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Aliases for ZZZ3 Gene

Aliases for ZZZ3 Gene

  • Zinc Finger, ZZ-Type Containing 3 2 3
  • ZZ-Type Zinc Finger-Containing Protein 3 3
  • ATAC Component 1 Homolog (Drosophila) 2
  • Zinc Finger, ZZ Domain Containing 3 3
  • ATAC Component 1 Homolog 3
  • ATAC1 3

External Ids for ZZZ3 Gene

Summaries for ZZZ3 Gene

GeneCards Summary for ZZZ3 Gene

ZZZ3 (Zinc Finger, ZZ-Type Containing 3) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for ZZZ3 Gene

  • Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Wiki entry for ZZZ3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZZZ3 Gene

Genomics for ZZZ3 Gene

Genomic Location for ZZZ3 Gene

Start:
77,562,416 bp from pter
End:
77,683,431 bp from pter
Size:
121,016 bases
Orientation:
Minus strand

Genomic View for ZZZ3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZZZ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZZZ3 Gene

Regulatory Elements for ZZZ3 Gene

Proteins for ZZZ3 Gene

  • Protein details for ZZZ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYH5-ZZZ3_HUMAN
    Recommended name:
    ZZ-type zinc finger-containing protein 3
    Protein Accession:
    Q8IYH5
    Secondary Accessions:
    • B7WPC6
    • Q6N004
    • Q6N070
    • Q8IYP0
    • Q8IYR1
    • Q8TEK4
    • Q9Y4U0

    Protein attributes for ZZZ3 Gene

    Size:
    903 amino acids
    Molecular mass:
    102023 Da
    Quaternary structure:
    • Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Three dimensional structures from OCA and Proteopedia for ZZZ3 Gene

    Alternative splice isoforms for ZZZ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZZZ3 Gene

Proteomics data for ZZZ3 Gene at MOPED

Post-translational modifications for ZZZ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZZZ3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZZZ3 Gene

Domains for ZZZ3 Gene

Gene Families for ZZZ3 Gene

HGNC:
  • ZZZ :Zinc fingers, ZZ-type

Protein Domains for ZZZ3 Gene

UniProtKB/Swiss-Prot:

ZZZ3_HUMAN
Domain:
  • Contains 1 HTH myb-type DNA-binding domain.:
    • Q8IYH5
Similarity:
  • Contains 1 ZZ-type zinc finger.:
    • Q8IYH5
genes like me logo Genes that share domains with ZZZ3: view

Function for ZZZ3 Gene

Molecular function for ZZZ3 Gene

UniProtKB/Swiss-Prot Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Ontology (GO) - Molecular Function for ZZZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 20562830
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZZZ3: view

Phenotypes for ZZZ3 Gene

MGI mutant phenotypes for ZZZ3:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZZZ3:
genes like me logo Genes that share phenotypes with ZZZ3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZZZ3 Gene

Localization for ZZZ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZZZ3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZZZ3 Gene COMPARTMENTS Subcellular localization image for ZZZ3 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZZZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA --
GO:0005730 nucleolus IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZZZ3: view

Pathways for ZZZ3 Gene

genes like me logo Genes that share pathways with ZZZ3: view

Pathways by source for ZZZ3 Gene

Gene Ontology (GO) - Biological Process for ZZZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZZZ3: view

Transcripts for ZZZ3 Gene

Unigene Clusters for ZZZ3 Gene

Zinc finger, ZZ-type containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZZZ3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1: - - -
SP2: - - - - - - - - - - - - - - -
SP3: - -
SP4: - -
SP5:
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - -
SP11: - - - - - - -
SP12:
SP13: -
SP14: - - - -

ExUns: 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ZZZ3 Gene

GeneLoc Exon Structure for
ZZZ3
ECgene alternative splicing isoforms for
ZZZ3

Expression for ZZZ3 Gene

mRNA expression in normal human tissues for ZZZ3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZZZ3 Gene

SOURCE GeneReport for Unigene cluster for ZZZ3 Gene Hs.480506

genes like me logo Genes that share expressions with ZZZ3: view

Orthologs for ZZZ3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZZZ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZZZ3 36
  • 99.82 (n)
  • 99.67 (a)
ZZZ3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZZZ3 36
  • 94.75 (n)
  • 94.01 (a)
ZZZ3 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZZZ3 36
  • 95.35 (n)
  • 95.68 (a)
ZZZ3 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zzz3 36
  • 88 (n)
  • 87.38 (a)
Zzz3 16
Zzz3 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 66 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
-- 37
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZZZ3 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zzz3 36
  • 88.84 (n)
  • 88.47 (a)
chicken
(Gallus gallus)
Aves ZZZ3 36
  • 81.61 (n)
  • 81.42 (a)
ZZZ3 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZZZ3 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3772 36
zzz3 36
  • 66.14 (n)
  • 59.43 (a)
zebrafish
(Danio rerio)
Actinopterygii zzz3 36
  • 59.99 (n)
  • 57.18 (a)
zzz3 37
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Atac1 36
  • 48.9 (n)
  • 46.7 (a)
Atac1 37
  • 35 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.536 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToOne
Species with no ortholog for ZZZ3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZZZ3 Gene

ENSEMBL:
Gene Tree for ZZZ3 (if available)
TreeFam:
Gene Tree for ZZZ3 (if available)

Paralogs for ZZZ3 Gene

No data available for Paralogs for ZZZ3 Gene

Variants for ZZZ3 Gene

Sequence variations from dbSNP and Humsavar for ZZZ3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13806 -- 77,562,461(+) TTTAT(G/T)ATTGA downstream-variant-500B
rs166770 -- 77,645,468(-) ctccc(C/T)ggaga intron-variant
rs203229 -- 77,684,256(+) AGGAA(A/G)ATAAA upstream-variant-2KB
rs278834 -- 77,653,622(-) gcatg(C/T)gccac intron-variant
rs278835 -- 77,653,328(-) atcac(C/T)ctaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZZZ3 Gene

Variant ID Type Subtype PubMed ID
nsv470719 CNV Gain 18288195
nsv871143 CNV Gain 21882294
nsv1533 CNV Loss 18451855
nsv870709 CNV Loss 21882294
nsv830303 CNV Loss 17160897

Relevant External Links for ZZZ3 Gene

HapMap Linkage Disequilibrium report
ZZZ3

Disorders for ZZZ3 Gene

No disorders were found for ZZZ3 Gene.

No data available for UniProtKB/Swiss-Prot for ZZZ3 Gene

Publications for ZZZ3 Gene

  1. NF-Y affects histone acetylation and H2A.Z deposition in cell cycle promoters. (PMID: 21304275) Gatta R. … Mantovani R. (Epigenetics 2011) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila. (PMID: 16428443) Guelman S. … Workman J.L. (Mol. Cell. Biol. 2006) 2 3
  4. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. (PMID: 18838386) Wang Y.L. … Martinez E. (J. Biol. Chem. 2008) 3
  5. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. (PMID: 19505873) Ku W.C. … Chen Y.J. (Mol. Cell Proteomics 2009) 3

Products for ZZZ3 Gene

Sources for ZZZ3 Gene

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