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Aliases for ZZEF1 Gene

Aliases for ZZEF1 Gene

  • Zinc Finger, ZZ-Type With EF-Hand Domain 1 2 3
  • Zinc Finger, ZZ-Type With EF Hand Domain 1 2 3
  • Zinc Finger ZZ-Type And EF-Hand Domain-Containing Protein 1 3
  • KIAA0399 4
  • ZZZ4 3

External Ids for ZZEF1 Gene

Previous GeneCards Identifiers for ZZEF1 Gene

  • GC17M004115
  • GC17M003854

Summaries for ZZEF1 Gene

GeneCards Summary for ZZEF1 Gene

ZZEF1 (Zinc Finger, ZZ-Type With EF-Hand Domain 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CUL7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZZEF1 Gene

Genomics for ZZEF1 Gene

Regulatory Elements for ZZEF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZZEF1 Gene

Start:
4,004,445 bp from pter
End:
4,143,020 bp from pter
Size:
138,576 bases
Orientation:
Minus strand

Genomic View for ZZEF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZZEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZZEF1 Gene

Proteins for ZZEF1 Gene

  • Protein details for ZZEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43149-ZZEF1_HUMAN
    Recommended name:
    Zinc finger ZZ-type and EF-hand domain-containing protein 1
    Protein Accession:
    O43149
    Secondary Accessions:
    • A7MBM5
    • Q6NXG0
    • Q6ZRA1
    • Q6ZSF4
    • Q9NVB9

    Protein attributes for ZZEF1 Gene

    Size:
    2961 amino acids
    Molecular mass:
    331075 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA23695.4; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91834.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZZEF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZZEF1 Gene

Proteomics data for ZZEF1 Gene at MOPED

Post-translational modifications for ZZEF1 Gene

  • Ubiquitination at Lys2501
  • Modification sites at PhosphoSitePlus

Other Protein References for ZZEF1 Gene

No data available for DME Specific Peptides for ZZEF1 Gene

Domains for ZZEF1 Gene

Gene Families for ZZEF1 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • ZZZ :Zinc fingers, ZZ-type

Protein Domains for ZZEF1 Gene

Suggested Antigen Peptide Sequences for ZZEF1 Gene

Graphical View of Domain Structure for InterPro Entry

O43149

UniProtKB/Swiss-Prot:

ZZEF1_HUMAN :
  • O43149
Domain:
  • Contains 1 DOC domain.
  • Contains 1 EF-hand domain.
Similarity:
  • Contains 2 ZZ-type zinc fingers.
genes like me logo Genes that share domains with ZZEF1: view

Function for ZZEF1 Gene

Gene Ontology (GO) - Molecular Function for ZZEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ZZEF1: view

Phenotypes for ZZEF1 Gene

GenomeRNAi human phenotypes for ZZEF1:
genes like me logo Genes that share phenotypes with ZZEF1: view

Animal Model Products

miRNA for ZZEF1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZZEF1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZZEF1 Gene

Localization for ZZEF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZZEF1 Gene COMPARTMENTS Subcellular localization image for ZZEF1 gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZZEF1 Gene

Pathways for ZZEF1 Gene

SuperPathways for ZZEF1 Gene

No Data Available

Interacting Proteins for ZZEF1 Gene

Gene Ontology (GO) - Biological Process for ZZEF1 Gene

None

No data available for Pathways by source for ZZEF1 Gene

Transcripts for ZZEF1 Gene

Unigene Clusters for ZZEF1 Gene

Zinc finger, ZZ-type with EF-hand domain 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZZEF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZZEF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:

ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b · 32c ^ 33 ^
SP1:
SP2: - - -
SP3:
SP4:
SP5: - -
SP6: - -
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14: -
SP15:

ExUns: 34 ^ 35 ^ 36
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ZZEF1 Gene

