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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BTK Gene

protein-coding   GIFtS: 77
GCID: GC0XM100604

Bruton agammaglobulinemia tyrosine kinase


(Previous symbols: AGMX1, IMD1)
 Explore 49 diseases affiliated with
BTK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BTK    

Aliases
for BTK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Bruton Agammaglobulinemia Tyrosine Kinase1 2     AT2 5
AGMX11 2 3 5     Agammaglobulinaemia Tyrosine Kinase2
ATK1 2 3     Dominant-Negative Kinase-Deficient Brutons Tyrosine Kinase2
IMD11 2 5     Tyrosine-Protein Kinase BTK2
XLA1 2 5     Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14)2
PSCTK11 2     Agammaglobulinemia Tyrosine Kinase3
BPK2 3     Bruton Tyrosine Kinase3
B-Cell Progenitor Kinase2 3     EC 2.7.108
EC 2.7.10.23 8     

External Ids:    HGNC: 11331   Entrez Gene: 6952   Ensembl: ENSG000000106717   OMIM: 3003005   UniProtKB: Q061873   

Export aliases for BTK gene to outside databases

Previous GC identifers: GC0XM095896 GC0XM097575 GC0XM098640 GC0XM099376 GC0XM100410 GC0XM100491 GC0XM090410


Summaries
for BTK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BTK:
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked
agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes,
and associated with a failure of Ig heavy chain rearrangement. (provided by RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: BTK_HUMAN, Q06187
Function: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.
Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation.
After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the
downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family
members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK.
BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor
signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as
a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the
detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in
regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which
leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of
NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling
pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine
residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate
gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of
functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a
dual role in the regulation of apoptosis

summary for BTK:
Bruton's Tyrosine Kinase (BTK) is member of the Tec family that is critically important for the growth,
differentiation and activation of myeloid-, mast- and B-cells. BTK is activated firstly by membrane
localization stimulated by PIP3 generation, and subsequently, by transphosphorylation of Tyr-551 by Src
family kinases. Activated BTK is involved in the phosphorylation of a number of signaling molecules involved
in the PLCgamma, JNK and p38 MAPK pathways, leading to Ca2+ mobilization, mRNA stabilization and the
induction of NF-kappaB and AP-1 transcription factors. BTK activity is negatively regulated by a number of
proteins including inhibitor of BTK (IBTK), Sab and c-Cbl. Mutations in this enzyme are known in humans and
result in the immunological disorder X-linked agammaglobulemia.

Gene Wiki entry for BTK (Bruton's tyrosine kinase)


Genomic Views
for BTK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BTK gene promoter:
         HOXA9B   HOXA9   C/EBPbeta   Meis-1b   AREB6   CREB   deltaCREB   STAT3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BTK promoter sequence
   Search SABiosciences Chromatin IP Primers for BTK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BTK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.33-q22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq21.33-q22

BTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTK gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM100604:  view genomic region     (about GC identifiers)

Start:
 100,604,435 bp from pter      End:
 100,641,212 bp from pter
Size:
 36,778 bases      Orientation:
 minus strand

Proteins
for BTK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BTK_HUMAN, Q06187 (See protein sequence)
Recommended Name: Tyrosine-protein kinase BTK  
Size: 659 amino acids; 76281 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its PH
domain. Interacts with ARID3A, CAV1, FASLG, PIN1, TLR8 and TLR9
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=In steady state, BTK is
predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane
through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK
also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor
CRM1
6/20 PDB 3D structures from and Proteopedia for BTK (see all 20):
1AWW (3D)        1AWX (3D)        1B55 (3D)        1BTK (3D)        1BWN (3D)        1K2P (3D)    
Secondary accessions: Q32ML5

Explore the universe of human proteins at neXtProt for BTK: NX_Q06187

Post-translational modifications:

  • Following B-cell receptor (BCR) engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-551
    • by LYN and SYK. Phosphorylation at Tyr-551 is followed by autophosphorylation of Tyr-223 which may create a docking
    site for a SH2 containing protein. Phosphorylation at Ser-180 by PRKCB, leads in translocation of BTK back to the
    cytoplasmic fraction. Phosphorylation at Ser-21 and Ser-115 creates a binding site for PIN1 at these Ser-Pro motifs,
    and promotes it's recruitment1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q06187

    • 4/10 DME Specific Peptides for BTK (Q06187) (see all 10)
     EAMEYLE  YYLAEKH  RDLAARN  LSYYEYD 

    BTK Protein expression data from MOPED and PaxDb:    About this image 
    BTK Protein Expression
    REFSEQ proteins: NP_000052.1  
    ENSEMBL proteins: 
     ENSP00000361971   ENSP00000308176  
    Reactome Protein details: Q06187
    Human Recombinant Protein Products for BTK: 
    EMD Millipore Purified and/or Recombinant BTK Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for BTK
    OriGene Purified Proteins (see all 2): BTK
    OriGene Protein Over-expression Lysate: BTK
    OriGene Custom Protein Services for BTK 
    GenScript Custom Purified and Recombinant Proteins Services for BTK
    Novus Biologicals BTK Proteins
    Novus Biologicals BTK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BTK

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS19290921
    GO:0005737cytoplasm TAS15046600
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    BTK for ontologies           About GeneDecksing



    BTK Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BTK
    R&D Systems Antibodies for BTK
    Cell Signaling Technology (CST) Antibodies for BTK 
    OriGene Antibodies (see all 15): BTK
    OriGene Custom Antibody Services for BTK 
    GenScript Custom Superior Antibodies Services for BTK
    Novus Biologicals BTK Antibodies
    Abcam antibodies for BTK 
    Uscn Antibodies for BTK
    ThermoFisher Antibody for BTK

    Assay Products for BTK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BTK
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    Uscn ELISAs and CLIAs for BTK

    Protein Domains /
    Families
    for BTK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BTK for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR001849 Pleckstrin_homology
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q06187

    ProtoNet protein and cluster: Q06187

    5 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: BTK_HUMAN, Q06187
    Domain: The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its targeting to
    the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec homology) domain,
    which consists of about 80 residues preceding the SH3 domain
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Function
    for BTK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BTK_HUMAN, Q06187
    Function: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling.
    Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation.
    After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the
    downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family
    members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK.
    BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor
    signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as
    a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the
    detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in
    regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which
    leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of
    NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling
    pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine
    residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate
    gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of
    functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a
    dual role in the regulation of apoptosis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by phosphorylation. In primary B lymphocytes, is almost always non-phosphorylated and is
    thus catalytically inactive. Stimulation of TLR8 and TLR9 causes BTK activation. As a negative feedback mechanism to
    fine-tune BCR signaling, activated PRKCB down-modulates BTK function via direct phosphorylation of BTK at Ser-180,
    resulting in translocation of BTK back to the cytoplasmic fraction. PIN1, SH3BP5, and IBTK were also identified as BTK
    activity inhibitors. Interaction with CAV1 leads to dramatic down-regulation of the kinase activity of BTK. LFM-13A is
    a specific inhibitor of BTK. Dasatinib, a cancer drug acting as a tyrosine kinase inhibitor, also blocks BTK activity

         Genatlas biochemistry entry for BTK:
    B cell progenitor tyrosine kinase

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS19290921
    GO:0005515protein binding IPI--
    GO:0005524ATP binding TAS11913944
    GO:0005543phospholipid binding ----
         
    BTK for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for BTK:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased gamma-H2AX phosphory 
     Increased mitotic index  Upregulation of Wnt/beta-caten 

         10 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Btk):
     cellular  digestive/alimentary  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  tumorigenesis 

    BTK for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Btktm1Wk for BTK
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BTK 

    miRNA
    Products:            		miRTarBase miRNAs that target BTK:
    hsa-mir-346 (MIRT001128)

