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CDK4 Gene

protein-coding GIFtS: 71

GC12M058142

cyclin-dependent kinase 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
cyclin-dependent kinase 4¹ ² ³		cell division kinase 4²
PSK-J3¹ ² ³		MGC14458²
CMM3² ⁵		melanoma cutaneous malignant, 3²
cell division protein kinase 4²		EC 2.7.11.22³

External Ids:	HGNC: 1773¹	Entrez Gene: 1019²	Ensembl: ENSG00000135446⁷	UniProtKB: P11802³

Search outside databases for aliases for CDK4 gene

Previous GC identifers: GC12M057743 GC12M058284 GC12M057858 GC12M056428

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK4:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to

the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex

that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase,

which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to

be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its

related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a

variety of cancers. Multiple polyadenylation sites of this gene have been reported. (provided by RefSeq)

UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802

Function: Probably involved in the control of the cell cycle

summary for CDK4:

Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the

cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk

genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following

extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D

and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces

transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E

complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M

phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation

of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,

including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by

molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks

is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.

Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to

Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential

targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic

strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK4 (Cyclin-dependent kinase 4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDK4 gene upstream (promoter) region

:
IRF-1 CREB deltaCREB C/EBPalpha AP-1 AP-2gamma AP-2alphaA NF-kappaB1 NF-kappaB c-Myb

Epigenetics:

SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for CDK4:

MePH16806-2A MePH16808-2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14 Ensembl cytogenetic band: 12q14.1 HGNC cytogenetic band: 12q13

CDK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M058142: view genomic region (about GC identifiers)

Start:	58,142,003 bp from pter
End:	58,146,164 bp from pter
Size:	4,162 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.11 NT_029419.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802 (See protein sequence)

Recommended Name: Cell division protein kinase 4

Size: 303 amino acids; 33730 Da

Subunit: Forms a stable complex with D-type G1 cyclins. Interacts with SEI1 and ZNF655/VIK

PDB structures from and Proteopedia :

1LD2 (3D)

2W96 (3D)

2W99 (3D)

2W9F (3D)

2W9Z (3D)

3G33 (3D)

Secondary accessions: O00576 Q6FG61

Post-translational modifications:

Thr-172 is probably phosphorylated by CAK¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000066.1

ENSEMBL proteins:

ENSP00000316889 ENSP00000257904

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CDK4
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CDK4
	HuPro® and/or Recombinant Proteins from Abnova for CDK4
	Origene Purified Recombinant Human Protein: CDK4
	Novus Biologicals Proteins for CDK4
	Novus Biologicals Lysates for CDK4
	Browse Sino Biological Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IDA	17420273
GO:0005634	nucleus	IDA	16109376
GO:0005654	nucleoplasm	EXP	9190208 16782892
GO:0005667	transcription factor complex	IEA	--
GO:0005829	cytosol	EXP	9106657

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CDK4 for ontologies About GeneDecksing

Antibodies for CDK4:

	Millipore Mono- and Polyclonal Antibodies for the study of CDK4
	Sigma-Aldrich Antibody Arrays and Antibodies for CDK4
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CDK4
	Monoclonal and Polyclonal Antibodies from Abnova (CDK4)
	Origene Antibodies: CDK4
	Novus Biologicals Antibodies for CDK4
	Epitomics antibodies for CDK4

Assays for CDK4:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for CDK4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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CDK4 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6 ):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_prot_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_prot_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry P11802

ProtoNet protein and cluster: P11802

UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Millipore RNAi Products for the Analysis of CDK4 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDK4)
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): CDK4 Origene shRNA RFP (see all 2): CDK4 Origene basic RS shRNA (see all 2): CDK4
		Applied Biosystems Silencer® siRNAs for CDK4
		Sigma-Aldrich siRNA Panels and siRNA for CDK4 Sigma-Aldrich shRNA Panels and shRNA for CDK4 Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector: CDK4 Origene Myc/DDK tagged cDNA clones in CMV expression vector: CDK4 Origene untagged cDNA clones in CMV expression vector (see all 5): CDK4
		Sino Biological Human cDNA Clone for CDK4

UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802

Function: Probably involved in the control of the cell cycle

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Phosphorylation at Thr-172 is necessary for enzymatic activity (By similarity)

Enzyme Number (IUBMB): EC 2.7.11.22

Genatlas biochemistry entry for CDK4:

cyclin dependent kinase 4 involved in cell cycle regulation (G1 to S transition),complexing with cyclin D

(D1,D2,D3),amplified in malignant glioblastoma and anaplastic astrocytoma,and in diffuse large B cell lymphoma ;

amplified in osteosarcoma with OS9,SAS and PRIM1and in sporadic breast carcinomas,predisposing to familial melanoma by

inducing abnormal repair of ultraviolet radiation. Loss of CDK4 expression causes insulin deficient diabetes,and CDK4

activation results in B islet cell hyperplasia in mice

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	--	--
GO:0004693	cyclin-dependent protein kinase activity	IDA	8114739
GO:0005515	protein binding	IPI	8078588 8259215 8741839 9106657 9529249 11896535 15232106 15558030 16326706 17274640 17353931 17517622 19447967

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CDK4 for ontologies About GeneDecksing

Animal Models: 15/21 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cdk4) (see all 21 ):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	liver/biliary system	muscle	nervous system

CDK4 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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CDK4 for pathways About GeneDecksing

5/13 Millipore Pathways for CDK4 (see all 13 )

	DNA damage ATM/ATR regulation of G1/S checkpoint
	Cell cycle Regulation of G1/S transition (part 2)
	Cell cycle Role of APC in cell cycle regulation
	Meiosis
	Cell cycle Regulation of G1/S transition (part 1)

5/18 Sigma-Aldrich "Your Favorite Gene" Pathways for CDK4 (Your Favorite Gene powered by Ingenuity) (see all 18 )

	Glioblastoma Multiforme Signaling
	Aryl Hydrocarbon Receptor Signaling
	Melanoma Signaling
	Inositol Phosphate Metabolism
	Bladder Cancer Signaling

5/14 GeneAssist Pathways for CDK4 (see all 14 )

	Pathogenesis of Gliomas
	Cell Cycle Control by BTG Proteins
	Pancreatic Adenocarcinoma
	Cyclins and Cell Cycle Regulation
	G1-S Phase Transition

5/12 Kegg Pathways (Kegg details for CDK4) (see all 12 ):

	hsa04110 Cell cycle
	hsa04115 p53 signaling pathway
	hsa04530 Tight junction
	hsa04660 T cell receptor signaling pathway
	hsa05200 Pathways in cancer

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDK4

5/67 Interacting proteins for CDK4 (ENSP00000257904³ P11802^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 67 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCND1	P24385¹^,²	STRING: ENSP00000227507 EBI-295644,EBI-375001 MINT-50433 EBI-295644,EBI-375001 MINT-50433
CCND3	P30281¹^,²	STRING: ENSP00000362082 EBI-295644,EBI-375013 MINT-50438 EBI-295644,EBI-375013 MINT-50438
CDC7	O00311¹^,²	STRING: ENSP00000359443 EBI-295644,EBI-374980 MINT-50416 EBI-295644,EBI-374980 MINT-50416
CDKN1B	P46527¹^,²	STRING: ENSP00000228872 EBI-295644,EBI-519280 MINT-3379718 EBI-295644,EBI-519280 MINT-3379718
MCM2	P49736¹^,²	STRING: ENSP00000265056 EBI-295644,EBI-374819 MINT-50417 EBI-295644,EBI-374819 MINT-50417

