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ZZEF1 Gene

protein-coding   GIFtS: 51
GCID: GC17M003854

Zinc Finger, ZZ-Type With EF-Hand Domain 1

(Previous names: zinc finger, ZZ-type with EF hand domain 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger, ZZ-Type With EF-Hand Domain 11 2
Zinc Finger, ZZ-Type With EF Hand Domain 11 2
ZZZ42
Zinc Finger ZZ-Type And EF-Hand Domain-Containing Protein 12
KIAA03993

External Ids:    HGNC: 290271   Entrez Gene: 231402   Ensembl: ENSG000000747557   UniProtKB: O431493   

Export aliases for ZZEF1 gene to outside databases

Previous GC identifer: GC17M004115


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZZEF1 Gene:
ZZEF1 (zinc finger, ZZ-type with EF-hand domain 1) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CUL7.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZZEF1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Pbx1a   NRSF form 1   NRSF form 2   POU2F2   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZZEF1 promoter sequence
   Search Chromatin IP Primers for ZZEF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZZEF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

ZZEF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZZEF1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003854:  view genomic region     (about GC identifiers)

Start:
3,907,739 bp from pter      End:
4,046,314 bp from pter
Size:
138,576 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZZEF1_HUMAN, O43149 (See protein sequence)
Recommended Name: Zinc finger ZZ-type and EF-hand domain-containing protein 1  
Size: 2961 amino acids; 331075 Da
Sequence caution: Sequence=BAA23695.4; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA91834.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A7MBM5 Q6NXG0 Q6ZRA1 Q6ZSF4 Q9NVB9
Alternative splicing: 3 isoforms:  O43149-1   O43149-2   O43149-3   (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZZEF1: NX_O43149

Explore proteomics data for ZZEF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys2501
  • Modification sites at PhosphoSitePlus

  • See ZZEF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055928.3  
    ENSEMBL proteins: 
     ENSP00000371051   ENSP00000459796   ENSP00000459023   ENSP00000458554   ENSP00000460633  

    ZZEF1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ZZEF1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing
    ZZZ: Zinc fingers, ZZ-type

    Selected InterPro protein domains (see all 6):
     IPR004939 APC_su10/DOC_dom
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR008979 Galactose-bd-like
     IPR000859 CUB_dom

    Graphical View of Domain Structure for InterPro Entry O43149

    ProtoNet protein and cluster: O43149

    1 Blocks protein domain: IPB000433 Zn-finger

    UniProtKB/Swiss-Prot: ZZEF1_HUMAN, O43149
    Similarity: Contains 1 DOC domain
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 2 ZZ-type zinc fingers


    Find genes that share domains with ZZEF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ZZEF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZZEF1:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Zzef1 (no phenotypes)

    Find genes that share phenotypes with ZZEF1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Zzef1tm2(KOMP)Vlcg for ZZEF1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZZEF1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZZEF1

    miRNA
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    miRTarBase miRNAs that target ZZEF1:
    hsa-mir-16-5p (MIRT051207), hsa-mir-615-3p (MIRT040251), hsa-mir-484 (MIRT042030), hsa-mir-125a-5p (MIRT045740)

    Block miRNA regulation of human, mouse, rat ZZEF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZZEF1 (see all 37):
    hsa-miR-330-5p hsa-let-7a-2* hsa-miR-346 hsa-miR-632 hsa-miR-570 hsa-miR-4267 hsa-miR-326 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidZZEF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZZEF1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ZZEF1 (NM_015113)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZZEF1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZZEF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    extracellular2
    mitochondrion2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZZEF1
    Interactions:

        Search GeneGlobe Interaction Network for ZZEF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for ZZEF1 (O431492, 3 ENSP000003710514) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61675 I2D: score=3 
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    PTPN4P290743, ENSP000002637084I2D: score=4 STRING: ENSP00000263708
    HSPB3Q129883I2D: score=4 
    PHYHIPQ925613I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZZEF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZZEF1 gene: 
    NM_015113.3  

    Unigene Cluster for ZZEF1:

    Zinc finger, ZZ-type with EF-hand domain 1
    Hs.277624  [show with all ESTs]
    Unigene Representative Sequence: NM_015113
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381638(uc002fxe.3 uc002fxi.3) ENST00000573536(uc002fxg.1)
    ENST00000572831 ENST00000575428 ENST00000571436 ENST00000573183(uc002fxh.3)
    ENST00000573606 ENST00000572426(uc002fxj.1) ENST00000570365 ENST00000572699
    ENST00000574474(uc002fxk.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ZZEF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZZEF1 (see all 37):
    hsa-miR-330-5p hsa-let-7a-2* hsa-miR-346 hsa-miR-632 hsa-miR-570 hsa-miR-4267 hsa-miR-326 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidZZEF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZZEF1
    Predesigned siRNA for gene silencing in human, mouse, rat ZZEF1
    Clone
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    OriGene clones in human, mouse for ZZEF1 (see all 5)
    OriGene ORF clones in mouse, rat for ZZEF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZZEF1 (NM_015113)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZZEF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZZEF1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ZZEF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZZEF1
      QuantiTect SYBR Green Assays in human, mouse, rat ZZEF1
      QuantiFast Probe-based Assays in human, mouse, rat ZZEF1