    OriGene 3'-UTR Clone: BTK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BTK
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate BTK:
    hsa-miR-374a* hsa-miR-590-5p hsa-miR-2116* hsa-miR-622 hsa-miR-513a-3p hsa-miR-205* hsa-miR-590-3p hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmid: BTK 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTK (see all 7)
    OriGene shRNA RFP: BTK
    OriGene siRNA: BTK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTK
    Sirion Biotech Custom design and validation of potent shRNA sequences against BTK 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BTK
    Sirion Biotech Customized adenovirus for overexpression of BTK 
    Sirion Biotech Customized adenovirus for potent knockdown of BTK

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTK (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTK (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BTK (NM_000061)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTK 

    Cell Line
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    Search LifeMap BioReagents cell lines for BTK
    Sirion Biotech Customized stable knockdown cell line services for BTK 
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    Sirion Biotech Customized inducible overexpressing cell line services for BTK

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTK


    Pathways & Interactions
    for BTK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/42 super-pathways (see all 42) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    8/11 pathways (see all 11)
    		PEDF Induced Signaling1.00
    		STAT3 Pathway0.47
    		MIF Mediated Glucocorticoid Regulation0.73
    		Endothelin-1 Signaling Pathway0.44
    		MIF Regulation of Innate Immune Cells0.71
    		NFAT Signaling and Lymphocyte Interactions0.37
    		IL-6 Pathway0.61
    		PGC1Alpha Pathway0.33
    2TRAF6 Mediated Induction of proinflammatory cytokines
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		Activated TLR4 signalling0.63
    		Toll Like Receptor TLR6:TLR2 Cascade0.78
    		Toll Like Receptor 4 (TLR4) Cascade0.61
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll-Like Receptors Cascades0.53
    		MyD88:Mal cascade initiated on plasma membrane0.78
    3TGF-Beta Pathway
    		TGF-Beta Pathway1.00
    		JNK Pathway0.50
    		MAPK Family Pathway0.60
    		Regulation of eIF4 and p70S6K0.43
    		JAK-STAT Pathway0.57
    		SOCS Pathway0.29
    4G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins
    		G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins1.00
    		G-protein signaling_G-Protein alpha-12 signaling pathway0.40
    		G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins1.00
    		G-protein signaling G-Protein alpha-12 signaling pathway0.40
    5Immune response Fc epsilon RI pathway
    		Immune response Fc epsilon RI pathway1.00
    		Fc-epsilon receptor I signaling in mast cells0.33
    		Immune response_Fc epsilon RI pathway0.99

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/8 EMD Millipore Pathways for BTK (see all 8)
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling G-Protein alpha-12 signaling pathway
    Immune response NFAT in immune response
    Immune response Fc epsilon RI pathway
    G-protein signaling G-Protein beta/gamma signaling cascades

    5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BTK (see all 38)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    G12-G13 in Cellular Signaling

    2 Cell Signaling Technology (CST) Pathways for BTK
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    5/8 GeneGo (Thomson Reuters) Pathways for BTK (see all 8)
        Development EPO-induced MAPK pathway
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response BCR pathway
    G-protein signaling G-Protein alpha-12 signaling pathway
    Immune response NFAT in immune response

    5/9 BioSystems Pathways for BTK (see all 9) 
        IL-5 Signaling Pathway
    IL-6 Signaling Pathway
    B Cell Receptor Signaling Pathway
    Kit Receptor Signaling Pathway
    FAS (CD95) signaling pathway

    5/17        Reactome Pathways for BTK (see all 17)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    DAP12 interactions
    DAP12 signaling


    4         Kegg Pathways  (Kegg details for BTK):
        Osteoclast differentiation
    B cell receptor signaling pathway
    Fc epsilon RI signaling pathway
    Primary immunodeficiency


