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Aliases for ZZEF1 Gene

Aliases for ZZEF1 Gene

  • Zinc Finger ZZ-Type And EF-Hand Domain Containing 1 2 3 5
  • Zinc Finger, ZZ-Type With EF Hand Domain 1 2 3
  • Zinc Finger ZZ-Type And EF-Hand Domain-Containing Protein 1 3
  • KIAA0399 4
  • ZZZ4 3

External Ids for ZZEF1 Gene

Previous GeneCards Identifiers for ZZEF1 Gene

  • GC17M004115
  • GC17M003854

Summaries for ZZEF1 Gene

GeneCards Summary for ZZEF1 Gene

ZZEF1 (Zinc Finger ZZ-Type And EF-Hand Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CUL9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZZEF1 Gene

Genomics for ZZEF1 Gene

Regulatory Elements for ZZEF1 Gene

Enhancers for ZZEF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F004167 0.2 ENCODE 21.9 -25.0 -24983 0.8 ZZEF1 CYB5D2 ANKFY1 PIR53225 PIR41558
GH17F004203 1.2 FANTOM5 ENCODE 21.2 -61.9 -61939 2.2 JUND BHLHE40 SIN3A PRDM10 FOS MAFK ZZEF1 CYB5D2 ANKFY1 LOC100420060 RYKP1
GH17F004194 1 Ensembl ENCODE 21 -52.7 -52728 1.7 ZNF316 EMSY MAFK ZZEF1 CYB5D2 ANKFY1 GGT6 GC17P004192 LOC100420060
GH17F004099 1 Ensembl ENCODE 20.1 +41.7 41691 2.7 HDGF ATF1 ARNT MLX ARID4B ZNF2 ZNF48 ZNF766 GATA2 ZNF143 CYB5D2 ZZEF1 ATP2A3 GC17P004083
GH17F004090 0.4 ENCODE 18.6 +51.9 51923 0.9 JUNB ZZEF1 CYB5D2 CAMKK1 GC17P004083
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZZEF1 on UCSC Golden Path with GeneCards custom track

Promoters for ZZEF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001339431 -180 3201 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for ZZEF1 Gene

4,004,445 bp from pter
4,143,020 bp from pter
138,576 bases
Minus strand

Genomic View for ZZEF1 Gene

Genes around ZZEF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZZEF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZZEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZZEF1 Gene

Proteins for ZZEF1 Gene

  • Protein details for ZZEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger ZZ-type and EF-hand domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A7MBM5
    • Q6NXG0
    • Q6ZRA1
    • Q6ZSF4
    • Q9NVB9

    Protein attributes for ZZEF1 Gene

    2961 amino acids
    Molecular mass:
    331075 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA23695.4; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91834.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZZEF1 Gene


neXtProt entry for ZZEF1 Gene

Post-translational modifications for ZZEF1 Gene

  • Ubiquitination at Lys 2501
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZZEF1 Gene

Domains & Families for ZZEF1 Gene

Gene Families for ZZEF1 Gene

Suggested Antigen Peptide Sequences for ZZEF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DOC domain.
  • Contains 2 ZZ-type zinc fingers.
  • Contains 1 DOC domain.
  • Contains 1 EF-hand domain.
  • Contains 2 ZZ-type zinc fingers.
genes like me logo Genes that share domains with ZZEF1: view

Function for ZZEF1 Gene

Gene Ontology (GO) - Molecular Function for ZZEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZZEF1: view
genes like me logo Genes that share phenotypes with ZZEF1: view

Animal Models for ZZEF1 Gene

MGI Knock Outs for ZZEF1:

Animal Model Products

miRNA for ZZEF1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZZEF1 Gene

Localization for ZZEF1 Gene

Subcellular locations from

Jensen Localization Image for ZZEF1 Gene COMPARTMENTS Subcellular localization image for ZZEF1 gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZZEF1 Gene

Pathways & Interactions for ZZEF1 Gene

SuperPathways for ZZEF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZZEF1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZZEF1 Gene

Transcripts for ZZEF1 Gene

Unigene Clusters for ZZEF1 Gene

Zinc finger, ZZ-type with EF-hand domain 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZZEF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP4: - -
SP9: -
SP10: - -

ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b ^ 30a · 30b ^ 31 ^ 32a · 32b · 32c ^ 33 ^
SP2: - - -
SP5: - -
SP6: - -
SP7: -
SP8: -
SP12: -
SP14: -

