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Aliases for ADH1C Gene

Aliases for ADH1C Gene

  • Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide 2 3 5
  • EC 1.1.1.1 4 61
  • ADH3 3 4
  • Alcohol Dehydrogenase 3 (Class I), Gamma Polypeptide 3
  • Alcohol Dehydrogenase Subunit Gamma 4
  • Alcohol Dehydrogenase 1C 3
  • Aldehyde Reductase 3
  • ADH, Gamma Subunit 3
  • EC 1.1.1 61

External Ids for ADH1C Gene

Previous HGNC Symbols for ADH1C Gene

  • ADH3

Previous GeneCards Identifiers for ADH1C Gene

  • GC04M100504
  • GC04M100386
  • GC04M100452
  • GC04M100457
  • GC04M100614
  • GC04M100257
  • GC04M095995

Summaries for ADH1C Gene

Entrez Gene Summary for ADH1C Gene

  • This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADH1C Gene

ADH1C (Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide) is a Protein Coding gene. Diseases associated with ADH1C include Alcohol Dependence and Parkinson Disease, Late-Onset. Among its related pathways are Cytochrome P450 - arranged by substrate type and Signaling by Retinoic Acid. GO annotations related to this gene include oxidoreductase activity and alcohol dehydrogenase (NAD) activity. An important paralog of this gene is ADH1B.

Gene Wiki entry for ADH1C Gene

PharmGKB "VIP" Summary for ADH1C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for ADH1C Gene

Genomics for ADH1C Gene

Regulatory Elements for ADH1C Gene

Enhancers for ADH1C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G099382 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -31.1 -31050 3.1 FOXA2 MAX RAD21 RARA YY1 HNF4G NFE2 MAFK NFE2L2 GATAD2A ADH1C ADH1A MTTP ADH5 LOC102723576
GH04G099381 0.5 FANTOM5 27.4 -28.1 -28102 0.2 YY1 ADH1A ADH4 ADH1C ADH1B ADH6 LOC100507053 LOC102723576
GH04G099394 1.1 Ensembl ENCODE dbSUPER 11.6 -42.5 -42464 1.9 ZNF316 MAFG HNF4A NFE2 EMSY MAFK NFE2L2 YY1 ADH1C LOC100507053 ADH1A RNU7-149P MTTP LOC102723576
GH04G099389 0.8 ENCODE dbSUPER 11.4 -37.3 -37346 1.7 CTCF FOXA2 CREB1 RAD21 ADH1C LOC100507053 ADH1A ADH5 LOC102723576
GH04G099321 1 Ensembl ENCODE 8.8 +29.3 29318 4.2 FOXA2 TAF1 FOXA3 MAX RAD21 NR2F2 GABPA YY1 FOXA1 JUND ADH1A LOC100507053 ADH1C ENSG00000272777 PIR40463 ADH1B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADH1C on UCSC Golden Path with GeneCards custom track

Genomic Location for ADH1C Gene

Chromosome:
4
Start:
99,336,492 bp from pter
End:
99,353,045 bp from pter
Size:
16,554 bases
Orientation:
Minus strand

Genomic View for ADH1C Gene

Genes around ADH1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADH1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADH1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADH1C Gene

Proteins for ADH1C Gene

  • Protein details for ADH1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00326-ADH1G_HUMAN
    Recommended name:
    Alcohol dehydrogenase 1C
    Protein Accession:
    P00326
    Secondary Accessions:
    • Q4PJ18
    • Q5WRV0
    • Q6LBW4
    • Q6NWV0
    • Q6NZA7

    Protein attributes for ADH1C Gene

    Size:
    375 amino acids
    Molecular mass:
    39868 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Dimer of identical or non-identical chains of three types; alpha, beta and gamma.
    Miscellaneous:
    • There are 7 different ADHs isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

    Three dimensional structures from OCA and Proteopedia for ADH1C Gene

neXtProt entry for ADH1C Gene

Selected DME Specific Peptides for ADH1C Gene

P00326:
  • CLIGCGF
  • EVAPPKA
  • FSQYTVV
  • KINEGFDLL
  • ESVGEGVT
  • VPKLVAD
  • ILGHEAAG
  • LLRSGKSIRT
  • EEVEVAPP
  • PQCGKCR
  • SVIVGVPP
  • EVRIKMV
  • GRTWKGA
  • GHEAAGIVES
  • NKDKFAKAK
  • CAVFGLGGVGLS
  • CINPQDY
  • GKVIKCKAA
  • DFMAKKF
  • PVILGHE
  • GCGFSTGYG
  • AKVTPGS
  • CKNPESN
  • KPIQEVL
  • EMTDGGV
  • VMGCKAAGA
  • PGDKVIPLF
  • DINKDKF
  • GATECINP
  • TAGKVIKC
  • PLEKVCL
  • GIVESVG

