Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZZEF1 Gene

protein-coding   GIFtS: 49
GCID: GC17M003854

Zinc Finger, ZZ-Type With EF-Hand Domain 1

(Previous names: zinc finger, ZZ-type with EF hand domain 1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger, ZZ-Type With EF-Hand Domain 11 2
Zinc Finger, ZZ-Type With EF Hand Domain 11 2
ZZZ42
Zinc Finger ZZ-Type And EF-Hand Domain-Containing Protein 12
KIAA03993

External Ids:    HGNC: 290271   Entrez Gene: 231402   Ensembl: ENSG000000747557   UniProtKB: O431493   

Export aliases for ZZEF1 gene to outside databases

Previous GC identifer: GC17M004115


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZZEF1 Gene: 
ZZEF1 (zinc finger, ZZ-type with EF-hand domain 1) is a protein-coding gene. Diseases associated with ZZEF1 include medulloblastoma. GO annotations related to this gene include zinc ion binding and calcium ion binding. An important paralog of this gene is CUL7.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZZEF1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Pbx1a   NRSF form 1   NRSF form 2   POU2F2   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZZEF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZZEF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZZEF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

ZZEF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZZEF1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003854:  view genomic region     (about GC identifiers)

Start:
3,907,739 bp from pter      End:
4,046,314 bp from pter
Size:
138,576 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZZEF1_HUMAN, O43149 (See protein sequence)
Recommended Name: Zinc finger ZZ-type and EF-hand domain-containing protein 1  
Size: 2961 amino acids; 331075 Da
Sequence caution: Sequence=BAA23695.4; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA91834.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A7MBM5 Q6NXG0 Q6ZRA1 Q6ZSF4 Q9NVB9
Alternative splicing: 3 isoforms:  O43149-1   O43149-2   O43149-3   (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZZEF1: NX_O43149

Explore proteomics data for ZZEF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43149

  • ZZEF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZZEF1 Protein Expression
    REFSEQ proteins: NP_055928.3  
    ENSEMBL proteins: 
     ENSP00000371051   ENSP00000459796   ENSP00000459023   ENSP00000458554   ENSP00000460633  

    Human Recombinant Protein Products for ZZEF1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ZZEF1
    GenScript Custom Purified and Recombinant Proteins Services for ZZEF1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ZZEF1 


    ZZEF1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ZZEF1
    GenScript Custom Superior Antibodies Services for ZZEF1
    Novus Biologicals ZZEF1 Antibodies
    Abcam antibodies for ZZEF1
    Cloud-Clone Corp. Antibodies for ZZEF1 
    Search ThermoFisher Antibodies for ZZEF1
    Search LSBio for Antibodies for ZZEF1 

    Assay Products for ZZEF1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ZZEF1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ZZEF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ZZEF1 
    Cloud-Clone Corp. CLIAs for ZZEF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing
    ZZZ: Zinc fingers, ZZ-type

    5/6 InterPro protein domains (see all 6):
     IPR000859 CUB_dom
     IPR004939 APC_su10/DOC_dom
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR000433 Znf_ZZ

    Graphical View of Domain Structure for InterPro Entry O43149

    ProtoNet protein and cluster: O43149

    1 Blocks protein domain: IPB000433 Zn-finger

    UniProtKB/Swiss-Prot: ZZEF1_HUMAN, O43149
    Similarity: Contains 1 DOC domain
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 2 ZZ-type zinc fingers


    ZZEF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZZEF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZZEF1:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Zzef1 (no phenotypes)

    ZZEF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Zzef1tm2(KOMP)Vlcg for ZZEF1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZZEF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZZEF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZZEF1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZZEF1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZZEF1
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate ZZEF1 (see all 37):
    hsa-miR-330-5p hsa-let-7a-2* hsa-miR-346 hsa-miR-632 hsa-miR-570 hsa-miR-4267 hsa-miR-326 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidZZEF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZZEF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZZEF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ZZEF1