GeneLoc Exon Structure for
ZZEF1
ECgene alternative splicing isoforms for
ZZEF1

Expression for ZZEF1 Gene

mRNA expression in normal human tissues for ZZEF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZZEF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.7) and Synovial fluid (18.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZZEF1 Gene

SOURCE GeneReport for Unigene cluster for ZZEF1 Gene Hs.277624

mRNA Expression by UniProt/SwissProt for ZZEF1 Gene

O43149-ZZEF1_HUMAN
Tissue specificity: Expressed at low levels in cerebellum.
genes like me logo Genes that share expressions with ZZEF1: view

Expression partners for ZZEF1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ZZEF1 Gene

Orthologs for ZZEF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZZEF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZZEF1 35
  • 89.43 (n)
  • 91.86 (a)
ZZEF1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZZEF1 35
  • 86.5 (n)
  • 87.92 (a)
ZZEF1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zzef1 35
  • 88.17 (n)
  • 91.25 (a)
Zzef1 16
Zzef1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZZEF1 35
  • 99.55 (n)
  • 99.59 (a)
ZZEF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zzef1 35
  • 88.34 (n)
  • 91.24 (a)
oppossum
(Monodelphis domestica)
Mammalia ZZEF1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZZEF1 35
  • 73.41 (n)
  • 76.08 (a)
ZZEF1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZZEF1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zzef1 35
  • 66.11 (n)
  • 65.72 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21226 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14071 35
zzef1 35
  • 63.11 (n)
  • 61.29 (a)
zzef1 36
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for ZZEF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZZEF1 Gene

ENSEMBL:
Gene Tree for ZZEF1 (if available)
TreeFam:
Gene Tree for ZZEF1 (if available)

Paralogs for ZZEF1 Gene

Paralogs for ZZEF1 Gene

genes like me logo Genes that share paralogs with ZZEF1: view

Variants for ZZEF1 Gene

Sequence variations from dbSNP and Humsavar for ZZEF1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3765 -- 4,023,477(-) ACATC(A/G)TAGTA intron-variant
rs711175 -- 4,033,386(-) tggac(A/G)acaga intron-variant
rs711176 -- 4,033,223(-) AGATA(C/T)TTTTG intron-variant
rs711177 - 4,022,816(+) CTCCT(C/G)AAAAC missense, reference, nc-transcript-variant
rs711178 -- 4,019,624(+) CACAT(A/G)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZZEF1 Gene

Variant ID Type Subtype PubMed ID
dgv3044n71 CNV Loss 21882294
dgv3045n71 CNV Loss 21882294
nsv1950 CNV Insertion 18451855
nsv833344 CNV Gain 17160897
esv268614 CNV Insertion 20981092
esv274362 CNV Insertion 20981092
nsv907586 CNV Gain 21882294
nsv907587 CNV Gain 21882294
esv25456 CNV Loss 19812545
nsv827861 CNV Gain 20364138
esv2715546 CNV Deletion 23290073
esv2391084 CNV Deletion 18987734
esv2715547 CNV Deletion 23290073
esv1422120 CNV Deletion 17803354
esv1786350 CNV Deletion 17803354
nsv457647 CNV Gain 19166990
esv2751682 CNV Gain 17911159
nsv827862 CNV Loss 20364138
esv2660488 CNV Deletion 23128226
esv1086827 CNV Insertion 17803354
esv2656666 CNV Deletion 23128226
esv2715548 CNV Deletion 23290073
esv989391 CNV Deletion 20482838
esv2676873 CNV Deletion 23128226
esv28297 CNV Gain 19812545

Relevant External Links for ZZEF1 Gene

HapMap Linkage Disequilibrium report
ZZEF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZZEF1 Gene

Disorders for ZZEF1 Gene

Relevant External Links for ZZEF1

Genetic Association Database (GAD)
ZZEF1
Human Genome Epidemiology (HuGE) Navigator
ZZEF1

No disorders were found for ZZEF1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZZEF1 Gene

Publications for ZZEF1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for ZZEF1 Gene

Sources for ZZEF1 Gene

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