Post-translational modifications for ADH1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADH1C Gene

Domains & Families for ADH1C Gene

Gene Families for ADH1C Gene

Suggested Antigen Peptide Sequences for ADH1C Gene

Graphical View of Domain Structure for InterPro Entry

P00326

UniProtKB/Swiss-Prot:

ADH1G_HUMAN :
  • Belongs to the zinc-containing alcohol dehydrogenase family.
Family:
  • Belongs to the zinc-containing alcohol dehydrogenase family.
genes like me logo Genes that share domains with ADH1C: view

Function for ADH1C Gene

Molecular function for ADH1C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An alcohol + NAD(+) = an aldehyde or ketone + NADH.

Enzyme Numbers (IUBMB) for ADH1C Gene

Gene Ontology (GO) - Molecular Function for ADH1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004022 alcohol dehydrogenase (NAD) activity IDA 6391957
GO:0004024 alcohol dehydrogenase activity, zinc-dependent EXP 9982
GO:0004745 retinol dehydrogenase activity TAS --
GO:0008270 zinc ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ADH1C: view
genes like me logo Genes that share phenotypes with ADH1C: view

Animal Models for ADH1C Gene

MGI Knock Outs for ADH1C:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADH1C Gene

Localization for ADH1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADH1C Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for ADH1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ADH1C: view

No data available for Subcellular locations from COMPARTMENTS for ADH1C Gene

Pathways & Interactions for ADH1C Gene

genes like me logo Genes that share pathways with ADH1C: view

Interacting Proteins for ADH1C Gene

Gene Ontology (GO) - Biological Process for ADH1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006069 ethanol oxidation TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ADH1C: view

No data available for SIGNOR curated interactions for ADH1C Gene

Drugs & Compounds for ADH1C Gene

(30) Drugs for ADH1C Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fomepizole Approved, Vet_approved Pharma inhibitor, Target 3
Ethanol Approved Pharma Enzyme 2137
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Vitamin A Approved, Vet_approved Nutra 492
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2770

(20) Additional Compounds for ADH1C Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Piperidinecarboxaldehyde
  • 1-Formyl-Piperidine
  • 1-Formylpiperidine
  • 1-Piperidinecarbaldehyde
  • Formylpiperidine
  • FPI
2591-86-8
2,2,2-Trichloroethanol
  • (Hydroxymethyl)trichloromethane
  • 2, 2,2-Trichloroethanol
  • 2,2,2-Trichloro-1-ethanol
  • 2,2,2-Trichloro-Ethanol
  • 2,2,2-Trichloroethanol
115-20-8
2-Phenyl-1,3-propanediol monocarbamate
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
13023-73-9
3,4-Dihydroxyphenylglycol
  • (3,4-Dihydroxyphenyl)ethylene glycol
  • 1-(3,4-Dihydroxyphenyl)-1,2-ethanediol
  • 3,4-Dihydroxyphenethyl glycol
  • 3,4-Dihydroxyphenylethyl glycol
  • 3,4-Dihydroxyphenylethyleneglycol
28822-73-3
genes like me logo Genes that share compounds with ADH1C: view

Transcripts for ADH1C Gene

Unigene Clusters for ADH1C Gene

Alcohol dehydrogenase 1C (class I), gamma polypeptide:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADH1C Gene

No ASD Table

Relevant External Links for ADH1C Gene

GeneLoc Exon Structure for
ADH1C
ECgene alternative splicing isoforms for
ADH1C

Expression for ADH1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADH1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADH1C Gene

This gene is overexpressed in Liver (x21.9), Colon - Transverse (x10.0), and Stomach (x5.4).