ExUns: 34 ^ 35 ^ 36

Relevant External Links for ZZEF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZZEF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZZEF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZZEF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.7) and Synovial fluid (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZZEF1 Gene

Protein tissue co-expression partners for ZZEF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZZEF1 Gene:


SOURCE GeneReport for Unigene cluster for ZZEF1 Gene:


mRNA Expression by UniProt/SwissProt for ZZEF1 Gene:

Tissue specificity: Expressed at low levels in cerebellum.
genes like me logo Genes that share expression patterns with ZZEF1: view

Primer Products

No data available for mRNA differential expression in normal tissues for ZZEF1 Gene

Orthologs for ZZEF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZZEF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZZEF1 34 35
  • 99.55 (n)
(Bos Taurus)
Mammalia ZZEF1 34 35
  • 89.43 (n)
(Rattus norvegicus)
Mammalia Zzef1 34
  • 88.34 (n)
(Mus musculus)
Mammalia Zzef1 34 16 35
  • 88.17 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
-- 35
  • 80 (a)
-- 35
  • 66 (a)
(Canis familiaris)
Mammalia ZZEF1 34 35
  • 86.5 (n)
(Monodelphis domestica)
Mammalia ZZEF1 35
  • 68 (a)
(Gallus gallus)
Aves ZZEF1 34 35
  • 73.41 (n)
(Anolis carolinensis)
Reptilia ZZEF1 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia zzef1 34
  • 66.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21226 34
(Danio rerio)
Actinopterygii zzef1 34 35
  • 63.11 (n)
Dr.14071 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
Species where no ortholog for ZZEF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZZEF1 Gene

Gene Tree for ZZEF1 (if available)
Gene Tree for ZZEF1 (if available)

Paralogs for ZZEF1 Gene

Paralogs for ZZEF1 Gene

genes like me logo Genes that share paralogs with ZZEF1: view

Variants for ZZEF1 Gene

Sequence variations from dbSNP and Humsavar for ZZEF1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1006149 -- 4,041,984(+) TAAGC(A/G)TAATA intron-variant
rs1006954 -- 4,044,239(-) GCCCA(C/T)CTACA nc-transcript-variant, reference, missense
rs10521127 -- 4,074,974(+) CTTCC(C/T)TTCAC intron-variant
rs10521129 -- 4,105,526(+) AAATA(A/G)TGGAC intron-variant
rs10522603 -- 4,087,807(+) ACACA(-/CACACACACACACACACACA)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZZEF1 Gene

Variant ID Type Subtype PubMed ID
dgv3086n100 CNV gain 25217958
dgv557e214 CNV gain 21293372
esv1086827 CNV insertion 17803354
esv1422120 CNV deletion 17803354
esv1786350 CNV deletion 17803354
esv2391084 CNV deletion 18987734
esv25456 CNV loss 19812545
esv2656666 CNV deletion 23128226
esv2660488 CNV deletion 23128226
esv2676873 CNV deletion 23128226
esv2715546 CNV deletion 23290073
esv2715547 CNV deletion 23290073
esv2715548 CNV deletion 23290073
esv2751682 CNV gain 17911159
esv28297 CNV gain 19812545
esv3304335 CNV mobile element insertion 20981092
esv3310090 CNV mobile element insertion 20981092
esv3362445 CNV insertion 20981092
esv3392132 CNV insertion 20981092
esv3554030 CNV deletion 23714750
esv3639766 CNV loss 21293372
esv3639767 CNV loss 21293372
esv989391 CNV deletion 20482838
nsv1065237 CNV gain 25217958
nsv1065665 CNV gain 25217958
nsv1070797 CNV deletion 25765185
nsv1950 CNV insertion 18451855
nsv457647 CNV gain 19166990
nsv574266 CNV gain 21841781
nsv827861 CNV gain 20364138
nsv827862 CNV loss 20364138
nsv833344 CNV gain 17160897
nsv954568 CNV deletion 24416366
nsv954603 CNV deletion 24416366

Variation tolerance for ZZEF1 Gene

Residual Variation Intolerance Score: 0.639% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.07; 96.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZZEF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZZEF1 Gene

Disorders for ZZEF1 Gene

Relevant External Links for ZZEF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZZEF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZZEF1 Gene

Publications for ZZEF1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3 64

Products for ZZEF1 Gene

Sources for ZZEF1 Gene

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