    BTK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BTK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/181 Interacting proteins for BTK (Q061871, 2, 3 ENSP000003081764) via UniProtKB, MINT, STRING, and/or I2D (see all 181)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2IP783471, 2, 3, ENSP000003225424EBI-624835,EBI-359622 MINT-7230971 I2D: score=3 STRING: ENSP00000322542
    BLNKQ8WV282, 3, ENSP000002243374MINT-59470 MINT-59465 MINT-3374560 MINT-3374585 I2D: score=5 STRING: ENSP00000224337
    IBTKQ9P2D02, 3, ENSP000003057214MINT-49849 MINT-49797 MINT-49799 MINT-49793 I2D: score=5 STRING: ENSP00000305721
    ARID3AQ998562, 3, ENSP000002636204MINT-7230949 MINT-7230913 MINT-7230932 MINT-7230971 I2D: score=4 STRING: ENSP00000263620
    DAAM1Q9Y4D12, 3, ENSP000002471704MINT-7146361 I2D: score=1 STRING: ENSP00000247170
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002250adaptive immune response TAS19290921
    GO:0002721regulation of B cell cytokine production TAS19290921
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002902regulation of B cell apoptotic process TAS19290921

    BTK for ontologies           About GeneDecksing



    Drugs & Compounds
    for BTK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BTK for compounds           About GeneDecksing

    EMD Millipore small molecules for BTK:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for BTK

    Compounds for BTK available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (-)-Terreic acidSelective inhibitor of BTK[121-40-4]
    LFM-A13 Potent, selective BTK inhibitor [62004-35-7]

    2 HMDB Compounds for BTK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for BTK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Inositol 1,3,4,5-Tetrakisphosphate-- --target--17139284 17016423

    10/36 Novoseek chemical compound relationships for BTK gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 89 1216 11413148 (5), 12437073 (5), 7565679 (5), 10051622 (4) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 75.7 10 11279148 (2), 10201980 (2), 11698416 (1), 12734372 (1) (see all 5)
    phosphoinositide 62 19 9928954 (3), 16619289 (3), 11756681 (2), 11329620 (1) (see all 12)
    piceatannol 57.9 1 15180535 (1)
    phosphatidylinositol 57 21 12215216 (2), 10201980 (2), 14610042 (1), 18657320 (1) (see all 14)
    leflunomide 48.4 9 12188892 (1), 17469650 (1), 10092645 (1), 9880544 (1) (see all 6)
    inositol 1,4,5 trisphosphate 43.8 6 9830001 (1), 10327049 (1), 16547971 (1), 17237388 (1) (see all 5)
    phosphotyrosine 42.1 5 10754312 (2), 10051622 (1), 9391111 (1), 7657668 (1)
    inositol 1,3,4,5-tetrakisphosphate 41.8 3 8939985 (2), 10196129 (1)
    wortmannin 34.8 11 10840066 (2), 11329620 (1), 16619289 (1), 10590061 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about BTK 

    Transcripts
    for BTK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BTK gene: 
    NM_000061.2  

    Unigene Cluster for BTK:

    Bruton agammaglobulinemia tyrosine kinase
    Hs.159494  [show with all ESTs]
    Unigene Representative Sequence: NM_000061
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372880(uc010nnn.2) ENST00000308731(uc004ehf.2 uc010nnh.2 uc010nni.2 uc004ehe.2 uc010nnj.2 uc010nnk.2 uc010nnl.2 uc010nnm.2 uc004ehh.1 uc004ehg.2 uc004ehi.3 uc010nno.2)
    ENST00000470069 ENST00000488970 ENST00000478995 ENST00000470329 ENST00000464006
    ENST00000464567

    miRNA
    Products:             		 OriGene 3'-UTR Clone: BTK
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BTK
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate BTK:
    hsa-miR-374a* hsa-miR-590-5p hsa-miR-2116* hsa-miR-622 hsa-miR-513a-3p hsa-miR-205* hsa-miR-590-3p hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmid: BTK 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BTK (see all 7)
    OriGene shRNA RFP: BTK
    OriGene siRNA: BTK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BTK
    Sirion Biotech Custom design and validation of potent shRNA sequences against BTK 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BTK (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BTK (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BTK (NM_000061)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTK 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BTK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BTK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BTK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTK

    Additional cDNA sequence: 

    AF153364.1 AF153755.1 AF153756.1 AF153757.1 AF153758.1 AF153759.1 AF153760.1 AF153761.1 
    AF153762.1 AF153763.1 AF153764.1 AJ888376.1 AJ888377.1 AJ888378.1 AJ888379.1 AJ888380.1 
    AJ888381.1 AK057105.1 AK225577.1 AK309851.1 AK314382.1 AM051275.1 AM051276.1 AM051277.1 
    AM051278.1 AM051279.1 AM051280.1 AM051281.1 AM051282.1 AM051283.1 AM051284.1 AM051285.1 
    AM051286.1 BC109079.1 BC109080.1 X58957.1 

    9 DOTS entries:

    DT.444365  DT.95165288  DT.121325060  DT.432796  DT.86849846  DT.91687758  DT.121325046  DT.112417 
    DT.446289 

    24/98 AceView cDNA sequences (see all 98):

    BF795127 BM458740 BQ059300 BI489714 BP345102 BM925197 AW402365 AI361486 
    BQ439666 CA435879 BI766828 AA346572 CD365313 BG106420 BM478046 BU619204 
    BQ642017 N75948 AF153758 AF153760 BE561776 BG256603 AF153761 AF153757 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for BTK (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^
    SP1:                    -     -                             -                 -                                                                                 
    SP2:                          -                             -                 -                                                                 -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                    -     -                             -                 -                                                                                 

    ExUns: 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b · 21c · 21d · 21e
    SP1:              -                                                         
    SP2:  -           -                                                         
    SP3:              -                       -                                 
    SP4:        -     -                                                         
    SP5:                                                                        


    ECgene alternative splicing isoforms for BTK

    Expression
    for BTK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BTK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATGAAGAAT
    BTK Expression
    About this image

    BTK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BTK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BTK

    SOURCE GeneReport for Unigene cluster: Hs.159494

    UniProtKB/Swiss-Prot: BTK_HUMAN, Q06187
    Tissue specificity: Predominantly expressed in B-lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including BTK: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BTK
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTK

    Orthologs
    for BTK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BTK gene from 6/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BTK1 Bruton agammaglobulinemia tyrosine kinase 79.19(n)
    86.26(a)    		   374075  NM_204233.2  NP_989564.2 
    lizard
    (Anolis carolinensis)    		 Reptilia BTK6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 GL343451.1(234133-244197)
    zebrafish
    (Danio rerio)    		 Actinopterygii btk1 Bruton agammaglobulinemia tyrosine kinase 65.98(n)
    65.98(a)    		   568653  XM_691995.4  XP_697087.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Btk29A3 male genital morphogenesis (sensu
    Holometabola) more    		 52(a)   29A1   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G576106
    AT1G795706
    (see all 7)    		 octicosapeptide/Phox/Bem1p domain-containing prote...
    octicosapeptide/Phox/Be.1 domain-containing protei...
    (see all 7)    		 9(a)
    9(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 5(23324791-23329347)
    1(29932578-29938856)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 protein kinase domain containing protein, expresse...
    protein kinase domain containing protein, expresse...
    (see all 5)    		 9(a)
    9(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 6(26398279-26404234)
    7(14722116-14730584)


    ENSEMBL Gene Tree for BTK (if available)
    TreeFam Gene Tree for BTK (if available) 