Protein differential expression in normal tissues from HIPED for ADH1C Gene

This gene is overexpressed in Liver, secretome (18.6), Gallbladder (9.5), Liver (8.5), and Stomach (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADH1C Gene



Protein tissue co-expression partners for ADH1C Gene

NURSA nuclear receptor signaling pathways regulating expression of ADH1C Gene:

ADH1C

SOURCE GeneReport for Unigene cluster for ADH1C Gene:

Hs.654537
genes like me logo Genes that share expression patterns with ADH1C: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADH1C Gene

Orthologs for ADH1C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADH1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADH1C 34
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 86 (a)
OneToMany
LOC100856533 34
  • 85.96 (n)
cow
(Bos Taurus)
Mammalia ADH1C 34
  • 85.51 (n)
-- 35
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Adh1 34 16 35
  • 82.22 (n)
rat
(Rattus norvegicus)
Mammalia Adh1 34
  • 81.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 71 (a)
OneToMany
ADH1C 34
  • 70.4 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 74 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adh1c 34
  • 66.31 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:63568 35
  • 56 (a)
ManyToMany
zgc:77938 35
  • 56 (a)
ManyToMany
adh8a 35
  • 54 (a)
ManyToMany
adh8b 35
  • 51 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Fdh 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H24K24.3 35
  • 50 (a)
ManyToMany
Y50D4C.2 35
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFA1 35
  • 45 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.12591 34
corn
(Zea mays)
Liliopsida Zm.2859 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1497 35
  • 54 (a)
OneToMany
Species where no ortholog for ADH1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADH1C Gene

ENSEMBL:
Gene Tree for ADH1C (if available)
TreeFam:
Gene Tree for ADH1C (if available)

Paralogs for ADH1C Gene

Paralogs for ADH1C Gene

(6) SIMAP similar genes for ADH1C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADH1C: view

Variants for ADH1C Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADH1C Gene

ADH1G_HUMAN-P00326
Two main alleles are known, ADH3*1 or gamma-1 has Arg-272/Ile-350 while ADH3*2 or gamma-2 has Gln-272/Val-350. ADH3*1 is associated with a fast rate of ethanol oxidation and ADH3*2 with a slow rate.

Sequence variations from dbSNP and Humsavar for ADH1C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1693482 other 99,342,808(+) CAAGC(C/T)GACCG intron-variant, reference, missense
rs283413 other 99,347,033(-) GTGTT(G/T)GAGAA nc-transcript-variant, reference, stop-gained
rs698 other 99,339,632(-) CAAAT(A/G/T)TTTTA nc-transcript-variant, reference, missense
rs1000177059 -- 99,354,773(+) TTCCT(C/T)CAGGG upstream-variant-2KB
rs1000410422 -- 99,350,389(+) CTGTA(A/T)CCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADH1C Gene

Variant ID Type Subtype PubMed ID
dgv5345n100 CNV gain 25217958
esv2659036 CNV deletion 23128226
nsv1002809 CNV gain 25217958
nsv293592 CNV deletion 16902084
nsv528518 CNV loss 19592680
nsv966301 CNV duplication 23825009
nsv980234 CNV duplication 23825009

Relevant External Links for ADH1C Gene

Human Gene Mutation Database (HGMD)
ADH1C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADH1C

No data available for Variation tolerance for ADH1C Gene

Disorders for ADH1C Gene

MalaCards: The human disease database

(11) MalaCards diseases for ADH1C Gene - From: OMIM, ClinVar, GeneTests, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ADH1C in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADH1C

Genetic Association Database (GAD)
ADH1C
Human Genome Epidemiology (HuGE) Navigator
ADH1C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADH1C
genes like me logo Genes that share disorders with ADH1C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADH1C Gene

Publications for ADH1C Gene

  1. CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk. (PMID: 19812523) Mohelnikova-Duchonova B. … Soucek P. (Pancreas 2010) 3 22 46 64
  2. Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men. (PMID: 20401433) Cichoz-Lach H. … Lis E. (Braz. J. Med. Biol. Res. 2010) 3 22 46 64
  3. Alcohol and colorectal cancer: the role of alcohol dehydrogenase 1C polymorphism. (PMID: 19120062) Homann N. … Seitz H.K. (Alcohol. Clin. Exp. Res. 2009) 3 22 46 64
  4. Genetic variation of alcohol dehydrogenase type 1C (ADH1C), alcohol consumption, and metabolic cardiovascular risk factors: results from the IMMIDIET study. (PMID: 19447389) Latella M.C. … Iacoviello L. (Atherosclerosis 2009) 3 22 46 64
  5. Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PMID: 19618839) Nishimura F.T. … Saijoh K. (Nihon Arukoru Yakubutsu Igakkai Zasshi 2009) 3 25 46 64

Products for ADH1C Gene

Sources for ADH1C Gene

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