    Additional mRNA sequence: 

    AB007859.4 AK001683.1 AK122719.1 AK124719.1 AK127482.1 AK128386.1 AL831960.1 BC035319.1 
    BC047285.1 BC067099.1 BC151836.1 U33270.1 

    12 DOTS entries:

    DT.75146263  DT.216417  DT.92012537  DT.101979432  DT.100717107  DT.95326300  DT.100773638  DT.92015246 
    DT.100773636  DT.120998535  DT.120998565  DT.91689250 

    Selected AceView cDNA sequences (see all 262):

    AI265928 CA435841 BF194889 BX509332 AI742735 AI205543 CB046746 BX094971 
    CB055268 BF732623 BE551094 BF055468 AI167137 CA944775 AA806452 AB007859 
    CA946290 CF619273 AI537136 T08478 CA396909 CN479962 AA970385 BF109295 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZZEF1 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                            -                 -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b · 32c ^ 33 ^
    SP1:                                                                                                                                                            
    SP2:              -     -                                   -                                                                                                   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                        -           -                                                                                       

    ExUns: 34 ^ 35 ^ 36
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ZZEF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZZEF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZZEF1 Expression
    About this image


    ZZEF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ZZEF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZZEF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.277624

    UniProtKB/Swiss-Prot: ZZEF1_HUMAN, O43149
    Tissue specificity: Expressed at low levels in cerebellum

        Custom PCR Arrays for ZZEF1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZZEF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZZEF1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zzef11 , 5 zinc finger, ZZ-type with EF hand domain 11, 5 88.17(n)1
    91.25(a)1
      11 (44.56 cM)5
    1950181  NM_001045536.21  NP_001039001.11 
     727962265 
    chicken
    (Gallus gallus)
    Aves ZZEF11 zinc finger, ZZ-type with EF-hand domain 1 73.41(n)
    76.08(a)
      417496  XM_415744.4  XP_415744.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZZEF16
    zinc finger, ZZ-type with EF-hand domain 1
    66(a)
    1 ↔ 1
    GL344155.1(8718-60087)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.212262 Xenopus laevis transcribed sequence 74.28(n)    BU908470.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.140712 Transcribed sequence with weak similarity to protein more 74.93(n)    57087701 


    ENSEMBL Gene Tree for ZZEF1 (if available)
    TreeFam Gene Tree for ZZEF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZZEF1 gene
    CUL72  CUL92  

    Find genes that share paralogs with ZZEF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZZEF1 (see all 3688)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80754291,2
    C,F,H--3907308(+) GTCCAG/AAGGCC 1 -- ds500119Minor allele frequency- A:0.47NS EA WA NA CSA 2338
    rs1131722211,2
    F--3907380(+) CCTCCG/AGGTTC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1509410301,2
    C--3907502(+) GCCGCA/CGGGGG 1 -- ds50010--------
    rs723043571,2
    C--3907557(+) GGCTT-/GGGCTC 1 -- ds50010--------
    rs1407002241,2
    C--3907847(+) ATCAAA/GATTCT 1 -- ut310--------
    rs1501266021,2
    --3907992(+) TTTACA/GGCGTA 1 -- ut310--------
    rs2020447371,2
    C--3908087(+) GCTCGA/GCAGCG 1 -- ut310--------
    rs1132022561,2
    C,F--3908143(+) GCAGCT/CGCGGG 1 -- ut311Minor allele frequency- C:0.00CSA 1
    rs1831576871,2
    --3908156(+) CGAGCA/GGACTC 1 -- ut310--------
    rs1414599171,2
    C--3908337(+) TACTC-/GGGAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZZEF1 (3907739 - 4046314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZZEF1 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1786350CNV Deletion17803354
    esv2715547CNV Deletion23290073
    esv2660488CNV Deletion23128226
    esv2391084CNV Deletion18987734
    esv989391CNV Deletion20482838
    esv2715546CNV Deletion23290073
    esv1422120CNV Deletion17803354
    esv2676873CNV Deletion23128226
    esv2656666CNV Deletion23128226
    esv2715548CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZZEF1           About GenesLikeMe

    Genetic Association Database (GAD): ZZEF1
    Human Genome Epidemiology (HuGE) Navigator: ZZEF1 (1 document)

    Export disorders for ZZEF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZZEF1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with ZZEF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Genetic predictors of risk and resilience in psychiatric disorders: A cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. (PubMed id 24039173)1 McGrath L.M....Smoller J.W. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23140 HGNC: 29027 AceView: ZZEF1 Ensembl:ENSG00000074755 euGenes: HUgn23140
    ECgene: ZZEF1 H-InvDB: ZZEF1

    (According to HUGE)
    About This Section

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    HUGE: KIAA0399

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZZEF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ZZEF1 gene:
    Search GeneIP for patents involving ZZEF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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