    Paralogs
    for BTK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BTK gene
    TEC2  FRK2  LCK2  BLK2  FGR2  ITK2  LYN2  TXK2  
    HCK2  YES12  PTK62  SRC2  ABL12  FYN2  BMX2  ABL22  
    SRMS2  
    18/54 SIMAP similar genes for BTK using alignment to 8 protein entries:     BTK_HUMAN (see all proteins) (see all similar genes):
    BTK kinase deficient isoform 7    BTK kinase deficient isoform 9    BTK kinase deficient isoform 5    BTK kinase deficient isoform 4    BTK kinase deficient isoform 3    BTK kinase deficient isoform 1
    BTK kinase deficient isoform 8    BTK kinase deficient isoform 2    BTK kinase deficient isoform 6    DKFZp686M05208    tec    NTRK3
    TXK    ABL1    NTRK1    c-fgr    ALK    EML4-ALK

    BTK for paralogs           About GeneDecksing



    Genomic Variants
    for BTK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/543 NCBI SNPs in BTK are shown (see all 543)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1048947701,2
    		Cpathogenic100608923(-) AGTCCC/GGTGGT 2 P R mis10--------
    rs1286201831,2
    		Cpathogenic100609675(-) AGCTCA/GAAACT 2 Q R mis10--------
    rs413107091,2
    		Cpathogenic100611100(-) TCCTTA/C/GCACAT 3 * C W stg1 mis12NA 4
    rs289354781,2
    		Cpathogenic100613318(-) TAACTA/GCCATC 2 Y C mis1 ese32Minor allele frequency- G:0.00NA 4
    rs1286201871,2
    		Cpathogenic100630236(-) TGAAGC/TGATCC 2 R * stg10--------
    rs1939221271,2
    		Cunknown100624842(-) AAAAA-/ATGGAT 1 -- int10--------
    rs30276481,2
    		C--100604176(-) CCTACA/GTCGGG 3 -- ds5001 us2k10--------
    rs2004452441,2
    		--100604530(+) ACCCC-/CACACAC 3 -- us2k1 ut310--------
    rs1836746181,2
    		--100604539(+) CACACA/CCCCCC 3 -- ut31 us2k10--------
    rs11227651,2
    		C,F,H--100604652(+) TAATTC/ATCTCG 3 -- us2k1 ut3114Minor allele frequency- A:0.00NA EA MN NS 1098

    HapMap Linkage Disequilibrium report for BTK (100604435 - 100641212 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BTK: --
    Human Gene Mutation Database (HGMD): BTK

    Locus Specific Mutation Databases (LSDB): BTK

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BTK
    DNA2.0 Custom Variant and Variant Library Synthesis for BTK

    Disorders / Diseases
    for BTK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BTK for disorders           About GeneDecksing

    OMIM gene information: 300300   
    OMIM disorders: 300755  307200  
    UniProtKB/Swiss-Prot: BTK_HUMAN, Q06187
  • Defects in BTK are the cause of X-linked agammaglobulinemia (XLA) [MIM:300755]; also known as X-linked
    • agammaglobulinemia type 1 (AGMX1) or immunodeficiency type 1 (IMD1). XLA is a humoral immunodeficiency disease which
    results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells
    in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of
    all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis in the
    first few years of life, or even some patients present overwhelming sepsis or meningitis, resulting in death in a few
    hours. Treatment in most cases is by infusion of intravenous immunoglobulin
  • Defects in BTK may be the cause of X-linked hypogammaglobulinemia and isolated growth hormone deficiency
    • (XLA-IGHD) [MIM:307200]; also known as agammaglobulinemia and isolated growth hormone deficiency or Fleisher syndrome
    or isolated growth hormone deficiency type 3 (IGHD3). In rare cases XLA is inherited together with isolated growth
    hormone deficiency (IGHD)

    20/49 diseases for BTK (see all 49):    About MalaCards
    agammaglobulinemia    mohr-tranebjaerg syndrome    agammaglobulinemia, x-linked 1    isolated growth hormone deficiency
    growth hormone deficiency    isolated growth hormone deficiency type 3    splenic marginal zone lymphoma    wiskott-aldrich syndrome
    common variable immunodeficiency    immunodeficiency    gamma chain deficiency    agammaglobulinemia and isolated hormone deficiency
    tropical spastic paraparesis    paralytic poliomyelitis    williams-beuren syndrome    congenital hypogammaglobulinemia
    fabry disease    poliomyelitis    pyoderma    spastic paraparesis

