8152017)3
    1761381  NM_066360.31  NP_498761.21 


    ENSEMBL Gene Tree for DICER1 (if available)
    TreeFam Gene Tree for DICER1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DICER1 gene
    IFIH12  DHX582  DDX582  
    1 SIMAP similar gene for DICER1 using alignment to 4 protein entries:     DICER_HUMAN (see all proteins):
    DKFZp434A0427

    DICER1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DICER1
    PGOHUM00000235615


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DICER1 (see all 1551)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0670934
    Non-epithelial ovarian tumor4--see VAR_0670932 D G mis40--------
    VAR_0653014
    Goiter multinodular 1, with or without Sertoli-Leydig cell tumors (MNG1)4--see VAR_0653012 S F mis40--------
    VAR_0670964
    Non-epithelial ovarian tumor4--see VAR_0670962 D N mis40--------
    VAR_0670974
    Non-epithelial ovarian tumor4--see VAR_0670972 D Y mis40--------
    VAR_0670914
    Non-epithelial ovarian tumor4--see VAR_0670912 E K mis40--------
    VAR_0631504
    Pleuropulmonary blastoma (PPB)4--see VAR_0631502 L R mis40--------
    VAR_0670954
    Non-epithelial ovarian tumor4--see VAR_0670952 D H mis40--------
    VAR_0671004
    Non-epithelial ovarian tumor4--see VAR_0671002 E Q mis40--------
    VAR_0670924
    Non-epithelial ovarian tumor4--see VAR_0670922 D E mis40--------
    VAR_0670984
    Non-epithelial ovarian tumor4--see VAR_0670982 E G mis40--------

    HapMap Linkage Disequilibrium report for DICER1 (95552565 - 95624347 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DICER1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv84515CNV Loss16902084

    Human Gene Mutation Database (HGMD): DICER1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DICER1
    DNA2.0 Custom Variant and Variant Library Synthesis for DICER1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606241   
    OMIM disorders: 601200  138800  180295  
    UniProtKB/Swiss-Prot: DICER_HUMAN, Q9UPY3
  • Pleuropulmonary blastoma (PPB) [MIM:601200]: A rare pediatric intrathoracic neoplasm. The tumor arises
    from the lung, pleura, or both, and appears to be purely mesenchymal in phenotype. It lacks malignant epithelial
    elements, a feature that distinguishes it from the classic adult-type pulmonary blastoma. It arises during fetal
    lung development and is often part of an inherited cancer syndrome. The tumor contain both epithelial and
    mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are lined with
    benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cyst
    walls and form a dense layer beneath the epithelial lining. In a subset of patients, overgrowth of the
    mesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis. Some patients have
    multilocular cystic nephroma, a benign kidney tumor. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Goiter multinodular 1, with or without Sertoli-Leydig cell tumors (MNG1) [MIM:138800]: A common disorder
    characterized by nodular overgrowth of the thyroid gland. Some individuals may also develop Sertoli-Leydig cell
    tumors, usually of the ovary. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Note=DICER1 mutations have been found in uterine cervix embryonal rhabdomyosarcoma, primitive
    neuroectodermal tumor, Wilms tumor, pulmonary sequestration and juvenile intestinal polyp (PubMed:21882293).
    Somatic missense mutations affecting the RNase IIIb domain of DICER1 are common in non-epithelial ovarian tumors.
    These mutations do not abolish DICER1 function but alter it in specific cell types, a novel mechanism through
    which perturbation of microRNA processing may be oncogenic (PubMed:22187960)

  • Selected diseases for DICER1 (see all 57):    
    About MalaCards
    pleuropulmonary blastoma    malignant sertoli-leydig cell tumor    leydig cell tumor    sertoli-leydig cell tumor
    ovarian malignant sertoli-leydig cell tumor    pulmonary sequestration    goiter, multinodular 1, with or without sertoli-leydig cell tumors    blastoma
    rhabdomyosarcoma, embryonal, 2    tumor predisposition syndrome    cystic nephroma    multinodular goiter
    goiter    embryonal rhabdomyosarcoma    fragile x syndrome    mucoepidermoid carcinoma
    primitive neuroectodermal tumor    temporal lobe epilepsy    cutaneous t cell lymphoma    rhabdomyosarcoma

    3 diseases from the University of Copenhagen DISEASES database for DICER1:
    Cystic nephroma     Cancer     Fragile X syndrome

    DICER1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DICER1
    Human Genome Epidemiology (HuGE) Navigator: DICER1 (9 documents)

    Export disorders for DICER1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DICER1 gene, integrated from 10 sources (see all 258):
    (articles sorted by number of sources associating them with DICER1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. (PubMed id 21205968)1, 2, 3 Rio Frio T....Tischkowitz M. (JAMA 2011)
    2. Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase. (PubMed id 10786632)1, 2, 3 Matsuda S....Hamaguchi M. (Biochim. Biophys. Acta 2000)
    3. Interaction of 5-lipoxygenase with cellular proteins. (PubMed id 10051563)1, 2, 3 Provost P.... Radmark O. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    4. Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. (PubMed id 14749716)1, 2, 9 Tahbaz N....Hobman T.C. (EMBO Rep. 2004)
    5. The role of PACT in the RNA silencing pathway. (PubMed id 16424907)1, 2, 9 Lee Y.... Kim V.N. (EMBO J. 2006)
    6. DICER1 mutations in familial pleuropulmonary blastoma. (PubMed id 19556464)1, 2, 9 Hill D.A....Goodfellow P.J. (Science 2009)
    7. A human, ATP-independent, RISC assembly machine fueled by pre- miRNA. (PubMed id 16357216)1, 2, 9 Maniataki E. and Mourelatos Z. (Genes Dev. 2005)
    8. Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers. (PubMed id 22187960)1, 2 Heravi-Moussavi A.... Huntsman D.G. (N. Engl. J. Med. 2012)
    9. Extending the phenotypes associated with DICER1 mutations. (PubMed id 21882293)1, 2 Foulkes W.D.... Priest J.R. (Hum. Mutat. 2011)
    10. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23405 HGNC: 17098 AceView: DICER1 Ensembl:ENSG00000100697 euGenes: HUgn23405
    ECgene: DICER1 Kegg: 23405 H-InvDB: DICER1

    (According to HUGE)
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    HUGE: KIAA0928

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DICER1 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/087

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DICER1 gene:
    Search GeneIP for patents involving DICER1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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