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5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IMP	7603984
GO:0006468	protein amino acid phosphorylation	IDA	8114739
GO:0007165	signal transduction	IEA	--
GO:0008284	positive regulation of cell proliferation	IMP	7603984
GO:0010468	regulation of gene expression	IMP	17420273

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CDK4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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CDK4 for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for CDK4

Sigma-Aldrich Small Molecules for CDK4:

Small Molecule - Inhibitor

Compounds for CDK4 available from Tocris Bioscience

Compound	Action	CAS number
Ryuvidine	Cyclin-dependent kinase 4 (cdk4) inhibitor	[265312-55-8]
NSC 625987	Cyclin-dependent kinase 4 (cdk4) inhibitor	[141992-47-4]

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10/308 Novoseek chemical compound relationships for CDK4 gene (see all 308 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fascaplysin	32.88	13	10973815 (4), 16816972 (2), 16750360 (2), 20055172 (1) (see all 8)
flavopiridol	12.10	12	8674031 (4), 9784425 (2), 10493518 (2), 19535344 (1) (see all 7)
bcl2	8.22	12	9639522 (2), 9546285 (1), 7643628 (1), 19509155 (1) (see all 11)
roscovitine	7.97	9	9828096 (1), 18202766 (1), 17081516 (1), 15696186 (1) (see all 9)
dpth	7.36	4	18649995 (2), 18295547 (1), 14667929 (1)
silibinin	7.31	12	16322307 (2), 9581834 (1), 19908243 (1), 19150384 (1) (see all 11)
ag 126	7.25	4	19080374 (1), 18703151 (1), 17374178 (1), 16125882 (1)
3-amino-9-thio-(10h)-acridone	6.17	2	18202766 (1), 15246544 (1)
pga2	5.63	5	8622677 (4), 8621603 (1)
nu6102	5.43	2	15928920 (2)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Millipore RNAi Products for the Analysis of CDK4 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDK4)
		Applied Biosystems Silencer® siRNAs: NM_000075
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): CDK4 Origene shRNA RFP (see all 2): CDK4 Origene basic RS shRNA (see all 2): CDK4
		Sigma-Aldrich siRNA Panels and siRNA for CDK4 Sigma-Aldrich shRNA Panels and shRNA for CDK4 Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:		2 SABiosciences microRNAs that regulate CDK4:
		hsa-miR-124 hsa-miR-486-5p

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_000075

Clones:

Origene GFP tagged cDNA clones in CMV expression vector: CDK4
Origene Myc/DDK tagged cDNA clones in CMV expression vector: CDK4
Origene untagged cDNA clones in CMV expression vector (see all 5): CDK4

Primers:		Origene genome-wide validated SYBR primer pairs: CDK4
		SABiosciences RT2 qPCR Primer Assay for CDK4: PPH00118A

REFSEQ mRNAs for CDK4 gene:

NM_000075.2

Additional cDNA sequence:

AK297901.1 AK310724.1 AK313701.1 BC003644.2 BC005864.2 BC010153.2 BC015669.2 CR407668.1

CR542247.1 CR590586.1 CR591116.1 CR594194.1 CR597992.1 CR598582.1 CR602761.1 CR602927.1

CR608247.1 CR609991.1 CR616342.1 CR622282.1 M14505.1 U79269.1 Z48970.1

24/28 DOTS entries (see all 28 ):

DT.219465 DT.100851448 DT.92408932 DT.40113477 DT.445603 DT.100851457 DT.95222712 DT.97856917

DT.100851439 DT.121198842 DT.121198896 DT.121642996 DT.95284131 DT.97789050 DT.121198761 DT.91928527

DT.95339116 DT.100701889 DT.100716609 DT.121198886 DT.40118681 DT.91772477 DT.91921800 DT.95339064

24/974 AceView cDNA sequences (see all 974 ):

BM853254 BE463902 CA448056 BE296487 AI567341 CR602927 BM781804 BF312644

AA339716 AU150289 BU165914 BC005864 BG254701 NM_000075 BE729063 AW410243

BC007968 BE388277 BU188856 BF308807 BG060154 BQ688124 BF316086 BE795990

highest scoring ESTs for CDK4:

AA315694 AA338741 AA339057 AA362679 AL546134 AL602986 AU117043 AW246398 AW410442 AW411404

Unigene Cluster for CDK4:

Cyclin-dependent kinase 4

Hs.95577 [show with all ESTs]

Unigene Representative Sequence: BM467999

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CDK4 (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b
SP1:											-																-		-
SP2:											-														-				-
SP3:											-		-		-												-		-
SP4:											-		-		-		-										-		-
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for CDK4

2 Ensembl transcripts including schematic representations:

ENST00000312990 ENST00000257904

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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CDK4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDK4

¹ / ² / ³

3 probe-sets matching CDK4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1942_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U37022	0.20	1.00	0.72	1
202246_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000075	0.40	0.67	0.55	1
202246_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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CDK4 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: GAAGGAAGAA

SOURCE GeneReport for Unigene cluster: Hs.95577

Expression variation in blood from EXPOLDB for CDK4

Primers:		Origene genome-wide validated SYBR primer pairs: CDK4
		SABiosciences RT2 qPCR Primer Assay for CDK4: PPH00118A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CDK4 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDK4¹	--	cyclin-dependent kinase 4	90.76(n) 97.03(a)	481131 XM_538252.2 XP_538252.1
chimpanzee (Pan troglodytes)	CDK4¹	--	cyclin-dependent kinase 4	99.89(n) 100(a)	452025 XM_509173.2 XP_509173.2
cow (Bos taurus)	CDK4¹	--	cyclin-dependent kinase 4	92.52(n) 97.03(a)	510618 NM_001037594.1 NP_001032683.1
rat (Rattus norvegicus)	Cdk4¹	--	cyclin-dependent kinase 4	87.9(n) 95.05(a)	94201 NM_053593.2 NP_446045.1
mouse (Mus musculus)	Cdk4^{1, 5}	10⁵	cyclin-dependent kinase 4^{1, 5}	88.12(n)¹ 94.72(a)¹	12567¹ NM_009870.2¹ NP_034000.1¹ AA791962⁵ AK003804⁵ (see all 25)

About this table Species with no ortholog for CDK4

ENSEMBL Gene Tree for CDK4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CDK4 gene

CDK6² CDK3² CDK5² CDK2² CDK1²

CDK4 for paralogs About GeneDecksing

Pseudogenes

1 related pseudogene

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/63 NCBI SNPs in CDK4 are shown (see all 63 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 60)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
--	rs184712^1,2	C,F,A	55178442(+)	`ctcacC/Tgcaac`	1	--	ng3¹		2	NS MN	360
--	rs238532^1,2	C,F,H	55183221(+)	`ACCCCC/TGCTGC`	1	--	ng5¹		8	EA NA NS	622
--	rs3211607^1,2	C,F,H	55183616(-)	`TAGAAG/TACCCC`	1	--	ng5¹		10	NS EA MN	972
	rs2069500^1,2	C,F,H	55183037(-)	`GTGGCG/AGTCAC`	1	--	ng5¹		5	NA EA NS	634
	rs2072052^1,2	C,F	55183559(+)	`CTGTCC/ACTGGC`	1	--	ng5¹		16	EA NS MN NA	2424
--	rs3472^1,2	C,F	55178711(-)	`ACTGAA/C/GAAAGC`	1	--	ng3¹		2	NS NA	248
	rs3473^1,2	C,F	55178778(-)	`GGACTT/GTCCTG`	1	--	ng3¹		7	NS EA NA WA	730
	rs34386532^1,2	C	58144863(+)	`ACTGGC/TGCATC`	2	H R	mis¹ ref¹		4	NS EA	420
--	rs3211635^1,2	C	55178708(-)	`GACAAA/CGCTTA`	1	--	ng3¹		1	NS	176
	rs3211612^1,2	H	58145099(-)	`ATCCCG/AAACTG`	2	/Q /R	mis¹ ref¹ ese³		5	NS EA	594

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HapMap Linkage Disequilibrium images for CDK4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDK4: --

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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CDK4 for disorders About GeneDecksing

OMIM: 123829 disorders: 609048

UniProtKB/Swiss-Prot: CDK4_HUMAN, P11802

Defects in CDK4 are a cause of susceptibility to cutaneous malignant melanoma type 3 (CMM3) [MIM:609048].

Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which

occurs most often in the skin but also may involve other sites

10/343 Novoseek disease relationships for CDK4 gene (see all 343 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	100.00	259	15753637 (6), 9703873 (4), 15161057 (4), 12657672 (3) (see all 100)
melanoma	69.04	167	16540642 (7), 9036865 (4), 18790768 (4), 11556834 (4) (see all 100)
dedifferentiated liposarcoma	59.06	30	16160477 (6), 19946100 (4), 15221942 (4), 19574885 (3) (see all 15)
germline mutation	39.17	40	9425228 (3), 17505264 (3), 10777219 (3), 10732752 (3) (see all 29)
atypical lipomatous tumor	23.57	13	10727978 (5), 20063101 (2), 19816710 (2), 19691106 (1) (see all 7)
growth arrest	20.27	31	11867521 (3), 8754845 (2), 11023508 (2), 9778049 (1) (see all 27)
multiple tumors	18.43	18	8821952 (2), 9827724 (1), 9698532 (1), 8887073 (1) (see all 17)
liposarcoma	17.78	21	14694526 (4), 9713346 (3), 19626636 (2), 16938516 (2) (see all 13)
chondrosarcoma	15.76	23	11314534 (6), 18624751 (5), 11377231 (5), 11332612 (4) (see all 6)
glioblastoma	15.26	32	8811128 (4), 8806696 (4), 9600204 (3), 9772286 (2) (see all 17)

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Human Gene Mutation Database: CDK4
Genetic Association Database: CDK4
Human Genome Epidemiology Navigator: CDK4 (38 documents)
Tumor Gene Database: CDK4

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/1469 PubMed articles for CDK4 gene (see all 1469 ):

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. (PubMed id 9425228)^{1, 3, 4} Soufir N.... Bressac-De Paillerets B. (1998)
Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. (PubMed id 8275715)^{1, 2, 3} Demetrick D.J....Beach D.H. (1994)
Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traits. (PubMed id 15821902)^{1, 3, 6} Nielsen E.M....Pedersen O. (2005)
A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare. (PubMed id 11668523)^{1, 3, 6} Kumar R....Hemminki K. (2001)
Absence of mutations in the CDKN2 binding site of CDK4 in childhood acute lymphoblastic leukemia. (PubMed id 11426564)^{1, 3, 6} Einsiedel H.G....Seeger K. (2001)
Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma. (PubMed id 9311594)^{1, 3, 4} Guldberg P....Zeuthen J. (1997)
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. (PubMed id 7652577)^{1, 3, 4} Wolfel T.... Beach D. (1995)
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. (PubMed id 8221695)^{1, 3, 4} Khatib Z.A....Look A.T. (1993)
Role of the CDKN2A locus in patients with multiple primary melanomas. (PubMed id 15860862)^{1, 3, 6} Puig S....Mila M. (2005)
Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). (PubMed id 10580009)^{1, 3, 4} Sugimoto M....Hara E. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1019	HGNC: 1773	AceView: CDK4	Ensembl:ENSG00000135446	euGenes: HUgn1019
ECgene: CDK4	Kegg: 1019	H-InvDB: CDK4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CDK4	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CDK4
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdk4/

Intellectual Property for CDK4 gene
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Patent Information for CDK4 gene:

Search GeneIP for patents involving CDK4

GeneCards and IP:

Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Products for CDK4:

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