    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ZZEF1 (see all 5)
    OriGene ORF clones in mouse, rat for ZZEF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZZEF1 (NM_015113)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZZEF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZZEF1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ZZEF1
    Search LifeMap BioReagents cell lines for ZZEF1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZZEF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZZEF1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for ZZEF1 (O431492, 3 ENSP000003710514) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61675 I2D: score=3 
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    PTPN4P290743, ENSP000002637084I2D: score=4 STRING: ENSP00000263708
    HSPB3Q129883I2D: score=4 
    PHYHIPQ925613I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZZEF1

    Search CenterWatch for drugs/clinical trials and news about ZZEF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZZEF1 gene: 
    NM_015113.3  

    Unigene Cluster for ZZEF1:

    Zinc finger, ZZ-type with EF-hand domain 1
    Hs.277624  [show with all ESTs]
    Unigene Representative Sequence: NM_015113
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381638(uc002fxe.3 uc002fxi.3) ENST00000573536(uc002fxg.1)
    ENST00000572831 ENST00000575428 ENST00000571436 ENST00000573183(uc002fxh.3)
    ENST00000573606 ENST00000572426(uc002fxj.1) ENST00000570365 ENST00000572699
    ENST00000574474(uc002fxk.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZZEF1
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate ZZEF1 (see all 37):
    hsa-miR-330-5p hsa-let-7a-2* hsa-miR-346 hsa-miR-632 hsa-miR-570 hsa-miR-4267 hsa-miR-326 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidZZEF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZZEF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZZEF1
    Clone
    Products:
         
    OriGene clones in human, mouse for ZZEF1 (see all 5)
    OriGene ORF clones in mouse, rat for ZZEF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ZZEF1 (NM_015113)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZZEF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZZEF1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ZZEF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZZEF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZZEF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZZEF1

    Additional mRNA sequence: 

    AB007859.4 AK001683.1 AK122719.1 AK124719.1 AK127482.1 AK128386.1 AL831960.1 BC035319.1 
    BC047285.1 BC067099.1 BC151836.1 U33270.1 

    12 DOTS entries:

    DT.75146263  DT.216417  DT.92012537  DT.101979432  DT.100717107  DT.95326300  DT.100773638  DT.92015246 
    DT.100773636  DT.120998535  DT.120998565  DT.91689250 

    24/262 AceView cDNA sequences (see all 262):

    AK127482 AI356810 AI265928 CA435841 BF194889 BX509332 AI742735 AI205543 
    CB046746 BX094971 CB055268 BF732623 BE551094 BF055468 AI167137 CA944775 
    AI242417 BM673114 BU678230 AW466932 AI075330 AI371068 CB054888 AI160392 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for ZZEF1 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                            -                 -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b · 32c ^ 33 ^
    SP1:                                                                                                                                                            
    SP2:              -     -                                   -                                                                                                   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                        -           -                                                                                       

    ExUns: 34 ^ 35 ^ 36
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for ZZEF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZZEF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZZEF1 Expression
    About this image


    See ZZEF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZZEF1

    SOURCE GeneReport for Unigene cluster: Hs.277624

    UniProtKB/Swiss-Prot: ZZEF1_HUMAN, O43149
    Tissue specificity: Expressed at low levels in cerebellum

        SABiosciences Custom PCR Arrays for ZZEF1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ZZEF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZZEF1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZZEF1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZZEF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZZEF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZZEF1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zzef11 , 5 zinc finger, ZZ-type with EF hand domain 11, 5 88.17(n)1
    91.25(a)1
      11 (44.56 cM)5
    1950181  NM_001045536.21  NP_001039001.11 
     727962265 
    chicken
    (Gallus gallus)
    Aves ZZEF11 zinc finger, ZZ-type with EF-hand domain 1 73.1(n)
    75.48(a)
      417496  XM_415744.3  XP_415744.3 
    lizard
    (Anolis carolinensis)
    Reptilia ZZEF16
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL344155.1(8718-60087)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.212262 Xenopus laevis transcribed sequence 74.28(n)    BU908470.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.140712 Transcribed sequence with weak similarity to protein more 74.93(n)    57087701 