    2 diseases from the University of Copenhagen DISEASES database for BTK:
    Agammaglobulinemia     Tropical spastic paraparesis

    10/37 Novoseek disease relationships for BTK gene (see all 37)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    x-linked agammaglobulinemia 98.8 328 9445504 (2), 17301411 (2), 8162056 (2), 18726917 (2) (see all 99)
    agammaglobulinemia 94.2 70 11577078 (3), 8090769 (2), 11698416 (2), 8934542 (2) (see all 33)
    hypogammaglobulinemia 78.6 14 11668622 (1), 16862044 (1), 16053733 (1), 19067895 (1) (see all 9)
    hypogammaglobulinemia x-linked 75.1 3 16264330 (1), 8364206 (1)
    immunodeficiency 74.7 167 7946052 (3), 10844531 (2), 8939985 (2), 10068673 (2) (see all 96)
    common variable immunodeficiency 70.7 6 10844531 (1), 11472409 (1), 17024564 (1), 18051214 (1) (see all 5)
    mohr-tranebjaerg syndrome 69.3 1 17851739 (1)
    wiskott-aldrich syndrome 56.2 6 11557038 (1), 16460447 (1), 10068673 (1), 9191173 (1)
    leukemia mast cell 55.7 1 8283037 (1)
    hyper-igm syndrome 54.5 2 11987983 (1)

    GeneTests: BTK
    X-Linked Agammaglobulinemia

    Genetic Association Database (GAD): BTK
    Human Genome Epidemiology (HuGE) Navigator: BTK (8 documents)

    Export disorders for BTK gene to outside databases

    Publications
    for BTK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BTK gene, integrated from 9 sources (see all 554):
    (articles sorted by number of sources associating them with BTK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. (PubMed id 8380905)1, 2, 3 Vetrie D.... Bentley D.R. (1993)
    2. Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia. (PubMed id 9218782)1, 2, 9 Hyvoenen M. and Saraste M. (1997)
    3. Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan. (PubMed id 8695804)1, 2, 9 Hashimoto S....Kishimoto T. (1996)
    4. Mutations in btk in patients with presumed X-linked agammaglobulinemia. (PubMed id 9545398)1, 2, 9 Conley M.E.... Rohrer J. (1998)
    5. BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. (PubMed id 9012831)1, 2, 9 Yang W. and Desiderio S. (1997)
    6. Molecular and structural characterization of five novel mutations in the Bruton's tyrosine kinase gene from patients with X-linked agammaglobulinemia. (PubMed id 9260159)1, 2, 9 Saha B.K.... Vihinen M. (1997)
    7. Regulation of Btk function by a major autophosphorylation site within the SH3 domain. (PubMed id 8630736)1, 2, 9 Park H....Witte O.N. (1996)
    8. Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci. (PubMed id 7626884)1, 2, 9 Oeltjen J.C....Gibbs R.A. (1995)
    9. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. (PubMed id 17932028)1, 2, 9 Doyle S.L....O'Neill L.A. (2007)
    10. Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production. (PubMed id 16517732)1, 2, 9 Horwood N.J....Foxwell B.M. (2006)

    External Searches for BTK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BTK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 695 HGNC: 1133 AceView: BTK Ensembl:ENSG00000010671 euGenes: HUgn695
    ECgene: BTK Kegg: 695 H-InvDB: BTK

    Other Databases showing BTK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BTK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BTK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BTK Genetics and Cytogenetics in Oncology and Haematology
    BTKbasehttp://bioinf.uta.fi/BTKbase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/BTK

    Intellectual Property
    for BTK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BTK gene:
    Search GeneIP for patents involving BTK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for BTK gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     EMD Millipore small molecules (inhibitor) for BTK
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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    VWF
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    von Willebrand factor
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