    ENSEMBL Gene Tree for ZZEF1 (if available)
    TreeFam Gene Tree for ZZEF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZZEF1 gene
    CUL72  CUL92  

    ZZEF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3688 SNPs in ZZEF1 are shown (see all 3688)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0325514
    ----see VAR_0325512 V A mis40--------
    rs80754291,2
    C,F,H--3907308(+) GTCCAG/AAGGCC 1 -- ds500119Minor allele frequency- A:0.47NS EA WA NA CSA 2338
    rs1131722211,2
    F--3907380(+) CCTCCG/AGGTTC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1509410301,2
    C--3907502(+) GCCGCA/CGGGGG 1 -- ds50010--------
    rs723043571,2
    C--3907557(+) GGCTT-/GGGCTC 1 -- ds50010--------
    rs1407002241,2
    C--3907847(+) ATCAAA/GATTCT 1 -- ut310--------
    rs1501266021,2
    --3907992(+) TTTACA/GGCGTA 1 -- ut310--------
    rs2020447371,2
    C--3908087(+) GCTCGA/GCAGCG 1 -- ut310--------
    rs1132022561,2
    C,F--3908143(+) GCAGCT/CGCGGG 1 -- ut311Minor allele frequency- C:0.00CSA 1
    rs1831576871,2
    --3908156(+) CGAGCA/GGACTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZZEF1 (3907739 - 4046314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for ZZEF1 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1786350CNV Deletion17803354
    esv2715547CNV Deletion23290073
    esv2660488CNV Deletion23128226
    esv2391084CNV Deletion18987734
    esv989391CNV Deletion20482838
    esv2715546CNV Deletion23290073
    esv1422120CNV Deletion17803354
    esv2676873CNV Deletion23128226
    esv2656666CNV Deletion23128226
    esv2715548CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ZZEF1
    DNA2.0 Custom Variant and Variant Library Synthesis for ZZEF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZZEF1:    About MalaCards
    medulloblastoma    


    ZZEF1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZZEF1
    Human Genome Epidemiology (HuGE) Navigator: ZZEF1 (1 document)

    Export disorders for ZZEF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZZEF1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ZZEF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23140 HGNC: 29027 AceView: ZZEF1 Ensembl:ENSG00000074755 euGenes: HUgn23140
    ECgene: ZZEF1 H-InvDB: ZZEF1

    (According to HUGE)
    About This Section
    HUGE: KIAA0399

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZZEF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZZEF1 gene:
    Search GeneIP for patents involving ZZEF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ZZEF1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ZZEF1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ZZEF1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ZZEF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ZZEF1   OriGene Custom Protein Services for ZZEF1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZZEF1
     QIAGEN SeqTarget long-range PCR primers for resequencing ZZEF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZZEF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZZEF1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZZEF1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZZEF1
     GenScript Custom Purified and Recombinant Proteins Services for ZZEF1 GenScript cDNA clones with any tag delivered in your preferred vector for ZZEF1
     GenScript Custom Assay Services for ZZEF1 GenScript Custom Superior Antibodies Services for ZZEF1
     GenScript Custom overexpressing Cell Line Services for ZZEF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ZZEF1 promoter
     Search Chromatin IP Primers for ZZEF1
     RT2 qPCR Primer Assay in human, mouse, rat ZZEF1
     Search GNC Networks for ZZEF1
     SABiosciences Custom PCR Arrays for ZZEF1
     Search Tocris compounds for ZZEF1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ZZEF1 antibodies
     Antibodies for ZZEF1
     See all of Abcam's Antibodies, Kits and Proteins for ZZEF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ZZEF1
     Antibodies for ZZEF1
     ELISAs for ZZEF1
     CLIAs for ZZEF1
     Search LifeMap BioReagents cell lines for ZZEF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZZEF1
     SwitchGear 3'UTR luciferase reporter plasmids for ZZEF1
     SwitchGear Promoter luciferase reporter plasmids for ZZEF1
     Search ThermoFisher Antibodies for ZZEF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZZEF1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ZZEF1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ZZEF1
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression
     Search LSBio for Antibodies for ZZEF1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ZZEF1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4